MiMeDB: Showing metabocard for Tartaric acid (MMDBc0000175)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:38:37 UTC

Update Date

2022-08-30 23:59:44 UTC

Metabolite ID

MMDBc0000175

Metabolite Identification

Common Name

Tartaric acid

Description

Tartaric acid is a white crystalline organic acid. It occurs naturally in many plants, particularly grapes and tamarinds, and is one of the main acids found in wine. It is added to other foods to give a sour taste, and is used as an antioxidant. Salts of tartaric acid are known as tartrates. It is a dihydroxy derivative of dicarboxylic acid. Tartaric acid is a muscle toxin, which works by inhibiting the production of malic acid, and in high doses causes paralysis and death. The minimum recorded fatal dose for a human is about 12 grams. In spite of that, it is included in many foods, especially sour-tasting sweets. As a food additive, tartaric acid is used as an antioxidant with E number E334, tartrates are other additives serving as antioxidants or emulsifiers. Naturally-occurring tartaric acid is chiral, meaning that it has molecules that are non-superimposable on their mirror-images. It is a useful raw material in organic chemistry for the synthesis of other chiral molecules. The naturally occurring form of the acid is L-(+)-tartaric acid or dextrotartaric acid. The mirror-image (enantiomeric) form, levotartaric acid or D-(-)-tartaric acid, and the achiral form, mesotartaric acid, can be made artificially. Tartarate is believed to play a role in inhibiting kidney stone formation. Most tartarate that is consumed by humans is metabolized by bacteria in the gastrointestinal tract -- primarily in the large instestine. Only about 15-20% of consumed tartaric acid is secreted in the urine unchanged. Tartaric acid is a biomarker for the consumption of wine and grapes (PMID: 24507823 ). Tartaric acid is also a fungal metabolite, elevated levels in the urine (especially in children) may be due to the presence of yeast (in the gut or bladder). It can be produced by Agrobacterium, Nocardia, Rhizobium, Saccharomyces as well (PMID: 7628083 ) (https://link.springer.com/article/10.1023/A:1005592104426). High levels of tartaric acid have been found in autistic children. In adults, tartaric acid may be due to the consumption of wine (https://www.greatplainslaboratory.com/articles-1/2015/11/13/candida-and-overgrowth-the-problem-bacteria-by-products) (PMID: 15738524 ; PMID: 24507823 ; PMID: 7628083 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

Synonyms

Value	Source
(+)-(R,R)-Tartaric acid	ChEBI
(+)-L-Tartaric acid	ChEBI
(+)-Tartaric acid	ChEBI
(+)-Weinsaeure	ChEBI
(2R,3R)-2,3-Dihydroxybernsteinsaeure	ChEBI
(2R,3R)-2,3-Dihydroxysuccinic acid	ChEBI
(2R,3R)-Tartaric acid	ChEBI
(R,R)-(+)-Tartaric acid	ChEBI
(R,R)-Tartaric acid	ChEBI
L(+)-TARTARIC ACID	ChEBI
L-Threaric acid	ChEBI
Rechtsweinsaeure	ChEBI
Weinsteinsaeure	ChEBI
(R,R)-Tartrate	Kegg
L-Tartaric acid	Kegg
Tartrate	Kegg
2,3-Dihydroxybutanedioic acid	Kegg
(+)-(R,R)-Tartarate	Generator
(+)-L-Tartarate	Generator
(+)-Tartarate	Generator
(2R,3R)-2,3-Dihydroxysuccinate	Generator
(2R,3R)-Tartarate	Generator
(R,R)-(+)-Tartarate	Generator
(R,R)-Tartarate	Generator
L(+)-TARTARate	Generator
L-Threarate	Generator
(R,R)-Tartric acid	Generator
L-Tartarate	Generator
Tartric acid	Generator
2,3-Dihydroxybutanedioate	Generator
Tartarate	Generator
Aluminum tartrate	HMDB
Ammonium tartrate	HMDB
Potassium tartrate	HMDB
Seignette salt	HMDB
Sodium ammonium tartrate	HMDB
Stannous tartrate	HMDB
Tartaric acid, calcium salt, (R-r,r)-isomer	HMDB
Calcium tartrate tetrahydrate	HMDB
Sodium tartrate	HMDB
Tartaric acid, ((r,r)-(+-))-isomer	HMDB
Tartaric acid, monoammonium salt, (R-(r,r))-isomer	HMDB
(R,r)-(+-)-2,3-dihydroxybutanedioic acid, monoammonium monosodium salt	HMDB
MN(III) tartrate	HMDB
Calcium tartrate	HMDB
Tartaric acid, (R-(r,r))-isomer	HMDB
Sodium potassium tartrate	HMDB
Tartaric acid, (r,s)-isomer	HMDB
Tartaric acid, (S-(r,r))-isomer	HMDB
Tartaric acid, ammonium sodium salt, (1:1:1) salt, (r,r)-(+-)-isomer	HMDB
(+)-(2R,3R)-Tartaric acid	HMDB
(1R,2R)-1,2-Dihydroxyethane-1,2-dicarboxylic acid	HMDB
(2R,3R)-2,3-Dihydroxybutanedioate	HMDB
(2R,3R)-2,3-Dihydroxybutanedioic acid	HMDB
(2R,3R)-2,3-Tartaric acid	HMDB
1,2-Dihydroxyethane-1,2-dicarboxylic acid	HMDB
2,3-Dihydroxy-succinate	HMDB
2,3-Dihydroxy-succinic acid	HMDB
2,3-Dihydroxysuccinic acid	HMDB
D-a,b-Dihydroxysuccinic acid	HMDB
D-Tartaric acid	HMDB
Dextrotartaric acid	HMDB
L-(+)-Tartaric acid	HMDB
Natural tartaric acid	HMDB
TAR	HMDB
Threaric acid	HMDB
TLA	HMDB
Weinsaeure	HMDB
(2R,3R)-(+)-Tartaric acid	HMDB
Dihydroxysuccinic acid	HMDB
Tartaric acid	HMDB

Molecular Formula

C₄H₆O₆

Average Mass

150.0868

Monoisotopic Mass

150.016437924

IUPAC Name

(2R,3R)-2,3-dihydroxybutanedioic acid

Traditional Name

L(+)-tartaric acid

CAS Registry Number

87-69-4

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/m1/s1

InChI Key

FEWJPZIEWOKRBE-JCYAYHJZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sugar acids and derivatives. Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Sugar acids and derivatives

Alternative Parents

Substituents

Sugar acid
Short-chain hydroxy acid
Beta-hydroxy acid
Fatty acid
Monosaccharide
Hydroxy acid
Dicarboxylic acid or derivatives
Alpha-hydroxy acid
Secondary alcohol
1,2-diol
Carboxylic acid
Carboxylic acid derivative
Organic oxide
Hydrocarbon derivative
Carbonyl group
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

tartaric acid (CHEBI:15671 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	161 g/L	ALOGPS
logP	-1.3	ALOGPS
logP	-1.8	ChemAxon
logS	0.03	ALOGPS
pKa (Strongest Acidic)	2.72	ChemAxon
pKa (Strongest Basic)	-4.3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	115.06 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	26.21 m³·mol⁻¹	ChemAxon
Polarizability	11.33 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-0002-0930000000-19235937e21066a9c484	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (4 TMS)	splash10-000f-0961000000-559c31b016f4fb3700d2	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-0007-0961000000-1b17d674621eb9d88c3c	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0002-0930000000-19235937e21066a9c484	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-000f-0961000000-559c31b016f4fb3700d2	2017-09-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0096-9200000000-df0ce9fba754b55674b1	2017-08-28	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_2) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_3) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_4) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_3_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_3_2) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_4_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_2) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_3) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_2_4) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_3_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_3_2) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_4_1) - 70eV, Positive	Not Available	2021-11-06	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)	splash10-000b-7900000000-d247ec12b77f427e9a76	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)	splash10-05fu-9000000000-4bf01ad116d24a453817	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)	splash10-0006-9000000000-4da65da10f3a34f77688	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0900000000-ecb902731b9f6eb3764d	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0072-9700000000-1e8e6f410c1d71af856e	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-00di-9000000000-f13ad2560d3e6818db9c	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-05fu-9000000000-f46a01eb933ba6fbceac	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-08dec35ca6a80add253a	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0002-0900000000-ecb902731b9f6eb3764d	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0072-9700000000-1e8e6f410c1d71af856e	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-00di-9000000000-f13ad2560d3e6818db9c	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-05fu-9000000000-f46a01eb933ba6fbceac	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-08dec35ca6a80add253a	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-05fu-9000000000-2bc9b64b80733677dbe6	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9000000000-e65d82322cd0037aa733	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-0072-9600000000-0276f4093011ce886f64	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-007a-9300000000-5ad0de9efcf7b25ff3dc	2021-09-20	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0ue9-1900000000-6a73140cfa5a0c0234e3	2017-07-25	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-056r-9600000000-ca8758d1e65f5dbe35d9	2017-07-25	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0a70-9100000000-1630b812321816f95d11	2017-07-25	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-05bb-7900000000-146a1c7b189a7bbacda0	2017-07-26	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0a4i-9500000000-f7af07684007cf14bdce	2017-07-26	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-9000000000-a8f5502da9e4d13e4144	2017-07-26	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0a4s-4900000000-4b81a8a41abed679d134	2021-09-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0a4i-9200000000-b73e0df104053da76268	2021-09-23	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-056r-9000000000-16517a02beb9427ceaff	2019-05-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)		2012-12-04	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-16	View Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)		2012-12-04	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)		2012-12-05	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Adipose Tissue
Blood
Feces
Platelet
Prostate
Urine

Tissue Locations

Adipose Tissue
Platelet
Prostate

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191770	Tartrate-resistant acid phosphatase type 5	Unknown	P13686	Homo sapiens
MMDBp0191771	Prostatic acid phosphatase	Enzyme	P15309	Homo sapiens
MMDBp0194109	Lysophosphatidic acid phosphatase type 6	Enzyme	Q9NPH0	Homo sapiens
MMDBp0196039	Testicular acid phosphatase	Enzyme	Q9BZG2	Homo sapiens
MMDBp0196206	Putative uncharacterized protein ACP1	Enzyme	B5MCC7	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0013208	Tartaric acid	Glyceric acid	Probable tartrate dehydrogenase/decarboxylase	Decarboxylation	RHEA	34755880
MMDBr0013402	Tartaric acid	2-Hydroxy-3-oxosuccinate	Probable tartrate dehydrogenase/decarboxylase	Decarboxylation	RHEA	34755880
MMDBr0013425	Tartaric acid	Water	L(+)-tartrate dehydratase subunit alpha	Hydration/dehydration of C-O bond	RHEA	34755880
MMDBr0019152	Tartaric acid	Oxalacetic acid	L(+)-tartrate dehydratase subunit alpha	Hydration/dehydration of C-O bond	PathBank	31602464
MMDBr0019153	Tartaric acid	Hydrogen Ion	D-malate dehydrogenase [decarboxylating]	Dehydrogenation	PathBank	31602464

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Lung cancer		Association	Human Urine	HMDB	22157537

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	12	Human ; Human feces	Microbial culture
Bacteria	Actinobacteria	1		Microbial culture
Bacteria	Firmicutes	1	Human feces
Bacteria/NULL	Proteobacteria	1	Human ; Human feces	Microbial culture
Archaea/Archaea	Euryarchaeota	1
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference
Food			FooDB	31437929
Food			FooDB	31437929
Food			FooDB	31437929
Food			FooDB	31437929
Food			FooDB	31437929
Plant	Fruit	Punica granatum	FooDB	31437929
Plant	Root	Beta vulgaris var. rubra	FooDB	31437929
Plant	Fruit	Prunus domestica	FooDB	31437929
Plant	Flower	Hibiscus sabdariffa	FooDB	31437929
Plant	Fruit	Prunus armeniaca	FooDB	31437929
Plant	Fruit	Persea americana	FooDB	31437929
Plant	Fruit	Prunus cerasus	FooDB	31437929
Plant	Plant	Cichorium intybus	FooDB	31437929
Plant	Plant	Taraxacum officinale	FooDB	31437929
Plant	Leaves	Lactuca sativa	FooDB	31437929
Plant	Fruit	Solanum lycopersicum var. lycopersicum	FooDB	31437929
Plant	Fruit	Vitis vinifera	FooDB	31437929
Plant	Fruit	Ribes rubrum	FooDB	31437929
Plant	Root	Apium graveolens	FooDB	31437929
Plant	Plant	Annona squamosa	FooDB	31437929
Plant	Root	Daucus carota ssp. sativus	FooDB	31437929
Plant	Fruit	Averrhoa carambola	FooDB	31437929
Plant	Seed	Theobroma cacao	FooDB	31437929
Plant	Bulb	Allium cepa	FooDB	31437929
Plant	Plant	Capparis spinosa	FooDB	31437929
Plant	Fruit	Tamarindus indica	FooDB	31437929
Plant	Root	Petroselinum crispum	FooDB	31437929
Plant	Seed	Cydonia oblonga	FooDB	31437929
Plant	Fruit	Ribes uva-crispa	FooDB	31437929
Plant	Fruit	Ficus carica	FooDB	31437929
Plant	Seed	Foeniculum vulgare	FooDB	31437929
Plant	Leaves	Tamarindus indica	FooDB	31437929
Plant	Root	Daucus carota	FooDB	31437929
Plant	Fruit	Carica papaya	FooDB	31437929
Plant	Leaves	Rumex acetosa	FooDB	31437929
Plant	Fruit	Musa x paradisiaca	FooDB	31437929
Plant	Seed	Helianthus annuus	FooDB	31437929
Plant	Plant	Solanum tuberosum	FooDB	31437929

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Urine	Detected and Quantified	12		1.3	46	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	2702744
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	20573794
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21389975
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Autosomal dominant polycystic kidney disease (ADPKD)	HMDB	21389975
Human Urine	Detected and Quantified	5		0	25	umol/mmol creatinine	Not Specified	Both	Lung cancer	HMDB	22157537
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Cardiosvacular risk	HMDB	22887155
Human Urine	Detected and Quantified	11.8		2.6	64.4	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Colorectal cancer	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25670064
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Bladder cancer	HMDB	28157703
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Urine	Detected and Quantified			0	60	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	31506554
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Urine	Detected and Quantified	13.217	13.438			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	38.183	53.107			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Diabetes mellitus	HMDB	Rosa Va ́zquez-Fresno et al. An NMR metabolomics approach reveals a combined-biomarkers model in a wine interventional trial with validation in free-living individuals of the PREDIMED study. Metabolomics (2015) 11:797- 806
Human Urine	Detected and Quantified	5		0	25	umol/mmol creatinine	Not Specified	Both	Lung cancer	HMDB	22157537
Human Urine	Detected and Quantified			0	60	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	31506554
Human Urine	Detected and Quantified	11.8		2.6	64.4	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected and Quantified	12		1.3	46	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	2702744
Human Urine	Detected and Quantified	38.183	53.107			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Adipose tissue	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Platelet	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Prostate	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21389975
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25670064
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	20573794
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

HMDB ID

HMDB0000956

DrugBank ID

DB09459

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB001113

KNApSAcK ID

C00001206

Chemspider ID

Not Available

KEGG Compound ID

C00898

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Tartaric acid

METLIN ID

Not Available

PubChem Compound

444305

PDB ID

Not Available

ChEBI ID

15671

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Petrarulo M, Marangella M, Bianco O, Linari F: Ion-chromatographic determination of L-tartrate in urine samples. Clin Chem. 1991 Jan;37(1):90-3. [PubMed:1988215 ]
Shaw W, Kassen E, Chaves E: Increased urinary excretion of analogs of Krebs cycle metabolites and arabinose in two brothers with autistic features. Clin Chem. 1995 Aug;41(8 Pt 1):1094-104. [PubMed:7628083 ]
Lord RS, Burdette CK, Bralley JA: Significance of urinary tartaric acid. Clin Chem. 2005 Mar;51(3):672-3. doi: 10.1373/clinchem.2004.036368. [PubMed:15738524 ]
Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
Regueiro J, Vallverdu-Queralt A, Simal-Gandara J, Estruch R, Lamuela-Raventos RM: Urinary tartaric acid as a potential biomarker for the dietary assessment of moderate wine consumption: a randomised controlled trial. Br J Nutr. 2014 May;111(9):1680-5. doi: 10.1017/S0007114513004108. Epub 2014 Feb 10. [PubMed:24507823 ]

Showing metabocard for Tartaric acid (MMDBc0000175)

MOL for #<Metabolite:0x00007f5abde90100>

3D MOL for #<Metabolite:0x00007f5abde90100>

3D SDF for #<Metabolite:0x00007f5abde90100>

3D-SDF for #<Metabolite:0x00007f5abde90100>

PDB for #<Metabolite:0x00007f5abde90100>

3D PDB for #<Metabolite:0x00007f5abde90100>

SMILES for #<Metabolite:0x00007f5abde90100>

INCHI for #<Metabolite:0x00007f5abde90100>

Structure for #<Metabolite:0x00007f5abde90100>

3D Structure for #<Metabolite:0x00007f5abde90100>