MiMeDB: Showing metabocard for Dimethylamine (MMDBc0000022)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:27:31 UTC

Update Date

2022-08-30 23:03:52 UTC

Metabolite ID

MMDBc0000022

Metabolite Identification

Common Name

Dimethylamine

Description

Dimethylamine (DMA) is an organic secondary amine. It is a colorless, liquefied and flammable gas with an ammonia and fish-like odor. Dimethylamine is abundantly present in human urine. Main sources of urinary DMA have been reported to include trimethylamine N-oxide, a common food component, and asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis. ADMA is excreted in the urine in part unmetabolized and in part after hydrolysis to DMA by dimethylarginine dimethylaminohydrolase (DDAH). Statistically significant increases in urinary DMA have been found in individuals after the consumption of fish and seafoods. The highest values were obtained for individuals that consumed coley, squid and whiting with cod, haddock, sardine, skate and swordfish (PMID: 18282650 ). It has also been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821 ). As a pure chemical substance Dimethylamine is used as dehairing agent in tanning, in dyes, in rubber accelerators, in soaps and cleaning compounds and as an agricultural fungicide. In the body, DMA also undergoes nitrosation under weak acid conditions to give dimethlynitrosamine. Study has shown that DMA is a metabolite of Arthrobacter and Micrococcus (PMID: 11422368 ; PMID: 7191 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

Synonyms

Value	Source
DMA	ChEBI
HNMe2	ChEBI
Me2nh	ChEBI
N,N-Dimethylamine	ChEBI
(CH3)2nh	Kegg
Dimethylamine anhydrous	HMDB
Dimethylamine anhydrous (dot)	HMDB
Dimethylamine aqueous solution	HMDB
Dimethylamine hydrobromide	HMDB
Dimethylamine solution	HMDB
N-Methyl-methanamine	HMDB
N-Methylmethanamine	HMDB
N-Methylmethanamine (acd/name 4.0)	HMDB
Dimethylamine nitrate	HMDB
Dimethylamine perchlorate	HMDB
Dimethylamine sulfate	HMDB
Dimethylamine hydrochloride	HMDB
Dimethylamine phosphate (3:1)	HMDB
Dimethylamine, conjugate acid	HMDB
Dimethylammonium chloride	HMDB
Dimethylamine sulfate (1:1)	HMDB
Dimethylammonium formate	HMDB
Dimethylamine monosulfate	HMDB

Molecular Formula

C₂H₇N

Average Mass

45.0837

Monoisotopic Mass

45.057849229

IUPAC Name

dimethylamine

Traditional Name

dimethylamine

CAS Registry Number

124-40-3

SMILES

CNC

InChI Identifier

InChI=1S/C2H7N/c1-3-2/h3H,1-2H3

InChI Key

ROSDSFDQCJNGOL-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen.

Kingdom

Organic compounds

Super Class

Organic nitrogen compounds

Class

Organonitrogen compounds

Sub Class

Amines

Direct Parent

Dialkylamines

Alternative Parents

Substituents

Secondary aliphatic amine
Organopnictogen compound
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

methylamines (CHEBI:17170 )
secondary aliphatic amine (CHEBI:17170 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	516 g/L	ALOGPS
logP	-0.53	ALOGPS
logP	-0.19	ChemAxon
logS	1.06	ALOGPS
pKa (Strongest Basic)	10.52	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	12.03 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	14.69 m³·mol⁻¹	ChemAxon
Polarizability	5.75 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-0006-9000000000-cfb8e10b3b28eba99793	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-0006-9000000000-cfb8e10b3b28eba99793	2018-05-18	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0002-9000000000-398c710ba4ea34342a91	2017-09-01	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI M-80B) , Positive	splash10-0006-9000000000-8b085007dc085a460422	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0002-9000000000-103f1d373ec0d015b807	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0002-9000000000-df28f146170e28bfcb5e	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-0002-9000000000-cd82fdde4d83a74d83f1	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-00wc-9100000000-aeb1521c62f5010e11aa	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-017i-9101000000-c269a0887eed5daf0e28	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0002-9000000000-103f1d373ec0d015b807	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0002-9000000000-df28f146170e28bfcb5e	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0002-9000000000-17646ed4f7c44ba14045	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-00wc-9100000000-aeb1521c62f5010e11aa	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-017i-9101000000-c269a0887eed5daf0e28	2017-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0002-9000000000-933c4b104db02265ac4a	2017-09-01	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0002-9000000000-e85cf853d2e7110d18c1	2017-09-01	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-014j-9000000000-2032c41c4ca525ff4e1c	2017-09-01	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0006-9000000000-32c57cc32d61a2feae23	2017-09-01	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0006-9000000000-36fe99d2cc96e560f509	2017-09-01	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9000000000-8914e111239eacc36328	2017-09-01	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0006-9000000000-46fb6b0f3d2dcd71d159	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0006-9000000000-46fb6b0f3d2dcd71d159	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9000000000-46fb6b0f3d2dcd71d159	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0002-9000000000-e97e92727205304cdb09	2021-09-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0002-9000000000-e97e92727205304cdb09	2021-09-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0006-9000000000-9cf36baccac69593c69f	2021-09-23	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-0006-9000000000-8ae4e0d1cb5c91c730c0	2014-09-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)		2012-12-04	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)		2012-12-04	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-29	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)		2021-10-10	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)		2012-12-04	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Blood
Cerebrospinal Fluid (CSF)
Feces
Fibroblasts
Neuron
Saliva
Sweat
Urine

Tissue Locations

Fibroblasts
Neuron

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191832	Amine oxidase [flavin-containing] B	Unknown	P27338	Homo sapiens
MMDBp0191840	Amine oxidase [flavin-containing] A	Unknown	P21397	Homo sapiens
MMDBp0192389	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Unknown	O94760	Homo sapiens
MMDBp0192390	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	Enzyme	O95865	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0008371	Asymmetric dimethylarginine	Citrulline	Not Available	NG,NG-Dimethyl-L-arginine dimethylamidohydrolase	VMH	30371894
MMDBr0010689	Asymmetric dimethylarginine	Citrulline	Dimethylarginine dimethylaminohydrolase 1	Nomega, Nomega'-Dimethyl-L-Arginine Dimethylamidohydrolase	VMH	30371894
MMDBr0012869	Dimethylamine	Formaldehyde	Dimethylamine dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0013057	Hydrogen Ion	Dimethylamine	Trimethylamine dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0013641	Water	Dimethylamine	N(G),N(G)-dimethylarginine dimethylaminohydrolase	Hydrolysis of bond	RHEA	34755880
MMDBr0013888	Water	Dimethylamine	N,N-dimethylformamidase alpha subunit	Amide hydrolysis	RHEA	34755880
MMDBr0015695	cobalt(+)	Dimethylamine	Trimethylamine methyltransferase MttB	Methylation	RHEA	34755880
MMDBr0015773	cobalt(+)	methyl-Co(2+)	Dimethylamine methyltransferase MtbB1	Methylation	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Diabetes mellitus type 2	Slight Decrease	Association	Human Urine	HMDB	7758205
Kidney disease		Association	Human Blood	HMDB	9174262
Rhabdomyolysis	Increased	Association	Human Urine	HMDB	12089184
Uremia	Increased	Association	Human Blood	HMDB	22626821
Eosinophilic esophagitis		Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Eosinophilic esophagitis		Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Diabetes mellitus type 1		Association	Human Urine	HMDB	Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Firmicutes	45	Human feces; Human stool; Human	Microbial culture; Metabolic reconstruction
Archaea	Euryarchaeota	2		Microbial culture
Bacteria	Bacteroidetes	18	Human feces; Human ; Human urine; Human stool; Human saliva; Human supragingival plaque; Human subgingival plaque	Microbial culture; Metabolic reconstruction
Bacteria	Actinobacteria	22	Human feces; Human ; Human stool; Human saliva; Human mucosa	Microbial culture; Metabolic reconstruction
Bacteria	Proteobacteria	22	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool	Microbial culture; Metabolic reconstruction
Bacteria	Fusobacteria	2	Human feces	Metabolic reconstruction
Bacteria	Tenericutes	1	Human feces	Metabolic reconstruction
Bacteria	Planctomycetes	1	Human feces	Metabolic reconstruction
Bacteria/NULL	Proteobacteria	1	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool	Microbial culture; Metabolic reconstruction
Archaea/Archaea	Euryarchaeota	4		Microbial culture
Archaea/Archaea	nah	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference
Animal	Milk	Bos taurus	FooDB	31437929
Animal	Milk	Bos taurus	FooDB	31437929
Animal	Milk	Bos taurus	FooDB	31437929
Animal	Milk	Bos taurus	FooDB	31437929
Animal	Milk	Bos taurus	FooDB	31437929
Animal	Milk	Bos taurus	FooDB	31437929
Animal	Milk	Bos taurus	FooDB	31437929
Food			FooDB	31437929
Food			FooDB	31437929
Plant	Seed	Glycine max	FooDB	31437929
Plant	Fruit juice	Vitis vinifera	FooDB	31437929
Plant	Leaves	Brassica oleracea l. var. capitata l. f. alba dc.	FooDB	31437929
Plant	Leaves	Brassica oleracea var. capitata	FooDB	31437929
Plant	Stem	Apium graveolens	FooDB	31437929
Plant	Fruit	Musa x paradisiaca	FooDB	31437929

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Blood	Detected and Quantified	20.18		3.33	53.22	uM	Adult (>18 years old)	Both	Normal	HMDB	1576707
Human Urine	Detected and Quantified	35.268		6.543	159.703	umol/mmol creatinine	Adult (>18 years old)	Both	Bladder infections	HMDB	1576707
Human Urine	Detected and Quantified	25.4		8.22	42.7	umol/mmol creatinine	Adult (>18 years old)	Both	Diabetes	HMDB	7758205
Human Blood	Detected and Quantified	29.1	12.1			uM	Adult (>18 years old)	Both	Kidney disease	HMDB	9174262
Human Blood	Detected and Quantified	3.3	1.5			uM	Adult (>18 years old)	Both	Normal	HMDB	9174262
Human Urine	Detected and Quantified	25.2	1.2			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	9665433
Human Urine	Detected and Quantified	52				umol/mmol creatinine	Adult (>18 years old)	Female	Rhabdomyolysis	HMDB	12089184
Human Saliva	Detected and Quantified	136		9	262	uM	Adult (>18 years old)	Both	Normal	HMDB	12097436
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Blood	Detected and Quantified	1.43	0.23			uM	Adult (>18 years old)	Female	Normal	HMDB	17400039
Human Urine	Detected and Quantified	34.4	9.3			umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	17474139
Human Urine	Detected and Quantified	39.3	8.3			umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	17474139
Human Cerebrospinal fluid (csf)	Detected and Quantified	2	1			uM	Adult (>18 years old)	Both	Normal	HMDB	18502700
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	19167006
Human Saliva	Detected and Quantified			1	65	uM	Adult (>18 years old)	Male	normal	HMDB	19259987
Human Saliva	Detected and Quantified			1	30	uM	Adult (>18 years old)	Male	normal	HMDB	19259987
Human Saliva	Detected and Quantified	13		1	50	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Saliva	Detected and Quantified	13		1	44	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Saliva	Detected and Quantified	16		1	57	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Saliva	Detected and Quantified	11		2	27	uM	Adult (>18 years old)	Female	Normal	HMDB	19259987
Human Urine	Detected and Quantified	19.2				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	19309105
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21389975
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Autosomal dominant polycystic kidney disease (ADPKD)	HMDB	21389975
Human Sweat	Detected and Quantified	< 10				uM	Adult (40 years old)	Male	Normal	HMDB	22194922
Human Sweat	Detected and Quantified	< 10				uM	Adult (60 years old)	Male	Normal	HMDB	22194922
Human Blood	Detected and Quantified	3.5 (1.4)				uM	Adult (>18 years old)	Female	Early preeclampsia	HMDB	22494326
Human Blood	Detected and Quantified	4.0 (2.7)				uM	Adult (>18 years old)	Female	Pregnancy	HMDB	22494326
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Pancreatic cancer	HMDB	22613268
Human Blood	Detected and Quantified	228.46	35.49			uM	Adult (>18 years old)	Both	uremia	HMDB	22626821
Human Blood	Detected and Quantified	48.36	7.32			uM	Adult (>18 years old)	Both	Normal	HMDB	22626821
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22932811
Human Blood	Detected and Quantified	3.2 (1.7)				uM	Adult (>18 years old)	Female	Late-onset preeclampsia	HMDB	23159745
Human Blood	Detected and Quantified	4.4 (2.1)				uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23159745
Human Blood	Detected and Quantified	33.6 (19.0)				uM	Adult (>18 years old)	Female	Down syndrome pregnancy	HMDB	23313728
Human Blood	Detected and Quantified	49.1 (30.6)				uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23313728
Human Urine	Detected and Quantified	30.8		20.3	59.2	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected and Quantified	0.22				umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	25012580
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25670064
Human Feces	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	25985090
Human Urine	Detected and Quantified	78.9	29.2			umol/mmol creatinine	Children (1-13 years old)	Male	Duchenne Muscular Dystrophy	HMDB	26066683
Human Urine	Detected and Quantified	48.1	47.6			umol/mmol creatinine	Children (1-13 years old)	Male	Normal	HMDB	26066683
Human Urine	Detected and Quantified			20	60	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	31506554
Human Urine	Detected and Quantified	0.0005	0.00055			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	31775291
Human Saliva	Detected and Quantified	7.82	3.13			uM	Adult (>18 years old)	Both	Normal	HMDB	Zerihun T. Dame, Farid Aziat, Rupasri Mandal, Ram Krishnamurthy, Souhaila Bouatra, Shima Borzouie, An Chi Guo, Tanvir Sajed, Lu Deng, Hong Lin, Philip Liu, Edison Dong, David S. Wishart "The human saliva metabolome" Metabolomics (2015) DOI 10.1007/s11306-015-0840-5
Human Urine	Detected and Quantified	15.4394	7.28			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Gastroesophageal reflux disease	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	17.059	6.3921			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	17.5908	6.4589			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	56.531	42.872			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	56.97	42.793			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	25		22	28	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	30.35		16.3	50.36	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	Lorena Ivona STEFAN, Alina NICOLESCU, Simona POPA, Maria MOTA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037
Human Urine	Detected and Quantified	32.42		4.89	61.25	umol/mmol creatinine	Adult (>18 years old)	Both	Type 1 diabetes Mellitus	HMDB	Lorena Ivona STEFAN, Alina NICOLESCU, Simona POPA, Maria MOTA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037
Human Urine	Detected and Quantified	36.13				umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	Shaykhutdinov RA, MacInnis GD, Dowlatabadi R, Weljie AM, Vogel HJ. Quantitative analysis of metabolite concentrations in human urine samples using 13C{1H} NMR spectroscopy. Metabolomics. 2009
Human Urine	Detected and Quantified	35.268		6.543	159.703	umol/mmol creatinine	Adult (>18 years old)	Both	Bladder infections	HMDB	1576707
Human Urine	Detected and Quantified	25.4		8.22	42.7	umol/mmol creatinine	Adult (>18 years old)	Both	Diabetes	HMDB	7758205
Human Urine	Detected and Quantified	78.9	29.2			umol/mmol creatinine	Children (1-13 years old)	Male	Duchenne Muscular Dystrophy	HMDB	26066683
Human Blood	Detected and Quantified	3.5	1.4			uM	Adult (>18 years old)	Female	Early preeclampsia	HMDB	22494326
Human Blood	Detected and Quantified	29.1	12.1			uM	Adult (>18 years old)	Both	Kidney disease	HMDB	9174262
Human Blood	Detected and Quantified	3.2	1.7			uM	Adult (>18 years old)	Female	Late-onset preeclampsia	HMDB	23159745
Human Blood	Detected and Quantified	4.0	2.7			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	22494326
Human Blood	Detected and Quantified	4.4	2.1			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23159745
Human Blood	Detected and Quantified	49.1	30.6			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23313728
Human Urine	Detected and Quantified	52				umol/mmol creatinine	Adult (>18 years old)	Female	Rhabdomyolysis	HMDB	12089184
Human Blood	Detected and Quantified	228.46	35.49			uM	Adult (>18 years old)	Both	uremia	HMDB	22626821
Human Urine	Detected and Quantified	0.22				umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	25012580
Human Urine	Detected and Quantified	19.2				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	19309105
Human Saliva	Detected and Quantified			1	30	uM	Adult (>18 years old)	Male	normal	HMDB	19259987
Human Sweat	Detected and Quantified	< 10				uM	Adult (60 years old)	Male	Normal	HMDB	22194922
Human Sweat	Detected and Quantified	< 10				uM	Adult (40 years old)	Male	Normal	HMDB	22194922
Human Urine	Detected and Quantified	0.00050	0.00055			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	31775291
Human Saliva	Detected and Quantified			1	65	uM	Adult (>18 years old)	Male	normal	HMDB	19259987
Human Blood	Detected and Quantified	1.43	0.23			uM	Adult (>18 years old)	Female	Normal	HMDB	17400039
Human Saliva	Detected and Quantified	11		2	27	uM	Adult (>18 years old)	Female	Normal	HMDB	19259987
Human Saliva	Detected and Quantified	13		1	44	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Saliva	Detected and Quantified	13		1	50	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Saliva	Detected and Quantified	136		9.00	262	uM	Adult (>18 years old)	Both	Normal	HMDB	12097436
Human Saliva	Detected and Quantified	16		1	57	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Cerebrospinal fluid (csf)	Detected and Quantified	2.0	1.0			uM	Adult (>18 years old)	Both	Normal	HMDB	18502700
Human Urine	Detected and Quantified			20	60	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	31506554
Human Blood	Detected and Quantified	20.18		3.33	53.22	uM	Adult (>18 years old)	Both	Normal	HMDB	1576707
Human Urine	Detected and Quantified	25.2	1.2			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	9665433
Human Blood	Detected and Quantified	3.3	1.5			uM	Adult (>18 years old)	Both	Normal	HMDB	9174262
Human Urine	Detected and Quantified	30.8		20.3	59.2	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected and Quantified	34.4	9.3			umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	17474139
Human Urine	Detected and Quantified	39.3	8.3			umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	17474139
Human Urine	Detected and Quantified	48.1	47.6			umol/mmol creatinine	Children (1-13 years old)	Male	Normal	HMDB	26066683
Human Blood	Detected and Quantified	48.36	7.32			uM	Adult (>18 years old)	Both	Normal	HMDB	22626821
Human Urine	Detected and Quantified	17.5908	6.4589			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	56.531	42.872			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	32.42	4.89 ‚Äì 61.25			umol/mmol creatinine	Adult (>18 years old)	Both	Type 1 diabetes Mellitus	HMDB	Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037
Human Urine	Detected and Quantified	17.059	6.3921			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	56.97	42.793			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	25.0		22.0	28.0	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	30.35	16.30 ‚Äì 50.36			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037
Human Urine	Detected and Quantified	36.13				umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	Shaykhutdinov RA, MacInnis GD, Dowlatabadi R, Weljie AM, Vogel HJ. Quantitative analysis of metabolite concentrations in human urine samples using 13C{1H} NMR spectroscopy. Metabolomics. 2009
Human Saliva	Detected and Quantified	7.82	3.13			uM	Adult (>18 years old)	Both	Normal	HMDB	Zerihun T. Dame, Farid Aziat, Rupasri Mandal, Ram Krishnamurthy, Souhaila Bouatra, Shima Borzouie, An Chi Guo, Tanvir Sajed, Lu Deng, Hong Lin, Philip Liu, Edison Dong, David S. Wishart "The human saliva metabolome" Metabolomics (2015) DOI 10.1007/s11306-015-0840-5
Human Fibroblasts	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Neuron	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22932811
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21389975
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	19167006
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25670064
Human Feces	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	25985090

External Links

HMDB ID

HMDB0000087

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB012589

KNApSAcK ID

Not Available

Chemspider ID

654

KEGG Compound ID

C00543

BioCyc ID

DIMETHYLAMINE

BiGG ID

Not Available

Wikipedia Link

Dimethylamine

METLIN ID

3758

PubChem Compound

674

PDB ID

Not Available

ChEBI ID

17170

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. doi: 10.1177/154405910208100613. [PubMed:12097436 ]
Zeisel SH, daCosta KA, Youssef M, Hensey S: Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship. J Nutr. 1989 May;119(5):800-4. doi: 10.1093/jn/119.5.800. [PubMed:2723829 ]
Lee L, Archer MC, Bruce WR: Absence of volatile nitrosamines in human feces. Cancer Res. 1981 Oct;41(10):3992-4. [PubMed:7285009 ]
Sharif NA, Crider JY, Davis TL: AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonists. J Pharm Pharmacol. 2000 Dec;52(12):1529-39. doi: 10.1211/0022357001777586. [PubMed:11197083 ]
Hughes R, Dart J, Kilvington S: Activity of the amidoamine myristamidopropyl dimethylamine against keratitis pathogens. J Antimicrob Chemother. 2003 Jun;51(6):1415-8. doi: 10.1093/jac/dkg259. Epub 2003 Apr 25. [PubMed:12716783 ]
Le Moyec L, Racine S, Le Toumelin P, Adnet F, Larue V, Cohen Y, Leroux Y, Cupa M, Hantz E: Aminoglycoside and glycopeptide renal toxicity in intensive care patients studied by proton magnetic resonance spectroscopy of urine. Crit Care Med. 2002 Jun;30(6):1242-5. doi: 10.1097/00003246-200206000-00013. [PubMed:12072675 ]
Lee SH, Kim SO, Chung BC: Gas chromatographic-mass spectrometric determination of urinary oxoacids using O-(2,3,4,5,6-pentafluorobenzyl)oxime-trimethylsilyl ester derivatization and cation-exchange chromatography. J Chromatogr B Biomed Sci Appl. 1998 Nov 20;719(1-2):1-7. doi: 10.1016/s0378-4347(98)00388-0. [PubMed:9869358 ]
Mulder C, Wahlund LO, Blomberg M, de Jong S, van Kamp GJ, Scheltens P, Teerlink T: Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid. J Neural Transm (Vienna). 2002 Sep;109(9):1203-8. doi: 10.1007/s00702-002-0760-1. [PubMed:12203047 ]
Sweatman BC, Farrant RD, Holmes E, Ghauri FY, Nicholson JK, Lindon JC: 600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances. J Pharm Biomed Anal. 1993 Aug;11(8):651-64. doi: 10.1016/0731-7085(93)80171-v. [PubMed:8257730 ]
Messana I, Forni F, Ferrari F, Rossi C, Giardina B, Zuppi C: Proton nuclear magnetic resonance spectral profiles of urine in type II diabetic patients. Clin Chem. 1998 Jul;44(7):1529-34. [PubMed:9665433 ]
Nicholson JK, Foxall PJ, Spraul M, Farrant RD, Lindon JC: 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. Anal Chem. 1995 Mar 1;67(5):793-811. doi: 10.1021/ac00101a004. [PubMed:7762816 ]
Lichtenberger LM, Gardner JW, Barreto JC, Morriss FH Jr: Evidence for a role of volatile amines in the development of neonatal hypergastrinemia. J Pediatr Gastroenterol Nutr. 1991 Nov;13(4):342-6. doi: 10.1097/00005176-199111000-00002. [PubMed:1779307 ]
Zhang AQ, Mitchell SC, Smith RL: Dimethylamine in human urine. Clin Chim Acta. 1995 Jan 16;233(1-2):81-8. doi: 10.1016/0009-8981(95)91628-e. [PubMed:7758205 ]
Choi SY, Chung MJ, Sung NJ: Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate. Food Chem Toxicol. 2002 Jul;40(7):949-57. doi: 10.1016/s0278-6915(02)00025-x. [PubMed:12065217 ]
Kilvington S, Hughes R, Byas J, Dart J: Activities of therapeutic agents and myristamidopropyl dimethylamine against Acanthamoeba isolates. Antimicrob Agents Chemother. 2002 Jun;46(6):2007-9. doi: 10.1128/AAC.46.6.2007-2009.2002. [PubMed:12019127 ]
Mitchell SC, Zhang AQ, Smith RL: Dimethylamine and diet. Food Chem Toxicol. 2008 May;46(5):1734-8. doi: 10.1016/j.fct.2008.01.010. Epub 2008 Jan 15. [PubMed:18282650 ]
Meskys R, Harris RJ, Casaite V, Basran J, Scrutton NS: Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter spp.: implications for glycine betaine catabolism. Eur J Biochem. 2001 Jun;268(12):3390-8. doi: 10.1046/j.1432-1327.2001.02239.x. [PubMed:11422368 ]
Tate RL 3rd, Alexander M: Microbial formation and degradation of dimethylamine. Appl Environ Microbiol. 1976 Mar;31(3):399-403. doi: 10.1128/aem.31.3.399-403.1976. [PubMed:7191 ]
Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24. [PubMed:22626821 ]

Showing metabocard for Dimethylamine (MMDBc0000022)

MOL for #<Metabolite:0x00007f5a90778ae8>

3D MOL for #<Metabolite:0x00007f5a90778ae8>

3D SDF for #<Metabolite:0x00007f5a90778ae8>

3D-SDF for #<Metabolite:0x00007f5a90778ae8>

PDB for #<Metabolite:0x00007f5a90778ae8>

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Structure for #<Metabolite:0x00007f5a90778ae8>

3D Structure for #<Metabolite:0x00007f5a90778ae8>