Showing metabocard for Mevalonic acid (MMDBc0000506)

Record Information
Version1.0
StatusDetected and Quantified
Creation Date2020-12-10 18:39:19 UTC
Update Date2024-04-30 19:32:41 UTC
Metabolite IDMMDBc0000506
Metabolite Identification
Common NameMevalonic acid
DescriptionMevalonic acid, also known as MVA, mevalonate, or hiochic acid, belongs to the class of organic compounds known as hydroxy fatty acids. These are fatty acids in which the chain bears a hydroxyl group. Mevalonic acid is a key organic compound in biochemistry. It is found in most higher organisms ranging from plants to animals. Mevalonic acid is a precursor in the biosynthetic pathway known as the mevalonate pathway that produces terpenes (in plants) and steroids (in animals). Mevalonic acid is the primary precursor of isopentenyl pyrophosphate (IPP), that is in turn the basis for all terpenoids. The production of mevalonic acid by the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, is the rate-limiting step in the biosynthesis of cholesterol (PMID: 12872277 ). The cholesterol biosynthetic pathway has three major steps: (1) acetate to mevalonate, (2) mevalonate to squalene, and (3) squalene to cholesterol. In the first step, which catalyzed by thiolase, two acetyl-CoA molecules form acetoacetyl-CoA and one CoA molecule is released, then the acetoacetyl-CoA reacts with another molecule of acetyl-CoA and generates 3-hydroxy-3-methylglutaryl-CoA (HMGCoA). The enzyme responsible for this reaction is 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase): In the pathway to synthesize cholesterol, one of the HMG-CoA carboxyl groups undergoes reduction to an alcohol, releasing CoA, leading to the formation of mevalonate, a six carbon compound. This reaction is catalyzed by hydroxy-methylglutaryl-CoA reductase, In the second step (mevalonate to squalene) mevalonate receives a phosphoryl group from ATP to form 5-phosphomevalonate. This compound accepts another phosphate to generate mevalonate-5-pyrophosphate. After a third phosphorylation, the compound is decarboxylated, loses water, and generates isopentenyl pyrophosphate (IPP). Then through successive condensations, IPP forms squalene, a terpene hydrocarbon that contains 30 carbon atoms. By cyclization and other changes, this compound will finally result in cholesterol. Mevalonic acid is found, on average, in the highest concentration within a few different foods, such as apples, corns, and wild carrots and in a lower concentration in garden tomato (var.), pepper (C. frutescens), and cucumbers. Mevalonic acid has also been detected, but not quantified in, several different foods, such as sweet oranges, potato, milk (cow), cabbages, and white cabbages. This could make mevalonic acid a potential biomarker for the consumption of these foods. Plasma concentrations and urinary excretion of MVA are decreased by HMG-CoA reductase inhibitor drugs such as pravastatin, simvastatin, and atorvastatin (PMID: 8808497 ).
Structure
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for #<Metabolite:0x00007fa5097de550>


  Mrv1652304242019462D          

 10  9  0  0  0  0            999 V2000
   -0.7155   -0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0006   -0.2069    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7141   -0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4319   -0.2069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456   -0.6187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4129    0.5093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4123    0.5093    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4304   -0.2069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1456   -0.6187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4304    0.6187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  8  1  0  0  0  0
  2  3  1  0  0  0  0
  2  6  1  1  0  0  0
  2  7  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
M  END
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3D MOL for #<Metabolite:0x00007fa5097de550>

HMDB0000227
     RDKit          3D
Mevalonic acid
 22 21  0  0  0  0  0  0  0  0999 V2000
   -0.7391   -2.0908    0.2135 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2165   -0.6033    0.3783 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0142   -0.4487    1.7261 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0833   -0.6459   -0.3396 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9245    0.5624   -0.4019 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3303    1.0384    0.8649 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2952    0.2265   -0.2221 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1693    1.6760   -0.1942 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3179    2.3698    0.3903 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1215    2.4451   -0.9162 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2501   -2.1319   -0.7494 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4553   -2.3047    1.0169 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -2.7774    0.2294 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5046    0.3254    2.0511 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9963   -1.0570   -1.3738 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6996   -1.4369    0.1997 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9260    0.1993   -0.8422 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6346    1.3530   -1.0901 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2543    1.4036    0.8440 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2696   -0.0260    0.3147 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5258   -0.1470   -1.2738 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0766    2.0703   -0.9662 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  1
  2  4  1  0
  4  5  1  0
  5  6  1  0
  2  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  3 14  1  0
  4 15  1  0
  4 16  1  0
  5 17  1  0
  5 18  1  0
  6 19  1  0
  7 20  1  0
  7 21  1  0
 10 22  1  0
M  END
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3D SDF for #<Metabolite:0x00007fa5097de550>


  Mrv1652304242019462D          

 10  9  0  0  0  0            999 V2000
   -0.7155   -0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0006   -0.2069    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7141   -0.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4319   -0.2069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456   -0.6187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4129    0.5093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4123    0.5093    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4304   -0.2069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1456   -0.6187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4304    0.6187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  8  1  0  0  0  0
  2  3  1  0  0  0  0
  2  6  1  1  0  0  0
  2  7  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0000506

> <DATABASE_NAME>
MIME

> <SMILES>
C[C@@](O)(CCO)CC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m1/s1

> <INCHI_KEY>
KJTLQQUUPVSXIM-ZCFIWIBFSA-N

> <FORMULA>
C6H12O4

> <MOLECULAR_WEIGHT>
148.1571

> <EXACT_MASS>
148.073558872

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
22

> <JCHEM_AVERAGE_POLARIZABILITY>
14.570780322838882

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(3R)-3,5-dihydroxy-3-methylpentanoic acid

> <ALOGPS_LOGP>
-0.90

> <JCHEM_LOGP>
-1.0933795586666666

> <ALOGPS_LOGS>
0.45

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
14.950224499840974

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.3846810662930205

> <JCHEM_PKA_STRONGEST_BASIC>
-2.413404454395632

> <JCHEM_POLAR_SURFACE_AREA>
77.75999999999999

> <JCHEM_REFRACTIVITY>
34.5114

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.14e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
mevalonic acid

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for #<Metabolite:0x00007fa5097de550>

HMDB0000227
     RDKit          3D
Mevalonic acid
 22 21  0  0  0  0  0  0  0  0999 V2000
   -0.7391   -2.0908    0.2135 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2165   -0.6033    0.3783 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0142   -0.4487    1.7261 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0833   -0.6459   -0.3396 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9245    0.5624   -0.4019 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3303    1.0384    0.8649 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2952    0.2265   -0.2221 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1693    1.6760   -0.1942 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3179    2.3698    0.3903 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1215    2.4451   -0.9162 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2501   -2.1319   -0.7494 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4553   -2.3047    1.0169 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -2.7774    0.2294 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5046    0.3254    2.0511 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9963   -1.0570   -1.3738 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6996   -1.4369    0.1997 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9260    0.1993   -0.8422 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6346    1.3530   -1.0901 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2543    1.4036    0.8440 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2696   -0.0260    0.3147 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5258   -0.1470   -1.2738 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0766    2.0703   -0.9662 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  1
  2  4  1  0
  4  5  1  0
  5  6  1  0
  2  7  1  0
  7  8  1  0
  8  9  2  0
  8 10  1  0
  1 11  1  0
  1 12  1  0
  1 13  1  0
  3 14  1  0
  4 15  1  0
  4 16  1  0
  5 17  1  0
  5 18  1  0
  6 19  1  0
  7 20  1  0
  7 21  1  0
 10 22  1  0
M  END
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PDB for #<Metabolite:0x00007fa5097de550>

HEADER    PROTEIN                                 24-APR-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-20         0                                  
HETATM    1  C   UNK     0      -1.336  -1.155   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.001  -0.386   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.333  -1.155   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.673  -0.386   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0       4.005  -1.155   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       0.771   0.951   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      -0.770   0.951   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -2.670  -0.386   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      -4.005  -1.155   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0      -2.670   1.155   0.000  0.00  0.00           O+0
CONECT    1    2    8                                                       
CONECT    2    1    3    6    7                                             
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4                                                            
CONECT    6    2                                                            
CONECT    7    2                                                            
CONECT    8    1    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8                                                            
MASTER        0    0    0    0    0    0    0    0   10    0   18    0
END
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3D PDB for #<Metabolite:0x00007fa5097de550>

COMPND    HMDB0000227
HETATM    1  C1  UNL     1      -0.739  -2.091   0.213  1.00  0.00           C  
HETATM    2  C2  UNL     1      -0.216  -0.603   0.378  1.00  0.00           C  
HETATM    3  O1  UNL     1      -0.014  -0.449   1.726  1.00  0.00           O  
HETATM    4  C3  UNL     1       1.083  -0.646  -0.340  1.00  0.00           C  
HETATM    5  C4  UNL     1       1.924   0.562  -0.402  1.00  0.00           C  
HETATM    6  O2  UNL     1       2.330   1.038   0.865  1.00  0.00           O  
HETATM    7  C5  UNL     1      -1.295   0.226  -0.222  1.00  0.00           C  
HETATM    8  C6  UNL     1      -1.169   1.676  -0.194  1.00  0.00           C  
HETATM    9  O3  UNL     1      -0.318   2.370   0.390  1.00  0.00           O  
HETATM   10  O4  UNL     1      -2.122   2.445  -0.916  1.00  0.00           O  
HETATM   11  H1  UNL     1      -1.250  -2.132  -0.749  1.00  0.00           H  
HETATM   12  H2  UNL     1      -1.455  -2.305   1.017  1.00  0.00           H  
HETATM   13  H3  UNL     1       0.107  -2.777   0.229  1.00  0.00           H  
HETATM   14  H4  UNL     1      -0.505   0.325   2.051  1.00  0.00           H  
HETATM   15  H5  UNL     1       0.996  -1.057  -1.374  1.00  0.00           H  
HETATM   16  H6  UNL     1       1.700  -1.437   0.200  1.00  0.00           H  
HETATM   17  H7  UNL     1       2.926   0.199  -0.842  1.00  0.00           H  
HETATM   18  H8  UNL     1       1.635   1.353  -1.090  1.00  0.00           H  
HETATM   19  H9  UNL     1       3.254   1.404   0.844  1.00  0.00           H  
HETATM   20  H10 UNL     1      -2.270  -0.026   0.315  1.00  0.00           H  
HETATM   21  H11 UNL     1      -1.526  -0.147  -1.274  1.00  0.00           H  
HETATM   22  H12 UNL     1      -3.077   2.070  -0.966  1.00  0.00           H  
CONECT    1    2   11   12   13
CONECT    2    3    4    7
CONECT    3   14
CONECT    4    5   15   16
CONECT    5    6   17   18
CONECT    6   19
CONECT    7    8   20   21
CONECT    8    9    9   10
CONECT   10   22
END
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SMILES for #<Metabolite:0x00007fa5097de550>

C[C@@](O)(CCO)CC(O)=O
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INCHI for #<Metabolite:0x00007fa5097de550>

InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m1/s1
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Synonyms
ValueSource
(R)-3,5-Dihydroxy-3-methylvaleric acidChEBI
(R)-MevalonateChEBI
3,5-Dihydroxy-3-methylvaleric acidChEBI
(R)-3,5-Dihydroxy-3-methylvalerateGenerator
(R)-Mevalonic acidGenerator
3,5-Dihydroxy-3-methylvalerateGenerator
MevalonateGenerator
Mevalonic acidChEBI
Acid, mevalonicMeSH
(3R)-3,5-Dihydroxy-3-methylpentanoic acidHMDB
(3R)-Mevalonic acidHMDB
(R)-(-)-Mevalonic acidHMDB
(R)-3,5-Dihydroxy-3-methylpentanoic acidHMDB
2,4-Dideoxy-3-C-methylpentonic acidHMDB
3,5-Dihydroxy-3-methylpentanoic acidHMDB
Hiochic acidHMDB
MVAHMDB
R-Mevalonic acidHMDB
beta,delta-Dihydroxy-beta-methylvaleric acidHMDB
β,δ-Dihydroxy-β-methylvaleric acidHMDB
Molecular FormulaC6H12O4
Average Mass148.1571
Monoisotopic Mass148.073558872
IUPAC Name(3R)-3,5-dihydroxy-3-methylpentanoic acid
Traditional Namemevalonic acid
CAS Registry NumberNot Available
SMILES
C[C@@](O)(CCO)CC(O)=O
InChI Identifier
InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m1/s1
InChI KeyKJTLQQUUPVSXIM-ZCFIWIBFSA-N