Mrv1652305152111102D
30 33 0 0 1 0 999 V2000
4.1864 2.3492 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.9371 -0.9356 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.4683 0.4142 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.2669 1.8833 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.7605 1.1820 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.3643 2.2794 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.8850 0.9521 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
5.0403 0.1418 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.1057 1.2228 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.4162 -0.3978 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.5337 -0.6667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.0612 1.3501 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.3130 -0.3960 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.4816 0.6832 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.6369 -0.1271 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.0904 -0.1271 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0
1.3385 0.9521 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
0.5592 1.2228 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.8697 -0.3978 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.3124 0.0391 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
3.0137 1.5327 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.6630 0.7859 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0
-0.0649 0.6832 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
2.9143 -0.5251 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
1.4938 0.1418 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
0.4039 2.0330 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
1.0250 -1.2080 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
0.2457 -0.9373 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
0.7145 0.4125 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
1.9617 -0.7077 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0
6 1 2 0 0 0 0
8 7 2 0 0 0 0
9 7 1 0 0 0 0
10 8 1 0 0 0 0
13 2 1 0 0 0 0
13 3 1 0 0 0 0
13 11 1 0 0 0 0
14 9 2 0 0 0 0
15 10 2 0 0 0 0
15 14 1 0 0 0 0
16 11 1 1 0 0 0
17 12 1 0 0 0 0
18 17 1 0 0 0 0
19 16 1 0 0 0 0
21 4 1 0 0 0 0
21 5 1 0 0 0 0
21 6 1 0 0 0 0
22 12 1 0 0 0 0
22 14 1 0 0 0 0
22 20 1 0 0 0 0
22 21 1 6 0 0 0
23 16 1 0 0 0 0
23 18 2 0 0 0 0
24 15 1 0 0 0 0
24 20 1 0 0 0 0
25 17 1 0 0 0 0
25 19 1 0 0 0 0
25 20 1 0 0 0 0
26 18 1 0 0 0 0
27 19 2 0 0 0 0
16 28 1 6 0 0 0
17 29 1 1 0 0 0
20 30 1 6 0 0 0
M END
> <DATABASE_ID>
MMDBc0019049
> <DATABASE_NAME>
MIME
> <SMILES>
[H][C@@]12C[C@]3(C4=CC=CC=C4N[C@@]3([H])N1C(=O)[C@@]([H])(CC(C)C)N=C2O)C(C)(C)C=C
> <INCHI_IDENTIFIER>
InChI=1S/C22H29N3O2/c1-6-21(4,5)22-12-17-18(26)23-16(11-13(2)3)19(27)25(17)20(22)24-15-10-8-7-9-14(15)22/h6-10,13,16-17,20,24H,1,11-12H2,2-5H3,(H,23,26)/t16-,17+,20+,22-/m1/s1
> <INCHI_KEY>
HAXPBJUEOMQIJN-HBCLNWRISA-N
> <FORMULA>
C22H29N3O2
> <MOLECULAR_WEIGHT>
367.493
> <EXACT_MASS>
367.225977186
> <JCHEM_ACCEPTOR_COUNT>
4
> <JCHEM_ATOM_COUNT>
56
> <JCHEM_AVERAGE_POLARIZABILITY>
41.25954111052773
> <JCHEM_BIOAVAILABILITY>
1
> <JCHEM_DONOR_COUNT>
2
> <JCHEM_FORMAL_CHARGE>
0
> <JCHEM_GHOSE_FILTER>
1
> <JCHEM_IUPAC>
(1S,4R,7S,9R)-6-hydroxy-9-(2-methylbut-3-en-2-yl)-4-(2-methylpropyl)-2,5,16-triazatetracyclo[7.7.0.0^{2,7}.0^{10,15}]hexadeca-5,10,12,14-tetraen-3-one
> <ALOGPS_LOGP>
3.71
> <JCHEM_LOGP>
3.949466329666667
> <ALOGPS_LOGS>
-3.54
> <JCHEM_MDDR_LIKE_RULE>
0
> <JCHEM_NUMBER_OF_RINGS>
4
> <JCHEM_PHYSIOLOGICAL_CHARGE>
0
> <JCHEM_PKA>
15.167864483800447
> <JCHEM_PKA_STRONGEST_ACIDIC>
4.812560944460725
> <JCHEM_PKA_STRONGEST_BASIC>
2.337804842479215
> <JCHEM_POLAR_SURFACE_AREA>
64.93
> <JCHEM_REFRACTIVITY>
106.67609999999999
> <JCHEM_ROTATABLE_BOND_COUNT>
4
> <JCHEM_RULE_OF_FIVE>
1
> <ALOGPS_SOLUBILITY>
1.06e-01 g/l
> <JCHEM_TRADITIONAL_IUPAC>
(1S,4R,7S,9R)-6-hydroxy-9-(2-methylbut-3-en-2-yl)-4-(2-methylpropyl)-2,5,16-triazatetracyclo[7.7.0.0^{2,7}.0^{10,15}]hexadeca-5,10,12,14-tetraen-3-one
> <JCHEM_VEBER_RULE>
0
$$$$