Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-17 23:24:09 UTC
Update Date2022-08-31 10:31:39 UTC
Metabolite IDMMDBc0029484
Metabolite Identification
Common NameNicotinamide ribotide
DescriptionNicotinamide ribotide (NMN) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Nicotinamide is directly converted to NMN by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction NMN + ATP = Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD, a molecule playing a fundamental role as a cofactor in cellular redox reactions. Thus NMN is an important metabolite for the maintenance of normal NAD biosynthesis, and circulating NMN levels may play an important role in regulating cell function in physiological and pathophysiological conditions. (PMID: 15078171 , 17983582 )
Structure
Synonyms
ValueSource
beta-Nicotinate D-ribonucleotideChEBI
Nicotinate ribonucleotideChEBI
Nicotinic acid ribonucleotideChEBI
b-Nicotinate D-ribonucleotideGenerator
b-Nicotinic acid D-ribonucleotideGenerator
beta-Nicotinic acid D-ribonucleotideGenerator
β-Nicotinate D-ribonucleotideGenerator
β-Nicotinic acid D-ribonucleotideGenerator
Nicotinic acid D-ribonucleotideGenerator
Nicotinate D-ribonucleotideChEBI
Nicotinate b-D-ribonucleotideGenerator
Nicotinate β-D-ribonucleotideGenerator
Nicotinic acid b-D-ribonucleotideGenerator
Nicotinic acid beta-D-ribonucleotideGenerator
Nicotinic acid β-D-ribonucleotideGenerator
Nicotinate mononucleotideMeSH
Nicotinic acid mononucleotideMeSH
Deamido nicotinamide ribonucleotideHMDB
Deamido-NMNHMDB
Nicotinic acid ribotideHMDB
Nicotinic mononucleotideHMDB
beta-Nicotinic acid mononucleotideHMDB
β-Nicotinic acid mononucleotideHMDB
Molecular FormulaC11H15NO9P
Average Mass336.2119
Monoisotopic Mass336.048442595
IUPAC Name3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1lambda5-pyridin-1-ylium
Traditional Name3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1lambda5-pyridin-1-ylium
CAS Registry Number1094-61-7
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)[N+]1=CC=CC(=C1)C(O)=O
InChI Identifier
InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/p+1/t7-,8-,9-,10-/m1/s1
InChI KeyJOUIQRNQJGXQDC-ZYUZMQFOSA-O