MiMeDB: Showing metabocard for Mannitol (MMDBc0000153)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:37:48 UTC

Update Date

2024-04-30 19:31:14 UTC

Metabolite ID

MMDBc0000153

Metabolite Identification

Common Name

Mannitol

Description

Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity. Chemically, mannitol is an alcohol and a sugar, or a polyol; it is similar to xylitol or sorbitol. However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic. For this, it is not uncommon to add a substance to adjust its pH, such as sodium bicarbonate. Mannitol is a non-permeating molecule i.e. it cannot cross biological membranes. Mannitol or hexan-1,2,3,4,5,6-hexol (C6H8(OH)6) is an osmotic diuretic agent and a weak renal vasodilator. It is a sorbitol isomer. Mannitol is found to be associated with cytochrome c oxidase deficiency and ribose-5-phosphate isomerase deficiency, which are inborn errors of metabolism. Mannitol is also a microbial metabolite found in Aspergillus, Candida, Clostridium, Gluconobacter, Lactobacillus, Lactococcus, Leuconostoc, Pseudomonas, Rhodobacteraceae, Saccharomyces, Streptococcus, Torulaspora and Zymomonas (PMID: 15240312 ; PMID: 29480337 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  C   UNK     0    8650.0488651.108   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8651.3808650.339   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8652.7168651.108   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8654.0518650.339   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0    8655.3838651.108   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8652.7168652.648   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0    8651.3808648.799   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0    8648.7148650.339   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8647.3798651.108   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0    8646.0458650.339   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0    8648.7148648.799   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0    8650.0488652.648   0.000  0.00  0.00           O+0
CONECT    1    2    8   12                                                  
CONECT    2    1    3    7                                                  
CONECT    3    2    4    6                                                  
CONECT    4    3    5                                                       
CONECT    5    4                                                            
CONECT    6    3                                                            
CONECT    7    2                                                            
CONECT    8    1    9   11                                                  
CONECT    9    8   10                                                       
CONECT   10    9                                                            
CONECT   11    8                                                            
CONECT   12    1                                                            
MASTER        0    0    0    0    0    0    0    0   12    0   22    0
END

Synonyms

Value	Source
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol	ChEBI
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol	ChEBI
D-(-)-Mannitol	ChEBI
Dulcite	ChEBI
e 421	ChEBI
e-421	ChEBI
e421	ChEBI
Manna sugar	ChEBI
Mannite	ChEBI
Osmitrol	ChEBI
D-Mannitol	Kegg
Tobrex	Kegg
Bronchitol	Kegg
1,2,3,4,5,6-Hexanehexol	HMDB
Cordycepate	HMDB
Cordycepic acid	HMDB
Diosmol	HMDB
Hexahydroxyhexane	HMDB
Hexanhexol	HMDB
Invenex	HMDB
Isotol	HMDB
Manicol	HMDB
Maniton S	HMDB
Maniton-S	HMDB
Mannazucker	HMDB
Mannidex	HMDB
Mannigen	HMDB
Mannistol	HMDB
Mannit	HMDB
Mannit p	HMDB
Mannogem 2080	HMDB
Marine crystal	HMDB
Mushroom sugar	HMDB
Osmofundin	HMDB
Osmosal	HMDB
Resectisol	HMDB
SDM No. 35	HMDB
(L)-Mannitol	HMDB
Mannitol	ChEBI

Molecular Formula

C₆H₁₄O₆

Average Mass

182.1718

Monoisotopic Mass

182.07903818

IUPAC Name

(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol

Traditional Name

mannitol

CAS Registry Number

69-65-8

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI Identifier

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI Key

FBPFZTCFMRRESA-KVTDHHQDSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Sugar alcohols

Alternative Parents

Substituents

Sugar alcohol
Monosaccharide
Secondary alcohol
Polyol
Hydrocarbon derivative
Primary alcohol
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

mannitol (CHEBI:16899 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	229 g/L	ALOGPS
logP	-2.7	ALOGPS
logP	-3.7	ChemAxon
logS	0.1	ALOGPS
pKa (Strongest Acidic)	12.59	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	121.38 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	38.4 m³·mol⁻¹	ChemAxon
Polarizability	17.04 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (6 TMS)	splash10-0ktb-0931000000-b481d576c5f24dd1b1d5	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-066s-0942000000-20043a375d72ca08dce9	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (6 TMS)	splash10-066r-1974000000-38a4beaca17ab8c750b6	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-0229-9100000000-5655e9df8e0fdcaa72a0	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-001i-9200000000-0dad802ab0000303cb33	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0ktb-0931000000-b481d576c5f24dd1b1d5	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-066s-0942000000-20043a375d72ca08dce9	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-066r-1974000000-38a4beaca17ab8c750b6	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-066s-0942000000-f4df881aeebac32de5c7	2017-09-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-03k9-9500000000-97c5853d3e9b96f9d054	2016-09-22	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (6 TMS) - 70eV, Positive	splash10-0a6s-7141193000-dcd9245e12314ee0ced4	2017-10-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_1) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_2) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_3) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_4) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_5) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_6) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_7) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_8) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_9) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_3_1) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-014j-9600000000-26f4335f7ef7c81ca261	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-066r-9000000000-73db1fbd51fb8c061bec	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-05mo-9000000000-45a4dea1d21286c4b8da	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-0089-6900000000-961d76d6550bc342ffa1	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0089-6900000000-061f88989a6ac71321e3	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , negative	splash10-0ik9-1900000000-eb8ea056f3b1dfe2fb1f	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , negative	splash10-03di-1900000000-6768b4744e1a4e56b18b	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-00kb-1900000000-0765563624accf132d03	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-00dr-0900000000-e159f4e76b7847313f35	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-0900-0910000000-8d56394cbc78dd3b5ca0	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-0079-0900000000-63517bff4abfbf09e1ca	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-0w2l-0940000000-dc20c851073dcbc4dba9	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-05ar-9500000000-c82bc4e2d1e173359c3e	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-0ab9-9000000000-47357f9a38864cba9668	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 20V, Positive	splash10-066r-9000000000-9cd6979ccf800d067e03	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-02tj-9400000000-b72fa250b3caa4a87682	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 40V, Positive	splash10-05mo-9000000000-fc27b5c54b0dd6fc8a39	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-014i-9100000000-0436dafd7f39b7c910e9	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 40V, Positive	splash10-066u-9000000000-fb4a8654ee07a1dcc56c	2021-09-20	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-001i-2900000000-ef92b9091ecf5d15cdee	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03di-9300000000-47f19bd4e51bff726536	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03dl-9100000000-60d5147d8e349337fe97	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-07ju-8900000000-36f0fe0f346a6424162a	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0c0c-9200000000-36e85b5ec098a45204c3	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0btc-9000000000-77703ee971336704163f	2016-09-12	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-00di-9000000000-d5db4fbf6c1eb9dd3564	2018-05-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)		2012-12-04	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-16	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)		2012-12-05	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Membrane

Biospecimen Locations

Blood
Brain
Cerebrospinal Fluid (CSF)
Epidermis
Feces
Placenta
Saliva
Urine

Tissue Locations

Brain
Epidermis
Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0193419	Multidrug resistance protein 1	Transporter	P08183	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0003982	Mannitol	Hydrogen Ion	Not Available	L-Iditol 2-Dehydrogenase	VMH	6870831
MMDBr0013078	D-Mannitol	D-Fructose	Mannitol dehydrogenase DSF1	Dehydrogenation	RHEA	34755880
MMDBr0013561	D-Mannitol	D-Fructose	NADP-dependent mannitol dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0013562	D-Mannitol	D-Fructose	NADP-dependent mannitol dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0013563	D-Fructose	D-Mannitol	NADP-dependent mannitol dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0013894	Mannitol 1-phosphate	D-Mannitol	Hexitol phosphatase A	Dephosphorylation	RHEA	34755880
MMDBr0024907	Mannitol	L-Histidine	PTS system mannitol-specific EIICB component	Phosphorylation	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Aids	Increased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	8748311
Alzheimer's disease		Association	Human Cerebrospinal Fluid (CSF)	HMDB	8595727
Cytochrome c oxidase deficiency	Decreased	Association	Human Blood	HMDB	7710082
Lung cancer		Association	Human Urine	HMDB	18953024
Ribose-5-phosphate isomerase deficiency	Decreased	Association	Human Blood	HMDB	14988808
Uremia	Slight Increase	Association	Human Blood	HMDB	12675874
Eosinophilic esophagitis		Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	10	Human ; Human mucosa; Human stool; Human supragingival plaque; Human feces; Human saliva; Human subgingival plaque	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen
Bacteria	Firmicutes	75	Human ; Human feces; Human supragingival plaque; Human urine; Human sputum; Human saliva; Human subgingival plaque; Human vaginal fluid; Human mucosa; Goat feces; Sheep feces; Human stool	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen
Bacteria	Bacteroidetes	15	Human saliva; Human ; Human stool; Human feces; Human urine; Human subgingival plaque	Microbial culture
Eukaryota/Fungi	Ascomycota	19	Human feces; Human saliva; Human supragingival plaque	Microbial culture
Bacteria	Actinobacteria	5	Human ; Human urine; Human feces	Microbial culture
Bacteria	Spirochaetes	2		Microbial culture
Bacteria	Deinococcus-thermus	1		Microbial culture
Bacteria	Chloroflexi	1		Microbial culture
Eukaryota/Fungi	Basidiomycota	2	Human feces

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Blood	Detected and Quantified	1.63		1.14	2.12	uM	Adult (>18 years old)	Both	Cytochrome C oxidase deficiency	HMDB	7710082
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.61		3.3	5.92	uM	Adult (>18 years old)	Both	Normal	HMDB	7710082
Human Cerebrospinal fluid (csf)	Detected and Quantified	5.54	0.82			uM	Not Specified	Not Specified	Alzheimer's disease	HMDB	8595727
Human Cerebrospinal fluid (csf)	Detected and Quantified	5.6	1.7			uM	Adult (>18 years old)	Both	Normal	HMDB	8595727
Human Cerebrospinal fluid (csf)	Detected and Quantified	5.6	1.1			uM	Adult (>18 years old)	Both	Alzheimer's disease	HMDB	8595727
Human Cerebrospinal fluid (csf)	Detected and Quantified	48.9		8.24	144	uM	Adult (>18 years old)	Both	AIDS	HMDB	8748311
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	12097436
Human Blood	Detected and Quantified	142.857	137.363			uM	Adult (>18 years old)	Both	Uremia	HMDB	12675874
Human Blood	Detected and Quantified	<7.143				uM	Adult (>18 years old)	Both	Normal	HMDB	12675874
Human Blood	Detected and Quantified	2		0	5	uM	Adult (>18 years old)	Both	Ribose-5-phosphate isomerase deficiency	HMDB	14988808
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.49				uM	Adult (>18 years old)	Both	Normal	HMDB	18502700
Human Urine	Detected and Quantified	41		0	486	umol/mmol creatinine	Not Specified	Both	Lung cancer	HMDB	18953024
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21389975
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Cardiosvacular risk	HMDB	22887155
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	22944170
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Cryptosporidium infection	HMDB	22944170
Human Urine	Detected and Quantified	32.4		5.2	85.1	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Colorectal cancer	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Bladder cancer	HMDB	28157703
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Blood	Detected and Quantified	34	18			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.8	2			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	116.989	152.291			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	62.692	69.964			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	10.26	9.14			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	120		0	245	umol/mmol creatinine	Children (1-13 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cerebrospinal fluid (csf)	Detected and Quantified	48.9		8.24	144	uM	Adult (>18 years old)	Both	AIDS	HMDB	8748311
Human Cerebrospinal fluid (csf)	Detected and Quantified	5.54	0.82			uM	Not Specified	Not Specified	Alzheimer's disease	HMDB	8595727
Human Cerebrospinal fluid (csf)	Detected and Quantified	5.6	1.1			uM	Adult (>18 years old)	Both	Alzheimer's disease	HMDB	8595727
Human Blood	Detected and Quantified	1.63		1.14	2.12	uM	Adult (>18 years old)	Both	Cytochrome C oxidase deficiency	HMDB	7710082
Human Urine	Detected and Quantified	41.0		0.0	486.0	umol/mmol creatinine	Not Specified	Both	Lung cancer	HMDB	18953024
Human Blood	Detected and Quantified	2.0		0.0	5.0	uM	Adult (>18 years old)	Both	Ribose-5-phosphate isomerase deficiency	HMDB	14988808
Human Blood	Detected and Quantified	142.857	137.363			uM	Adult (>18 years old)	Both	Uremia	HMDB	12675874
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.49				uM	Adult (>18 years old)	Both	Normal	HMDB	18502700
Human Blood	Detected and Quantified	<7.143				uM	Adult (>18 years old)	Both	Normal	HMDB	12675874
Human Urine	Detected and Quantified	32.4		5.2	85.1	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.61		3.30	5.92	uM	Adult (>18 years old)	Both	Normal	HMDB	7710082
Human Cerebrospinal fluid (csf)	Detected and Quantified	5.6	1.7			uM	Adult (>18 years old)	Both	Normal	HMDB	8595727
Human Urine	Detected and Quantified	116.989	152.291			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	62.692	69.964			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	10.26	9.14			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	120.0		0.0	245.0	umol/mmol creatinine	Children (1-13 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	34.0	18.0			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.8	2.0			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Brain	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Epidermis	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Placenta	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21389975
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	12097436
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	22944170
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030

External Links

HMDB ID

HMDB0000765

DrugBank ID

DB00742

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Mannitol

METLIN ID

142

PubChem Compound

6251

PDB ID

Not Available

ChEBI ID

16899

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

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Megson GM, Stevens DA, Hamilton JR, Denning DW: D-mannitol in cerebrospinal fluid of patients with AIDS and cryptococcal meningitis. J Clin Microbiol. 1996 Jan;34(1):218-21. doi: 10.1128/jcm.34.1.218-221.1996. [PubMed:8748311 ]
Zunkeler B, Carson RE, Olson J, Blasberg RG, DeVroom H, Lutz RJ, Saris SC, Wright DC, Kammerer W, Patronas NJ, Dedrick RL, Herscovitch P, Oldfield EH: Quantification and pharmacokinetics of blood-brain barrier disruption in humans. J Neurosurg. 1996 Dec;85(6):1056-65. doi: 10.3171/jns.1996.85.6.1056. [PubMed:8929495 ]
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Barben J, Roberts M, Chew N, Carlin JB, Robertson CF: Repeatability of bronchial responsiveness to mannitol dry powder in children with asthma. Pediatr Pulmonol. 2003 Dec;36(6):490-4. doi: 10.1002/ppul.10378. [PubMed:14618640 ]
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Showing metabocard for Mannitol (MMDBc0000153)

MOL for #<Metabolite:0x00007fd0ecdf3698>

3D MOL for #<Metabolite:0x00007fd0ecdf3698>

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3D-SDF for #<Metabolite:0x00007fd0ecdf3698>

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Structure for #<Metabolite:0x00007fd0ecdf3698>

3D Structure for #<Metabolite:0x00007fd0ecdf3698>