Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-18 01:48:16 UTC
Update Date2022-08-31 18:24:26 UTC
Metabolite IDMMDBc0031761
Metabolite Identification
Common Name5-Hydroxyisourate
Description5-Hydroxyisourate is involved in purine degradation. It is a substrate of the enzyme hydroxyisourate hydrolase which catalyzes the reaction 5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate. In most organisms, including some bacteria (such as E. coli), plants, and certain animals, urate is metabolized via a common pathway, producing the stereospecific form S-allantoin as the final product. In the first step of the pathway factor-independent urate hydroxylase catalyzes the conversion of urate to 5-hydroxyisourate.
Structure
Synonyms
ValueSource
5-Hydroxyisouric acidGenerator
5-Hydroxy-2,6-dioxo-2,5,6,7-tetrahydro-1H-purin-8-olateHMDB
5-Hydroxy-5,7-dihydro-1H-purine-2,6,8(9H)-trioneHMDB
Molecular FormulaC5H4N4O4
Average Mass184.1097
Monoisotopic Mass184.023254636
IUPAC Name5-hydroxy-2,3,5,6,7,8-hexahydro-1H-purine-2,6,8-trione
Traditional Name5-hydroxyisourate
CAS Registry NumberNot Available
SMILES
OC12NC(=O)N=C1NC(=O)NC2=O
InChI Identifier
InChI=1S/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)
InChI KeyLTQYPAVLAYVKTK-UHFFFAOYSA-N