Mrv1652305152110532D
90 93 0 0 1 0 999 V2000
-1.2576 0.4733 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.4987 -6.8402 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.1889 -1.1879 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.9806 0.2257 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.3962 0.3494 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.9599 0.8000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.6468 -7.0184 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.5267 -7.9056 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.7326 -1.1357 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.3344 -4.8238 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.9190 -2.4903 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.8010 -2.1567 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.7684 -4.5882 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.2444 -2.0326 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.2302 -4.9991 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.9819 -3.1023 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.9835 0.0811 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.0466 -6.2234 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.9367 -8.3588 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-5.1954 -5.0526 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.2342 -8.7913 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.9134 -7.5341 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.9353 -5.8355 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.6475 -4.4359 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.1867 -3.9995 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.5083 -8.3991 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.1876 -7.1420 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.1272 -6.0017 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.8394 -4.6020 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.2210 -3.1753 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.2638 -4.4165 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.8605 -0.6615 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.7592 -7.1823 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.7712 -5.5511 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.6767 -0.5412 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.4119 0.1833 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.8306 -7.1387 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.0068 -0.7435 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0
3.7865 -5.4405 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
-1.4850 -7.5745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.5792 -5.3849 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.5565 -1.4285 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
-0.7359 -6.3577 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
-2.4477 -2.8879 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
-2.2232 -4.9343 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
-1.3042 -1.1760 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
0.6721 -0.5996 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
1.3184 -6.4920 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
2.9784 -5.2744 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0
3.4673 -3.2746 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0
-2.1437 -2.1210 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.4802 -0.7658 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.5022 -6.6122 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.4384 -5.9251 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.0688 -2.0752 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.4834 -4.1514 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.5784 -0.7839 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.4304 -5.8911 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.4440 -4.0993 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.1932 -2.8825 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.7403 -1.5487 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-0.0100 -5.9655 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.3275 -2.0007 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.4151 -5.1005 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
0.1241 -1.2164 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
1.6223 -5.7250 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
2.7648 -2.8421 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-1.9354 -3.5347 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-2.6560 -1.4743 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
2.0281 -0.1490 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
0.1982 -7.3792 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
-2.1643 -6.3173 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
3.8078 -1.7086 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
-3.2348 -4.4920 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
-0.5551 0.0408 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
2.6906 -6.6740 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
4.1466 -4.5318 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
4.5853 -3.6083 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
2.7182 -4.4915 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
-2.7093 -0.3110 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
4.5946 -5.6067 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
3.3727 -1.3082 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
-0.0333 -6.7902 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
-3.0247 -2.2983 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
-1.9631 -5.7172 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
-2.0301 -1.5682 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
-0.1360 -0.4335 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
2.1346 -6.3717 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
3.5263 -4.6576 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
3.4906 -2.4500 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
17 1 1 0 0 0 0
18 2 1 0 0 0 0
21 19 2 0 0 0 0
22 19 1 0 0 0 0
23 20 2 0 0 0 0
24 20 1 0 0 0 0
26 21 1 0 0 0 0
27 22 2 0 0 0 0
28 23 1 0 0 0 0
29 24 2 0 0 0 0
30 25 1 0 0 0 0
31 25 1 0 0 0 0
35 3 1 0 0 0 0
35 4 1 0 0 0 0
35 32 1 0 0 0 0
36 5 1 0 0 0 0
36 6 1 0 0 0 0
37 7 1 0 0 0 0
37 8 1 0 0 0 0
38 9 1 6 0 0 0
38 17 1 0 0 0 0
39 10 1 1 0 0 0
39 18 1 0 0 0 0
40 26 2 0 0 0 0
40 27 1 0 0 0 0
40 33 1 0 0 0 0
41 28 2 0 0 0 0
41 29 1 0 0 0 0
41 34 1 0 0 0 0
42 32 1 1 0 0 0
43 33 1 1 0 0 0
44 30 1 0 0 0 0
45 34 1 1 0 0 0
46 38 1 1 0 0 0
47 36 1 1 0 0 0
48 37 1 1 0 0 0
49 39 1 6 0 0 0
51 44 1 0 0 0 0
52 47 1 0 0 0 0
53 48 1 0 0 0 0
54 43 1 0 0 0 0
55 42 1 0 0 0 0
56 45 1 0 0 0 0
57 46 1 0 0 0 0
58 49 1 0 0 0 0
59 50 1 0 0 0 0
60 11 1 0 0 0 0
60 12 1 0 0 0 0
50 60 1 1 0 0 0
61 42 1 0 0 0 0
61 52 2 0 0 0 0
62 43 1 0 0 0 0
62 53 2 0 0 0 0
63 46 1 0 0 0 0
63 51 2 0 0 0 0
64 13 1 0 0 0 0
64 45 1 0 0 0 0
64 54 1 0 0 0 0
65 14 1 0 0 0 0
65 47 1 0 0 0 0
65 57 1 0 0 0 0
66 15 1 0 0 0 0
66 48 1 0 0 0 0
66 58 1 0 0 0 0
67 16 1 0 0 0 0
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67 55 1 0 0 0 0
68 31 1 0 0 0 0
68 44 1 0 0 0 0
68 56 1 0 0 0 0
51 69 1 4 0 0 0
52 70 1 4 0 0 0
53 71 1 4 0 0 0
72 54 2 0 0 0 0
73 55 2 0 0 0 0
74 56 2 0 0 0 0
75 57 2 0 0 0 0
76 58 2 0 0 0 0
77 59 2 0 0 0 0
78 60 1 0 0 0 0
79 49 1 0 0 0 0
79 59 1 0 0 0 0
38 80 1 1 0 0 0
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42 82 1 6 0 0 0
43 83 1 6 0 0 0
44 84 1 6 0 0 0
45 85 1 6 0 0 0
46 86 1 6 0 0 0
47 87 1 6 0 0 0
48 88 1 6 0 0 0
49 89 1 1 0 0 0
50 90 1 6 0 0 0
M END
> <DATABASE_ID>
MMDBc0018722
> <DATABASE_NAME>
MIME
> <SMILES>
[H][C@](C)(CC)[C@@]1([H])OC(=O)[C@@]([H])(N(C)C(=O)[C@]([H])(CC(C)C)N=C(O)[C@]([H])(C(C)C)N(C)C(=O)[C@@]([H])(N=C(O)[C@]2([H])CCCN2C(=O)[C@]([H])(CC2=CC=CC=C2)N(C)C(=O)[C@]([H])(CC2=CC=CC=C2)N=C(O)[C@]([H])(C(C)C)N(C)C1=O)[C@]([H])(C)CC)C(C)(C)O
> <INCHI_IDENTIFIER>
InChI=1S/C60H92N8O11/c1-17-38(9)46-57(75)65(14)47(36(5)6)52(70)61-42(32-35(3)4)55(73)67(16)50(60(11,12)78)59(77)79-49(39(10)18-2)58(76)66(15)48(37(7)8)53(71)62-43(33-40-26-21-19-22-27-40)54(72)64(13)45(34-41-28-23-20-24-29-41)56(74)68-31-25-30-44(68)51(69)63-46/h19-24,26-29,35-39,42-50,78H,17-18,25,30-34H2,1-16H3,(H,61,70)(H,62,71)(H,63,69)/t38-,39+,42+,43+,44+,45+,46+,47+,48+,49-,50-/m1/s1
> <INCHI_KEY>
RLMLFADXHJLPSQ-QLLGQPFOSA-N
> <FORMULA>
C60H92N8O11
> <MOLECULAR_WEIGHT>
1101.441
> <EXACT_MASS>
1100.688555814
> <JCHEM_ACCEPTOR_COUNT>
13
> <JCHEM_ATOM_COUNT>
171
> <JCHEM_AVERAGE_POLARIZABILITY>
120.60581716039708
> <JCHEM_BIOAVAILABILITY>
0
> <JCHEM_DONOR_COUNT>
4
> <JCHEM_FORMAL_CHARGE>
0
> <JCHEM_GHOSE_FILTER>
0
> <JCHEM_IUPAC>
(3S,6S,9S,12S,15R,18S,21S,24S,29aS)-21,24-dibenzyl-3-[(2R)-butan-2-yl]-15-[(2S)-butan-2-yl]-1,7,19-trihydroxy-12-(2-hydroxypropan-2-yl)-5,11,17,23-tetramethyl-9-(2-methylpropyl)-6,18-bis(propan-2-yl)-3H,4H,5H,6H,9H,10H,11H,12H,13H,15H,16H,17H,18H,21H,22H,23H,24H,25H,27H,28H,29H,29aH-pyrrolo[1,2-m]1-oxa-4,7,10,13,16,19,22,25-octaazacycloheptacosane-4,10,13,16,22,25-hexone
> <ALOGPS_LOGP>
4.70
> <JCHEM_LOGP>
8.182794682666668
> <ALOGPS_LOGS>
-5.44
> <JCHEM_MDDR_LIKE_RULE>
1
> <JCHEM_NUMBER_OF_RINGS>
4
> <JCHEM_PHYSIOLOGICAL_CHARGE>
0
> <JCHEM_PKA>
4.520806289043787
> <JCHEM_PKA_STRONGEST_ACIDIC>
4.029444470327475
> <JCHEM_PKA_STRONGEST_BASIC>
1.6584523780322844
> <JCHEM_POLAR_SURFACE_AREA>
245.84999999999997
> <JCHEM_REFRACTIVITY>
301.2645
> <JCHEM_ROTATABLE_BOND_COUNT>
13
> <JCHEM_RULE_OF_FIVE>
0
> <ALOGPS_SOLUBILITY>
4.00e-03 g/l
> <JCHEM_TRADITIONAL_IUPAC>
(3S,6S,9S,12S,15R,18S,21S,24S,29aS)-21,24-dibenzyl-3-[(2R)-butan-2-yl]-15-[(2S)-butan-2-yl]-1,7,19-trihydroxy-12-(2-hydroxypropan-2-yl)-6,18-diisopropyl-5,11,17,23-tetramethyl-9-(2-methylpropyl)-3H,6H,9H,12H,15H,18H,21H,24H,27H,28H,29H,29aH-pyrrolo[1,2-m]1-oxa-4,7,10,13,16,19,22,25-octaazacycloheptacosane-4,10,13,16,22,25-hexone
> <JCHEM_VEBER_RULE>
0
$$$$