MiMeDB: Showing metabocard for Wickerol B (MMDBc0009409)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-15 01:55:46 UTC

Update Date

2022-08-31 06:30:00 UTC

Metabolite ID

MMDBc0009409

Metabolite Identification

Common Name

Wickerol B

Description

Wickerol B belongs to the class of organic compounds known as chamigranes. These are sesquiterpenoids characterized by a 1,1,5,9-tetramethylspiro[5,5]undecane skeleton, formally obtained by linking the C1-C6 and C6-C11 of farnesane together. They are predominantly isolated from algae. Based on a literature review very few articles have been published on Wickerol B.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152103552D          

 27 30  0  0  1  0            999 V2000
    1.0471   -1.8257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1037    0.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3463   -0.7490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4299    1.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3895   -1.7548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3042   -0.4166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0071    0.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8226   -2.1870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1496   -1.7021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6231   -0.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5178    0.8512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2631   -1.0294    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6662   -0.9768    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7009    0.5916    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8663    0.3684    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9667   -0.5279    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9058   -0.1427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1770    0.3023    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5669   -1.8169    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1368   -0.8469    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2911    0.9598    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7856   -2.6123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8290   -1.6297    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3965   -1.3607    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4693    1.3834    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0856    1.1638    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3497    0.0198    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  1  0  0  0  0
  9  8  1  0  0  0  0
 12  1  1  6  0  0  0
 12 10  1  0  0  0  0
 13  6  1  0  0  0  0
 14 11  1  0  0  0  0
 15 10  1  0  0  0  0
 15 14  1  0  0  0  0
 16 13  1  0  0  0  0
 17  2  1  0  0  0  0
 17  3  1  0  0  0  0
 17 14  1  0  0  0  0
 18  4  1  1  0  0  0
 18  7  1  0  0  0  0
 18 11  1  0  0  0  0
 18 16  1  0  0  0  0
 19  5  1  6  0  0  0
 19  8  1  0  0  0  0
 19 13  1  0  0  0  0
 20  9  1  6  0  0  0
 20 12  1  0  0  0  0
 20 16  1  0  0  0  0
 20 17  1  0  0  0  0
 15 21  1  6  0  0  0
 19 22  1  1  0  0  0
 12 23  1  1  0  0  0
 13 24  1  1  0  0  0
 14 25  1  6  0  0  0
 15 26  1  1  0  0  0
 16 27  1  6  0  0  0
M  END


  Mrv1652305152103552D          

 27 30  0  0  1  0            999 V2000
    1.0471   -1.8257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1037    0.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3463   -0.7490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4299    1.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3895   -1.7548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3042   -0.4166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0071    0.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8226   -2.1870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1496   -1.7021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6231   -0.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5178    0.8512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2631   -1.0294    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6662   -0.9768    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7009    0.5916    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8663    0.3684    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9667   -0.5279    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9058   -0.1427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1770    0.3023    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5669   -1.8169    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1368   -0.8469    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2911    0.9598    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7856   -2.6123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8290   -1.6297    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3965   -1.3607    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4693    1.3834    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0856    1.1638    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3497    0.0198    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  1  0  0  0  0
  9  8  1  0  0  0  0
 12  1  1  6  0  0  0
 12 10  1  0  0  0  0
 13  6  1  0  0  0  0
 14 11  1  0  0  0  0
 15 10  1  0  0  0  0
 15 14  1  0  0  0  0
 16 13  1  0  0  0  0
 17  2  1  0  0  0  0
 17  3  1  0  0  0  0
 17 14  1  0  0  0  0
 18  4  1  1  0  0  0
 18  7  1  0  0  0  0
 18 11  1  0  0  0  0
 18 16  1  0  0  0  0
 19  5  1  6  0  0  0
 19  8  1  0  0  0  0
 19 13  1  0  0  0  0
 20  9  1  6  0  0  0
 20 12  1  0  0  0  0
 20 16  1  0  0  0  0
 20 17  1  0  0  0  0
 15 21  1  6  0  0  0
 19 22  1  1  0  0  0
 12 23  1  1  0  0  0
 13 24  1  1  0  0  0
 14 25  1  6  0  0  0
 15 26  1  1  0  0  0
 16 27  1  6  0  0  0
M  END
> <DATABASE_ID>
MMDBc0009409

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]12CC[C@@]3(C)C[C@]4([H])[C@@]([H])(O)C[C@@]([H])(C)[C@](CC[C@]1(C)O)([C@]23[H])C4(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C20H34O2/c1-12-10-15(21)14-11-18(4)7-6-13-16(18)20(12,17(14,2)3)9-8-19(13,5)22/h12-16,21-22H,6-11H2,1-5H3/t12-,13+,14-,15+,16-,18+,19+,20-/m1/s1

> <INCHI_KEY>
WNNOQHXNMDRPDQ-ACRGTBQJSA-N

> <FORMULA>
C20H34O2

> <MOLECULAR_WEIGHT>
306.49

> <EXACT_MASS>
306.255880335

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
56

> <JCHEM_AVERAGE_POLARIZABILITY>
36.161608982546895

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,4S,5S,8S,10S,11S,13R,14R)-4,8,13,15,15-pentamethyltetracyclo[6.5.1.1^{1,10}.0^{5,14}]pentadecane-4,11-diol

> <ALOGPS_LOGP>
3.57

> <JCHEM_LOGP>
3.182262385666666

> <ALOGPS_LOGS>
-4.10

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
19.901003251405655

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.872236041767987

> <JCHEM_PKA_STRONGEST_BASIC>
-0.3603170025434653

> <JCHEM_POLAR_SURFACE_AREA>
40.46

> <JCHEM_REFRACTIVITY>
89.09109999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.44e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,4S,5S,8S,10S,11S,13R,14R)-4,8,13,15,15-pentamethyltetracyclo[6.5.1.1^{1,10}.0^{5,14}]pentadecane-4,11-diol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0       1.955  -3.408   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.060   0.095   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.513  -1.398   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.402   2.030   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       8.194  -3.276   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.034  -0.778   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.480   0.675   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       5.269  -4.082   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.013  -3.177   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.163  -0.840   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.700   1.589   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.358  -1.922   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.844  -1.823   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.175   1.104   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       1.617   0.688   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.538  -0.985   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       3.557  -0.266   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.930   0.564   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.658  -3.392   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.989  -1.581   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       0.543   1.792   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0       7.067  -4.876   0.000  0.00  0.00           O+0
HETATM   23  H   UNK     0       3.414  -3.042   0.000  0.00  0.00           H+0
HETATM   24  H   UNK     0       8.207  -2.540   0.000  0.00  0.00           H+0
HETATM   25  H   UNK     0       2.743   2.582   0.000  0.00  0.00           H+0
HETATM   26  H   UNK     0       2.026   2.172   0.000  0.00  0.00           H+0
HETATM   27  H   UNK     0       4.386   0.037   0.000  0.00  0.00           H+0
CONECT    1   12                                                            
CONECT    2   17                                                            
CONECT    3   17                                                            
CONECT    4   18                                                            
CONECT    5   19                                                            
CONECT    6    7   13                                                       
CONECT    7    6   18                                                       
CONECT    8    9   19                                                       
CONECT    9    8   20                                                       
CONECT   10   12   15                                                       
CONECT   11   14   18                                                       
CONECT   12    1   10   20   23                                             
CONECT   13    6   16   19   24                                             
CONECT   14   11   15   17   25                                             
CONECT   15   10   14   21   26                                             
CONECT   16   13   18   20   27                                             
CONECT   17    2    3   14   20                                             
CONECT   18    4    7   11   16                                             
CONECT   19    5    8   13   22                                             
CONECT   20    9   12   16   17                                             
CONECT   21   15                                                            
CONECT   22   19                                                            
CONECT   23   12                                                            
CONECT   24   13                                                            
CONECT   25   14                                                            
CONECT   26   15                                                            
CONECT   27   16                                                            
MASTER        0    0    0    0    0    0    0    0   27    0   60    0
END

Synonyms

Not Available

Molecular Formula

C₂₀H₃₄O₂

Average Mass

306.49

Monoisotopic Mass

306.255880335

IUPAC Name

(1R,4S,5S,8S,10S,11S,13R,14R)-4,8,13,15,15-pentamethyltetracyclo[6.5.1.1^{1,10}.0^{5,14}]pentadecane-4,11-diol

Traditional Name

(1R,4S,5S,8S,10S,11S,13R,14R)-4,8,13,15,15-pentamethyltetracyclo[6.5.1.1^{1,10}.0^{5,14}]pentadecane-4,11-diol

CAS Registry Number

Not Available

SMILES

[H][C@@]12CC[C@@]3(C)C[C@]4([H])[C@@]([H])(O)C[C@@]([H])(C)[C@](CC[C@]1(C)O)([C@]23[H])C4(C)C

InChI Identifier

InChI=1S/C20H34O2/c1-12-10-15(21)14-11-18(4)7-6-13-16(18)20(12,17(14,2)3)9-8-19(13,5)22/h12-16,21-22H,6-11H2,1-5H3/t12-,13+,14-,15+,16-,18+,19+,20-/m1/s1

InChI Key

WNNOQHXNMDRPDQ-ACRGTBQJSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as chamigranes. These are sesquiterpenoids characterized by a 1,1,5,9-tetramethylspiro[5,5]undecane skeleton, formally obtained by linking the C1-C6 and C6-C11 of farnesane together. They are predominantly isolated from algae.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Chamigranes

Alternative Parents

Substituents

Chamigrane sesquiterpenoid
Tertiary alcohol
Cyclic alcohol
Secondary alcohol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.024 g/L	ALOGPS
logP	3.57	ALOGPS
logP	3.18	ChemAxon
logS	-4.1	ALOGPS
pKa (Strongest Acidic)	19.87	ChemAxon
pKa (Strongest Basic)	-0.36	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	40.46 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	89.09 m³·mol⁻¹	ChemAxon
Polarizability	36.16 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_1) - 70eV, Positive	Not Available	2022-08-08	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2022-08-10	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2022-08-10	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-21	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-21	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Not Available

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78437307

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

71499838

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Wickerol B (MMDBc0009409)

MOL for #<Metabolite:0x00007f469dfc3f88>

3D MOL for #<Metabolite:0x00007f469dfc3f88>

3D SDF for #<Metabolite:0x00007f469dfc3f88>

3D-SDF for #<Metabolite:0x00007f469dfc3f88>

PDB for #<Metabolite:0x00007f469dfc3f88>

3D PDB for #<Metabolite:0x00007f469dfc3f88>

SMILES for #<Metabolite:0x00007f469dfc3f88>

INCHI for #<Metabolite:0x00007f469dfc3f88>

Structure for #<Metabolite:0x00007f469dfc3f88>

3D Structure for #<Metabolite:0x00007f469dfc3f88>