MiMeDB: Showing metabocard for N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine (MMDBc0056107)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2022-06-17 20:16:52 UTC

Update Date

2022-08-12 20:09:35 UTC

Metabolite ID

MMDBc0056107

Metabolite Identification

Common Name

N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine

Description

N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another. Based on a literature review very few articles have been published on N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652306172222162D          

 21 20  0  0  1  0            999 V2000
   -2.3349    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6204    0.7145    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1914    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0493   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349   -0.5230    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9059    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1914   -0.1105    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.0493   -2.5855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7638   -1.3480    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.9059   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349    0.3020    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  4  3  1  0  0  0  0
  6  2  1  0  0  0  0
  7  3  1  0  0  0  0
  8  4  1  0  0  0  0
  9  5  1  0  0  0  0
 10  6  1  0  0  0  0
 11  7  1  0  0  0  0
 12  5  1  4  0  0  0
 12 10  2  0  0  0  0
  6 13  1  1  0  0  0
 13  8  2  0  0  0  0
 14  7  2  0  0  0  0
  8 15  1  4  0  0  0
 16  9  2  0  0  0  0
 17  9  1  0  0  0  0
 18 10  1  0  0  0  0
 19 11  1  0  0  0  0
 20 11  2  0  0  0  0
  6 21  1  1  0  0  0
M  CHG  2  15  -1  17  -1
M  END
> <DATABASE_ID>
MMDBc0056107

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@](CC)(N=C([O-])CCC(=O)C(O)=O)C(O)=NCC([O-])=O

> <INCHI_IDENTIFIER>
InChI=1S/C11H16N2O7/c1-2-6(10(18)12-5-9(16)17)13-8(15)4-3-7(14)11(19)20/h6H,2-5H2,1H3,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/p-2/t6-/m0/s1

> <INCHI_KEY>
RRBLCHIJUKCUNR-LURJTMIESA-L

> <FORMULA>
C11H14N2O7

> <MOLECULAR_WEIGHT>
286.241

> <EXACT_MASS>
286.081197959

> <JCHEM_ACCEPTOR_COUNT>
9

> <JCHEM_ATOM_COUNT>
34

> <JCHEM_AVERAGE_POLARIZABILITY>
26.154781020912722

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
-2

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2-{[(2S)-2-[(4-carboxy-1-oxido-4-oxobutylidene)amino]-1-hydroxybutylidene]amino}acetate

> <JCHEM_LOGP>
0.16060465879223318

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.5801891753307857

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.8872678282749984

> <JCHEM_PKA_STRONGEST_BASIC>
1.690107352962254

> <JCHEM_POLAR_SURFACE_AREA>
162.51

> <JCHEM_REFRACTIVITY>
85.93870000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
9

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
{[(2S)-2-[(4-carboxy-1-oxido-4-oxobutylidene)amino]-1-hydroxybutylidene]amino}acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-JUN-22         0                                  
HETATM    1  C   UNK     0      -4.358   3.644   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -4.358   2.104   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.310   1.334   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.976   2.104   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -4.358  -2.516   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -3.025   1.334   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.644   2.104   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -0.357   1.334   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -5.692  -3.286   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -3.025  -0.206   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.977   1.334   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0      -4.358  -0.976   0.000  0.00  0.00           N+0
HETATM   13  N   UNK     0      -1.691   2.104   0.000  0.00  0.00           N+0
HETATM   14  O   UNK     0       3.644   3.644   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0      -0.357  -0.206   0.000  0.00  0.00           O-1
HETATM   16  O   UNK     0      -5.692  -4.826   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0      -7.026  -2.516   0.000  0.00  0.00           O-1
HETATM   18  O   UNK     0      -1.691  -0.976   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0       6.311   2.104   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0       4.977  -0.206   0.000  0.00  0.00           O+0
HETATM   21  H   UNK     0      -4.358   0.564   0.000  0.00  0.00           H+0
CONECT    1    2                                                            
CONECT    2    1    6                                                       
CONECT    3    4    7                                                       
CONECT    4    3    8                                                       
CONECT    5    9   12                                                       
CONECT    6    2   10   13   21                                             
CONECT    7    3   11   14                                                  
CONECT    8    4   13   15                                                  
CONECT    9    5   16   17                                                  
CONECT   10    6   12   18                                                  
CONECT   11    7   19   20                                                  
CONECT   12    5   10                                                       
CONECT   13    6    8                                                       
CONECT   14    7                                                            
CONECT   15    8                                                            
CONECT   16    9                                                            
CONECT   17    9                                                            
CONECT   18   10                                                            
CONECT   19   11                                                            
CONECT   20   11                                                            
CONECT   21    6                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   40    0
END

Synonyms

Value	Source
N-(4-Carboxylato-4-oxobutanoyl)-L-ethylglycylglycinate	ChEBI
N-[(2S)-2-(4-Carboxylato-4-oxobutanoylamino)butanoyl]glycinate	ChEBI
N-(4-Carboxylato-4-oxobutanoyl)-L-ethylglycylglycinic acid	Generator
N-[(2S)-2-(4-Carboxylato-4-oxobutanoylamino)butanoyl]glycinic acid	Generator

Molecular Formula

C₁₁H₁₄N₂O₇

Average Mass

286.241

Monoisotopic Mass

286.081197959

IUPAC Name

2-{[(2S)-2-[(4-carboxy-1-oxido-4-oxobutylidene)amino]-1-hydroxybutylidene]amino}acetate

Traditional Name

{[(2S)-2-[(4-carboxy-1-oxido-4-oxobutylidene)amino]-1-hydroxybutylidene]amino}acetate

CAS Registry Number

Not Available

SMILES

[H][C@@](CC)(N=C([O-])CCC(=O)C(O)=O)C(O)=NCC([O-])=O

InChI Identifier

InChI=1S/C11H16N2O7/c1-2-6(10(18)12-5-9(16)17)13-8(15)4-3-7(14)11(19)20/h6H,2-5H2,1H3,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/p-2/t6-/m0/s1

InChI Key

RRBLCHIJUKCUNR-LURJTMIESA-L

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Peptides

Alternative Parents

Substituents

Alpha peptide
N-acyl-alpha amino acid or derivatives
N-acyl-alpha-amino acid
Alpha-amino acid or derivatives
Short-chain keto acid
Keto acid
Dicarboxylic acid or derivatives
Alpha-keto acid
Alpha-hydroxy ketone
Ketone
Carboxylic acid
Carboximidic acid derivative
Carboximidic acid
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Carbonyl group
Organic anion
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	0.16	ChemAxon
pKa (Strongest Acidic)	2.89	ChemAxon
pKa (Strongest Basic)	1.69	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	9	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	162.51 Å²	ChemAxon
Rotatable Bond Count	9	ChemAxon
Refractivity	85.94 m³·mol⁻¹	ChemAxon
Polarizability	26.15 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-20	View Spectrum

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

138911169

PDB ID

Not Available

ChEBI ID

144697

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine (MMDBc0056107)

MOL for #<Metabolite:0x00007fece88c58e8>

3D MOL for #<Metabolite:0x00007fece88c58e8>

3D SDF for #<Metabolite:0x00007fece88c58e8>

3D-SDF for #<Metabolite:0x00007fece88c58e8>

PDB for #<Metabolite:0x00007fece88c58e8>

3D PDB for #<Metabolite:0x00007fece88c58e8>

SMILES for #<Metabolite:0x00007fece88c58e8>

INCHI for #<Metabolite:0x00007fece88c58e8>

Structure for #<Metabolite:0x00007fece88c58e8>

3D Structure for #<Metabolite:0x00007fece88c58e8>