MiMeDB: Showing metabocard for Ubiquinol-2 (MMDBc0031712)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-18 01:45:23 UTC

Update Date

2024-04-30 19:51:39 UTC

Metabolite ID

MMDBc0031712

Metabolite Identification

Common Name

Ubiquinol-2

Description

Ubiquinol-2 is a member of the chemical class known as Polyprenylbenzoquinols. They are reduced forms of polyprenylbenzoquinines (ubiquinones). These are compounds containing a polyisoprene chain attached to a quinol at the second ring position. Ubiquiol-2 has just 2 isoprene units. Normally in E. coli the active form of Ubiquinol has 8 isoprene units (Ubiquinol-8) and in humans it normally has 10. Ubiquinol-2 is a ‚Äúfailed‚Äù or incomplete version of Ubiquinol 8 that arises from conjugation by a shortened prenyl tail via 4-hydroxybenzoate polyprenyltransferase. Coenzyme Q(n) exists in three redox states, fully oxidized (ubiquinone), partially reduced (semiquinones or ubisemiquinones), and fully reduced (ubiquinols). The redox functions of ubiquinol in cellular energy production and antioxidant protection are based on the ability to exchange two electrons in a redox cycle between ubiquinol (reduced) and the ubiquinone (oxidized) form. Ubiquionols are important in cellular respiration. They are fat-soluble and therefore mobile in cellular membranes; they play a unique role in the electron transport chain (ETC). In the inner bacterial membrane, electrons from NADH and succinate pass through the ETC to the oxygen, which is then reduced to water. The transfer of electrons through ETC results in the pumping of H+ across the membrane creating a proton gradient across the membrane, which is used by ATP synthase (located on the membrane) to generate ATP.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0001304
     RDKit          3D
QH2
 51 51  0  0  0  0  0  0  0  0999 V2000
   -6.7801    0.1799   -0.4914 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5323    0.1352   -1.1282 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3208   -0.0854   -0.4940 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7927   -1.3531   -0.3214 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5430   -2.4125   -0.8205 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5962   -1.6127    0.3007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0788   -2.9973    0.4662 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8615   -0.5101    0.7952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6099   -0.8062    1.4818 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4617    0.1612    1.4954 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7105   -0.1646    1.1191 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0715   -1.5426    0.6615 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7599    0.8790    1.2217 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4478    1.2600   -0.0218 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1574    0.2018   -0.7546 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4896    0.1556   -0.8413 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3430    1.2007   -0.1809 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1669   -0.9344   -1.5818 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4006    0.7592    0.6162 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7089    1.8607    1.0857 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5998    1.0013   -0.0088 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0751    2.3011   -0.1490 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7338    2.9690   -1.3748 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6983    0.1618    0.6168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3289   -0.7415   -0.7953 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3737    1.0611   -0.7459 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4251   -2.2963   -1.2870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5257   -3.1582    1.3993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9758   -3.6706    0.4651 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5385   -3.2432   -0.4619 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1992   -1.7323    0.9486 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8296   -1.1974    2.5102 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3112    1.2123    1.8213 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6729   -1.6638   -0.3556 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5930   -2.2920    1.3550 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1792   -1.6941    0.7216 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3227    1.8379    1.6582 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4731    0.5664    2.0500 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7294    1.8245   -0.6579 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2205    2.0405    0.2671 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5966   -0.5635   -1.2629 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1948    2.1928   -0.6016 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4193    0.9276   -0.2442 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1149    1.1933    0.9264 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4712   -1.6453   -2.0353 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.8565   -1.4099   -0.8314 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7683   -0.4511   -2.3952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0316    2.7956    1.0025 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7363    2.6031   -1.6842 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4554    2.6379   -2.1692 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7806    4.0587   -1.2892 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 16 18  1  0
  8 19  1  0
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 23  1  0
 21  3  1  0
  1 24  1  0
  1 25  1  0
  1 26  1  0
  5 27  1  0
  7 28  1  0
  7 29  1  0
  7 30  1  0
  9 31  1  0
  9 32  1  0
 10 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 13 38  1  0
 14 39  1  0
 14 40  1  0
 15 41  1  0
 17 42  1  0
 17 43  1  0
 17 44  1  0
 18 45  1  0
 18 46  1  0
 18 47  1  0
 20 48  1  0
 23 49  1  0
 23 50  1  0
 23 51  1  0
M  END


  Mrv1652309042000212D          

 23 23  0  0  0  0            999 V2000
    3.5669  -12.4704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8496  -12.8888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5669  -11.6395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4150  -12.8819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1357  -12.4704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8496  -13.7127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8496  -11.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2810  -11.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1289  -12.4669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1357  -11.6395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4210  -12.8785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8496  -10.4033    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8394  -12.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4244  -11.2238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7070  -12.4635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5534  -12.4669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8394  -13.6991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2574  -12.8706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9632  -12.4638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6732  -12.8706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6722  -13.6885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3814  -12.4646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288  -10.4059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  3  7  1  0  0  0  0
  3  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
  7 10  2  0  0  0  0
 16 18  1  0  0  0  0
  1  2  1  0  0  0  0
 18 19  1  0  0  0  0
  1  3  2  0  0  0  0
 19 20  2  0  0  0  0
  1  4  1  0  0  0  0
 20 21  1  0  0  0  0
  2  5  2  0  0  0  0
 20 22  1  0  0  0  0
  2  6  1  0  0  0  0
 14 23  1  0  0  0  0
M  STY  1   1 SRU
M  SCN  1   1 HT 
M  SAL   1  5   4   9  13  16  17
M  SDI   1  4    3.9558  -13.3721    3.9558  -12.2063
M  SDI   1  4    6.9451  -12.1964    6.9451  -13.3721
M  SBL   1  2  18  13
M  SMT   1 n
M  END
> <DATABASE_ID>
MMDBc0031712

> <DATABASE_NAME>
MIME

> <SMILES>
COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC

> <INCHI_IDENTIFIER>
InChI=1S/C19H28O4/c1-12(2)8-7-9-13(3)10-11-15-14(4)16(20)18(22-5)19(23-6)17(15)21/h8,10,20-21H,7,9,11H2,1-6H3/b13-10+

> <INCHI_KEY>
RNUCUWWMTTWKAH-JLHYYAGUSA-N

> <FORMULA>
(C5H8)nC14H20O4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <ALOGPS_LOGP>
4.41

> <ALOGPS_LOGS>
-4.41

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.25e-02 g/l

$$$$

HMDB0001304
     RDKit          3D
QH2
 51 51  0  0  0  0  0  0  0  0999 V2000
   -6.7801    0.1799   -0.4914 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5323    0.1352   -1.1282 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3208   -0.0854   -0.4940 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7927   -1.3531   -0.3214 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5430   -2.4125   -0.8205 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5962   -1.6127    0.3007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0788   -2.9973    0.4662 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8615   -0.5101    0.7952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6099   -0.8062    1.4818 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4617    0.1612    1.4954 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7105   -0.1646    1.1191 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0715   -1.5426    0.6615 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7599    0.8790    1.2217 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4478    1.2600   -0.0218 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1574    0.2018   -0.7546 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4896    0.1556   -0.8413 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3430    1.2007   -0.1809 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1669   -0.9344   -1.5818 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4006    0.7592    0.6162 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7089    1.8607    1.0857 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5998    1.0013   -0.0088 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0751    2.3011   -0.1490 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7338    2.9690   -1.3748 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6983    0.1618    0.6168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3289   -0.7415   -0.7953 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3737    1.0611   -0.7459 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4251   -2.2963   -1.2870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5257   -3.1582    1.3993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9758   -3.6706    0.4651 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5385   -3.2432   -0.4619 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1992   -1.7323    0.9486 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8296   -1.1974    2.5102 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3112    1.2123    1.8213 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6729   -1.6638   -0.3556 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5930   -2.2920    1.3550 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1792   -1.6941    0.7216 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3227    1.8379    1.6582 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4731    0.5664    2.0500 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7294    1.8245   -0.6579 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2205    2.0405    0.2671 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5966   -0.5635   -1.2629 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1948    2.1928   -0.6016 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4193    0.9276   -0.2442 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1149    1.1933    0.9264 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4712   -1.6453   -2.0353 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.8565   -1.4099   -0.8314 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7683   -0.4511   -2.3952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0316    2.7956    1.0025 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7363    2.6031   -1.6842 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4554    2.6379   -2.1692 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7806    4.0587   -1.2892 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 16 18  1  0
  8 19  1  0
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 23  1  0
 21  3  1  0
  1 24  1  0
  1 25  1  0
  1 26  1  0
  5 27  1  0
  7 28  1  0
  7 29  1  0
  7 30  1  0
  9 31  1  0
  9 32  1  0
 10 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 13 38  1  0
 14 39  1  0
 14 40  1  0
 15 41  1  0
 17 42  1  0
 17 43  1  0
 17 44  1  0
 18 45  1  0
 18 46  1  0
 18 47  1  0
 20 48  1  0
 23 49  1  0
 23 50  1  0
 23 51  1  0
M  END

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  C   UNK     0       6.658 -23.278   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       5.319 -24.059   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       6.658 -21.727   0.000  0.00  0.00           C+0
HETATM    4  C     n     1       8.241 -24.046   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.987 -23.278   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       5.319 -25.597   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       5.319 -20.951   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.991 -20.951   0.000  0.00  0.00           C+0
HETATM    9  C     n     1       9.574 -23.272   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.987 -21.727   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       2.653 -24.040   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0       5.319 -19.419   0.000  0.00  0.00           O+0
HETATM   13  C     n     1      10.900 -24.040   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       2.659 -20.951   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       1.320 -23.265   0.000  0.00  0.00           C+0
HETATM   16  C     n     1      12.233 -23.272   0.000  0.00  0.00           C+0
HETATM   17  C     n     1      10.900 -25.572   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.547 -24.025   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      14.865 -23.266   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      16.190 -24.025   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      16.188 -25.552   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      17.512 -23.267   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.667 -19.424   0.000  0.00  0.00           C+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5    6                                                  
CONECT    3    7    8    1                                                  
CONECT    4    9    1                                                       
CONECT    5   10   11    2                                                  
CONECT    6    2                                                            
CONECT    7    3   12   10                                                  
CONECT    8    3                                                            
CONECT    9    4   13                                                       
CONECT   10    5   14    7                                                  
CONECT   11    5   15                                                       
CONECT   12    7                                                            
CONECT   13    9   16   17                                                  
CONECT   14   10   23                                                       
CONECT   15   11                                                            
CONECT   16   13   18                                                       
CONECT   17   13                                                            
CONECT   18   16   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20                                                            
CONECT   23   14                                                            
MASTER        0    0    0    0    0    0    0    0   23    0   46    0
END

COMPND    HMDB0001304
HETATM    1  C1  UNL     1      -6.780   0.180  -0.491  1.00  0.00           C  
HETATM    2  O1  UNL     1      -5.532   0.135  -1.128  1.00  0.00           O  
HETATM    3  C2  UNL     1      -4.321  -0.085  -0.494  1.00  0.00           C  
HETATM    4  C3  UNL     1      -3.793  -1.353  -0.321  1.00  0.00           C  
HETATM    5  O2  UNL     1      -4.543  -2.413  -0.820  1.00  0.00           O  
HETATM    6  C4  UNL     1      -2.596  -1.613   0.301  1.00  0.00           C  
HETATM    7  C5  UNL     1      -2.079  -2.997   0.466  1.00  0.00           C  
HETATM    8  C6  UNL     1      -1.861  -0.510   0.795  1.00  0.00           C  
HETATM    9  C7  UNL     1      -0.610  -0.806   1.482  1.00  0.00           C  
HETATM   10  C8  UNL     1       0.462   0.161   1.495  1.00  0.00           C  
HETATM   11  C9  UNL     1       1.710  -0.165   1.119  1.00  0.00           C  
HETATM   12  C10 UNL     1       2.071  -1.543   0.662  1.00  0.00           C  
HETATM   13  C11 UNL     1       2.760   0.879   1.222  1.00  0.00           C  
HETATM   14  C12 UNL     1       3.448   1.260  -0.022  1.00  0.00           C  
HETATM   15  C13 UNL     1       4.157   0.202  -0.755  1.00  0.00           C  
HETATM   16  C14 UNL     1       5.490   0.156  -0.841  1.00  0.00           C  
HETATM   17  C15 UNL     1       6.343   1.201  -0.181  1.00  0.00           C  
HETATM   18  C16 UNL     1       6.167  -0.934  -1.582  1.00  0.00           C  
HETATM   19  C17 UNL     1      -2.401   0.759   0.616  1.00  0.00           C  
HETATM   20  O3  UNL     1      -1.709   1.861   1.086  1.00  0.00           O  
HETATM   21  C18 UNL     1      -3.600   1.001  -0.009  1.00  0.00           C  
HETATM   22  O4  UNL     1      -4.075   2.301  -0.149  1.00  0.00           O  
HETATM   23  C19 UNL     1      -3.734   2.969  -1.375  1.00  0.00           C  
HETATM   24  H1  UNL     1      -6.698   0.162   0.617  1.00  0.00           H  
HETATM   25  H2  UNL     1      -7.329  -0.741  -0.795  1.00  0.00           H  
HETATM   26  H3  UNL     1      -7.374   1.061  -0.746  1.00  0.00           H  
HETATM   27  H4  UNL     1      -5.425  -2.296  -1.287  1.00  0.00           H  
HETATM   28  H5  UNL     1      -1.526  -3.158   1.399  1.00  0.00           H  
HETATM   29  H6  UNL     1      -2.976  -3.671   0.465  1.00  0.00           H  
HETATM   30  H7  UNL     1      -1.538  -3.243  -0.462  1.00  0.00           H  
HETATM   31  H8  UNL     1      -0.199  -1.732   0.949  1.00  0.00           H  
HETATM   32  H9  UNL     1      -0.830  -1.197   2.510  1.00  0.00           H  
HETATM   33  H10 UNL     1       0.311   1.212   1.821  1.00  0.00           H  
HETATM   34  H11 UNL     1       1.673  -1.664  -0.356  1.00  0.00           H  
HETATM   35  H12 UNL     1       1.593  -2.292   1.355  1.00  0.00           H  
HETATM   36  H13 UNL     1       3.179  -1.694   0.722  1.00  0.00           H  
HETATM   37  H14 UNL     1       2.323   1.838   1.658  1.00  0.00           H  
HETATM   38  H15 UNL     1       3.473   0.566   2.050  1.00  0.00           H  
HETATM   39  H16 UNL     1       2.729   1.825  -0.658  1.00  0.00           H  
HETATM   40  H17 UNL     1       4.221   2.040   0.267  1.00  0.00           H  
HETATM   41  H18 UNL     1       3.597  -0.564  -1.263  1.00  0.00           H  
HETATM   42  H19 UNL     1       6.195   2.193  -0.602  1.00  0.00           H  
HETATM   43  H20 UNL     1       7.419   0.928  -0.244  1.00  0.00           H  
HETATM   44  H21 UNL     1       6.115   1.193   0.926  1.00  0.00           H  
HETATM   45  H22 UNL     1       5.471  -1.645  -2.035  1.00  0.00           H  
HETATM   46  H23 UNL     1       6.857  -1.410  -0.831  1.00  0.00           H  
HETATM   47  H24 UNL     1       6.768  -0.451  -2.395  1.00  0.00           H  
HETATM   48  H25 UNL     1      -2.032   2.796   1.002  1.00  0.00           H  
HETATM   49  H26 UNL     1      -2.736   2.603  -1.684  1.00  0.00           H  
HETATM   50  H27 UNL     1      -4.455   2.638  -2.169  1.00  0.00           H  
HETATM   51  H28 UNL     1      -3.781   4.059  -1.289  1.00  0.00           H  
CONECT    1    2   24   25   26
CONECT    2    3
CONECT    3    4    4   21
CONECT    4    5    6
CONECT    5   27
CONECT    6    7    8    8
CONECT    7   28   29   30
CONECT    8    9   19
CONECT    9   10   31   32
CONECT   10   11   11   33
CONECT   11   12   13
CONECT   12   34   35   36
CONECT   13   14   37   38
CONECT   14   15   39   40
CONECT   15   16   16   41
CONECT   16   17   18
CONECT   17   42   43   44
CONECT   18   45   46   47
CONECT   19   20   21   21
CONECT   20   48
CONECT   21   22
CONECT   22   23
CONECT   23   49   50   51
END

HMDB0001304
     RDKit          3D
QH2
 51 51  0  0  0  0  0  0  0  0999 V2000
   -6.7801    0.1799   -0.4914 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5323    0.1352   -1.1282 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3208   -0.0854   -0.4940 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7927   -1.3531   -0.3214 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5430   -2.4125   -0.8205 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5962   -1.6127    0.3007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0788   -2.9973    0.4662 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8615   -0.5101    0.7952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6099   -0.8062    1.4818 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4617    0.1612    1.4954 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7105   -0.1646    1.1191 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0715   -1.5426    0.6615 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7599    0.8790    1.2217 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4478    1.2600   -0.0218 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1574    0.2018   -0.7546 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4896    0.1556   -0.8413 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3430    1.2007   -0.1809 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1669   -0.9344   -1.5818 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4006    0.7592    0.6162 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7089    1.8607    1.0857 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5998    1.0013   -0.0088 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0751    2.3011   -0.1490 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7338    2.9690   -1.3748 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6983    0.1618    0.6168 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3289   -0.7415   -0.7953 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3737    1.0611   -0.7459 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4251   -2.2963   -1.2870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5257   -3.1582    1.3993 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9758   -3.6706    0.4651 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5385   -3.2432   -0.4619 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1992   -1.7323    0.9486 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8296   -1.1974    2.5102 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3112    1.2123    1.8213 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6729   -1.6638   -0.3556 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5930   -2.2920    1.3550 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1792   -1.6941    0.7216 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3227    1.8379    1.6582 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4731    0.5664    2.0500 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7294    1.8245   -0.6579 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2205    2.0405    0.2671 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5966   -0.5635   -1.2629 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1948    2.1928   -0.6016 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.4193    0.9276   -0.2442 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1149    1.1933    0.9264 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4712   -1.6453   -2.0353 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.8565   -1.4099   -0.8314 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7683   -0.4511   -2.3952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0316    2.7956    1.0025 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7363    2.6031   -1.6842 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4554    2.6379   -2.1692 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7806    4.0587   -1.2892 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  6  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  3
 16 17  1  0
 16 18  1  0
  8 19  1  0
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 23  1  0
 21  3  1  0
  1 24  1  0
  1 25  1  0
  1 26  1  0
  5 27  1  0
  7 28  1  0
  7 29  1  0
  7 30  1  0
  9 31  1  0
  9 32  1  0
 10 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 13 38  1  0
 14 39  1  0
 14 40  1  0
 15 41  1  0
 17 42  1  0
 17 43  1  0
 17 44  1  0
 18 45  1  0
 18 46  1  0
 18 47  1  0
 20 48  1  0
 23 49  1  0
 23 50  1  0
 23 51  1  0
M  END

Synonyms

Value	Source
CoQH2	Kegg
Coenzymes QH2	HMDB
Reduced ubiquinone	HMDB
Ubiquinol	HMDB
Ubiquinone-1	HMDB
Coenzyme Q10, reduced	HMDB
Ubiquinol-10	HMDB

Molecular Formula

(C₅H₈)nC₁₄H₂₀O₄

Average Mass

Not Available

Monoisotopic Mass

Not Available

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC

InChI Identifier

InChI=1S/C19H28O4/c1-12(2)8-7-9-13(3)10-11-15-14(4)16(20)18(22-5)19(23-6)17(15)21/h8,10,20-21H,7,9,11H2,1-6H3/b13-10+

InChI Key

RNUCUWWMTTWKAH-JLHYYAGUSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as ubiquinols. These are coenzyme Q derivatives containing a 5, 6-dimethoxy-3-methylbenzene-1,4-diol moiety to which an isoprenyl group is attached at ring position 2(or 6).

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Quinone and hydroquinone lipids

Direct Parent

Ubiquinols

Alternative Parents

Substituents

Ubiquinol skeleton
Aromatic monoterpenoid
Methoxyphenol
Monocyclic monoterpenoid
Monoterpenoid
O-dimethoxybenzene
Dimethoxybenzene
Anisole
Phenoxy compound
Hydroquinone
M-cresol
Methoxybenzene
O-cresol
Phenol ether
Alkyl aryl ether
Phenol
Toluene
Monocyclic benzene moiety
Benzenoid
Ether
Hydrocarbon derivative
Organic oxygen compound
Organooxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.012 g/L	ALOGPS
logP	4.41	ALOGPS
logS	-4.4	ALOGPS
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0a4r-4193000000-48fe18179b80bb21b5c7	2017-11-06	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-0239000000-bbff225e78add9a452cd	2019-02-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-05fs-5941000000-9f3d49dffc1fee6bce79	2019-02-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0690-9510000000-6b82f15187f9c07ab964	2019-02-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-014i-0009000000-538077b5337d583f80b6	2019-02-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00kb-1195000000-ee266dcd83a76f9e4973	2019-02-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0aba-5390000000-aa9db1cbd8b9e542a924	2019-02-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-1229000000-bcae25f8e04aef2f7f2e	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0002-4971000000-a2a095c9a71f782655e6	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-05pw-6930000000-256eb8fb25dcd7ed3a83	2021-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-014i-0009000000-0385a0c55ac9f0aa5ed4	2021-09-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-014i-0559000000-c001cae147213a35d7d5	2021-09-23	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0kdr-1981000000-d586cd100610d78946f2	2021-09-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-18	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-18	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Inner mitochondrial membrane
Membrane

Biospecimen Locations

Blood
Epidermis
Skeletal Muscle
Testis

Tissue Locations

Epidermis
Skeletal Muscle
Testis

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191788	NADH-ubiquinone oxidoreductase chain 1	Unknown	P03886	Homo sapiens
MMDBp0191789	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	Enzyme	O75438	Homo sapiens
MMDBp0191791	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Unknown	O75306	Homo sapiens
MMDBp0191792	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Unknown	Q99643	Homo sapiens
MMDBp0191795	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	Enzyme	Q9UI09	Homo sapiens
MMDBp0191798	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	Enzyme	O15239	Homo sapiens
MMDBp0191799	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	Enzyme	Q9NRX3	Homo sapiens
MMDBp0191800	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	Enzyme	O95167	Homo sapiens
MMDBp0191801	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	Enzyme	P51970	Homo sapiens
MMDBp0191802	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	Enzyme	O00483	Homo sapiens
MMDBp0191803	NADH-ubiquinone oxidoreductase chain 4L	Unknown	P03901	Homo sapiens
MMDBp0191804	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	Enzyme	Q86Y39	Homo sapiens
MMDBp0191808	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	Unknown	O43181	Homo sapiens
MMDBp0191810	NADH-ubiquinone oxidoreductase chain 5	Unknown	P03915	Homo sapiens
MMDBp0191811	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	Unknown	O75489	Homo sapiens
MMDBp0191812	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	Unknown	O43920	Homo sapiens
MMDBp0191813	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	Unknown	P19404	Homo sapiens
MMDBp0191815	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	Unknown	O95299	Homo sapiens
MMDBp0191816	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	Enzyme	P56556	Homo sapiens
MMDBp0191820	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	Enzyme	O95168	Homo sapiens
MMDBp0191821	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Unknown	P31040	Homo sapiens
MMDBp0191823	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	Unknown	O00217	Homo sapiens
MMDBp0191825	NADH-ubiquinone oxidoreductase chain 2	Unknown	P03891	Homo sapiens
MMDBp0191828	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	Enzyme	O95182	Homo sapiens
MMDBp0191830	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	Enzyme	O43678	Homo sapiens
MMDBp0191833	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	Unknown	P28331	Homo sapiens
MMDBp0191834	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	Enzyme	O43674	Homo sapiens
MMDBp0191841	NADH dehydrogenase [ubiquinone] 1 subunit C2	Enzyme	O95298	Homo sapiens
MMDBp0191843	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	Enzyme	O43676	Homo sapiens
MMDBp0191844	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	Enzyme	P17568	Homo sapiens
MMDBp0191845	Acyl carrier protein, mitochondrial	Enzyme	O14561	Homo sapiens
MMDBp0191846	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	Enzyme	Q16718	Homo sapiens
MMDBp0191847	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial	Unknown	Q16134	Homo sapiens
MMDBp0191848	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	Unknown	Q16795	Homo sapiens
MMDBp0191849	NADH-ubiquinone oxidoreductase chain 4	Unknown	P03905	Homo sapiens
MMDBp0191850	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	Unknown	O14521	Homo sapiens
MMDBp0191851	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	Unknown	O75251	Homo sapiens
MMDBp0191853	NADH-ubiquinone oxidoreductase chain 3	Unknown	P03897	Homo sapiens
MMDBp0191857	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	Unknown	P49821	Homo sapiens
MMDBp0191858	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	Enzyme	Q9Y6M9	Homo sapiens
MMDBp0191860	NADH-ubiquinone oxidoreductase chain 6	Unknown	P03923	Homo sapiens
MMDBp0191861	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Enzyme	Q9P0J0	Homo sapiens
MMDBp0191862	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	Unknown	O75380	Homo sapiens
MMDBp0191864	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Unknown	P21912	Homo sapiens
MMDBp0192597	Cytochrome b-c1 complex subunit 2, mitochondrial	Unknown	P22695	Homo sapiens
MMDBp0192598	Cytochrome b-c1 complex subunit 9	Unknown	Q9UDW1	Homo sapiens
MMDBp0192599	Cytochrome b-c1 complex subunit 1, mitochondrial	Unknown	P31930	Homo sapiens
MMDBp0192600	Cytochrome b-c1 complex subunit 7	Enzyme	P14927	Homo sapiens
MMDBp0192602	Cytochrome b-c1 complex subunit Rieske, mitochondrial	Enzyme	P47985	Homo sapiens
MMDBp0192603	Cytochrome c1, heme protein, mitochondrial	Unknown	P08574	Homo sapiens
MMDBp0192604	Cytochrome b-c1 complex subunit 6, mitochondrial	Unknown	P07919	Homo sapiens
MMDBp0192712	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	Enzyme	Q9NX14	Homo sapiens
MMDBp0193481	Cytochrome b-c1 complex subunit 8	Enzyme	O14949	Homo sapiens
MMDBp0193819	Cytochrome b-c1 complex subunit 10	Unknown	O14957	Homo sapiens
MMDBp0196143	NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDa	Enzyme	A4D1T5	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank
Immunometabolism Pathway (Bacterial Activation)
Immunometabolism Pathway (Viral Activation)
Viral Sepsis

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Heart failure		Association	Human Blood	HMDB	17482886

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	1	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool	Unknown

Exposure Sources

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Units	Age	Sex	Health Condition	Data Source	Reference
Human Blood	Detected and Quantified	7.4	2.7	uM	Adult (>18 years old)	Both	Heart failure	HMDB	17482886
Human Epidermis	Detected but not Quantified				Not Specified	Not Specified	Normal	HMDB	34986597
Human Skeletal muscle	Detected but not Quantified				Not Specified	Not Specified	Normal	HMDB	34986597
Human Testis	Detected but not Quantified				Not Specified	Not Specified	Normal	HMDB	34986597

External Links

HMDB ID

HMDB0001304

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB022543

KNApSAcK ID

Not Available

Chemspider ID

4444052

KEGG Compound ID

C00390

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Coenzyme Q10

METLIN ID

6146

PubChem Compound

5280344

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Halliwell B, Hu ML, Louie S, Duvall TR, Tarkington BK, Motchnik P, Cross CE: Interaction of nitrogen dioxide with human plasma. Antioxidant depletion and oxidative damage. FEBS Lett. 1992 Nov 16;313(1):62-6. doi: 10.1016/0014-5793(92)81185-o. [PubMed:1426270 ]
Neuzil J, Stocker R: Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem. 1994 Jun 17;269(24):16712-9. [PubMed:8206992 ]
Shindo Y, Witt E, Han D, Epstein W, Packer L: Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol. 1994 Jan;102(1):122-4. doi: 10.1111/1523-1747.ep12371744. [PubMed:8288904 ]
Peltola V, Huhtaniemi I, Metsa-Ketela T, Ahotupa M: Induction of lipid peroxidation during steroidogenesis in the rat testis. Endocrinology. 1996 Jan;137(1):105-12. doi: 10.1210/endo.137.1.8536600. [PubMed:8536600 ]
Lonnrot K, Metsa-Ketela T, Molnar G, Ahonen JP, Latvala M, Peltola J, Pietila T, Alho H: The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity. Free Radic Biol Med. 1996;21(2):211-7. doi: 10.1016/0891-5849(95)02207-4. [PubMed:8818636 ]
Kontush A, Reich A, Baum K, Spranger T, Finckh B, Kohlschutter A, Beisiegel U: Plasma ubiquinol-10 is decreased in patients with hyperlipidaemia. Atherosclerosis. 1997 Feb 28;129(1):119-26. doi: 10.1016/s0021-9150(96)06021-2. [PubMed:9069526 ]
Passi S, Grandinetti M, Maggio F, Stancato A, De Luca C: Epidermal oxidative stress in vitiligo. Pigment Cell Res. 1998 Apr;11(2):81-5. doi: 10.1111/j.1600-0749.1998.tb00714.x. [PubMed:9585244 ]
Kontush A, Spranger T, Reich A, Baum K, Beisiegel U: Lipophilic antioxidants in blood plasma as markers of atherosclerosis: the role of alpha-carotene and gamma-tocopherol. Atherosclerosis. 1999 May;144(1):117-22. doi: 10.1016/s0021-9150(99)00044-1. [PubMed:10381285 ]
Mohr D, Umeda Y, Redgrave TG, Stocker R: Antioxidant defenses in rat intestine and mesenteric lymph. Redox Rep. 1999;4(3):79-87. doi: 10.1179/135100099101534756. [PubMed:10496410 ]
Hargreaves P, Rahman S, Guthrie P, Taanman JW, Leonard JV, Land JM, Heales SJ: Diagnostic value of succinate ubiquinone reductase activity in the identification of patients with mitochondrial DNA depletion. J Inherit Metab Dis. 2002 Feb;25(1):7-16. doi: 10.1023/a:1015104910239. [PubMed:12004863 ]
Miles L, Miles MV, Tang PH, Horn PS, Wong BL, DeGrauw TJ, Morehart PJ, Bove KE: Muscle coenzyme Q: a potential test for mitochondrial activity and redox status. Pediatr Neurol. 2005 May;32(5):318-24. doi: 10.1016/j.pediatrneurol.2005.01.009. [PubMed:15866432 ]

Showing metabocard for Ubiquinol-2 (MMDBc0031712)

MOL for #<Metabolite:0x00007fdb06b16a50>

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Structure for #<Metabolite:0x00007fdb06b16a50>

3D Structure for #<Metabolite:0x00007fdb06b16a50>