MiMeDB: Showing metabocard for Brevione K (MMDBc0017745)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-05-15 08:03:51 UTC

Update Date

2022-08-31 06:42:51 UTC

Metabolite ID

MMDBc0017745

Metabolite Identification

Common Name

Brevione K

Description

Brevione K belongs to the class of organic compounds known as pyranones and derivatives. Pyranones and derivatives are compounds containing a pyran ring which bears a ketone. Based on a literature review very few articles have been published on Brevione K.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652305152110032D          

 34 38  0  0  1  0            999 V2000
    9.4450   -3.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2619    0.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9539   -2.9414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3049   -2.8830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0272   -0.2173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0582   -1.5843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5198   -0.7623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3019   -2.2531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7225   -0.5504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6024   -1.8156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4672   -2.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6900    0.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1909   -0.1916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6569   -2.4030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9614    0.2709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5669   -2.2128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7424   -2.1836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8512   -1.5178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6175   -0.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0305   -1.8661    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.3894    0.2204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0044   -1.5134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3602   -0.6041    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.7930   -0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0597   -1.0416    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.6316   -0.9911    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.9322   -0.5536    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.6757   -1.5470    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1180    0.6073    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4060   -0.0269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3555   -1.4550    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8170   -1.3705    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7860   -1.5347    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.6608   -0.1666    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  9  7  2  0  0  0  0
 10  8  1  0  0  0  0
 14  1  1  0  0  0  0
 14 11  2  0  0  0  0
 15  2  1  0  0  0  0
 15 12  2  0  0  0  0
 16  3  1  0  0  0  0
 17  4  1  0  0  0  0
 17 16  2  0  0  0  0
 18  7  1  0  0  0  0
 18 11  1  0  0  0  0
 19 13  1  0  0  0  0
 20  8  1  0  0  0  0
 20 14  1  0  0  0  0
 21 12  1  0  0  0  0
 22 16  1  0  0  0  0
 22 19  2  0  0  0  0
 23 21  1  0  0  0  0
 24 19  1  0  0  0  0
 25  5  1  6  0  0  0
 25  9  1  0  0  0  0
 25 20  1  0  0  0  0
 25 23  1  0  0  0  0
 26  6  1  6  0  0  0
 26 10  1  0  0  0  0
 26 23  1  0  0  0  0
 27 13  1  0  0  0  0
 27 15  1  0  0  0  0
 27 26  1  0  0  0  0
 28 18  2  0  0  0  0
 29 21  2  0  0  0  0
 30 24  2  0  0  0  0
 31 17  1  0  0  0  0
 31 24  1  0  0  0  0
 32 22  1  0  0  0  0
 27 32  1  1  0  0  0
 20 33  1  1  0  0  0
 23 34  1  1  0  0  0
M  END


  Mrv1652305152110032D          

 34 38  0  0  1  0            999 V2000
    9.4450   -3.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2619    0.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9539   -2.9414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3049   -2.8830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0272   -0.2173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0582   -1.5843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5198   -0.7623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3019   -2.2531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7225   -0.5504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6024   -1.8156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4672   -2.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6900    0.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1909   -0.1916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6569   -2.4030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9614    0.2709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5669   -2.2128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7424   -2.1836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8512   -1.5178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6175   -0.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0305   -1.8661    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.3894    0.2204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0044   -1.5134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3602   -0.6041    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.7930   -0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0597   -1.0416    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.6316   -0.9911    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.9322   -0.5536    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.6757   -1.5470    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1180    0.6073    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4060   -0.0269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3555   -1.4550    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8170   -1.3705    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7860   -1.5347    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.6608   -0.1666    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  9  7  2  0  0  0  0
 10  8  1  0  0  0  0
 14  1  1  0  0  0  0
 14 11  2  0  0  0  0
 15  2  1  0  0  0  0
 15 12  2  0  0  0  0
 16  3  1  0  0  0  0
 17  4  1  0  0  0  0
 17 16  2  0  0  0  0
 18  7  1  0  0  0  0
 18 11  1  0  0  0  0
 19 13  1  0  0  0  0
 20  8  1  0  0  0  0
 20 14  1  0  0  0  0
 21 12  1  0  0  0  0
 22 16  1  0  0  0  0
 22 19  2  0  0  0  0
 23 21  1  0  0  0  0
 24 19  1  0  0  0  0
 25  5  1  6  0  0  0
 25  9  1  0  0  0  0
 25 20  1  0  0  0  0
 25 23  1  0  0  0  0
 26  6  1  6  0  0  0
 26 10  1  0  0  0  0
 26 23  1  0  0  0  0
 27 13  1  0  0  0  0
 27 15  1  0  0  0  0
 27 26  1  0  0  0  0
 28 18  2  0  0  0  0
 29 21  2  0  0  0  0
 30 24  2  0  0  0  0
 31 17  1  0  0  0  0
 31 24  1  0  0  0  0
 32 22  1  0  0  0  0
 27 32  1  1  0  0  0
 20 33  1  1  0  0  0
 23 34  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0017745

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]12CC[C@]3(C)[C@]([H])(C(=O)C=C(C)[C@@]33CC4=C(O3)C(C)=C(C)OC4=O)[C@@]1(C)C=CC(=O)C=C2C

> <INCHI_IDENTIFIER>
InChI=1S/C27H30O5/c1-14-11-18(28)7-9-25(5)20(14)8-10-26(6)23(25)21(29)12-15(2)27(26)13-19-22(32-27)16(3)17(4)31-24(19)30/h7,9,11-12,20,23H,8,10,13H2,1-6H3/t20-,23+,25-,26+,27-/m0/s1

> <INCHI_KEY>
QLGBMJAKRNXWHJ-QCYUWTFZSA-N

> <FORMULA>
C27H30O5

> <MOLECULAR_WEIGHT>
434.532

> <EXACT_MASS>
434.209324066

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
62

> <JCHEM_AVERAGE_POLARIZABILITY>
47.77165111869258

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(4S,4aR,6aS,11aS,11bR)-3,4a,6',7,7',11a-hexamethyl-1,3',4',4a,5,6,6a,9,11a,11b-decahydrospiro[cyclohepta[a]naphthalene-4,2'-furo[3,2-c]pyran]-1,4',9-trione

> <ALOGPS_LOGP>
4.69

> <JCHEM_LOGP>
4.283428970999999

> <ALOGPS_LOGS>
-5.00

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-4.412326253678223

> <JCHEM_POLAR_SURFACE_AREA>
69.67

> <JCHEM_REFRACTIVITY>
125.75919999999992

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.34e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(4S,4aR,6aS,11aS,11bR)-3,4a,6',7,7',11a-hexamethyl-5,6,6a,11b-tetrahydro-3'H-spiro[cyclohepta[a]naphthalene-4,2'-furo[3,2-c]pyran]-1,4',9-trione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-MAY-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAY-21         0                                  
HETATM    1  C   UNK     0      17.631  -5.974   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      11.689   1.322   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      11.114  -5.491   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.036  -5.382   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      16.851  -0.406   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      13.175  -2.957   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      19.637  -1.423   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      15.497  -4.206   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      18.149  -1.027   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      14.191  -3.389   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      19.539  -4.196   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      14.355   1.228   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      11.556  -0.358   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      18.026  -4.486   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      12.995   0.506   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      10.392  -4.131   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       8.853  -4.076   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      20.256  -2.833   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      10.486  -1.465   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      16.857  -3.483   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      15.660   0.411   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      11.208  -2.825   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      15.606  -1.128   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       8.947  -1.410   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      16.911  -1.944   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      14.246  -1.850   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      12.940  -1.033   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      21.795  -2.888   0.000  0.00  0.00           O+0
HETATM   29  O   UNK     0      17.020   1.134   0.000  0.00  0.00           O+0
HETATM   30  O   UNK     0       8.225  -0.050   0.000  0.00  0.00           O+0
HETATM   31  O   UNK     0       8.130  -2.716   0.000  0.00  0.00           O+0
HETATM   32  O   UNK     0      12.725  -2.558   0.000  0.00  0.00           O+0
HETATM   33  H   UNK     0      18.267  -2.865   0.000  0.00  0.00           H+0
HETATM   34  H   UNK     0      14.300  -0.311   0.000  0.00  0.00           H+0
CONECT    1   14                                                            
CONECT    2   15                                                            
CONECT    3   16                                                            
CONECT    4   17                                                            
CONECT    5   25                                                            
CONECT    6   26                                                            
CONECT    7    9   18                                                       
CONECT    8   10   20                                                       
CONECT    9    7   25                                                       
CONECT   10    8   26                                                       
CONECT   11   14   18                                                       
CONECT   12   15   21                                                       
CONECT   13   19   27                                                       
CONECT   14    1   11   20                                                  
CONECT   15    2   12   27                                                  
CONECT   16    3   17   22                                                  
CONECT   17    4   16   31                                                  
CONECT   18    7   11   28                                                  
CONECT   19   13   22   24                                                  
CONECT   20    8   14   25   33                                             
CONECT   21   12   23   29                                                  
CONECT   22   16   19   32                                                  
CONECT   23   21   25   26   34                                             
CONECT   24   19   30   31                                                  
CONECT   25    5    9   20   23                                             
CONECT   26    6   10   23   27                                             
CONECT   27   13   15   26   32                                             
CONECT   28   18                                                            
CONECT   29   21                                                            
CONECT   30   24                                                            
CONECT   31   17   24                                                       
CONECT   32   22   27                                                       
CONECT   33   20                                                            
CONECT   34   23                                                            
MASTER        0    0    0    0    0    0    0    0   34    0   76    0
END

Synonyms

Not Available

Molecular Formula

C₂₇H₃₀O₅

Average Mass

434.532

Monoisotopic Mass

434.209324066

IUPAC Name

(4S,4aR,6aS,11aS,11bR)-3,4a,6',7,7',11a-hexamethyl-1,3',4',4a,5,6,6a,9,11a,11b-decahydrospiro[cyclohepta[a]naphthalene-4,2'-furo[3,2-c]pyran]-1,4',9-trione

Traditional Name

(4S,4aR,6aS,11aS,11bR)-3,4a,6',7,7',11a-hexamethyl-5,6,6a,11b-tetrahydro-3'H-spiro[cyclohepta[a]naphthalene-4,2'-furo[3,2-c]pyran]-1,4',9-trione

CAS Registry Number

Not Available

SMILES

[H][C@@]12CC[C@]3(C)[C@]([H])(C(=O)C=C(C)[C@@]33CC4=C(O3)C(C)=C(C)OC4=O)[C@@]1(C)C=CC(=O)C=C2C

InChI Identifier

InChI=1S/C27H30O5/c1-14-11-18(28)7-9-25(5)20(14)8-10-26(6)23(25)21(29)12-15(2)27(26)13-19-22(32-27)16(3)17(4)31-24(19)30/h7,9,11-12,20,23H,8,10,13H2,1-6H3/t20-,23+,25-,26+,27-/m0/s1

InChI Key

QLGBMJAKRNXWHJ-QCYUWTFZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyranones and derivatives. Pyranones and derivatives are compounds containing a pyran ring which bears a ketone.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrans

Sub Class

Pyranones and derivatives

Direct Parent

Pyranones and derivatives

Alternative Parents

Substituents

Alkyl aryl ether
Pyranone
Cyclohexenone
Vinylogous ester
Heteroaromatic compound
Ketone
Lactone
Cyclic ketone
Ether
Oxacycle
Organic oxide
Organooxygen compound
Organic oxygen compound
Carbonyl group
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.0043 g/L	ALOGPS
logP	4.69	ALOGPS
logP	4.28	ChemAxon
logS	-5	ALOGPS
pKa (Strongest Basic)	-4.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	69.67 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	125.76 m³·mol⁻¹	ChemAxon
Polarizability	47.77 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Not Available

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1	Human feces	Metabolic reconstruction

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

29214757

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139587992

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, Linington RG: The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Res. 2022 Jan 7;50(D1):D1317-D1323. doi: 10.1093/nar/gkab941. [PubMed:34718710 ]

Showing metabocard for Brevione K (MMDBc0017745)

MOL for #<Metabolite:0x00007fecc1d48ae0>

3D MOL for #<Metabolite:0x00007fecc1d48ae0>

3D SDF for #<Metabolite:0x00007fecc1d48ae0>

3D-SDF for #<Metabolite:0x00007fecc1d48ae0>

PDB for #<Metabolite:0x00007fecc1d48ae0>

3D PDB for #<Metabolite:0x00007fecc1d48ae0>

SMILES for #<Metabolite:0x00007fecc1d48ae0>

INCHI for #<Metabolite:0x00007fecc1d48ae0>

Structure for #<Metabolite:0x00007fecc1d48ae0>

3D Structure for #<Metabolite:0x00007fecc1d48ae0>