MiMeDB: Showing metabocard for Methane (MMDBc0000219)

Read more...Show more...

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:40:13 UTC

Update Date

2024-10-09 20:49:32 UTC

Metabolite ID

MMDBc0000219

Metabolite Identification

Common Name

Methane

Description

Methane (CH4), is a gas produced by a group of colonic anaerobes, absorbed from the colon and excreted in expired air. As a result, breath CH4 excretion can be used as an indicator of the in situ activity of the methanogenic flora. All CH4 produced in human beings is a metabolic product of intestinal bacteria, and about 50% of CH4 produced in the gut is absorbed and excreted in expired air. Because there appears to be no catabolism of this gas by other colonic organisms or host cells, breath CH4 measurements provide a rapid, simple means of semi quantitatively assessing the ongoing in situ metabolism of the methanogenic flora. It could seem likely that the intracolonic activity of a variety of bacteria similarly might be assessed quantitatively via analysis of expired air. However, the application of this methodology has been confounded by the rapid catabolism of many volatile bacterial products by other bacteria or human tissue. A striking aspect of the studies of breath CH4 measurements is the enormous individual variations in the excretion of this gas. Virtually all children under 5 years of age and 66% of the adult population do not exhale appreciable quantities of CH4. The remaining 34% of the adult population has appreciable breath methane concentrations of up to 80 ppm (mean, 15.2 ppm; median, 11.8 ppm). On this basis the population can be divided into CH4 producers or nonproducers, although a more accurate term would be to define subjects as being low or high CH4 producers. The primary methanogen present in the human colon, Methanobrevibacter smithii, produces methane via a reaction that relies entirely on H2 produced by other organisms to reduce CO2 to CH4. Thus, breath CH4 concentrations might be expected to mirror breath H2 concentrations; however, the high levels of CH4 observed in the fasting state may result from H2 derived from endogenous rather than dietary substrates. A diverse assortment of conditions has been associated with a high prevalence of methane producers including diverticulosis, cystic fibrosis, high fasting serum cholesterol levels, encopresis in children, and aorto-iliac vascular disease, whereas obesity (measured as skin-fold thickness) was related inversely to methane production. The challenge that remains is to determine to what extent methanogens actively influence body physiology vs. simply serve as passive indicators of colonic function. (PMID: 16469670 , Clinical Gastroenterology and Hepatology Volume 4, Issue 2, February 2006, Pages 123-129). Methane can be found in Desulfovibrio, Methanobacterium, Methanobrevibacter, Methanococcus, Methanocorpusculum, Methanoculleus, Methanoflorens, Methanofollis, Methanogenium, Methanomicrobium, Methanopyrus, Methanoregula, Methanosaeta, Methanosarcina, Methanosphaera, Methanospirillium, Methanothermobacter (Wikipedia ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

Synonyms

Value	Source
CH4	ChEBI
Marsh gas	ChEBI
Metano	ChEBI
Methan	ChEBI
Methyl hydride	ChEBI
Acticarbone	HMDB
Adsorbit	HMDB
Anthrasorb	HMDB
Aquadag	HMDB
Aroflow	HMDB
Arogen	HMDB
Arotone	HMDB
Arovel	HMDB
Arrow	HMDB
Atlantic	HMDB
Biogas	HMDB
Cancarb	HMDB
Canesorb	HMDB
Canlub	HMDB
Carbene	HMDB
Carbodis	HMDB
Carbolac	HMDB
Carbomet	HMDB
Carbone	HMDB
Carbonium	HMDB
Carbono	HMDB
Carbosieve	HMDB
Cecarbon	HMDB
Collocarb	HMDB
Conductex	HMDB
Continex	HMDB
Croflex	HMDB
Crolac	HMDB
Darco	HMDB
Degussa	HMDB
Electrographite	HMDB
Elftex	HMDB
Essex	HMDB
Excelsior	HMDB
Farbruss	HMDB
Fecto	HMDB
Filtrasorb	HMDB
Fire dAMP	HMDB
Flamruss	HMDB
Furnal	HMDB
Furnex	HMDB
Gastex	HMDB
Grafoil	HMDB
Grosafe	HMDB
Huber	HMDB
Humenegro	HMDB
Hydrodarco	HMDB
Kohlenstoff	HMDB
Korobon	HMDB
Kosmink	HMDB
Kosmobil	HMDB
Kosmolak	HMDB
Kosmos	HMDB
Kosmotherm	HMDB
Kosmovar	HMDB
Lampblack	HMDB
Magecol	HMDB
Metanex	HMDB
Methane in gaseus STate	HMDB
Methylene	HMDB
Methylidyne	HMDB
Micronex	HMDB
Modulex	HMDB
Molacco	HMDB
Neotex	HMDB
Nuchar	HMDB
Papyex	HMDB
Pelletex	HMDB
Philblack	HMDB
Plumbago	HMDB
Printex	HMDB
R 50	HMDB
Rebonex	HMDB
Schungite	HMDB
Sevacarb	HMDB
Shungite	HMDB
Spheron	HMDB
Statex	HMDB
Superba	HMDB
Thermatomic	HMDB
Thermax	HMDB
Thermblack	HMDB
Tinolite	HMDB
Watercarb	HMDB

Molecular Formula

CH₄

Average Mass

16.0425

Monoisotopic Mass

16.031300128

IUPAC Name

methane

Traditional Name

methane

CAS Registry Number

74-82-8

SMILES

InChI Identifier

InChI=1S/CH4/h1H4

InChI Key

VNWKTOKETHGBQD-UHFFFAOYSA-N

Chemical Taxonomy

Functional Ontology

Physical Properties

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-014i-9000000000-42e2bf163f3e1178d2b7	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-014i-9000000000-42e2bf163f3e1178d2b7	2018-05-18	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-014i-9000000000-c8167f7817582bf388a4	2017-09-01	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-9000000000-9d8342b86bcfe423c16e	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-014i-9000000000-9d8342b86bcfe423c16e	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-014i-9000000000-9d8342b86bcfe423c16e	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-014i-9000000000-c888af3d1348fef91ee6	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-014i-9000000000-c888af3d1348fef91ee6	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-014i-9000000000-c888af3d1348fef91ee6	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-014i-9000000000-996987cf9a722fe9a805	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-014i-9000000000-996987cf9a722fe9a805	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-014i-9000000000-996987cf9a722fe9a805	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-9000000000-cc06d3599ff6d095d471	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-014i-9000000000-cc06d3599ff6d095d471	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-014i-9000000000-cc06d3599ff6d095d471	2021-09-22	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-014i-9000000000-349ab823203cc040e2ee	2014-09-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, CCl₄, experimental)		2014-09-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-25	View Spectrum

Biological Properties

Human Proteins and Enzymes

Human Pathways

Metabolic Reactions

Health Effects and Bioactivity

Microbial Sources

Exposure Sources

Host Biospecimen and Location

External Links

References

General References

Poyart C, Bursaux E, Freminet A, Bertin M: Interactions of short chain aliphatic hydrocarbons with human blood and haemoglobin A solutions. Biomedicine. 1976 Jul;25(6):224-7. [PubMed:963185 ]
Supko JG, Malspeis L: Characterization of the urinary metabolites of merbarone in cancer patients. Drug Metab Dispos. 1991 Jan-Feb;19(1):263-73. [PubMed:1673412 ]
Masson P, Marnot B, Lombard JY, Morelis P: [Electrophoretic study of aged butyrylcholinesterase after inhibition by soman]. Biochimie. 1984 Mar;66(3):235-49. doi: 10.1016/0300-9084(84)90067-1. [PubMed:6331528 ]
Escobar R, Cano Pavon JM: Selective spectrophotometric determination of trace amounts of iron with di(2-pyridyl)-NN-di[(8-quinolyl)amino]methane: determination of iron in blood serum. Analyst. 1983 Jul;108(1288):821-6. doi: 10.1039/an9830800821. [PubMed:6614500 ]
Eastwood MA, Brydon WG, Anderson DM: The effects of dietary gum karaya (Sterculia) in man. Toxicol Lett. 1983 Jun;17(1-2):159-66. doi: 10.1016/0378-4274(83)90052-8. [PubMed:6623502 ]
Wolever TM, Fernandes J, Rao VA, Chiasson JL, Josse RG, Leiter LA: Positive methane-producing status associated with increased serum cholesterol in subjects with impaired glucose tolerance. Diabetes Care. 1995 Jul;18(7):1010-2. doi: 10.2337/diacare.18.7.1010. [PubMed:7555532 ]
Florin TH, Woods HJ: Inhibition of methanogenesis by human bile. Gut. 1995 Sep;37(3):418-21. doi: 10.1136/gut.37.3.418. [PubMed:7590441 ]
Castelain P, Van Hummelen P, Deleener A, Kirsch-Volders M: Automated detection of cytochalasin-B blocked binucleated lymphocytes for scoring micronuclei. Mutagenesis. 1993 Jul;8(4):285-93. doi: 10.1093/mutage/8.4.285. [PubMed:7690875 ]
Bernalier A, Willems A, Leclerc M, Rochet V, Collins MD: Ruminococcus hydrogenotrophicus sp. nov., a new H2/CO2-utilizing acetogenic bacterium isolated from human feces. Arch Microbiol. 1996 Sep;166(3):176-83. doi: 10.1007/s002030050373. [PubMed:8703194 ]
Nagao M, Takatori T, Oono T, Iwase H, Iwadate K, Yamada Y, Nakajima M: Death due to a methane gas explosion in a tunnel on urban reclaimed land. Am J Forensic Med Pathol. 1997 Jun;18(2):135-9. doi: 10.1097/00000433-199706000-00005. [PubMed:9185928 ]
Rabot S, Viso M, Martin F, Blanquie JP, Popot F, Bensaada M, Vaissade P, Searby N, Szylit O: Effects of chair-restraint on gastrointestinal transit time and colonic fermentation in male rhesus monkey (Macaca mulatta). J Med Primatol. 1997 Aug;26(4):190-5. doi: 10.1111/j.1600-0684.1997.tb00051.x. [PubMed:9416569 ]
Rumessen JJ, Gudmand-Hoyer E: Fructans of chicory: intestinal transport and fermentation of different chain lengths and relation to fructose and sorbitol malabsorption. Am J Clin Nutr. 1998 Aug;68(2):357-64. doi: 10.1093/ajcn/68.2.357. [PubMed:9701194 ]
Kayar SR, Miller TL, Wolin MJ, Aukhert EO, Axley MJ, Kiesow LA: Decompression sickness risk in rats by microbial removal of dissolved gas. Am J Physiol. 1998 Sep;275(3):R677-82. doi: 10.1152/ajpregu.1998.275.3.R677. [PubMed:9728062 ]
Kresimon J, Gruter UM, Hirner AV: HG/LT-GC/ICP-MS coupling for identification of metal(loid) species in human urine after fish consumption. Fresenius J Anal Chem. 2001 Nov;371(5):586-90. doi: 10.1007/s002160101087. [PubMed:11767883 ]
Minh NH, Someya M, Minh TB, Kunisue T, Iwata H, Watanabe M, Tanabe S, Viet PH, Tuyen BC: Persistent organochlorine residues in human breast milk from Hanoi and Hochiminh City, Vietnam: contamination, accumulation kinetics and risk assessment for infants. Environ Pollut. 2004 Jun;129(3):431-41. doi: 10.1016/j.envpol.2003.11.012. [PubMed:15016464 ]
Chien YH, Bau DT, Jan KY: Nitric oxide inhibits DNA-adduct excision in nucleotide excision repair. Free Radic Biol Med. 2004 Apr 15;36(8):1011-7. doi: 10.1016/j.freeradbiomed.2004.01.011. [PubMed:15059641 ]
Tsai WB, Shi Q, Grunkemeier JM, McFarland C, Horbett TA: Platelet adhesion to radiofrequency glow-discharge-deposited fluorocarbon polymers preadsorbed with selectively depleted plasmas show the primary role of fibrinogen. J Biomater Sci Polym Ed. 2004;15(7):817-40. doi: 10.1163/1568562041271093. [PubMed:15318794 ]
Nakamura M, Ueki S, Hara H, Arata T: Calcium structural transition of human cardiac troponin C in reconstituted muscle fibres as studied by site-directed spin labelling. J Mol Biol. 2005 Apr 22;348(1):127-37. doi: 10.1016/j.jmb.2005.02.018. [PubMed:15808858 ]
Sudaryanto A, Kunisue T, Tanabe S, Niida M, Hashim H: Persistent organochlorine compounds in human breast milk from mothers living in Penang and Kedah, Malaysia. Arch Environ Contam Toxicol. 2005 Oct;49(3):429-37. doi: 10.1007/s00244-004-0208-8. Epub 2005 Aug 24. [PubMed:16132420 ]
Levitt MD, Furne JK, Kuskowski M, Ruddy J: Stability of human methanogenic flora over 35 years and a review of insights obtained from breath methane measurements. Clin Gastroenterol Hepatol. 2006 Feb;4(2):123-9. doi: 10.1016/j.cgh.2005.11.006. [PubMed:16469670 ]
Ringvoll J, Nordstrand LM, Vagbo CB, Talstad V, Reite K, Aas PA, Lauritzen KH, Liabakk NB, Bjork A, Doughty RW, Falnes PO, Krokan HE, Klungland A: Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J. 2006 May 17;25(10):2189-98. doi: 10.1038/sj.emboj.7601109. Epub 2006 Apr 27. [PubMed:16642038 ]

Showing metabocard for Methane (MMDBc0000219)

MOL for #<Metabolite:0x00007fd5f9479cb8>

3D MOL for #<Metabolite:0x00007fd5f9479cb8>

3D SDF for #<Metabolite:0x00007fd5f9479cb8>

3D-SDF for #<Metabolite:0x00007fd5f9479cb8>

PDB for #<Metabolite:0x00007fd5f9479cb8>

3D PDB for #<Metabolite:0x00007fd5f9479cb8>

SMILES for #<Metabolite:0x00007fd5f9479cb8>

INCHI for #<Metabolite:0x00007fd5f9479cb8>

Structure for #<Metabolite:0x00007fd5f9479cb8>

3D Structure for #<Metabolite:0x00007fd5f9479cb8>