MiMeDB: Showing metabocard for Biotin (MMDBc0000006)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:13:29 UTC

Update Date

2023-08-08 20:09:31 UTC

Metabolite ID

MMDBc0000006

Metabolite Identification

Common Name

Biotin

Description

Biotin is an enzyme co-factor present in minute amounts in every living cell. Biotin is also known as coenzyme R and vitamin H or B7. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin has been recognized as an essential nutrient. Humans fulfill their biotin requirement through their diet through endogenous reutilization of biotin and perhaps through the capture of biotin generated in the intestinal flora. The utilization of biotin for covalent attachment to carboxylases and its reutilization through the release of carboxylase biotin after proteolytic degradation constitutes the 'biotin cycle'. Biotin deficiency is associated with neurological manifestations, skin rash, hair loss, and metabolic disturbances that are thought to relate to the various carboxylase deficiencies (metabolic ketoacidosis with lactic acidosis). It has also been suggested that biotin deficiency is associated with protein malnutrition, and that marginal biotin deficiency in pregnant women may be teratogenic. Biotin acts as a carboxyl carrier in carboxylation reactions. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC), and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a lysine residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signalling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signalling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-kappaB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signalling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to the effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signalling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology (PMID: 15992684 , 16011464 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0000030
     RDKit          3D
Biotin
 32 33  0  0  0  0  0  0  0  0999 V2000
    4.5260    1.0153   -1.5312 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6260    1.0044   -0.6334 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3170    2.2164   -0.0508 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9582   -0.2628   -0.2514 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    0.0572    0.8273 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2001   -1.1680    1.2955 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4203   -1.8425    0.2480 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6502   -1.1698   -0.4508 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2127    0.3276   -1.3780 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9186    1.0135   -1.4599 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7184   -0.0840   -0.7978 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.7041    0.5915    0.0447 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9367    1.1338    1.1155 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3431    2.0119    1.9161 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    0.4975    1.1034 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8267   -0.6793    0.3065 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2398    3.0246   -0.6568 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7298   -0.9573    0.1455 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5575   -0.7250   -1.1482 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5727    0.3863    1.7110 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3289    0.9037    0.5515 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0083   -1.8536    1.6970 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6313   -0.8898    2.2055 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0272   -2.8070    0.6839 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1572   -2.2137   -0.5280 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0690   -1.8661   -1.2439 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1460    1.0902   -2.5429 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9747    1.9757   -0.9491 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1306   -0.8258   -1.4615 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7274    0.6418   -0.1329 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8246    0.9079    1.6047 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4311   -1.4545    0.7860 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16  8  1  0
 16 11  1  0
  3 17  1  0
  4 18  1  0
  4 19  1  0
  5 20  1  0
  5 21  1  0
  6 22  1  0
  6 23  1  0
  7 24  1  0
  7 25  1  0
  8 26  1  6
 10 27  1  0
 10 28  1  0
 11 29  1  6
 12 30  1  0
 15 31  1  0
 16 32  1  1
M  END


  Mrv1652309032023502D          

 18 19  0  0  1  0            999 V2000
    0.4125   -1.2695    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4125   -1.2695    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6674   -2.0541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6675   -2.0541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6675   -0.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3641    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2374   -1.2695    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2374   -1.2695    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3818   -0.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -0.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8108   -0.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -0.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -0.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9542   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398    0.7526    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -0.4849    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
 18  1  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
 18  6  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  2  0  0  0  0
  4  7  1  0  0  0  0
  5  6  1  0  0  0  0
  1  9  1  6  0  0  0
  2 10  1  6  0  0  0
 18 11  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 17  2  0  0  0  0
 15 16  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0000006

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

> <INCHI_IDENTIFIER>
InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

> <INCHI_KEY>
YBJHBAHKTGYVGT-ZKWXMUAHSA-N

> <FORMULA>
C10H16N2O3S

> <MOLECULAR_WEIGHT>
244.311

> <EXACT_MASS>
244.088163078

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
32

> <JCHEM_AVERAGE_POLARIZABILITY>
24.919241786433474

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid

> <ALOGPS_LOGP>
0.17

> <JCHEM_LOGP>
0.31942364800000006

> <ALOGPS_LOGS>
-2.30

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
13.546990539562877

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.4043165776835425

> <JCHEM_PKA_STRONGEST_BASIC>
-1.863639696129737

> <JCHEM_POLAR_SURFACE_AREA>
78.42999999999999

> <JCHEM_REFRACTIVITY>
60.0509

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.22e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
5-[(3aS,4S,6aR)-2-oxo-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0000030
     RDKit          3D
Biotin
 32 33  0  0  0  0  0  0  0  0999 V2000
    4.5260    1.0153   -1.5312 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6260    1.0044   -0.6334 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3170    2.2164   -0.0508 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9582   -0.2628   -0.2514 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    0.0572    0.8273 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2001   -1.1680    1.2955 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4203   -1.8425    0.2480 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6502   -1.1698   -0.4508 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2127    0.3276   -1.3780 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9186    1.0135   -1.4599 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7184   -0.0840   -0.7978 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.7041    0.5915    0.0447 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9367    1.1338    1.1155 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3431    2.0119    1.9161 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    0.4975    1.1034 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8267   -0.6793    0.3065 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2398    3.0246   -0.6568 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7298   -0.9573    0.1455 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5575   -0.7250   -1.1482 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5727    0.3863    1.7110 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3289    0.9037    0.5515 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0083   -1.8536    1.6970 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6313   -0.8898    2.2055 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0272   -2.8070    0.6839 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1572   -2.2137   -0.5280 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0690   -1.8661   -1.2439 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1460    1.0902   -2.5429 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9747    1.9757   -0.9491 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1306   -0.8258   -1.4615 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7274    0.6418   -0.1329 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8246    0.9079    1.6047 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4311   -1.4545    0.7860 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16  8  1  0
 16 11  1  0
  3 17  1  0
  4 18  1  0
  4 19  1  0
  5 20  1  0
  5 21  1  0
  6 22  1  0
  6 23  1  0
  7 24  1  0
  7 25  1  0
  8 26  1  6
 10 27  1  0
 10 28  1  0
 11 29  1  6
 12 30  1  0
 15 31  1  0
 16 32  1  1
M  END

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  C   UNK     0       0.770  -2.370   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.770  -2.370   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0       1.246  -3.834   0.000  0.00  0.00           N+0
HETATM    4  N   UNK     0      -1.246  -3.834   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0      -1.246  -0.905   0.000  0.00  0.00           C+0
HETATM    6  S   UNK     0       0.000   0.000   0.000  0.00  0.00           S+0
HETATM    7  C   UNK     0       0.000  -4.740   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       0.000  -6.280   0.000  0.00  0.00           O+0
HETATM    9  H   UNK     0       2.310  -2.370   0.000  0.00  0.00           H+0
HETATM   10  H   UNK     0      -2.310  -2.370   0.000  0.00  0.00           H+0
HETATM   11  C   UNK     0       2.579  -0.135   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.913  -0.905   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.247  -0.135   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.581  -0.905   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.914  -0.135   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       9.248  -0.905   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       7.914   1.405   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       1.246  -0.905   0.000  0.00  0.00           C+0
CONECT    1    2   18    3    9                                             
CONECT    2    1    4    5   10                                             
CONECT    3    1    7                                                       
CONECT    4    2    7                                                       
CONECT    5    2    6                                                       
CONECT    6   18    5                                                       
CONECT    7    3    8    4                                                  
CONECT    8    7                                                            
CONECT    9    1                                                            
CONECT   10    2                                                            
CONECT   11   18   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   17   16                                                  
CONECT   16   15                                                            
CONECT   17   15                                                            
CONECT   18    1    6   11                                                  
MASTER        0    0    0    0    0    0    0    0   18    0   38    0
END

COMPND    HMDB0000030
HETATM    1  O1  UNL     1       4.526   1.015  -1.531  1.00  0.00           O  
HETATM    2  C1  UNL     1       3.626   1.004  -0.633  1.00  0.00           C  
HETATM    3  O2  UNL     1       3.317   2.216  -0.051  1.00  0.00           O  
HETATM    4  C2  UNL     1       2.958  -0.263  -0.251  1.00  0.00           C  
HETATM    5  C3  UNL     1       1.952   0.057   0.827  1.00  0.00           C  
HETATM    6  C4  UNL     1       1.200  -1.168   1.295  1.00  0.00           C  
HETATM    7  C5  UNL     1       0.420  -1.842   0.248  1.00  0.00           C  
HETATM    8  C6  UNL     1      -0.650  -1.170  -0.451  1.00  0.00           C  
HETATM    9  S1  UNL     1      -0.213   0.328  -1.378  1.00  0.00           S  
HETATM   10  C7  UNL     1      -1.919   1.013  -1.460  1.00  0.00           C  
HETATM   11  C8  UNL     1      -2.718  -0.084  -0.798  1.00  0.00           C  
HETATM   12  N1  UNL     1      -3.704   0.592   0.045  1.00  0.00           N  
HETATM   13  C9  UNL     1      -2.937   1.134   1.115  1.00  0.00           C  
HETATM   14  O3  UNL     1      -3.343   2.012   1.916  1.00  0.00           O  
HETATM   15  N2  UNL     1      -1.638   0.497   1.103  1.00  0.00           N  
HETATM   16  C10 UNL     1      -1.827  -0.679   0.307  1.00  0.00           C  
HETATM   17  H1  UNL     1       3.240   3.025  -0.657  1.00  0.00           H  
HETATM   18  H2  UNL     1       3.730  -0.957   0.146  1.00  0.00           H  
HETATM   19  H3  UNL     1       2.558  -0.725  -1.148  1.00  0.00           H  
HETATM   20  H4  UNL     1       2.573   0.386   1.711  1.00  0.00           H  
HETATM   21  H5  UNL     1       1.329   0.904   0.551  1.00  0.00           H  
HETATM   22  H6  UNL     1       2.008  -1.854   1.697  1.00  0.00           H  
HETATM   23  H7  UNL     1       0.631  -0.890   2.205  1.00  0.00           H  
HETATM   24  H8  UNL     1       0.027  -2.807   0.684  1.00  0.00           H  
HETATM   25  H9  UNL     1       1.157  -2.214  -0.528  1.00  0.00           H  
HETATM   26  H10 UNL     1      -1.069  -1.866  -1.244  1.00  0.00           H  
HETATM   27  H11 UNL     1      -2.146   1.090  -2.543  1.00  0.00           H  
HETATM   28  H12 UNL     1      -1.975   1.976  -0.949  1.00  0.00           H  
HETATM   29  H13 UNL     1      -3.131  -0.826  -1.462  1.00  0.00           H  
HETATM   30  H14 UNL     1      -4.727   0.642  -0.133  1.00  0.00           H  
HETATM   31  H15 UNL     1      -0.825   0.908   1.605  1.00  0.00           H  
HETATM   32  H16 UNL     1      -2.431  -1.455   0.786  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   17
CONECT    4    5   18   19
CONECT    5    6   20   21
CONECT    6    7   22   23
CONECT    7    8   24   25
CONECT    8    9   16   26
CONECT    9   10
CONECT   10   11   27   28
CONECT   11   12   16   29
CONECT   12   13   30
CONECT   13   14   14   15
CONECT   15   16   31
CONECT   16   32
END

HMDB0000030
     RDKit          3D
Biotin
 32 33  0  0  0  0  0  0  0  0999 V2000
    4.5260    1.0153   -1.5312 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6260    1.0044   -0.6334 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3170    2.2164   -0.0508 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9582   -0.2628   -0.2514 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    0.0572    0.8273 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2001   -1.1680    1.2955 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4203   -1.8425    0.2480 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6502   -1.1698   -0.4508 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2127    0.3276   -1.3780 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9186    1.0135   -1.4599 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7184   -0.0840   -0.7978 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.7041    0.5915    0.0447 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9367    1.1338    1.1155 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3431    2.0119    1.9161 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    0.4975    1.1034 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8267   -0.6793    0.3065 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2398    3.0246   -0.6568 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7298   -0.9573    0.1455 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5575   -0.7250   -1.1482 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5727    0.3863    1.7110 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3289    0.9037    0.5515 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0083   -1.8536    1.6970 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6313   -0.8898    2.2055 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0272   -2.8070    0.6839 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1572   -2.2137   -0.5280 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0690   -1.8661   -1.2439 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1460    1.0902   -2.5429 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9747    1.9757   -0.9491 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1306   -0.8258   -1.4615 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7274    0.6418   -0.1329 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8246    0.9079    1.6047 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4311   -1.4545    0.7860 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  0
 13 15  1  0
 15 16  1  0
 16  8  1  0
 16 11  1  0
  3 17  1  0
  4 18  1  0
  4 19  1  0
  5 20  1  0
  5 21  1  0
  6 22  1  0
  6 23  1  0
  7 24  1  0
  7 25  1  0
  8 26  1  6
 10 27  1  0
 10 28  1  0
 11 29  1  6
 12 30  1  0
 15 31  1  0
 16 32  1  1
M  END

Synonyms

Value	Source
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid	ChEBI
(3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid	ChEBI
5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoic acid	ChEBI
Biotina	ChEBI
Biotine	ChEBI
Biotinum	ChEBI
cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid	ChEBI
cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid	ChEBI
cis-Tetrahydro-2-oxothieno(3,4-D)imidazoline-4-valeric acid	ChEBI
Coenzyme R	ChEBI
D-(+)-Biotin	ChEBI
D-Biotin	ChEBI
Vitamin b7	ChEBI
Vitamin H	ChEBI
Bioepiderm	Kegg
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valerate	Generator
(3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valerate	Generator
5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoate	Generator
cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valerate	Generator
cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valerate	Generator
cis-Tetrahydro-2-oxothieno(3,4-D)imidazoline-4-valerate	Generator
(+)-Biotin	HMDB
-(+)-Biotin	HMDB
1SWK	HMDB
1SWN	HMDB
1SWR	HMDB
Biodermatin	HMDB
Bios H	HMDB
Bios II	HMDB
D(+)-Biotin	HMDB
D-Biotin factor S	HMDB
delta-(+)-Biotin	HMDB
delta-Biotin	HMDB
delta-Biotin factor S	HMDB
Factor S	HMDB
Factor S (vitamin)	HMDB
Hexahydro-2-oxo-1H-thieno(3,4-D)imidazole-4-pentanoate	HMDB
Hexahydro-2-oxo-1H-thieno(3,4-D)imidazole-4-pentanoic acid	HMDB
Hexahydro-2-oxo-[3as-(3aa,4b,6aa)]-1H-thieno[3,4-D]imidazole-4-pentanoate	HMDB
Hexahydro-2-oxo-[3as-(3aa,4b,6aa)]-1H-thieno[3,4-D]imidazole-4-pentanoic acid	HMDB
Hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-thieno[3,4-D]imidazole-4-pentanoate	HMDB
Hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-thieno[3,4-D]imidazole-4-pentanoic acid	HMDB
Lutavit H2	HMDB
Meribin	HMDB
Rovimix H 2	HMDB
Vitamin-H	HMDB
Biotin hermes brand	HMDB
Biotin roche brand	HMDB
Biotin simons brand	HMDB
Biotin strathmann brand	HMDB
Biotin ziethen brand	HMDB
Biotin ratiopharm	HMDB
Roche brand OF biotin	HMDB
Roche, biotine	HMDB
E+b pharma brand OF biotin	HMDB
Medobiotin	HMDB
Biokur	HMDB
Biotinratiopharm	HMDB
Gelfert, biotin	HMDB
Hermes brand OF biotin	HMDB
Hermes, biotin	HMDB
Medopharm brand OF biotin	HMDB
Ratiopharm brand OF biotin	HMDB
Biocur brand OF biotin	HMDB
Biotin dermapharm brand	HMDB
Biotine roche	HMDB
Deacura	HMDB
Dermapharm brand OF biotin	HMDB
Gabunat	HMDB
Medebiotin	HMDB
Rombellin	HMDB
Ziethen brand OF biotin	HMDB
Biotin biocur brand	HMDB
Biotin gelfert	HMDB
Biotin hermes	HMDB
Biotin medopharm brand	HMDB
Biotin ratiopharm brand	HMDB
Biotin-ratiopharm	HMDB
H, Vitamin	HMDB
Medea brand OF biotin sodium salt	HMDB
Simons brand OF biotin	HMDB
Strathmann brand OF biotin	HMDB

Molecular Formula

C₁₀H₁₆N₂O₃S

Average Mass

244.311

Monoisotopic Mass

244.088163078

IUPAC Name

5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid

Traditional Name

5-[(3aS,4S,6aR)-2-oxo-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid

CAS Registry Number

58-85-5

SMILES

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

InChI Identifier

InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI Key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as biotin and derivatives. These are organic compounds containing a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Biotin and derivatives

Sub Class

Not Available

Direct Parent

Biotin and derivatives

Alternative Parents

Substituents

Biotin
Imidazolyl carboxylic acid derivative
Medium-chain fatty acid
Heterocyclic fatty acid
Thia fatty acid
Fatty acid
Fatty acyl
Thiolane
2-imidazoline
Isourea
Azacycle
Dialkylthioether
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Carboximidamide
Carboxylic acid derivative
Thioether
Carboxylic acid
Monocarboxylic acid or derivatives
Organic nitrogen compound
Organonitrogen compound
Organopnictogen compound
Organooxygen compound
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

biotins (CHEBI:15956 )
Water-soluble vitamins (C00120 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	1.22 g/L	ALOGPS
logP	0.17	ALOGPS
logP	0.32	ChemAxon
logS	-2.3	ALOGPS
pKa (Strongest Acidic)	4.4	ChemAxon
pKa (Strongest Basic)	-1.9	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	78.43 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	60.05 m³·mol⁻¹	ChemAxon
Polarizability	24.92 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-0f76-1960000000-b21ddd69490cac3254f8	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-0f76-3960000000-a8a94e2de123f66979d8	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0f76-1960000000-b21ddd69490cac3254f8	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-0f76-3960000000-a8a94e2de123f66979d8	2017-09-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0006-6910000000-11bfe0a5a77f7dfaa8c5	2016-09-22	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive	splash10-00dl-9680000000-eb01d8147a82f7982b54	2017-10-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_3) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0006-0090000000-6d956bb533d353d449c9	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0006-0190000000-01f67d1bdf8c742e48c8	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0fxx-3920000000-f0b9613cbd9371e4be92	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9400000000-107f2a44f521c2513578	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-1a3f65d909dc40055e87	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-004i-0090000000-c928e8d0a18f3f848262	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-066s-1920000000-5f795e0b7f1d7cf986e5	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-0ar1-1920000000-c298be862857cb3bbc7f	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-000t-0900000000-cdc4a4c359ff765fd32d	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	splash10-05xs-1920000000-3be430b63e9c748c681a	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0006-0090000000-bcffb0dcf77e8fd727a4	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0f6x-0390000000-c209523d36e9a7681f44	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-0090000000-c0f81ee86772310db415	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-0190000000-016eb89528e564c74720	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0fxx-3920000000-f0b9613cbd9371e4be92	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9400000000-107f2a44f521c2513578	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-d08e1b3709844e1e91b0	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-0006-0190000000-21d0f2512788276bbb89	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , negative	splash10-0udj-0690000000-dc372934024e58bdcc60	2017-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-002b-0290000000-43932f104dea28cbdfb8	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0002-1960000000-d3673c6bc624b97f35be	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-052f-9600000000-00a4e152d89024a9b423	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0006-1390000000-3f4b512cfa57b894ff94	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0f6y-7890000000-ea1e647fc5b31e42af0b	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9100000000-e139c928dcc46b225bdb	2016-09-12	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-01pt-9500000000-a1e1ec56cf32236ac6b1	2018-05-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)		2012-12-04	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, 100%_DMSO, experimental)		2012-12-04	View Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)		2012-12-04	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Mitochondria
Nucleus

Biospecimen Locations

All Tissues
Blood
Cerebrospinal Fluid (CSF)
Feces
Prostate
Saliva
Urine

Tissue Locations

All Tissues
Prostate

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191694	Acetyl-CoA carboxylase 2	Unknown	O00763	Homo sapiens
MMDBp0191695	Pyruvate carboxylase, mitochondrial	Unknown	P11498	Homo sapiens
MMDBp0191721	Acetyl-CoA carboxylase 1	Unknown	Q13085	Homo sapiens
MMDBp0191928	Propionyl-CoA carboxylase beta chain, mitochondrial	Enzyme	P05166	Homo sapiens
MMDBp0191929	Propionyl-CoA carboxylase alpha chain, mitochondrial	Enzyme	P05165	Homo sapiens
MMDBp0192162	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	Enzyme	Q9HCC0	Homo sapiens
MMDBp0192163	Biotin--protein ligase	Enzyme	P50747	Homo sapiens
MMDBp0192164	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	Enzyme	Q96RQ3	Homo sapiens
MMDBp0192193	Biotinidase	Enzyme	P43251	Homo sapiens
MMDBp0193102	Cytochrome P450 1B1	Unknown	Q16678	Homo sapiens
MMDBp0193609	Sodium-dependent multivitamin transporter	Unknown	Q9Y289	Homo sapiens
MMDBp0196344	Putative uncharacterized protein DKFZp686B20267	Unknown	Q68D27	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank
LPS and Citrate Signaling and Inflammation
Acylcarnitine 3-Hydroxydecanoylcarnitine
Acylcarnitine (7Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-7,9,12,15,18,21-hexaenoylcarnitine
Acylcarnitine Pentacosanoylcarnitine
Acylcarnitine Hexacosanoylcarnitine

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0000370	Adenosine triphosphate	Biotinyl-5'-AMP	Holocarboxylase synthetase (biotin-(proprionyl-coa-carboxylase (atp-hydrolysing)) ligase)	Biotin-[Acetyl Coenzyme A-Carboxylase] Ligase	VMH	12459313 7842009
MMDBr0000371	Adenosine triphosphate	Biotinyl-5'-AMP	Holocarboxylase synthetase (biotin-(proprionyl-coa-carboxylase (atp-hydrolysing)) ligase)	Biotin-[Acetyl Coenzyme A-Carboxylase] Ligase, Mitochondrial	VMH	12459313 7842009
MMDBr0000397	Biocytin	Biotin	Not Available	Biotinidase (Biotin)	VMH	12459313 15059618
MMDBr0000398	Biocytin	Biotin	Biotinidase	Biotinidase (Biotin), Nuclear	VMH	16011464 5867120 7758201 8593541
MMDBr0000399	Biocytin	Biotin	Biotinidase	Biotinidase (Biotin), Extracellular	VMH	12459313 7509806 8001986
MMDBr0000400	Biocytin	Biotin	Biotinidase	Biotinidase (Biotin), Mitochondrial	VMH	12459313 15059618
MMDBr0000401	Biotin	Biotin	Solute carrier family 16 (monocarboxylate transporter), member 1	Biotin Reversible Transport via Proton Symport	VMH	10510291 12739169 7835905 8476015 9508842 9649795 9824713
MMDBr0000402	Biotin	Biotin	Solute carrier family 16 (monocarboxylate transporter), member 1	Biotin Reversible Transport via Proton Symport, Mitochondria	VMH	12949353 15121743 16011464
MMDBr0000403	Adenosine triphosphate	ADP	Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	Biotin Transport via Sodium Symport	VMH	10329687 10334869 12646417 15561972 9516450
MMDBr0000404	Biotin	Biotin	Solute carrier family 19 (thiamine transporter), member 3	Biotin Uptake (Antiport)	VMH	14770311 15623830
MMDBr0000405	Biotin	Biotin	Not Available	Biotin Transport, Nuclear	VMH	16011464 5867120 7758201 8593541
MMDBr0005432	Adenosine triphosphate	ADP	Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	Biotin Transport via Sodium Symport	VMH	30371894
MMDBr0007179	D-Biotin D-sulfoxide	Biotin	Not Available	Biotin sulfoxide reductase	VMH	30371894
MMDBr0007180	D-Biotin D-sulfoxide	Biotin	Not Available	Biotin sulfoxide reductase	VMH	30371894
MMDBr0007277	Biotinyl-5'-AMP	Adenosine triphosphate	Not Available	Biotin-[acetyl-CoA-carboxylase] ligase, irreversible	VMH	30371894
MMDBr0007279	S-Adenosylmethionine	Biotin	Not Available	Biotin synthase	VMH	30371894
MMDBr0008067	Adenosine triphosphate	ADP	Not Available	Biotin transport via ABC system	VMH	30371894
MMDBr0010717	Biotin	Biotin	Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	HMR_9609	VMH	30371894
MMDBr0014839	Biotin	Biotin	Biotin transporter	Transport	RHEA	34755880
MMDBr0014840	Biotin	Biotin	Biotin transporter	Transport	RHEA	34755880
MMDBr0015024	Adenosine triphosphate	Biotinyl-5'-AMP	Biotin--[acetyl-CoA-carboxylase] ligase	Carboxylation	RHEA	34755880
MMDBr0015025	Adenosine triphosphate	Biotinyl-5'-AMP	Biotin--[acetyl-CoA-carboxylase] ligase	Carboxylation	RHEA	34755880
MMDBr0018047	Hydrogen Ion	Biotin	Biotin synthase	Synthesis	PathBank	31602464
MMDBr0018048	Biotin	Biotinyl-5'-AMP	Bifunctional ligase/repressor BirA	Ligation	PathBank	31602464
MMDBr0019295	Biotin	Hydrogen Ion	Bifunctional ligase/repressor BirA	Ligation	PathBank	31602464
MMDBr0019422	S-Adenosylmethionine	Biotin	Biotin synthase, mitochondrial	Synthesis	PathBank	31602464
MMDBr0024373	Adenosine triphosphate	Hydrogen Ion	Biotin--protein ligase	Ligation	RHEA	34755880
MMDBr0024393	Adenosine triphosphate	Hydrogen Ion	Putative biotin ligase	Ligation	RHEA	34755880
MMDBr0024394	Adenosine triphosphate	Hydrogen Ion	Biotin--[acetyl-CoA-carboxylase] ligase	Ligation	RHEA	34755880
MMDBr0024707	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Biotin synthase	Synthesis	RHEA	34755880
MMDBr0024708	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Biotin synthase	Synthesis	RHEA	34755880
MMDBr0024748	Adenosine triphosphate	Hydrogen Ion	Biotin--protein ligase	Ligation	RHEA	34755880
MMDBr0024777	Adenosine triphosphate	Hydrogen Ion	Biotin--protein ligase	Ligation	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Evidence Type	Host and Biospecimen	Data Source	Reference
Acute lymphoblastic leukemia	Association	Human Cerebrospinal Fluid (CSF)	HMDB	18996865
Dementia	Association	Human Cerebrospinal Fluid (CSF)	HMDB	10577274
Epilepsy	Association	Human Cerebrospinal Fluid (CSF)	HMDB	10577274
Motor neuron disease	Association	Human Cerebrospinal Fluid (CSF)	HMDB	10577274
Multiple sclerosis	Association	Human Cerebrospinal Fluid (CSF)	HMDB	10577274
Eosinophilic esophagitis	Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Fibrobacteres	1		Microbial culture
Eukaryota	Apicomplexa	1		Microbial culture
Bacteria	Firmicutes	740	Human feces; Human ; Human vaginal secretion; Human mucosa; Human saliva; Human subgingival plaque; Goat feces; Sheep feces; Human stool; Human supragingival plaque; Human urine; Human sputum; Human pleural fluid plaque; Pig ; Cattle	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Spirochaetes	2	Human feces	Microbial culture; Metabolic reconstruction
Bacteria	Proteobacteria	244	Human feces; Human ; Human feces; pleural fluid plaque; bal; Human stool; Human mucosa; Human supragingival plaque; Human saliva; Human subgingival plaque; Human sputum; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Deinococcus-thermus	1		Microbial culture
Bacteria	Actinobacteria	222	Human feces; Human ; Human stool; Human saliva; Human mucosa; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human supragingival plaque; Human subgingival plaque	Microbial culture; Metabolic reconstruction
Bacteria	Verrucomicrobia	3	Human feces; Human stool; Human ; Human urine	Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Archaea	Euryarchaeota	9	Human feces; Human	Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Bacteroidetes	153	Human feces; Human appendix biopsy; Human ; Human stool; Human saliva; Human gastric fluid; Human urine; Human subgingival plaque; Human supragingival plaque	Metabolic reconstruction
Bacteria	Synergistetes	7	Human feces	Metabolic reconstruction
Archaea	Thaumarchaeota	1		Metabolic reconstruction
Bacteria	Fusobacteria	36	Human feces; Human	Metabolic reconstruction
Bacteria	Candidatus melainabacteria	2	Human feces	Metabolic reconstruction
Bacteria	Planctomycetes	1	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	1		Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference
		Microstomus kitt	FooDB	31437929
		Clupeinae	FooDB	31437929
		Limanda limanda	FooDB	31437929
		Vaccinium vitis-idaea	FooDB	31437929
Animal	Meat	Meleagris gallopavo	FooDB	31437929
Animal		Microstomus kitt	FooDB	31437929
Animal	Meat	Gallus gallus	FooDB	31437929
Animal		Nephropidae	FooDB	31437929
Animal	Filet	Scombridae	FooDB	31437929
Animal		Scombridae	FooDB	31437929
Animal		Thunnus	FooDB	31437929
Animal		Thunnus	FooDB	31437929
Animal		Thunnus	FooDB	31437929
Animal		Nephropidae	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal		Caridea	FooDB	31437929
Animal	Tongue	Sus scrofa domesticus	FooDB	31437929
Animal	Meat and skin	Gallus gallus	FooDB	31437929
Animal	Meat	Gallus gallus	FooDB	31437929
Animal	Meat and skin	Gallus gallus	FooDB	31437929
Animal	Meat	Gallus gallus	FooDB	31437929
Animal	Roe	Gadus	FooDB	31437929
Animal	Gizzard	Gallus gallus	FooDB	31437929
Animal		Clupeinae	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Meat	Ovis aries	FooDB	31437929
Animal	Liver	Gallus gallus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal		Clupeinae	FooDB	31437929
Animal		Clupeinae	FooDB	31437929
Animal		Caridea	FooDB	31437929
Animal		Clupeinae	FooDB	31437929
Animal		Clupeinae	FooDB	31437929
Animal	Thymus	Ovis aries	FooDB	31437929
Animal	Tongue	Bos taurus	FooDB	31437929
Animal	Tongue	Bos taurus	FooDB	31437929
Animal	Meat	Meleagris gallopavo	FooDB	31437929
Animal	Meat	Bos taurus	FooDB	31437929
Animal	Meat	Bos taurus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal		Hippoglossus hippoglossus	FooDB	31437929
Animal		Scombridae	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Bos taurus	FooDB	31437929
Animal		Salmonidae	FooDB	31437929
Animal		Salmonidae	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Bos taurus	FooDB	31437929
Animal	Meat	Bos taurus	FooDB	31437929
Animal	Meat	Bos taurus	FooDB	31437929
Animal	Fillet	Gadus	FooDB	31437929
Animal	Roe	Gadus	FooDB	31437929
Animal	Meat and skin	Anatidae	FooDB	31437929
Animal		Pleuronectiformes	FooDB	31437929
Animal		Belone belone	FooDB	31437929
Animal		Melanogrammus aeglefinus	FooDB	31437929
Animal		Hippoglossus hippoglossus	FooDB	31437929
Animal	Meat	Lepus timidus	FooDB	31437929
Animal	Heart	Bos taurus	FooDB	31437929
Animal	Heart	Sus scrofa domesticus	FooDB	31437929
Animal	Heart	Bos taurus	FooDB	31437929
Animal		Clupeinae	FooDB	31437929
Animal		Clupeinae	FooDB	31437929
Animal	Kidney	Bos taurus	FooDB	31437929
Animal	Kidney	Bos taurus	FooDB	31437929
Animal	Kidney	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Bos taurus	FooDB	31437929
Animal	Liver	Bos taurus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal		Nephropidae	FooDB	31437929
Animal		Scombridae	FooDB	31437929
Animal		Nephrops norvegicus	FooDB	31437929
Animal		Pleurotus ostreatus	FooDB	31437929
Animal		Pleuronectidae	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Liver	Sus scrofa domesticus	FooDB	31437929
Animal	Meat	Leporidae	FooDB	31437929
Animal		Salmonidae	FooDB	31437929
Animal	Tongue	Bos taurus	FooDB	31437929
Animal	Tongue	Bos taurus	FooDB	31437929
Animal	Tongue	Sus scrofa domesticus	FooDB	31437929
Animal		Thunnus	FooDB	31437929
Animal	Meat and skin	Meleagris gallopavo	FooDB	31437929
Animal	Meat	Meleagris gallopavo	FooDB	31437929
Plant	Juice	Citrus limon	FooDB	31437929
Plant		Brassica rapa subsp. rapa	FooDB	31437929
Plant		Ribes uva-crispa	FooDB	31437929
Plant	Kernel	Triticum	FooDB	31437929
Plant	Fruit	Malus pumila	FooDB	31437929
Plant	Fruit	Prunus armeniaca	FooDB	31437929
Plant	Bean	Phaseolus vulgaris	FooDB	31437929
Plant	Fruit	Prunus persica	FooDB	31437929
Plant	Bean	Glycine max	FooDB	31437929
Plant	Fruit	Cucurbita	FooDB	31437929
Plant	Bean	Phaseolus vulgaris	FooDB	31437929
Plant	Fruit	Solanum lycopersicum	FooDB	31437929
Plant	Fruit	Ficus carica	FooDB	31437929
Plant	Fruit	Solanum lycopersicum	FooDB	31437929
Plant	Nut	Corylus	FooDB	31437929
Plant	Nut	Arachis hypogaea	FooDB	31437929
Plant	Bean	Phaseolus vulgaris	FooDB	31437929
Plant		Brassica oleracea var. gemmifera	FooDB	31437929
Plant	Leaves	Anthriscus cerefolium	FooDB	31437929
Plant	Bean	Pisum sativum	FooDB	31437929
Plant	Leaves	Spinacia oleracea	FooDB	31437929
Plant	Kernel	Zea mays	FooDB	31437929
Plant	Fruit	Solanum lycopersicum	FooDB	31437929
Plant	Nut	Juglans nigra	FooDB	31437929
Plant	Shoot	Asparagus officinalis	FooDB	31437929
Plant	Bean	Phaseolus vulgaris	FooDB	31437929
Plant	Leaves	Brassica oleracea	FooDB	31437929
Plant	Leaves	Brassica oleracea	FooDB	31437929
Plant	Fruit	Cucumis sativus	FooDB	31437929
Plant	Flour	Oryza sativa	FooDB	31437929
Plant	Fruit	Cucumis sativus	FooDB	31437929
Plant	Flour	Secale cereale	FooDB	31437929
Plant	Fruit	Ficus carica	FooDB	31437929
Plant	Flour	Fagopyrum esculentum	FooDB	31437929
Plant	Flour	Triticum	FooDB	31437929
Plant	Juice	Citrus x paradisi	FooDB	31437929
Plant		Agaricus bisporus	FooDB	31437929
Plant	Nut	Arachis hypogaea	FooDB	31437929
Plant		Avena sativa	FooDB	31437929
Plant		Avena sativa	FooDB	31437929
Plant		Avena sativa	FooDB	31437929
Plant	Juice	Citrus sinensis	FooDB	31437929
Plant	Fruit	Fragaria x ananassa	FooDB	31437929
Plant	Kernel	Zea mays	FooDB	31437929
Plant	Fruit	Citrus reticulata	FooDB	31437929
Plant	Fruit	Solanum lycopersicum	FooDB	31437929
Plant		Sesamum indicum	FooDB	31437929
Plant	Seed	Hordeum vulgare	FooDB	31437929
Plant	Fruit	Sambucus nigra	FooDB	31437929
Plant	Nut	Bertholletia excelsa	FooDB	31437929
Plant		Gossypium	FooDB	31437929
Plant	Seed	Lens culinaris	FooDB	31437929
Plant	Fruit	Fragaria x ananassa	FooDB	31437929
Plant		Avena sativa	FooDB	31437929
Plant		Zea mays	FooDB	31437929
Plant		Zea mays	FooDB	31437929
Plant		Solanum tuberosum	FooDB	31437929
Plant		Solanum tuberosum	FooDB	31437929
Plant	Kernel	Secale cereale	FooDB	31437929
Plant	Flour	Secale cereale	FooDB	31437929
Plant		Triticum aestivum	FooDB	31437929
Plant	Kernel	Triticum	FooDB	31437929
Plant	Nut	Prunus dulcis	FooDB	31437929
Plant	Fruit	Malus pumila	FooDB	31437929
Plant	Fruit	Malus pumila	FooDB	31437929
Plant	Fruit	Ananas comosus	FooDB	31437929
Plant	Shoot	Asparagus officinalis	FooDB	31437929
Plant	Fruit	Persea americana	FooDB	31437929
Plant	Fruit	Persea americana	FooDB	31437929
Plant	Fruit	Capsicum annuum	FooDB	31437929
Plant	Bean	Glycine max	FooDB	31437929
Plant	Bean	Phaseolus vulgaris	FooDB	31437929
Plant	Bean	Phaseolus vulgaris	FooDB	31437929
Plant	Bean	Vicia faba	FooDB	31437929
Plant		Brassica oleracea var. italica	FooDB	31437929
Plant		Brassica oleracea var. gemmifera	FooDB	31437929
Plant	Leaves	Lactuca sativa	FooDB	31437929
Plant	Leaves	Brassica oleracea	FooDB	31437929
Plant	Leaves	Brassica oleracea	FooDB	31437929
Plant	Root	Daucus carota subsp. sativus	FooDB	31437929
Plant		Brassica oleracea var. botrytis	FooDB	31437929
Plant		Brassica oleracea var. botrytis	FooDB	31437929
Plant		Brassica oleracea var. botrytis	FooDB	31437929
Plant	Root	Apium graveolens rapaceum group	FooDB	31437929
Plant		Apium graveolens	FooDB	31437929
Plant	Fruit	Prunus	FooDB	31437929
Plant	Leaves	Anthriscus cerefolium	FooDB	31437929
Plant	Tuber	Castanea	FooDB	31437929
Plant	Leaves	Cichorium intybus	FooDB	31437929
Plant	Leaves	Allium schoenoprasum	FooDB	31437929
Plant		Zea mays	FooDB	31437929
Plant		Lepidium sativum	FooDB	31437929
Plant	Fruit	Cucumis sativus	FooDB	31437929
Plant	Fruit	Ribes nigrum	FooDB	31437929
Plant	Fruit	Ribes rubrum	FooDB	31437929
Plant		Anethum graveolens	FooDB	31437929
Plant	Fruit	Sambucus	FooDB	31437929
Plant	Nut	Juglans regia	FooDB	31437929
Plant	Bulb	Allium sativum	FooDB	31437929
Plant	Fruit	Ribes uva-crispa	FooDB	31437929
Plant	Fruit	Vitis	FooDB	31437929
Plant	Fruit	Citrus x paradisi	FooDB	31437929
Plant		Helianthus tuberosus	FooDB	31437929
Plant		Brassica oleracea	FooDB	31437929
Plant	Fruit	Citrus limon	FooDB	31437929
Plant		Agaricus bisporus	FooDB	31437929
Plant	Fruit	Cocos nucifera	FooDB	31437929
Plant	Bulb	Allium	FooDB	31437929
Plant	Fruit	Citrus sinensis	FooDB	31437929
Plant	Leaves	Petroselinum crispum	FooDB	31437929
Plant	Root	Pastinaca sativa	FooDB	31437929
Plant	Bean	Pisum sativum	FooDB	31437929
Plant	Fruit	Prunus persica	FooDB	31437929
Plant	Fruit	Pyrus communis	FooDB	31437929
Plant	Bean	Pisum sativum	FooDB	31437929
Plant	Bean	Pisum sativum	FooDB	31437929
Plant		Ipomoea batatas	FooDB	31437929
Plant	Fruit	Cucurbita	FooDB	31437929
Plant	Kernel	Oryza sativa	FooDB	31437929
Plant		Oryza sativa	FooDB	31437929
Plant		Oryza sativa	FooDB	31437929
Plant		Oryza sativa	FooDB	31437929
Plant	Leaves	Spinacia oleracea	FooDB	31437929
Plant	Fruit	Fragaria x ananassa	FooDB	31437929
Plant		Brassica napus	FooDB	31437929
Plant		Zea mays	FooDB	31437929
Plant	Fruit	Citrus reticulata	FooDB	31437929
Plant	Fruit	Solanum lycopersicum	FooDB	31437929
Plant	Fruit	Solanum lycopersicum	FooDB	31437929
Plant	Fruit	Solanum lycopersicum	FooDB	31437929

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.08198		0.00033	0.421	uM	Not Specified	Not Specified	Acute lymphoblastic leukemia	HMDB	18996865
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.000447	0.000217			uM	Not Specified	Not Specified	Dementia	HMDB	10577274
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.000336	0.00008603			uM	Not Specified	Not Specified	Epilepsy	HMDB	10577274
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0229				uM	Not Specified	Not Specified	Head injury	HMDB	18996865
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.000545		0.00004799	0.00192	uM	Not Specified	Not Specified	Motor neuron disease (MND)	HMDB	10577274
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.000324	0.000107			uM	Not Specified	Not Specified	Multiple sclerosis	HMDB	10577274
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0005	0.0002			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	10701954
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.000557	0.000307			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	10577274
Human Blood	Detected and Quantified	0.00127	0.00067			uM	Adult (>18 years old)	Both	Normal	HMDB	1814646
Human Urine	Detected and Quantified	0.023		0.013	0.032	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	9022537
Human Urine	Detected and Quantified	0.049	0.035			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	1814646
Human Urine	Detected and Quantified	58.242	21.921			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Blood	Detected and Quantified	0.0016		0.0009	0.0028	uM	Children (1-13 years old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	0.0024		0.0008	0.0041	uM	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	0.0034		0.002	0.0051	uM	Newborn (0-30 days old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	0.014		0.002	0.044	umol/mmol creatinine	Children (1-13 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Saliva	Detected and Quantified	0.123	0.141			uM	Adult (>18 years old)	Male	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.296	0.150			uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.071	0.041			uM	Adult (>18 years old)	Both	Normal	HMDB	Zerihun T. Dame, Farid Aziat, Rupasri Mandal, Ram Krishnamurthy, Souhaila Bouatra, Shima Borzouie, An Chi Guo, Tanvir Sajed, Lu Deng, Hong Lin, Philip Liu, Edison Dong, David S. Wishart "The human saliva metabolome" Metabolomics (2015) DOI 10.1007/s11306-015-0840-5
Human Blood	Detected and Quantified			0.11	0.13	uM	Adult (>18 years old)	Both	Normal	HMDB	Molecular You (https://molecularyou.com)
Human All tissues	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Prostate	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

HMDB ID

HMDB0000030

DrugBank ID

DB00121

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

15956

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Thuy LP, Belmont J, Nyhan WL: Prenatal diagnosis and treatment of holocarboxylase synthetase deficiency. Prenat Diagn. 1999 Feb;19(2):108-12. doi: 10.1002/(sici)1097-0223(199902)19:2<108::aid-pd476>3.0.co;2-e. [PubMed:10215065 ]
Zempleni J, McCormick DB, Mock DM: Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine. Am J Clin Nutr. 1997 Feb;65(2):508-11. doi: 10.1093/ajcn/65.2.508. [PubMed:9022537 ]
Bussolati G, Gugliotta P, Volante M, Pace M, Papotti M: Retrieved endogenous biotin: a novel marker and a potential pitfall in diagnostic immunohistochemistry. Histopathology. 1997 Nov;31(5):400-7. doi: 10.1046/j.1365-2559.1997.3020895.x. [PubMed:9416479 ]
Mock DM, Stadler DD, Stratton SL, Mock NI: Biotin status assessed longitudinally in pregnant women. J Nutr. 1997 May;127(5):710-6. doi: 10.1093/jn/127.5.710. [PubMed:9164991 ]
Thuy LP, Sweetman L, Nyhan WL: A new immunochemical assay for biotin. Clin Chim Acta. 1991 Oct 31;202(3):191-7. doi: 10.1016/0009-8981(91)90049-i. [PubMed:1814646 ]
Limat A, Suormala T, Hunziker T, Waelti ER, Braathen LR, Baumgartner R: Proliferation and differentiation of cultured human follicular keratinocytes are not influenced by biotin. Arch Dermatol Res. 1996;288(1):31-8. doi: 10.1007/BF02505040. [PubMed:8750932 ]
Bigham SL, Ballard JD, Giles KD, Clelland CS, Jeffcoat R, Griffin KS, Farley TD, Bushman DR, Wright JR: Synthesis and possible applications of biotin-linked copper clusters. Physiol Chem Phys Med NMR. 1990;22(2):63-72. [PubMed:2100006 ]
Mock DM, Stadler DD: Conflicting indicators of biotin status from a cross-sectional study of normal pregnancy. J Am Coll Nutr. 1997 Jun;16(3):252-7. doi: 10.1080/07315724.1997.10718682. [PubMed:9176832 ]
Bingham JP, Bian S, Tan ZY, Takacs Z, Moczydlowski E: Synthesis of a biotin derivative of iberiotoxin: binding interactions with streptavidin and the BK Ca2+-activated K+ channel expressed in a human cell line. Bioconjug Chem. 2006 May-Jun;17(3):689-99. doi: 10.1021/bc060002u. [PubMed:16704206 ]
Mock DM: Biotin status: which are valid indicators and how do we know? J Nutr. 1999 Feb;129(2S Suppl):498S-503S. doi: 10.1093/jn/129.2.498S. [PubMed:10064317 ]
Mock DM, Dyken ME: Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants. Neurology. 1997 Nov;49(5):1444-7. doi: 10.1212/wnl.49.5.1444. [PubMed:9371938 ]
Mock DM, Nyalala JO, Raguseo RM: A direct streptavidin-binding assay does not accurately quantitate biotin in human urine. J Nutr. 2001 Aug;131(8):2208-14. doi: 10.1093/jn/131.8.2208. [PubMed:11481419 ]
Mardach R, Zempleni J, Wolf B, Cannon MJ, Jennings ML, Cress S, Boylan J, Roth S, Cederbaum S, Mock DM: Biotin dependency due to a defect in biotin transport. J Clin Invest. 2002 Jun;109(12):1617-23. doi: 10.1172/JCI13138. [PubMed:12070309 ]
Mock DM, Heird GM: Urinary biotin analogs increase in humans during chronic supplementation: the analogs are biotin metabolites. Am J Physiol. 1997 Jan;272(1 Pt 1):E83-5. doi: 10.1152/ajpendo.1997.272.1.E83. [PubMed:9038855 ]
Fujimoto W, Inaoki M, Fukui T, Inoue Y, Kuhara T: Biotin deficiency in an infant fed with amino acid formula. J Dermatol. 2005 Apr;32(4):256-61. doi: 10.1111/j.1346-8138.2005.tb00758.x. [PubMed:15863846 ]
Schenker S, Hu ZQ, Johnson RF, Yang Y, Frosto T, Elliott BD, Henderson GI, Mock DM: Human placental biotin transport: normal characteristics and effect of ethanol. Alcohol Clin Exp Res. 1993 Jun;17(3):566-75. doi: 10.1111/j.1530-0277.1993.tb00801.x. [PubMed:8333586 ]
Mock NI, Malik MI, Stumbo PJ, Bishop WP, Mock DM: Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased biotin status in experimental biotin deficiency. Am J Clin Nutr. 1997 Apr;65(4):951-8. doi: 10.1093/ajcn/65.4.951. [PubMed:9094878 ]
Grafe F, Wohlrab W, Neubert RH, Brandsch M: Transport of biotin in human keratinocytes. J Invest Dermatol. 2003 Mar;120(3):428-33. doi: 10.1046/j.1523-1747.2003.12058.x. [PubMed:12603856 ]
Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
Gravel RA, Narang MA: Molecular genetics of biotin metabolism: old vitamin, new science. J Nutr Biochem. 2005 Jul;16(7):428-31. doi: 10.1016/j.jnutbio.2005.03.020. [PubMed:15992684 ]
Zempleni J: Uptake, localization, and noncarboxylase roles of biotin. Annu Rev Nutr. 2005;25:175-96. doi: 10.1146/annurev.nutr.25.121304.131724. [PubMed:16011464 ]
Holmberg A, Blomstergren A, Nord O, Lukacs M, Lundeberg J, Uhlen M: The biotin-streptavidin interaction can be reversibly broken using water at elevated temperatures. Electrophoresis. 2005 Feb;26(3):501-10. doi: 10.1002/elps.200410070. [PubMed:15690449 ]

Showing metabocard for Biotin (MMDBc0000006)

MOL for #<Metabolite:0x00007f5a8802c440>

3D MOL for #<Metabolite:0x00007f5a8802c440>

3D SDF for #<Metabolite:0x00007f5a8802c440>

3D-SDF for #<Metabolite:0x00007f5a8802c440>

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Structure for #<Metabolite:0x00007f5a8802c440>

3D Structure for #<Metabolite:0x00007f5a8802c440>