MiMeDB: Showing metabocard for D-Mannose 1-phosphate (MMDBc0029651)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:36:09 UTC

Update Date

2024-10-11 04:27:31 UTC

Metabolite ID

MMDBc0029651

Metabolite Identification

Common Name

D-Mannose 1-phosphate

Description

D-Mannose 1-phosphate is a normal metabolite intermediate in the Fructose and mannose metabolism, and substrate of phosphomannomutase 1 (PMM, EC: 5.4.2.8), an enzyme necessary for the synthesis of GDP-mannose. PMM converts mannose 6-phosphate to mannose-1-phosphate, which is required for the synthesis of GDP-mannose, a substrate for dolichol-linked oligosaccharide synthesis.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
D-Mannose 1-phosphates	ChEBI
Mannose 1-phosphate	ChEBI
Mannose 1-phosphoric acid	Generator
D-Mannose 1-phosphoric acid	Generator
1-(Dihydrogen phosphate)-D-mannopyranose	HMDB
1-(Dihydrogen phosphate)-delta-mannopyranose	HMDB
alpha-D-Mannose 1-phosphate	HMDB
alpha-delta-Mannose 1-phosphate	HMDB
D-Mannose-1-phosphate	HMDB
delta-Mannose 1-phosphates	HMDB
delta-Mannose-1-phosphate	HMDB
Mannose 1-phosphate-mannopyranose	HMDB
Mannose-1-P	HMDB

Molecular Formula

C₆H₁₃O₉P

Average Mass

260.1358

Monoisotopic Mass

260.029718526

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

27251-84-9

SMILES

Not Available

InChI Identifier

InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1

InChI Key

HXXFSFRBOHSIMQ-QTVWNMPRSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Monosaccharide phosphates

Alternative Parents

Substituents

Hexose monosaccharide
Monosaccharide phosphate
Monoalkyl phosphate
Organic phosphoric acid derivative
Oxane
Alkyl phosphate
Phosphoric acid ester
Secondary alcohol
Oxacycle
Organoheterocyclic compound
Polyol
Alcohol
Hydrocarbon derivative
Primary alcohol
Organic oxide
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

mannose phosphate (CHEBI:35374 )

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Data Source	Reference
MMDBr0000230	ADP-Mannose	D-Mannose 1-phosphate	nudix (nucleoside diphosphate linked moiety X)-type motif 5	VMH	10567213 10722730 12717453
MMDBr0002486	Guanosine triphosphate	Guanosine diphosphate mannose	GDP-mannose pyrophosphorylase A	VMH	10025667 8549746 9451026
MMDBr0003985	D-Mannose 1-phosphate	L-Alanyl-tRNA	Not Available	VMH	10085245
MMDBr0007483	Guanosine diphosphate	Guanosine diphosphate mannose	Not Available	VMH; KEGG	30371894
MMDBr0007530	D-Mannose 1-phosphate	Mannose 6-phosphate	Not Available	VMH; KEGG	30371894
MMDBr0008361	Guanosine triphosphate	Guanosine diphosphate mannose	Not Available	VMH; KEGG	30371894

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	130	Human feces; Human sputum; Human pleural fluid plaque; Human ; Human feces; pleural fluid plaque; bal; Human stool; Human unknown; Pig ; Human dental plaque; Human nasal swab	Unknown; Metabolic reconstruction
Bacteria	Actinobacteria	80	Human feces; Human pleural fluid plaque; Human dental plaque; Human sputum; Human ; Human nasopharyngeal swab; Human mucosa; Human supragingival plaque; Human subgingival plaque; Human saliva	Metabolic reconstruction
Bacteria	Verrucomicrobia	1	Human ; Human feces	Metabolic reconstruction
Bacteria	Bacteroidetes	116	Human feces; Human appendix biopsy; Human ; Human stool; Human saliva; Human gastric fluid; Human urine; Human subgingival plaque; Human supragingival plaque	Metabolic reconstruction
Bacteria	Firmicutes	251	Human feces; Human ; Human stool; Pig ; Human subgingival plaque; Human saliva	Metabolic reconstruction
Bacteria	Spirochaetes	1	Human feces	Metabolic reconstruction
Archaea	Thaumarchaeota	1		Metabolic reconstruction
Bacteria	Fusobacteria	3	Human feces; Human	Metabolic reconstruction
Bacteria	Planctomycetes	1	Human feces	Metabolic reconstruction
Bacteria	Synergistetes	2	Human feces	Metabolic reconstruction
Archaea	Euryarchaeota	5		Metabolic reconstruction
Archaea	Crenarchaeota	1		Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Source Type	Activity	Data Source	Reference
Drugs	Antimicrobial	U.S. Environmental Protection Agency	CompTox
Cosmetics	Not Available	U.S. Environmental Protection Agency	CompTox
Domestics	Not Available	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB

External Links

HMDB ID

Not Available

DrugBank ID

DB02867

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB023892

KNApSAcK ID

C00007389

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Mannose_1-phosphate

METLIN ID

Not Available

PubChem Compound

644175

PDB ID

Not Available

ChEBI ID

35374

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Pirard M, Achouri Y, Collet JF, Schollen E, Matthijs G, Van Schaftingen E: Kinetic properties and tissular distribution of mammalian phosphomannomutase isozymes. Biochem J. 1999 Apr 1;339 ( Pt 1):201-7. [PubMed:10085245 ]
Noronha A, Modamio J, Jarosz Y, Guerard E, Sompairac N, Preciat G, Danielsdottir AD, Krecke M, Merten D, Haraldsdottir HS, Heinken A, Heirendt L, Magnusdottir S, Ravcheev DA, Sahoo S, Gawron P, Friscioni L, Garcia B, Prendergast M, Puente A, Rodrigues M, Roy A, Rouquaya M, Wiltgen L, Zagare A, John E, Krueger M, Kuperstein I, Zinovyev A, Schneider R, Fleming RMT, Thiele I: The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992. [PubMed:30371894 ]
Wishart DS, Li C, Marcu A, Badran H, Pon A, Budinski Z, Patron J, Lipton D, Cao X, Oler E, Li K, Paccoud M, Hong C, Guo AC, Chan C, Wei W, Ramirez-Gaona M: PathBank: a comprehensive pathway database for model organisms. Nucleic Acids Res. 2020 Jan 8;48(D1):D470-D478. doi: 10.1093/nar/gkz861. [PubMed:31602464 ]

Showing metabocard for D-Mannose 1-phosphate (MMDBc0029651)

MOL for #<Metabolite:0x00007fdb51439d90>

3D MOL for #<Metabolite:0x00007fdb51439d90>

3D SDF for #<Metabolite:0x00007fdb51439d90>

3D-SDF for #<Metabolite:0x00007fdb51439d90>

PDB for #<Metabolite:0x00007fdb51439d90>

3D PDB for #<Metabolite:0x00007fdb51439d90>

SMILES for #<Metabolite:0x00007fdb51439d90>

INCHI for #<Metabolite:0x00007fdb51439d90>

Structure for #<Metabolite:0x00007fdb51439d90>

3D Structure for #<Metabolite:0x00007fdb51439d90>