MiMeDB: Showing metabocard for N(6)-(D-fructosyl)-L-lysine (MMDBc0056195)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2022-06-17 20:19:12 UTC

Update Date

2022-08-12 20:09:37 UTC

Metabolite ID

MMDBc0056195

Metabolite Identification

Common Name

N(6)-(D-fructosyl)-L-lysine

Description

fructosyllysine(1+), also known as fructosyllysine cation, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Based on a literature review a significant number of articles have been published on fructosyllysine(1+).

Structure

MOL SDF PDB SMILES InChI


  Mrv1652306172222192D          

 25 24  0  0  1  0            999 V2000
   10.1427    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4283    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8572    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5717    2.5559    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.5704    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    2.5559    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.8559    2.5559    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.1414    2.1434    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.2862    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5717    3.3809    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.9993    2.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    3.3809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8559    3.3809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1414    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.0006    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.2862    1.3184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5717    1.7309    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    1.7309    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8559    1.7309    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1414    2.9684    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  1  1  0  0  0  0
  4  2  1  0  0  0  0
  7  3  1  0  0  0  0
  8  5  1  0  0  0  0
  9  6  1  0  0  0  0
 10  8  1  0  0  0  0
 11  9  1  0  0  0  0
 11 10  1  0  0  0  0
 12  7  1  0  0  0  0
  7 13  1  1  0  0  0
 14  4  1  0  0  0  0
 14  5  1  0  0  0  0
 15  6  1  0  0  0  0
 16  8  2  0  0  0  0
  9 17  1  6  0  0  0
 10 18  1  1  0  0  0
 11 19  1  1  0  0  0
 20 12  2  0  0  0  0
 21 12  1  0  0  0  0
  7 22  1  1  0  0  0
  9 23  1  6  0  0  0
 10 24  1  1  0  0  0
 11 25  1  1  0  0  0
M  CHG  1  13   1
M  END
> <DATABASE_ID>
MMDBc0056195

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@]([NH3+])(CCCCNCC(=O)[C@@]([H])(O)[C@]([H])(O)[C@]([H])(O)CO)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C12H24N2O7/c13-7(12(20)21)3-1-2-4-14-5-8(16)10(18)11(19)9(17)6-15/h7,9-11,14-15,17-19H,1-6,13H2,(H,20,21)/p+1/t7-,9+,10+,11+/m0/s1

> <INCHI_KEY>
BFSYFTQDGRDJNV-AYHFEMFVSA-O

> <FORMULA>
C12H25N2O7

> <MOLECULAR_WEIGHT>
309.338

> <EXACT_MASS>
309.165627573

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
46

> <JCHEM_AVERAGE_POLARIZABILITY>
31.597863489547183

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
7

> <JCHEM_FORMAL_CHARGE>
1

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S)-1-carboxy-5-{[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]amino}pentan-1-aminium

> <JCHEM_LOGP>
-5.489549887517673

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
10.566939799692467

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.2424727413798884

> <JCHEM_PKA_STRONGEST_BASIC>
9.321590571141122

> <JCHEM_POLAR_SURFACE_AREA>
174.95999999999998

> <JCHEM_REFRACTIVITY>
83.17739999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
12

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1S)-1-carboxy-5-{[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]amino}pentan-1-aminium

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-JUN-22         0                                  
HETATM    1  C   UNK     0      18.933   4.771   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      17.599   4.001   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      20.267   4.001   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      16.266   4.771   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      13.598   4.771   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.930   4.001   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      21.600   4.771   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      12.265   4.001   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.264   4.771   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      10.931   4.771   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       9.597   4.001   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      22.934   4.001   0.000  0.00  0.00           C+0
HETATM   13  N   UNK     0      21.600   6.311   0.000  0.00  0.00           N+1
HETATM   14  N   UNK     0      14.932   4.001   0.000  0.00  0.00           N+0
HETATM   15  O   UNK     0       5.596   4.771   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0      12.265   2.461   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       8.264   6.311   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0      10.931   6.311   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0       9.597   2.461   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0      24.268   4.771   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0      22.934   2.461   0.000  0.00  0.00           O+0
HETATM   22  H   UNK     0      21.600   3.231   0.000  0.00  0.00           H+0
HETATM   23  H   UNK     0       8.264   3.231   0.000  0.00  0.00           H+0
HETATM   24  H   UNK     0      10.931   3.231   0.000  0.00  0.00           H+0
HETATM   25  H   UNK     0       9.597   5.541   0.000  0.00  0.00           H+0
CONECT    1    2    3                                                       
CONECT    2    1    4                                                       
CONECT    3    1    7                                                       
CONECT    4    2   14                                                       
CONECT    5    8   14                                                       
CONECT    6    9   15                                                       
CONECT    7    3   12   13   22                                             
CONECT    8    5   10   16                                                  
CONECT    9    6   11   17   23                                             
CONECT   10    8   11   18   24                                             
CONECT   11    9   10   19   25                                             
CONECT   12    7   20   21                                                  
CONECT   13    7                                                            
CONECT   14    4    5                                                       
CONECT   15    6                                                            
CONECT   16    8                                                            
CONECT   17    9                                                            
CONECT   18   10                                                            
CONECT   19   11                                                            
CONECT   20   12                                                            
CONECT   21   12                                                            
CONECT   22    7                                                            
CONECT   23    9                                                            
CONECT   24   10                                                            
CONECT   25   11                                                            
MASTER        0    0    0    0    0    0    0    0   25    0   48    0
END

Synonyms

Value	Source
D-Fructosyl-L-lysine(1+)	ChEBI
Fructose lysine(1+)	ChEBI
Fructoselysine(1+)	ChEBI
Fructosyllysine cation	ChEBI
N(6)-(D-Fructosyl)-L-lysine	ChEBI
Fructose lysine	MeSH
Fructosyl-lysine	MeSH
Fructosyllysine	MeSH
Fructoselysine	MeSH

Molecular Formula

C₁₂H₂₅N₂O₇

Average Mass

309.338

Monoisotopic Mass

309.165627573

IUPAC Name

(1S)-1-carboxy-5-{[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]amino}pentan-1-aminium

Traditional Name

(1S)-1-carboxy-5-{[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]amino}pentan-1-aminium

CAS Registry Number

Not Available

SMILES

[H][C@]([NH3+])(CCCCNCC(=O)[C@@]([H])(O)[C@]([H])(O)[C@]([H])(O)CO)C(O)=O

InChI Identifier

InChI=1S/C12H24N2O7/c13-7(12(20)21)3-1-2-4-14-5-8(16)10(18)11(19)9(17)6-15/h7,9-11,14-15,17-19H,1-6,13H2,(H,20,21)/p+1/t7-,9+,10+,11+/m0/s1

InChI Key

BFSYFTQDGRDJNV-AYHFEMFVSA-O

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Medium-chain fatty acid
Amino fatty acid
Hydroxy fatty acid
Acyloin
Monosaccharide
Fatty acyl
Fatty acid
Beta-hydroxy ketone
1,3-aminoalcohol
Alpha-aminoketone
Alpha-hydroxy ketone
Amino acid
Ketone
Carboxylic acid salt
Secondary alcohol
Polyol
Secondary aliphatic amine
Carboxylic acid
Monocarboxylic acid or derivatives
Secondary amine
Organic nitrogen compound
Organic oxygen compound
Primary aliphatic amine
Organonitrogen compound
Organooxygen compound
Primary alcohol
Primary amine
Carbonyl group
Organic salt
Hydrocarbon derivative
Amine
Organic oxide
Organopnictogen compound
Alcohol
Organic cation
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

amino-acid cation (CHEBI:61393 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	-5.5	ChemAxon
pKa (Strongest Acidic)	2.24	ChemAxon
pKa (Strongest Basic)	9.32	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	174.96 Å²	ChemAxon
Rotatable Bond Count	12	ChemAxon
Refractivity	83.18 m³·mol⁻¹	ChemAxon
Polarizability	31.6 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0014823	Adenosine triphosphate	ADP	Fructoselysine 6-kinase	Phosphorylation	RHEA	34755880
MMDBr0014826	N(6)-(D-psicosyl)-L-lysine	N(6)-(D-fructosyl)-L-lysine	Fructoselysine 3-epimerase	Epimerization	RHEA	34755880
MMDBr0014837	N(6)-(D-fructosyl)-L-lysine	N(6)-(D-fructosyl)-L-lysine	Probable fructoselysine/psicoselysine transporter FrlA	Transport	RHEA	34755880
MMDBr0014838	N(6)-(D-fructosyl)-L-lysine	N(6)-(D-fructosyl)-L-lysine	Probable fructoselysine/psicoselysine transporter FrlA	Transport	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	3	Human ; Human feces

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

26332216

KEGG Compound ID

Not Available

BioCyc ID

FRUCTOSELYSINE

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

49859675

PDB ID

Not Available

ChEBI ID

61393

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for N(6)-(D-fructosyl)-L-lysine (MMDBc0056195)

MOL for #<Metabolite:0x0000564af384f0a0>

3D MOL for #<Metabolite:0x0000564af384f0a0>

3D SDF for #<Metabolite:0x0000564af384f0a0>

3D-SDF for #<Metabolite:0x0000564af384f0a0>

PDB for #<Metabolite:0x0000564af384f0a0>

3D PDB for #<Metabolite:0x0000564af384f0a0>

SMILES for #<Metabolite:0x0000564af384f0a0>

INCHI for #<Metabolite:0x0000564af384f0a0>

Structure for #<Metabolite:0x0000564af384f0a0>

3D Structure for #<Metabolite:0x0000564af384f0a0>