Record Information
Version1.0
StatusDetected and Quantified
Creation Date2022-04-29 22:34:12 UTC
Update Date2024-04-30 20:38:11 UTC
Metabolite IDMMDBc0049458
Metabolite Identification
Common NameFarnesylcysteine
DescriptionIn patients with chronic fatigue syndrome (CFS) we found increased IgM levels to S-farnesyl-L-cysteine. S-farnesyl-L-cysteine plays a key role in regulating cell growth, differentiation and apoptosis through RAS protein activity. The latter depends on their anchorage to the inner surface of the plasma membrane, which is promoted by their common carboxy-terminal S-farnesyl-cysteine. The presence of antibodies to S-farnesyl-L-cysteine suggest that RAS functions may have undergone damage by oxidative/nitrosative stress, causing disturbed functional activity in the regulation of cell growth. (PMID 17159817 ).
Structure
Synonyms
ValueSource
S-(2E,6E)-Farnesyl-L-cysteineChEBI
S-trans-trans-FarnesylcysteineKegg
(e,e)-L-S-(3,7,11-Trimethyl-2,6,10-dodecatrienyl)-cysteineHMDB
S-all-trans-Farnesyl-L-cysteineHMDB
S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]-L-cysteineHMDB
S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]-L-cysteine,(9ci)HMDB
S-Farnesyl cysteineMeSH, HMDB
S-FarnesylcysteineMeSH, HMDB
Molecular FormulaC18H31NO2S
Average Mass325.509
Monoisotopic Mass325.207549931
IUPAC Name(2R)-2-amino-3-{[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl}propanoic acid
Traditional NameS-farnesylcysteine
CAS Registry Number68000-92-0
SMILES
CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@H](N)C(O)=O
InChI Identifier
InChI=1S/C18H31NO2S/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-22-13-17(19)18(20)21/h7,9,11,17H,5-6,8,10,12-13,19H2,1-4H3,(H,20,21)/b15-9+,16-11+/t17-/m0/s1
InChI KeySYSLNQMKLROGCL-BCYUYYMPSA-N