Showing metabocard for Trigonelline (MMDBc0000553)

Record Information
Version1.0
StatusDetected and Quantified
Creation Date2020-12-10 18:40:23 UTC
Update Date2024-04-30 19:32:58 UTC
Metabolite IDMMDBc0000553
Metabolite Identification
Common NameTrigonelline
DescriptionTrigonelline, also known as caffearin or gynesine, belongs to the class of organic compounds known as alkaloids and derivatives. These are naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and more rarely other elements such as chlorine, bromine, and phosphorus. It is also found in coffee, where it may help to prevent dental caries by preventing the bacteria Streptococcus mutans from adhering to teeth. Trigonelline is an alkaloid with chemical formula C7H7NO2 and CAS number 535-83-1. Trigonelline is a product of the metabolism of niacin (vitamin B3) which is excreted in the urine. High amounts of trigonelline have been found in arabica coffee, fenugreeks, and common peas. Another foods such as yellow bell peppers, orange bellpeppers and muskmelons also contain trigonelline but in lower concentrations. Trigonelline has also been detected but not quantified in several different foods, such as rices, triticales, alfalfa, cereals and cereal products, and ryes. Trigonelline in the urine is a biomarker for the consumption of coffee, legumes and soy products.
Structure
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for #<Metabolite:0x000055e8c8ed8738>


  Mrv1652303202019022D          

 10 10  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
M  CHG  2   2   1  10  -1
M  END
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3D MOL for #<Metabolite:0x000055e8c8ed8738>

HMDB0000875
     RDKit          3D
Trigonelline
 17 17  0  0  0  0  0  0  0  0999 V2000
   -2.2900   -0.8452    0.3632 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0354   -0.1682    0.1192 N   0  0  0  0  0  4  0  0  0  0  0  0
   -1.0669    1.1443   -0.1856 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0914    1.8560   -0.4311 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3042    1.1850   -0.3570 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3551   -0.1614   -0.0457 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6109   -0.8924    0.0395 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7092   -0.3032   -0.1733 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5478   -2.2406    0.3590 O   0  0  0  0  0  1  0  0  0  0  0  0
    0.1567   -0.7922    0.1837 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1284   -0.3720   -0.1821 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1737   -1.8758   -0.0766 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5505   -0.9454    1.4138 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0338    1.6645   -0.2412 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0876    2.9163   -0.6788 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2554    1.6922   -0.5406 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1606   -1.8619    0.4335 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  6 10  2  0
 10  2  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  3 14  1  0
  4 15  1  0
  5 16  1  0
 10 17  1  0
M  CHG  2   2   1   9  -1
M  END
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3D SDF for #<Metabolite:0x000055e8c8ed8738>


  Mrv1652303202019022D          

 10 10  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
M  CHG  2   2   1  10  -1
M  END
> <DATABASE_ID>
MMDBc0000553

> <DATABASE_NAME>
MIME

> <SMILES>
C[N+]1=CC=CC(=C1)C([O-])=O

> <INCHI_IDENTIFIER>
InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3

> <INCHI_KEY>
WWNNZCOKKKDOPX-UHFFFAOYSA-N

> <FORMULA>
C7H7NO2

> <MOLECULAR_WEIGHT>
137.136

> <EXACT_MASS>
137.047678473

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
17

> <JCHEM_AVERAGE_POLARIZABILITY>
13.401438455568746

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
1-methylpyridin-1-ium-3-carboxylate

> <ALOGPS_LOGP>
-3.30

> <JCHEM_LOGP>
-3.5302120628050786

> <ALOGPS_LOGS>
-2.77

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.7829632948236522

> <JCHEM_POLAR_SURFACE_AREA>
44.01

> <JCHEM_REFRACTIVITY>
48.1498

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.23e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
trigonelline

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for #<Metabolite:0x000055e8c8ed8738>

HMDB0000875
     RDKit          3D
Trigonelline
 17 17  0  0  0  0  0  0  0  0999 V2000
   -2.2900   -0.8452    0.3632 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0354   -0.1682    0.1192 N   0  0  0  0  0  4  0  0  0  0  0  0
   -1.0669    1.1443   -0.1856 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0914    1.8560   -0.4311 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3042    1.1850   -0.3570 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3551   -0.1614   -0.0457 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6109   -0.8924    0.0395 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7092   -0.3032   -0.1733 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5478   -2.2406    0.3590 O   0  0  0  0  0  1  0  0  0  0  0  0
    0.1567   -0.7922    0.1837 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1284   -0.3720   -0.1821 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1737   -1.8758   -0.0766 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5505   -0.9454    1.4138 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0338    1.6645   -0.2412 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0876    2.9163   -0.6788 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2554    1.6922   -0.5406 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1606   -1.8619    0.4335 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  7  9  1  0
  6 10  2  0
 10  2  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  3 14  1  0
  4 15  1  0
  5 16  1  0
 10 17  1  0
M  CHG  2   2   1   9  -1
M  END
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PDB for #<Metabolite:0x000055e8c8ed8738>

HEADER    PROTEIN                                 20-MAR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   20-MAR-20         0                                  
HETATM    1  C   UNK     0       1.334   3.850   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       1.334   2.310   0.000  0.00  0.00           N+1
HETATM    3  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      -1.334  -2.310   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0      -2.667   0.000   0.000  0.00  0.00           O-1
CONECT    1    2                                                            
CONECT    2    1    3    7                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6    2                                                       
CONECT    8    6    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8                                                            
MASTER        0    0    0    0    0    0    0    0   10    0   20    0
END
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3D PDB for #<Metabolite:0x000055e8c8ed8738>

COMPND    HMDB0000875
HETATM    1  C1  UNL     1      -2.290  -0.845   0.363  1.00  0.00           C  
HETATM    2  N1  UNL     1      -1.035  -0.168   0.119  1.00  0.00           N1+
HETATM    3  C2  UNL     1      -1.067   1.144  -0.186  1.00  0.00           C  
HETATM    4  C3  UNL     1       0.091   1.856  -0.431  1.00  0.00           C  
HETATM    5  C4  UNL     1       1.304   1.185  -0.357  1.00  0.00           C  
HETATM    6  C5  UNL     1       1.355  -0.161  -0.046  1.00  0.00           C  
HETATM    7  C6  UNL     1       2.611  -0.892   0.039  1.00  0.00           C  
HETATM    8  O1  UNL     1       3.709  -0.303  -0.173  1.00  0.00           O  
HETATM    9  O2  UNL     1       2.548  -2.241   0.359  1.00  0.00           O1-
HETATM   10  C7  UNL     1       0.157  -0.792   0.184  1.00  0.00           C  
HETATM   11  H1  UNL     1      -3.128  -0.372  -0.182  1.00  0.00           H  
HETATM   12  H2  UNL     1      -2.174  -1.876  -0.077  1.00  0.00           H  
HETATM   13  H3  UNL     1      -2.550  -0.945   1.414  1.00  0.00           H  
HETATM   14  H4  UNL     1      -2.034   1.664  -0.241  1.00  0.00           H  
HETATM   15  H5  UNL     1       0.088   2.916  -0.679  1.00  0.00           H  
HETATM   16  H6  UNL     1       2.255   1.692  -0.541  1.00  0.00           H  
HETATM   17  H7  UNL     1       0.161  -1.862   0.434  1.00  0.00           H  
CONECT    1    2   11   12   13
CONECT    2    3    3   10
CONECT    3    4   14
CONECT    4    5    5   15
CONECT    5    6   16
CONECT    6    7   10   10
CONECT    7    8    8    9
CONECT   10   17
END
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SMILES for #<Metabolite:0x000055e8c8ed8738>

C[N+]1=CC=CC(=C1)C([O-])=O
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INCHI for #<Metabolite:0x000055e8c8ed8738>

InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3
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Synonyms
ValueSource
1-Methyl-3-pyridiniumcarboxylateChEBI
1-MethylnicotinateChEBI
1-Methylpyridinio-3-carboxylateChEBI
3-Carboxy-1-methylpyridinium hydroxide inner saltChEBI
Betain nicotinateChEBI
Betaine nicotinateChEBI
CaffearinChEBI
CaffearineChEBI
CoffearinChEBI
GynesineChEBI
N'-methylnicotinateChEBI
N-Methyl-nicotinateChEBI
Nicotinic acid N-methylbetaineChEBI
TrigenellineChEBI
TrigonellinChEBI
1-Methyl-3-pyridiniumcarboxylic acidGenerator
1-Methylnicotinic acidGenerator
1-Methylpyridinio-3-carboxylic acidGenerator
Betain nicotinic acidGenerator
Betaine nicotinic acidGenerator
N'-methylnicotinic acidGenerator
N-Methyl-nicotinic acidGenerator
Nicotinate N-methylbetaineGenerator
N-Methylnicotinic acidHMDB
Trigonelline chlorideHMDB
Trigonelline iodideHMDB
Trigonelline tosylateHMDB
Trigonelline ionHMDB
3-Carboxy-1-methyl-pyridinium hydroxide inner saltHMDB
CoffearineHMDB
N-MethylnicotinateHMDB
TrigenollineHMDB
TrigonellineChEBI
Molecular FormulaC7H7NO2
Average Mass137.136
Monoisotopic Mass137.047678473
IUPAC Name1-methylpyridin-1-ium-3-carboxylate
Traditional Nametrigonelline
CAS Registry NumberNot Available
SMILES
C[N+]1=CC=CC(=C1)C([O-])=O
InChI Identifier
InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3
InChI KeyWWNNZCOKKKDOPX-UHFFFAOYSA-N