Showing metabocard for Estrone (MMDBc0047903)

Not Available
Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-23 23:10:07 UTC
Update Date2024-10-09 20:15:49 UTC
Metabolite IDMMDBc0047903
Metabolite Identification
Common NameEstrone
DescriptionEstrone is a major mammalian estrogen. The conversion of the natural C19 steroids, testosterone and androstenedione into estrone is dependent on a complex key reaction catalyzed by the cytochrome P450 aromatase (EC 1.14.14.1, unspecific monooxygenase), which is expressed in many tissues of the adult human (e.g. ovary, fat tissue), but not in the liver. The ovaries after menopause continue to produce androstenedione and testosterone in significant amounts and these androgens are converted in fat, muscle, and skin into estrone. When women between the ages of 45 and 64 years have prophylactic oophorectomy (when hysterectomy is performed for benign disease to prevent the development of ovarian cancer), evidence suggests that oophorectomy increases the subsequent risk of coronary heart disease (CHD) and osteoporosis. Whereas 14,000 women die of ovarian cancer every year nearly 490,000 women die of heart disease and 48,000 women die within 1 year after hip fracture. Therefore, the decision to perform prophylactic oophorectomy should be approached with great caution for the majority of women who are at low risk of developing ovarian cancer. Steroid sulfatase (EC 3.1.6.2, STS) hydrolyzes steroid sulfates, such as estrone sulfate to estrone which can be converted to steroids with potent estrogenic properties, that is, estradiol; STS activity is much higher in breast tumors and high levels of STS mRNA expression in tumors are associated with a poor prognosis. The biological roles of estrogens in tumorigenesis are certainly different between the endometrium and breast, although both are considered "estrogen-dependent tissues". 17beta-hydroxysteroid dehydrogenases (EC 1.1.1.62, 17-HSDs) are enzymes involved in the formation of active sex steroids. estrone is interconverted by two enzymes 17-HSD types. Type 1 converts estrone to estradiol and Type 2 catalyzes the reverse reaction. (PMID: 17653961 , 17513923 , 17470679 , 17464097 ).
Structure
MOLSDFPDBSMILESInChI

MOL for #<Metabolite:0x00007fdb71936080>


  Mrv1652310301918522D          

 23 26  0  0  0  0            999 V2000
10001.446810001.4422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.1679 9998.1252    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.0195 9998.9603    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
10000.731110000.1943    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
10001.4468 9998.9603    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
10000.0192 9999.7809    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10000.0192 9998.1309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.7337 9998.5433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.7337 9999.3684    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10000.732510001.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.018010000.6136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5939 9999.7799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8795 9999.3674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8795 9998.5423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5939 9998.1298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3084 9998.5423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3084 9999.3674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.231610000.8686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.447010000.6136    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10001.4470 9999.7886    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10002.2316 9999.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.716510000.2011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.486510001.6532    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 11  6  1  0  0  0  0
  6  3  1  6  0  0  0
  9  4  1  1  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 12  1  0  0  0  0
 14  2  1  0  0  0  0
  6 17  1  0  0  0  0
 16  7  1  0  0  0  0
 18 19  1  0  0  0  0
 18 22  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 23  2  0  0  0  0
 20  5  1  6  0  0  0
  9 20  1  0  0  0  0
 10 19  1  0  0  0  0
 19  1  1  1  0  0  0
M  END
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3D MOL for #<Metabolite:0x00007fdb71936080>

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3D SDF for #<Metabolite:0x00007fdb71936080>

  Mrv1652310301918522D          

 23 26  0  0  0  0            999 V2000
10001.446810001.4422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.1679 9998.1252    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.0195 9998.9603    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
10000.731110000.1943    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
10001.4468 9998.9603    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
10000.0192 9999.7809    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
10000.0192 9998.1309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.7337 9998.5433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.7337 9999.3684    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10000.732510001.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10000.018010000.6136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5939 9999.7799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8795 9999.3674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.8795 9998.5423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.5939 9998.1298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3084 9998.5423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.3084 9999.3674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.231610000.8686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.447010000.6136    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10001.4470 9999.7886    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10002.2316 9999.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.716510000.2011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.486510001.6532    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 11  6  1  0  0  0  0
  6  3  1  6  0  0  0
  9  4  1  1  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 12  1  0  0  0  0
 14  2  1  0  0  0  0
  6 17  1  0  0  0  0
 16  7  1  0  0  0  0
 18 19  1  0  0  0  0
 18 22  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 23  2  0  0  0  0
 20  5  1  6  0  0  0
  9 20  1  0  0  0  0
 10 19  1  0  0  0  0
 19  1  1  1  0  0  0
M  END
> <DATABASE_ID>
MMDBc0047903

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3

> <INCHI_IDENTIFIER>
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

> <INCHI_KEY>
DNXHEGUUPJUMQT-CBZIJGRNSA-N

> <FORMULA>
C18H22O2

> <MOLECULAR_WEIGHT>
270.3661

> <EXACT_MASS>
270.161979948

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
42

> <JCHEM_AVERAGE_POLARIZABILITY>
31.24404121393373

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-14-one

> <ALOGPS_LOGP>
4.03

> <JCHEM_LOGP>
4.309029034000001

> <ALOGPS_LOGS>
-4.84

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
19.957534565528498

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.32695754200012

> <JCHEM_PKA_STRONGEST_BASIC>
-5.448299376893847

> <JCHEM_POLAR_SURFACE_AREA>
37.3

> <JCHEM_REFRACTIVITY>
79.0824

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.94e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-14-one

> <JCHEM_VEBER_RULE>
1

$$$$

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3D-SDF for #<Metabolite:0x00007fdb71936080>
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PDB for #<Metabolite:0x00007fdb71936080>
HEADER    PROTEIN                                 30-OCT-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   30-OCT-19         0                                  
HETATM    1  C   UNK     0    8669.3678669.359   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0    8661.3808663.167   0.000  0.00  0.00           O+0
HETATM    3  H   UNK     0    8666.7038664.726   0.000  0.00  0.00           H+0
HETATM    4  H   UNK     0    8668.0318667.029   0.000  0.00  0.00           H+0
HETATM    5  H   UNK     0    8669.3678664.726   0.000  0.00  0.00           H+0
HETATM    6  C   UNK     0    8666.7038666.258   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0    8666.7038663.178   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8668.0368663.947   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8668.0368665.488   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8668.0348668.582   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0    8666.7008667.812   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8664.0428666.256   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0    8662.7088665.486   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0    8662.7088663.946   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0    8664.0428663.176   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0    8665.3768663.946   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0    8665.3768665.486   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0    8670.8328668.288   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0    8669.3688667.812   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0    8669.3688666.272   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0    8670.8328665.796   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0    8671.7378667.042   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0    8671.3088669.753   0.000  0.00  0.00           O+0
CONECT    1   19                                                            
CONECT    2   14                                                            
CONECT    3    6                                                            
CONECT    4    9                                                            
CONECT    5   20                                                            
CONECT    6    9   11    3   17                                             
CONECT    7    8   16                                                       
CONECT    8    7    9                                                       
CONECT    9    6    8    4   20                                             
CONECT   10   11   19                                                       
CONECT   11   10    6                                                       
CONECT   12   13   17                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15    2                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17    7                                                  
CONECT   17   16   12    6                                                  
CONECT   18   19   22   23                                                  
CONECT   19   18   20   10    1                                             
CONECT   20   19   21    5    9                                             
CONECT   21   20   22                                                       
CONECT   22   18   21                                                       
CONECT   23   18                                                            
MASTER        0    0    0    0    0    0    0    0   23    0   52    0
END

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3D PDB for #<Metabolite:0x00007fdb71936080>
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SMILES for #<Metabolite:0x00007fdb71936080>
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INCHI for #<Metabolite:0x00007fdb71936080>
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Synonyms
ValueSource
3-Hydroxy-1,3,5(10)-estratrien-17-oneChEBI
Follicular hormoneChEBI
FolliculinChEBI
OestroneChEBI
(+)-EstroneHMDB
1,3,5(10)-Estratrien-3-ol-17-oneHMDB
3-Hydroxy-17-keto-estra-1,3,5-trieneHMDB
3-Hydroxyestra-1,3,5(10)-trien-17-oneHMDB
3-Hydroxyestra-1,3,5(10)-triene-17-oneHMDB
3-Hydroxyoestra-1,3,5(10)-trien-17-oneHMDB
D1,3,5(10)-Estratrien-3-ol-17-oneHMDB
Estrone, (+-)-isomerHMDB
Hyrex brand OF estroneHMDB
Estrone, (9 beta)-isomerHMDB
EstrovarinHMDB
KestroneHMDB
WehgenHMDB
Estrone, (8 alpha)-isomerHMDB
Hauck brand OF estroneHMDB
UnigenHMDB
Vortech brand OF estroneHMDB
Molecular FormulaC18H22O2
Average Mass270.3661
Monoisotopic Mass270.161979948
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number53-16-7
SMILESNot Available
InChI Identifier
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
InChI KeyDNXHEGUUPJUMQT-CBZIJGRNSA-N