Showing metabocard for Hypoxanthine (MMDBc0000497)

Not Available
Record Information
Version1.0
StatusDetected and Quantified
Creation Date2020-12-10 18:39:07 UTC
Update Date2024-10-11 02:59:37 UTC
Metabolite IDMMDBc0000497
Metabolite Identification
Common NameHypoxanthine
DescriptionHypoxanthine, also known as purine-6-ol or Hyp, belongs to the class of organic compounds known as purines. Purines are a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. Hypoxanthine is also classified as an oxopurine, Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the nucleotide salvage pathway. Hypoxanthine exists in all living species, ranging from bacteria to plants to humans. Hypoxanthine has been detected, but not quantified in, several different foods, such as radish (var.), mountain yams, welsh onions, greenthread tea, and common beets. Hypoxanthine is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. Biologically, hypoxanthine can be formed a number of ways. For instance, it is one of the products of the action of xanthine oxidase on xanthine. However, more frequently xanthine is formed from oxidation of hypoxanthine by xanthine oxidoreductase. The enzyme hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in the nucleotide salvage pathway. Hypoxanthine is also a spontaneous deamination product of adenine. Under normal circumstances hypoxanthine is readily converted to uric acid. In this process, hypoxanthine is first oxidized to xanthine, which is further oxidized to uric acid by xanthine oxidase. Molecular oxygen, the oxidant in both reactions, is reduced to H2O2 and other reactive oxygen species. In humans, uric acid is the final product of purine degradation and is excreted in the urine. Within humans, hypoxanthine participates in a number of other enzymatic reactions. In particular, hypoxanthine and ribose 1-phosphate can be biosynthesized from inosine through its interaction with the enzyme purine nucleoside phosphorylase. Hypoxanthine is also involved in the metabolic disorder called the purine nucleoside phosphorylase deficiency. Purine nucleoside phosphorylase (PNP) deficiency is a disorder of the immune system (primary immunodeficiency) characterized by recurrent infections, neurologic symptoms, and autoimmune disorders. PNP deficiency causes a shortage of white blood cells, called T-cells, that help fight infection. Affected individuals develop neurologic symptoms, such as stiff or rigid muscles (spasticity), uncoordinated movements (ataxia), developmental delay, and intellectual disability. PNP deficiency is associated with an increased risk to develop autoimmune disorders, such as autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura (ITP), autoimmune neutropenia, thyroiditis, and lupus.
Structure
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for #<Metabolite:0x00007fdb50151b10>

Hypoxanthine.mol
  Mrv1652309032023542D          

 10 11  0  0  0  0            999 V2000
    0.8643    0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3492   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8643   -1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0797   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6348   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3492   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3492    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6348    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6348    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0797    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  1 10  1  0  0  0  0
  4 10  2  0  0  0  0
M  END
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3D MOL for #<Metabolite:0x00007fdb50151b10>

HMDB0000157
     RDKit          3D
Hypoxanthine
 14 15  0  0  0  0  0  0  0  0999 V2000
    0.9522    2.2049   -0.4111 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9951    0.8403   -0.1712 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1426    0.1543   -0.0098 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1416   -1.1774    0.2228 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9580   -1.7939    0.2876 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2266   -1.1687    0.1354 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5168   -1.5621    0.1574 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3107   -0.4972   -0.0574 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5008    0.5652   -0.2136 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2222    0.1859   -0.1010 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6791    2.8534    0.3125 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0880   -1.6921    0.3470 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4100   -0.4808   -0.1001 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7694    1.5682   -0.3985 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10  2  1  0
 10  6  2  0
  1 11  1  0
  4 12  1  0
  8 13  1  0
  9 14  1  0
M  END
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3D SDF for #<Metabolite:0x00007fdb50151b10>

Hypoxanthine.mol
  Mrv1652309032023542D          

 10 11  0  0  0  0            999 V2000
    0.8643    0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3492   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8643   -1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0797   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6348   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3492   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3492    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6348    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6348    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0797    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  1 10  1  0  0  0  0
  4 10  2  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0000497

> <DATABASE_NAME>
MIME

> <SMILES>
OC1=NC=NC2=C1NC=N2

> <INCHI_IDENTIFIER>
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

> <INCHI_KEY>
FDGQSTZJBFJUBT-UHFFFAOYSA-N

> <FORMULA>
C5H4N4O

> <MOLECULAR_WEIGHT>
136.1115

> <EXACT_MASS>
136.03851077

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
14

> <JCHEM_AVERAGE_POLARIZABILITY>
11.817749402233233

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
7H-purin-6-ol

> <ALOGPS_LOGP>
-0.55

> <JCHEM_LOGP>
-0.048109598333333205

> <ALOGPS_LOGS>
-1.02

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.243772630076094

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.715984164481101

> <JCHEM_PKA_STRONGEST_BASIC>
1.7329101446499238

> <JCHEM_POLAR_SURFACE_AREA>
74.69

> <JCHEM_REFRACTIVITY>
35.49999999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.30e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
6-hydroxypurine

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for #<Metabolite:0x00007fdb50151b10>

HMDB0000157
     RDKit          3D
Hypoxanthine
 14 15  0  0  0  0  0  0  0  0999 V2000
    0.9522    2.2049   -0.4111 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9951    0.8403   -0.1712 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1426    0.1543   -0.0098 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1416   -1.1774    0.2228 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9580   -1.7939    0.2876 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2266   -1.1687    0.1354 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5168   -1.5621    0.1574 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3107   -0.4972   -0.0574 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5008    0.5652   -0.2136 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2222    0.1859   -0.1010 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6791    2.8534    0.3125 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0880   -1.6921    0.3470 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4100   -0.4808   -0.1001 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7694    1.5682   -0.3985 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10  2  1  0
 10  6  2  0
  1 11  1  0
  4 12  1  0
  8 13  1  0
  9 14  1  0
M  END
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PDB for #<Metabolite:0x00007fdb50151b10>

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: Hypoxanthine.mol                                  
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  N   UNK     0       1.613   0.476   0.000  0.00  0.00           N+0
HETATM    2  C   UNK     0       2.519  -0.770   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0       1.613  -2.016   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0       0.149  -1.540   0.000  0.00  0.00           C+0
HETATM    5  N   UNK     0      -1.185  -2.310   0.000  0.00  0.00           N+0
HETATM    6  C   UNK     0      -2.519  -1.540   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0      -2.519   0.000   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0      -1.185   0.770   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      -1.185   2.310   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       0.149   0.000   0.000  0.00  0.00           C+0
CONECT    1    2   10                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5   10                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8    1    4                                                  
MASTER        0    0    0    0    0    0    0    0   10    0   22    0
END
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3D PDB for #<Metabolite:0x00007fdb50151b10>

COMPND    HMDB0000157
HETATM    1  O1  UNL     1       0.952   2.205  -0.411  1.00  0.00           O  
HETATM    2  C1  UNL     1       0.995   0.840  -0.171  1.00  0.00           C  
HETATM    3  N1  UNL     1       2.143   0.154  -0.010  1.00  0.00           N  
HETATM    4  C2  UNL     1       2.142  -1.177   0.223  1.00  0.00           C  
HETATM    5  N2  UNL     1       0.958  -1.794   0.288  1.00  0.00           N  
HETATM    6  C3  UNL     1      -0.227  -1.169   0.135  1.00  0.00           C  
HETATM    7  N3  UNL     1      -1.517  -1.562   0.157  1.00  0.00           N  
HETATM    8  C4  UNL     1      -2.311  -0.497  -0.057  1.00  0.00           C  
HETATM    9  N4  UNL     1      -1.501   0.565  -0.214  1.00  0.00           N  
HETATM   10  C5  UNL     1      -0.222   0.186  -0.101  1.00  0.00           C  
HETATM   11  H1  UNL     1       0.679   2.853   0.312  1.00  0.00           H  
HETATM   12  H2  UNL     1       3.088  -1.692   0.347  1.00  0.00           H  
HETATM   13  H3  UNL     1      -3.410  -0.481  -0.100  1.00  0.00           H  
HETATM   14  H4  UNL     1      -1.769   1.568  -0.398  1.00  0.00           H  
CONECT    1    2   11
CONECT    2    3    3   10
CONECT    3    4
CONECT    4    5    5   12
CONECT    5    6
CONECT    6    7   10   10
CONECT    7    8    8
CONECT    8    9   13
CONECT    9   10   14
END
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SMILES for #<Metabolite:0x00007fdb50151b10>

OC1=NC=NC2=C1NC=N2
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INCHI for #<Metabolite:0x00007fdb50151b10>

InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
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Synonyms
ValueSource
6(1H)-PurinoneChEBI
6-OxopurineChEBI
9H-Purin-6(1H)-oneChEBI
HypChEBI
Purin-6(1H)-oneChEBI
Purine-6-olChEBI
1,7-Dihydro-6H-purin-6-oneHMDB
1,7-Dihydro-6H-purine-6-oneHMDB
1H,7H-HypoxanthineHMDB
3H-Purin-6-olHMDB
4-Hydroxy-1H-purineHMDB
6-Hydroxy-1H-purineHMDB
6-HydroxypurineHMDB
7H-Purin-6-olHMDB
9H-Purin-6-olHMDB
Hypoxanthine enolHMDB
Purin-6(3H)-oneHMDB
Purin-6-olHMDB
SarcineHMDB
SarkinHMDB
SarkineHMDB
Molecular FormulaC5H4N4O
Average Mass136.1115
Monoisotopic Mass136.03851077
IUPAC Name7H-purin-6-ol
Traditional Name6-hydroxypurine
CAS Registry NumberNot Available
SMILES
OC1=NC=NC2=C1NC=N2
InChI Identifier
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI KeyFDGQSTZJBFJUBT-UHFFFAOYSA-N