MiMeDB: Showing metabocard for 4-Hydroxycinnamic acid (MMDBc0000581)

Not Available

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-12-10 18:50:25 UTC

Update Date

2024-10-09 21:50:59 UTC

Metabolite ID

MMDBc0000581

Metabolite Identification

Common Name

4-Hydroxycinnamic acid

Description

4-Hydroxycinnamic acid, also known as p-Coumaric acid, is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate. p-coumaric acid is an organic compound that is a hydroxy derivative of cinnamic acid. There are three isomers of coumaric acid: o-coumaric acid, m-coumaric acid, and p-coumaric acid, that differ by the position of the hydroxy substitution of the phenyl group. p-Coumaric acid is the most abundant isomer of the three in nature. p-Coumaric acid exists in two forms trans-p-coumaric acid and cis-p-coumaric acid. It is a crystalline solid that is slightly soluble in water, but very soluble in ethanol and diethyl ether. 4-Hydroxycinnamic acid belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. 4-Hydroxycinnamic acid exists in all living species, ranging from bacteria to humans. Outside of the human body, 4-Hydroxycinnamic acid is found, on average, in the highest concentration within a few different foods, such as pepper (Capsicum frutescens), pineapples, and sunflowers and in a lower concentration in spinachs, kiwis, and sweet oranges. 4-Hydroxycinnamic acid has also been detected, but not quantified in several different foods, such as wild rices, soursops, garden onions, hyssops, and avocado.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  O   UNK     0    8663.4698663.582   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0    8668.8068666.663   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8670.1398665.892   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    8671.4758666.663   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0    8672.8088665.892   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0    8671.4758668.203   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0    8667.4738665.892   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8666.1398666.662   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8664.8058665.892   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8664.8058664.352   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0    8666.1398663.582   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8667.4738664.352   0.000  0.00  0.00           C+0
CONECT    1   10                                                            
CONECT    2    3    7                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4                                                            
CONECT    7    8   12    2                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11    1                                                  
CONECT   11   10   12                                                       
CONECT   12   11    7                                                       
MASTER        0    0    0    0    0    0    0    0   12    0   24    0
END

Synonyms

Value	Source
(2E)-3-(4-Hydroxyphenyl)acrylic acid	ChEBI
(e)-3-(4-Hydroxyphenyl)-2-propenoic acid	ChEBI
(e)-p-Coumaric acid	ChEBI
(e)-p-Hydroxycinnamic acid	ChEBI
4'-HYDROXYCINNAMIC ACID	ChEBI
Naringeninic acid	ChEBI
p-Coumaric acid	ChEBI
trans-p-Coumaric acid	ChEBI
trans-p-Coumarinic acid	ChEBI
trans-p-Hydroxycinnamate	ChEBI
trans-p-Hydroxycinnamic acid	ChEBI
trans-4-Hydroxycinnamate	Kegg
4-Hydroxycinnamate	Kegg
(2E)-3-(4-Hydroxyphenyl)acrylate	Generator
(e)-3-(4-Hydroxyphenyl)-2-propenoate	Generator
(e)-p-Coumarate	Generator
(e)-p-Hydroxycinnamate	Generator
4'-HYDROXYCINNAMate	Generator
Naringeninate	Generator
p-Coumarate	Generator
trans-p-Coumarate	Generator
trans-p-Coumarinate	Generator
4-Coumaric acid, (e)-isomer	MeSH
4-Coumaric acid, (Z)-isomer	MeSH
4-Coumaric acid, disodium salt	MeSH
p-Coumaryl alcohol	MeSH
p-Hydroxycinnamic acid	MeSH
Para-coumaric acid	MeSH
trans-3-(4'-Hydroxyphenyl)-2-propenoic acid	MeSH
trans-HPPA	MeSH
3-(4-Hydroxyphenyl)-2-propenoate	HMDB
3-(4-Hydroxyphenyl)-2-propenoic acid	HMDB
3-(4-Hydroxyphenyl)acrylate	HMDB
3-(4-Hydroxyphenyl)acrylic acid	HMDB
4-Coumarate	HMDB
4-Hydroxy cinnamate	HMDB
4-Hydroxy cinnamic acid	HMDB
4-Hydroxyphenylpropenoate	HMDB
4-Hydroxyphenylpropenoic acid	HMDB
b-[4-Hydroxyphenyl]acrylate	HMDB
b-[4-Hydroxyphenyl]acrylic acid	HMDB
beta-[4-Hydroxyphenyl]acrylate	HMDB
beta-[4-Hydroxyphenyl]acrylic acid	HMDB
cis-P-Coumarate	HMDB
Hydroxycinnamate	HMDB
Hydroxycinnamic acid	HMDB
P-Cumarate	HMDB
P-Cumaric acid	HMDB
P-Hydroxycinnamate	HMDB
P-Hydroxyphenylacrylate	HMDB
P-Hydroxyphenylacrylic acid	HMDB
Para coumarate	HMDB
Para coumaric acid	HMDB
Para-coumarate	HMDB
4-Hydroxycinnamic acid	ChEBI
trans-4-Coumarate	Generator, HMDB
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid	HMDB
(2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid	HMDB
(E)-3-(4-Hydroxyphenyl)acrylic acid	HMDB
(E)-4-Hydroxycinnamic acid	HMDB
4’-Hydroxycinnamic acid	HMDB
p-Cumaric acid	HMDB
p-Hydroxy-trans-cinnamic acid	HMDB
p-Hydroxyphenylacrylic acid	HMDB
p-trans-Coumaric acid	HMDB
trans-3-(4-Hydroxyphenyl)-2-propenoic acid	HMDB
trans-4-Coumaric acid	HMDB
β-[4-Hydroxyphenyl]acrylic acid	HMDB

Molecular Formula

C₉H₈O₃

Average Mass

164.158

Monoisotopic Mass

164.047344122

IUPAC Name

(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid

Traditional Name

coumaric acid

CAS Registry Number

Not Available

SMILES

OC(=O)\C=C\C1=CC=C(O)C=C1

InChI Identifier

InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+

InChI Key

NGSWKAQJJWESNS-ZZXKWVIFSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Cinnamic acids and derivatives

Sub Class

Hydroxycinnamic acids and derivatives

Direct Parent

Hydroxycinnamic acids

Alternative Parents

Substituents

Cinnamic acid
Coumaric acid
Coumaric acid or derivatives
Hydroxycinnamic acid
Styrene
1-hydroxy-2-unsubstituted benzenoid
Phenol
Monocyclic benzene moiety
Benzenoid
Carboxylic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Organic oxide
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

4-coumaric acid (CHEBI:32374 )
Paracoumaryl alcohol derivatives (C00811 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	1.02 g/L	ALOGPS
logP	1.74	ALOGPS
logP	1.83	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Acidic)	4	ChemAxon
pKa (Strongest Basic)	-6	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	57.53 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	45.04 m³·mol⁻¹	ChemAxon
Polarizability	16.43 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-014m-1981000000-e7648e85764a445a919c	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (2 TMS)	splash10-066v-3791000000-a5712bbe8401ef499b5a	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-03di-8900000000-3bb023f80c1f54a16adc	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-03xr-5900000000-a364c62c9122c0fbe6de	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-014m-1981000000-e7648e85764a445a919c	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-066v-3791000000-a5712bbe8401ef499b5a	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-014m-1891000000-d8804981d3918cac534d	2017-09-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-014j-2900000000-7075c3e10f9df528109e	2016-09-22	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive	splash10-00xu-6390000000-3110f0f6eb462a38bb64	2017-10-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-03di-0900000000-b58aab08954c973df04e	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-014i-0900000000-3ddb41572ba36a950e37	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-014i-0900000000-ccac7f071084bc660095	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-014i-3900000000-5dc8af06da0120779cff	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-00kf-9500000000-9187edc4498ab4345e5a	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-014i-0900000000-3d831c6acd9d3188de2f	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-03di-0900000000-fbb6439b7d012045f3a8	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Negative	splash10-0002-0900000000-9e18d43a8d86f9b9e72b	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - DI-ESI-qTof , Negative	splash10-014i-0900000000-c45397049a7ba500b332	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-03di-0900000000-b58aab08954c973df04e	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-0900000000-3ddb41572ba36a950e37	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-0900000000-ccac7f071084bc660095	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-3900000000-5dc8af06da0120779cff	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-00kf-9500000000-9187edc4498ab4345e5a	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-014i-0900000000-3d831c6acd9d3188de2f	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-03di-0900000000-fbb6439b7d012045f3a8	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0002-0900000000-9e18d43a8d86f9b9e72b	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-03di-0900000000-c6491d0aaba639e3ae07	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0002-0900000000-9e18d43a8d86f9b9e72b	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-014i-0900000000-a183cce49af676c95d4e	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-014i-0900000000-1f13fa0e7a24be298cfb	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-00kf-9200000000-206402014014906dbe29	2021-09-20	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI M-52) , Positive	splash10-03di-8900000000-3bb023f80c1f54a16adc	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-00kb-3900000000-1118928776a5a6e213db	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - DI-ESI-qTof , Positive	splash10-0002-0900000000-c5faa58d353ca1466c3c	2017-09-14	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-03xr-6900000000-348f5c7c030570e0612f	2015-03-01	View Spectrum
1D NMR	¹H NMR Spectrum (1D, DMSO, experimental)		2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, DMSO, experimental)		2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-22	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Mitochondria

Biospecimen Locations

Blood
Feces
Fibroblasts
Urine

Tissue Locations

Fibroblasts

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191760	Tyrosinase	Unknown	P14679	Homo sapiens
MMDBp0192140	UDP-glucuronosyltransferase 1-1	Enzyme	P22309	Homo sapiens
MMDBp0193791	Cytosolic beta-glucosidase	Unknown	Q9H227	Homo sapiens
MMDBp0197061	Sulfotransferase 1A3	Enzyme	P0DMM9	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Data Source	Reference
MMDBr0000525	4-Hydroxycinnamic acid	4-Coumaroyl-CoA	Not Available	VMH; KEGG	11583838 12232327
MMDBr0002191	Hydroxyphenyllactic acid	4-Hydroxycinnamic acid	Not Available	VMH; KEGG	30371894
MMDBr0002192	4-Hydroxycinnamic acid	Caffeic acid	tyrosinase	VMH	30371894
MMDBr0010415	4-Hydroxycinnamic acid	4-Coumaroyl-CoA	Not Available	VMH; KEGG	30371894

Multistep Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0012762	Luteolin	4-Hydroxycinnamic acid	Not Available			Manually annotated by MiMeDB team
MMDBr0012805	4-Vinylphenol	4-Ethylphenol	Not Available	vinyl phenol reductase

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0012763	Apigenin	4-Hydroxycinnamic acid	Not Available			Manually annotated by MiMeDB team
MMDBr0012805	4-Vinylphenol	4-Ethylphenol	Not Available	vinyl phenol reductase

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0012770	Hydroxyphenyllactic acid	4-Hydroxycinnamic acid	Not Available			19961416
MMDBr0012805	4-Vinylphenol	4-Ethylphenol	Not Available	vinyl phenol reductase

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Adenocarcinoma				Pubchem	29879413
Alcoholic liver disease				Pubchem	32151596
Obesity				Pubchem	23810795
Cardiotoxicity	reduces	Animal_model	Rat	Pubchem	23194016
Glucose uptake	increases	Cell culture	3T3-L1 adipocytes	PubMed	28230764
Free radical scavenger		Chemical reaction		Pubchem	28415050

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Firmicutes	1	Human feces	Indirect association between microbiota composition and metabolites measured in host biospecimen
Bacteria	Actinobacteria	1	Human ; Human feces; Human sputum; Human saliva; Human supragingival plaque; Human subgingival plaque	Indirect association between microbiota composition and metabolites measured in host biospecimen
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference
Animal	Milk	Bos taurus	FooDB	14168161
Food	Cocoa products	Theobroma cacao	FooDB	Phenol Explorer
Food			FooDB	Phenol Explorer
Food			FooDB	19074160
Food		Coffea arabica	FooDB	Phenol Explorer
Food		Coffea arabica	FooDB	Phenol Explorer
Food		Coffea canephora	FooDB	Phenol Explorer
Food		Coffea canephora	FooDB	Phenol Explorer
Food			FooDB	D. KOMES et al. Study of phenolic and volatile composition of white wine during fermentation. Vitis 46 (2), 77-84 (2007)
Food			FooDB	Phenol Explorer
Food			FooDB	Phenol Explorer
Food			FooDB	Phenol Explorer
Food			FooDB	Phenol Explorer
Food	Beer	Barley	FooDB	Not Available
Food			FooDB	Phenol Explorer
Food			FooDB	Phenol Explorer
Food			FooDB	Julia Wannenmacher, Martina Gastl, and Thomas Becker. Phenolic Substances in Beer: Structural Diversity, Reactive Potential and Relevance for Brewing Process and Beer Quality. Comprehensive Reviews in Food Science and Food Safety, 2018, 17, 953-988. doi:10.1111/1541-4337.12352
Food			FooDB	Phenol Explorer
Food			FooDB	Dominik Szwajgier. Content of Individual Phenolic Acids in Worts and Beers and their Possible Contribution to the Antiradical Activity of Beer. J. Inst. Brew. 115(3), 2009, 243
Food			FooDB	12617582
Plant	Seed	Pisum sativum	FooDB	Phenol Explorer
Plant		Spinach	HMDB	34986597
Plant	Fruit	Sesamum orientale	FooDB	DUKE
Plant		Sunflower	HMDB	34986597
Plant	Fruit	Laurus nobilis	FooDB	DUKE
Plant		Pineapple	HMDB	34986597
Plant		Garden onion	HMDB	34986597
Plant		Tilia tomentosa	FooDB	Phenol Explorer
Plant		Kiwi	HMDB	34986597
Plant	Oil	Olea europaea	FooDB	Phenol Explorer
Plant	Wood	Ficus carica	FooDB	DUKE
Plant	Fruit	Pyrus communis	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium angustifolium x vaccinium corymbosum	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium macrocarpon	FooDB	DUKE
Plant	Plant	Vaccinium corymbosum	FooDB	DUKE
Plant	Seed	Arachis hypogaea	FooDB	DUKE
Plant		Lens culinaris	FooDB	Phenol Explorer
Plant		Crocus sativus	FooDB	24285751
Plant		Cuminum cyminum	FooDB	Phenol Explorer
Plant		Annona muricata	FooDB	24285751
Plant	Fruit	Rubus idaeus	FooDB	Phenol Explorer
Plant	Fruit	Rubus idaeus	FooDB	Phenol Explorer
Plant	Fruit	Coriandrum sativum	FooDB	DUKE
Plant	Fruit	Citrus sinensis	FooDB	DUKE
Plant		Hyssopus officinalis	FooDB	Phenol Explorer
Plant	Flower	Sambucus nigra	FooDB	DUKE
Plant	Shoot	Melissa officinalis	FooDB	DUKE
Plant	Fruit	Vaccinium corymbosum	FooDB	S.Hakkinen, M. Heinonen, S. Karenlampi, H. Mykkanen, J. Ruuskanen, R. Torronen. Screening of selected flavonoids and phenolic acids in 19 berries. Food Research International 32 (1999) 345-353. https://www.sciencedirect.com/science/article/pii/S0963996999000952
Plant	Leaves	Juglans regia	FooDB	DUKE
Plant	Fruit	Vaccinium macrocarpon	FooDB	Phenol Explorer
Plant	Seed	Cajanus cajan	FooDB	Phenol Explorer
Plant	Leaves	Brassica oleracea var. italica	FooDB	DUKE
Plant		Thymus vulgaris	FooDB	Phenol Explorer
Plant	Leaves	Origanum majorana	FooDB	DUKE
Plant	Fruit	Vaccinium macrocarpon	FooDB	Phenol Explorer
Plant		Thymus vulgaris	FooDB	Phenol Explorer
Plant		Olea europaea	FooDB	PhytoHub
Plant	Leaves	Rubus spectabilis	FooDB	DUKE
Plant		Rubus	FooDB	PhytoHub
Plant	Fruit juice	Punica granatum	FooDB	DUKE
Plant		Fragaria x ananassa	FooDB	PhytoHub
Plant	Juice	Malus pumila	FooDB	Phenol Explorer
Plant	Fruit	Rubus idaeus	FooDB	S.Hakkinen, M. Heinonen, S. Karenlampi, H. Mykkanen, J. Ruuskanen, R. Torronen. Screening of selected flavonoids and phenolic acids in 19 berries. Food Research International 32 (1999) 345-353. https://www.sciencedirect.com/science/article/pii/S0963996999000952
Plant	Fruit	Malus pumila	FooDB	Phenol Explorer
Plant		Illicium verum	FooDB	Phenol Explorer
Plant	Juice	Hippophae rhamnoides	FooDB	Phenol Explorer
Plant	Fruit	Prunus domestica	FooDB	DUKE
Plant	Juice	Pyrus communis	FooDB	Dilek Tanrioven and Aziz Eksi. Phenolic compounds in pear juice from different cultivars. Food Chemistry. 2005, 93(1), 89-93
Plant		Melissa officinalis	FooDB	Phenol Explorer
Plant		Solanum lycopersicum	FooDB	PhytoHub
Plant	Juice	Malus pumila	FooDB	Phenol Explorer
Plant	Juice	Pyrus communis	FooDB	Dilek Tanrioven and Aziz Eksi. Phenolic compounds in pear juice from different cultivars. Food Chemistry. 2005, 93(1), 89-93
Plant		Foeniculum vulgare	FooDB	Phenol Explorer
Plant	Juice	Malus pumila	FooDB	Phenol Explorer
Plant	Juice	Actinidia chinensis	FooDB	Phenol Explorer
Plant		Mentha spicata	FooDB	Phenol Explorer
Plant	Fruit	Malus pumila	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium corymbosum	FooDB	Phenol Explorer
Plant	Juice	Actinidia chinensis	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium corymbosum	FooDB	Phenol Explorer
Plant	Leaves	Foeniculum vulgare	FooDB	Phenol Explorer
Plant	Tuber	Solanum tuberosum	FooDB	DUKE
Plant		Arachis hypogaea	FooDB	PhytoHub
Plant		Laurus nobilis	FooDB	Phenol Explorer
Plant	Fruit	Phoenix dactylifera	FooDB	Phenol Explorer
Plant	Seed	Juglans regia	FooDB	DUKE
Plant		Origanum majorana	FooDB	Phenol Explorer
Plant		Origanum majorana	FooDB	Phenol Explorer
Plant	Juice	Malus pumila	FooDB	Phenol Explorer
Plant	Plant	Trigonella foenum-graecum	FooDB	DUKE
Plant	Juice	Punica granatum	FooDB	Phenol Explorer
Plant	Root	Daucus carota ssp. sativus	FooDB	Phenol Explorer
Plant	Flower	Taraxacum officinale	FooDB	DUKE
Plant	Root	Daucus carota ssp. sativus	FooDB	Phenol Explorer
Plant	Fruit	Prunus domestica	FooDB	Phenol Explorer
Plant	Fruit	Prunus domestica	FooDB	Phenol Explorer
Plant	Seed	Linum usitatissimum	FooDB	DUKE
Plant	Plant	Gossypium	FooDB	DUKE
Plant	Fruit	Malus pumila	FooDB	Phenol Explorer
Plant	Bulb	Allium sativum l. var. sativum	FooDB	DUKE
Plant		Rosmarinus officinalis	FooDB	Phenol Explorer
Plant	Sprout seedling	Vigna mungo	FooDB	DUKE
Plant	Fruit	Vaccinium angustifolium	FooDB	Phenol Explorer
Plant		Rosmarinus officinalis	FooDB	Phenol Explorer
Plant	Testa	Juglans regia	FooDB	DUKE
Plant	Pericarp	Citrus sinensis	FooDB	DUKE
Plant	Root	Zingiber officinale	FooDB	Phenol Explorer
Plant	Seed	Vigna unguiculata	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium corymbosum	FooDB	Phenol Explorer
Plant	Fruit	Persea americana	FooDB	DUKE
Plant	Fruit	Ribes nigrum	FooDB	DUKE
Plant	Plant	Matricaria recutita	FooDB	DUKE
Plant	Plant	Prunus armeniaca	FooDB	DUKE
Plant	Fruit	Malus pumila	FooDB	Phenol Explorer
Plant	Fruit	Prunus domestica	FooDB	Phenol Explorer
Plant	Fruit	Phoenix dactylifera	FooDB	Phenol Explorer
Plant	Fruit	Malus pumila	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium corymbosum	FooDB	Sellappan S, Akoh CC, Krewer G. Phenolic Compounds and Antioxidant Capacity of Georgia-Grown Blueberries and Blackberries. 2002. J. Agric. Food Chem. 2002, 50, 2432-2438
Plant	Fruit	Prunus cerasus	FooDB	DUKE
Plant	Juice	Citrus sinensis	FooDB	Phenol Explorer
Plant	Fruit	Prunus armeniaca	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium myrtillus	FooDB	DUKE
Plant	Juice	Citrus sinensis	FooDB	Phenol Explorer
Plant	Fruit	Cucumis sativus	FooDB	24285751
Plant	Fruit	Solanum lycopersicum var. cerasiforme	FooDB	Phenol Explorer
Plant	Plant	Ananas comosus	FooDB	DUKE
Plant	Seed	Pimpinella anisum	FooDB	DUKE
Plant	Plant	Apium graveolens	FooDB	DUKE
Plant		Matricaria recutita	FooDB	Phenol Explorer
Plant	Plant	Phaseolus vulgaris	FooDB	DUKE
Plant	Seed	Pisum sativum	FooDB	DUKE
Plant	Leaves	Ocimum basilicum	FooDB	DUKE
Plant	Juice	Citrus sinensis	FooDB	Phenol Explorer
Plant		Brassica oleracea var. botrytis	FooDB	Phenol Explorer
Plant	Juice	Citrus sinensis	FooDB	Phenol Explorer
Plant		Vaccinium macrocarpon	FooDB	PhytoHub
Plant	Seed	Phaseolus lunatus	FooDB	Phenol Explorer
Plant	Sprout	Glycine max	FooDB	Phenol Explorer
Plant	Leaves	Cocos nucifera	FooDB	DUKE
Plant		Pimpinella anisum	FooDB	Phenol Explorer
Plant	Plant	Artemisia dracunculus	FooDB	DUKE
Plant	Nut	Juglans regia	FooDB	Phenol Explorer
Plant	Fruit	Elettaria cardamomum	FooDB	DUKE
Plant	Fruit	Prunus cerasus	FooDB	Phenol Explorer
Plant	Fruit	Pyrus communis	FooDB	A. Escarpa and M. C. Gonzalez. Evaluation of High-Performance Liquid Chromatography for Determination of Phenolic Compounds in Pear Horticultural Cultivars. Chromatographia Vol. 51, No. 1/2, January 2000, 37-43
Plant		Cinnamomum verum	FooDB	Phenol Explorer
Plant	Rhizome	Curcuma longa	FooDB	DUKE
Plant	Fruit	Pyrus communis	FooDB	A. Escarpa and M. C. Gonzalez. Evaluation of High-Performance Liquid Chromatography for Determination of Phenolic Compounds in Pear Horticultural Cultivars. Chromatographia Vol. 51, No. 1/2, January 2000, 37-43
Plant	Fruit	Solanum melongena	FooDB	Phenol Explorer
Plant		Anethum graveolens	FooDB	Phenol Explorer
Plant	Fruit	Solanum melongena	FooDB	Phenol Explorer
Plant	Juice	Pyrus communis	FooDB	Dilek Tanrioven and Aziz Eksi. Phenolic compounds in pear juice from different cultivars. Food Chemistry. 2005, 93(1), 89-93
Plant	Juice	Pyrus communis	FooDB	Dilek Tanrioven and Aziz Eksi. Phenolic compounds in pear juice from different cultivars. Food Chemistry. 2005, 93(1), 89-93
Plant	Fruit	Vitis vinifera	FooDB	DUKE
Plant	Fruit	Ribes nigrum	FooDB	S.Hakkinen, M. Heinonen, S. Karenlampi, H. Mykkanen, J. Ruuskanen, R. Torronen. Screening of selected flavonoids and phenolic acids in 19 berries. Food Research International 32 (1999) 345-353. https://www.sciencedirect.com/science/article/pii/S0963996999000952
Plant		Eragrostis tef	FooDB	Manually Annotated
Plant		Cicer arietinum	FooDB	Phenol Explorer
Plant		Coriandrum sativum	FooDB	Phenol Explorer
Plant	Peel	Pyrus communis	FooDB	A. Escarpa and M. C. Gonzalez. Evaluation of High-Performance Liquid Chromatography for Determination of Phenolic Compounds in Pear Horticultural Cultivars. Chromatographia Vol. 51, No. 1/2, January 2000, 37-43
Plant	Fruit	Ribes nigrum	FooDB	Phenol Explorer
Plant	Fruit	Solanum lycopersicum var. lycopersicum	FooDB	DUKE
Plant	Fruit	Rubus	FooDB	Sellappan S, Akoh CC, Krewer G. Phenolic Compounds and Antioxidant Capacity of Georgia-Grown Blueberries and Blackberries. 2002. J. Agric. Food Chem. 2002, 50, 2432-2438
Plant	Leaves	Allium schoenoprasum	FooDB	DUKE
Plant	Fruit	Pyrus communis	FooDB	A. Escarpa and M. C. Gonzalez. Evaluation of High-Performance Liquid Chromatography for Determination of Phenolic Compounds in Pear Horticultural Cultivars. Chromatographia Vol. 51, No. 1/2, January 2000, 37-43
Plant	Fruit	Piper nigrum	FooDB	DUKE
Plant	Bark	Cinnamomum verum	FooDB	DUKE
Plant	Plant	Basella alba	FooDB	DUKE
Plant	Fruit	Prunus armeniaca	FooDB	Phenol Explorer
Plant	Fruit	Ribes rubrum	FooDB	Phenol Explorer
Plant	Fruit	Fragaria x ananassa	FooDB	Phenol Explorer
Plant	Fruit	Rubus chamaemorus	FooDB	Phenol Explorer
Plant	Fruit	Fragaria x ananassa	FooDB	Phenol Explorer
Plant	Peel	Pyrus communis	FooDB	A. Escarpa and M. C. Gonzalez. Evaluation of High-Performance Liquid Chromatography for Determination of Phenolic Compounds in Pear Horticultural Cultivars. Chromatographia Vol. 51, No. 1/2, January 2000, 37-43
Plant	Flour	Glycine max	FooDB	Phenol Explorer
Plant	Seed	Vicia faba	FooDB	Phenol Explorer
Plant	Fruit	Olea europaea	FooDB	DUKE
Plant	Fruit	Vaccinium virgatum	FooDB	Sellappan S, Akoh CC, Krewer G. Phenolic Compounds and Antioxidant Capacity of Georgia-Grown Blueberries and Blackberries. 2002. J. Agric. Food Chem. 2002, 50, 2432-2438
Plant		Elettaria cardamomum	FooDB	Phenol Explorer
Plant	Plant	Averrhoa carambola	FooDB	DUKE
Plant	Fruit	Gaylussacia baccata	FooDB	Phenol Explorer
Plant		Malus pumila	FooDB	PhytoHub
Plant	Flower	Tilia	FooDB	DUKE
Plant	Oil	Glycine max	FooDB	Phenol Explorer
Plant	Leaves	Spinacia oleracea	FooDB	DUKE
Plant	Fruit	Vaccinium myrtillus	FooDB	Phenol Explorer
Plant	Fruit	Cucurbita	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium myrtillus	FooDB	Phenol Explorer
Plant	Root	Daucus carota ssp. sativus	FooDB	DUKE
Plant	Shoot	Mentha x piperita	FooDB	DUKE
Plant	Fruit	Fragaria x ananassa	FooDB	S.Hakkinen, M. Heinonen, S. Karenlampi, H. Mykkanen, J. Ruuskanen, R. Torronen. Screening of selected flavonoids and phenolic acids in 19 berries. Food Research International 32 (1999) 345-353. https://www.sciencedirect.com/science/article/pii/S0963996999000952
Plant	Bean	Phaseolus vulgaris	FooDB	Phenol Explorer
Plant	Fruit	Capsicum annuum var. annuum	FooDB	DUKE
Plant	Plant	Vicia faba	FooDB	DUKE
Plant	Leaves	Origanum vulgare	FooDB	DUKE
Plant		Chenopodium quinoa	FooDB	Manually Annotated
Plant		Piper nigrum	FooDB	Phenol Explorer
Plant		Glycine max	FooDB	Manually Annotated
Plant	Plant	Allium ampeloprasum	FooDB	DUKE
Plant	Leaves	Brassica oleracea var. gemmifera	FooDB	DUKE
Plant	Seed	Carum carvi	FooDB	DUKE
Plant	Bean	Phaseolus vulgaris	FooDB	Phenol Explorer
Plant	Nut	Arachis hypogaea	FooDB	Phenol Explorer
Plant	Fruit	Citrus limon	FooDB	24285751
Plant	Fruit	Vaccinium deliciosum	FooDB	Phenol Explorer
Plant		Piper nigrum	FooDB	Phenol Explorer
Plant	Fruit	Pyrus communis	FooDB	A. Escarpa and M. C. Gonzalez. Evaluation of High-Performance Liquid Chromatography for Determination of Phenolic Compounds in Pear Horticultural Cultivars. Chromatographia Vol. 51, No. 1/2, January 2000, 37-43
Plant	Fruit	Solanum lycopersicum var. lycopersicum	FooDB	Phenol Explorer
Plant	Fruit	Solanum lycopersicum var. lycopersicum	FooDB	Phenol Explorer
Plant	Fruit	Olea europaea	FooDB	Phenol Explorer
Plant	Plant	Lactuca sativa	FooDB	DUKE
Plant	Juice	Pyrus communis	FooDB	Dilek Tanrioven and Aziz Eksi. Phenolic compounds in pear juice from different cultivars. Food Chemistry. 2005, 93(1), 89-93
Plant	Fruit	Olea europaea	FooDB	Phenol Explorer
Plant	Bean	Phaseolus vulgaris	FooDB	Phenol Explorer
Plant	Bulb	Allium cepa	FooDB	DUKE
Plant	Plant	Prunus dulcis	FooDB	DUKE
Plant		Piper nigrum	FooDB	Phenol Explorer
Plant	Root	Daucus carota ssp. sativus	FooDB	Adrian J. Parr, Annie Ng, and Keith W. Waldron Ester-Linked Phenolic Components of Carrot Cell Walls. J. Agric. Food Chem., 1997, 45 (7), pp 2468-2471 DOI: 10.1021/jf960982k
Plant	Plant	Lens culinaris	FooDB	DUKE
Plant		Ocimum basilicum	FooDB	Phenol Explorer
Plant	Leaves	Brassica oleracea l. var. capitata l. f. alba dc.	FooDB	DUKE
Plant	Bean	Phaseolus vulgaris	FooDB	Phenol Explorer
Plant	Leaves	Brassica oleracea var. capitata	FooDB	DUKE
Plant	Fruit	Prunus avium	FooDB	L. Gao, and G. Mazza. Characterization, Quantitation, and Distribution of Anthocyanins and Colorless Phenolics in Sweet Cherries. J. Agric. Food Chem., 1995, 43 (2), pp 343-346
Plant	Seed	Theobroma cacao	FooDB	DUKE
Plant	Seed	Myristica fragrans	FooDB	DUKE
Plant	Rhizome	Zingiber officinale	FooDB	DUKE
Plant	Plant	Vigna radiata	FooDB	DUKE
Plant	Fruit	Rubus occidentalis	FooDB	Phenol Explorer
Plant		Carum carvi	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium oxycoccos	FooDB	Phenol Explorer
Plant	Leaves	Oenothera biennis	FooDB	DUKE
Plant	Fruit	Vaccinium oxycoccos	FooDB	Phenol Explorer
Plant		Lens culinaris	FooDB	Phenol Explorer
Plant		Salvia officinalis	FooDB	Phenol Explorer
Plant		Salvia officinalis	FooDB	Phenol Explorer
Plant	Fruit	Cydonia oblonga	FooDB	DUKE
Plant	Fruit	Capsicum annuum	FooDB	Wikipedia
Plant	Fruit	Olea europaea	FooDB	Phenol Explorer
Plant	Fruit	Olea europaea	FooDB	Phenol Explorer
Plant		Myristica fragrans	FooDB	Phenol Explorer
Plant		Lens culinaris	FooDB	24285751
Plant	Stem	Petroselinum crispum	FooDB	DUKE
Plant		Vaccinium oxycoccos	FooDB	PhytoHub
Plant	Pollen or spore	Ginkgo biloba	FooDB	DUKE
Plant	Fruit	Vaccinium ovalifolium	FooDB	Phenol Explorer
Plant	Bark	Rubus idaeus	FooDB	DUKE
Plant	Fruit	Vaccinium parvifolium	FooDB	Phenol Explorer
Plant		Myristica fragrans	FooDB	Phenol Explorer
Plant	Seed oil	Brassica napus var. napus	FooDB	Phenol Explorer
Plant	Shoot	Phyllostachys edulis	FooDB	24285751
Plant		Syzygium aromaticum	FooDB	Phenol Explorer
Plant	Fruit	Ribes uva-crispa	FooDB	DUKE
Plant	Fruit	Prunus persica var. persica	FooDB	Phenol Explorer
Plant		Origanum vulgare	FooDB	Phenol Explorer
Plant	Pollen or spore	Helianthus annuus	FooDB	DUKE
Plant	Fruit	Pyrus communis	FooDB	Phenol Explorer
Plant	Fruit	Malus pumila	FooDB	DUKE
Plant	Fruit	Photinia melanocarpa	FooDB	Phenol Explorer
Plant	Juice	Vitis vinifera	FooDB	Phenol Explorer
Plant	Plant	Coffea arabica	FooDB	DUKE
Plant	Juice	Pyrus communis	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium uliginosum	FooDB	Phenol Explorer
Plant	Seed	Foeniculum vulgare	FooDB	DUKE
Plant	Fruit	Prunus avium	FooDB	Phenol Explorer
Plant	Leaves	Prunus persica	FooDB	DUKE
Plant	Leaves	Beta vulgaris ssp. cicla	FooDB	Phenol Explorer
Plant	Fruit	Vaccinium vitis-idaea	FooDB	Phenol Explorer
Plant	Root	Daucus carota	FooDB	DUKE
Plant	Leaves	Thymus vulgaris	FooDB	DUKE
Plant	Plant	Castanea sativa	FooDB	DUKE
Plant	Leaves	Beta vulgaris ssp. cicla	FooDB	Phenol Explorer
Plant	Fruit	Prunus avium	FooDB	24285751
Plant	Leaves	Glycine max	FooDB	DUKE
Plant	Plant	Salvia officinalis	FooDB	DUKE
Plant	Plant	Annona muricata	FooDB	DUKE
Plant	Fruit	Vaccinium ovatum	FooDB	Phenol Explorer
Plant	Seed	Helianthus annuus	FooDB	DUKE
Plant	Stem	Beta vulgaris ssp. cicla	FooDB	Phenol Explorer
Plant	Plant	Beta vulgaris var. rubra	FooDB	DUKE
Plant	Leaves	Anethum graveolens	FooDB	DUKE
Plant	Fruit	Capsicum annuum	FooDB	DUKE
Plant		Petroselinum crispum	FooDB	Phenol Explorer
Plant	Seed	Vigna radiata	FooDB	Phenol Explorer
Plant	Oil	Olea europaea	FooDB	Phenol Explorer
Plant	Root	Raphanus sativus	FooDB	DUKE
Plant	Plant	Mangifera indica	FooDB	DUKE
Plant		Solanum tuberosum	FooDB	24285751
Plant	Fruit	Citrus x paradisi	FooDB	Phenol Explorer
Plant	Fruit	Citrus x paradisi	FooDB	Phenol Explorer
Plant	Plant	Actinidia chinensis	FooDB	DUKE
Plant	Stem	Beta vulgaris ssp. cicla	FooDB	Phenol Explorer
Plant		Avocado	HMDB	34986597
Plant	Fruit	Citrus limon	FooDB	DUKE

Source Type	Activity	Data Source	Reference
Drugs	Antimicrobial	U.S. Environmental Protection Agency	CompTox
Cosmetics	Not Available	U.S. Environmental Protection Agency	CompTox
Domestics	Not Available	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Blood	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	12592675
Human Urine	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	12592675
Human Blood	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	12771321
Human Urine	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	12771321
Human Blood	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	19333587
Human Urine	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	19333587
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	19573517
Human Blood	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	19671472
Human Urine	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	19671472
Human Blood	Detected and Quantified	0.052	0.01			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.94	0.897			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.148	0.033			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.071	0.024			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.057	0.014			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.6	0.253			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.049	0.004			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.174	0.045			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.116	0.045			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	20222713
Human Urine	Detected but not Quantified						NULL	NULL	Consuming polyphenols described by Phenol-Explorer entry 454	HMDB	20222713
Human Feces	Detected but not Quantified						Infant (0-1 year old)	Both	Normal	HMDB	22411374
Human Feces	Detected and Quantified	7.98	0.244			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Feces	Detected and Quantified	8.467	1.218			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Feces	Detected and Quantified	9.381	2.0712			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Feces	Detected and Quantified	9.0766	2.132			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Colorectal cancer	HMDB	25037050
Human Urine	Detected and Quantified			0.016	2.94	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	26814424
Human Urine	Detected and Quantified			0.31	0.57	umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	27012787
Human Urine	Detected and Quantified			0.29	0.45	umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	27012787
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Colorectal cancer	HMDB	27015276
Human Urine	Detected and Quantified	0.142				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	27273479
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected and Quantified	0.323		0.0122	1.578	nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	28029051
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Urine	Detected and Quantified	0.142				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	27273479
Human Urine	Detected and Quantified			0.0160	2.940	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	26814424
Human Blood	Detected and Quantified	0.049	0.004			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.052	0.01			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.057	0.014			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.071	0.024			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.116	0.045			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.148	0.033			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.174	0.045			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Urine	Detected and Quantified			0.29	0.45	umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	27012787
Human Urine	Detected and Quantified			0.31	0.57	umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	27012787
Human Feces	Detected and Quantified	0.323		0.0122	1.578	nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	28029051
Human Blood	Detected and Quantified	0.6	0.253			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Blood	Detected and Quantified	0.94	0.897			uM	Adult (>18 years old)	Male	Normal	HMDB	19812218
Human Feces	Detected and Quantified	7.980	0.244			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Feces	Detected and Quantified	8.467	1.218			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Feces	Detected and Quantified	9.0766	2.132			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Feces	Detected and Quantified	9.381	2.0712			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	24010549
Human Fibroblasts	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	19573517
Human Feces	Detected but not Quantified						Infant (0-1 year old)	Both	Normal	HMDB	22411374
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

HMDB ID

HMDB0002035

DrugBank ID

DB04066

Phenol Explorer Compound ID

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

32374

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Nakazawa T, Ohsawa K: Metabolites of orally administered Perilla frutescens extract in rats and humans. Biol Pharm Bull. 2000 Jan;23(1):122-7. doi: 10.1248/bpb.23.122. [PubMed:10706426 ]
Brivet M, Garcia-Cazorla A, Lyonnet S, Dumez Y, Nassogne MC, Slama A, Boutron A, Touati G, Legrand A, Saudubray JM: Impaired mitochondrial pyruvate importation in a patient and a fetus at risk. Mol Genet Metab. 2003 Mar;78(3):186-92. doi: 10.1016/s1096-7192(03)00016-7. [PubMed:12649063 ]
Phan TT, Sun L, Bay BH, Chan SY, Lee ST: Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring. J Trauma. 2003 Jun;54(6):1212-24. doi: 10.1097/01.TA.0000030630.72836.32. [PubMed:12813346 ]
Zhao Z, Egashira Y, Sanada H: Phenolic antioxidants richly contained in corn bran are slightly bioavailable in rats. J Agric Food Chem. 2005 Jun 15;53(12):5030-5. doi: 10.1021/jf050111n. [PubMed:15941352 ]
Vargas-Tah A, Gosset G: Production of Cinnamic and p-Hydroxycinnamic Acids in Engineered Microbes. Front Bioeng Biotechnol. 2015 Aug 20;3:116. doi: 10.3389/fbioe.2015.00116. eCollection 2015. [PubMed:26347861 ]

Showing metabocard for 4-Hydroxycinnamic acid (MMDBc0000581)

MOL for #<Metabolite:0x00007fdb37a554f0>

3D MOL for #<Metabolite:0x00007fdb37a554f0>

3D SDF for #<Metabolite:0x00007fdb37a554f0>

3D-SDF for #<Metabolite:0x00007fdb37a554f0>

PDB for #<Metabolite:0x00007fdb37a554f0>

3D PDB for #<Metabolite:0x00007fdb37a554f0>

SMILES for #<Metabolite:0x00007fdb37a554f0>

INCHI for #<Metabolite:0x00007fdb37a554f0>

Structure for #<Metabolite:0x00007fdb37a554f0>

3D Structure for #<Metabolite:0x00007fdb37a554f0>