MiMeDB: Showing metabocard for Guanosine 3',5'-bis(diphosphate) (MMDBc0030068)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:52:42 UTC

Update Date

2024-10-13 11:18:28 UTC

Metabolite ID

MMDBc0030068

Metabolite Identification

Common Name

Guanosine 3',5'-bis(diphosphate)

Description

(p)ppGpp, guanosine pentaphosphate or tetraphosphate is an alarmone which is involved in the stringent response in bacteria, causing the inhibition of RNA synthesis when there is a shortage of amino acids present. This causes translation to decrease and the amino acids present are therefore conserved. (p)ppGpp is an effector molecule which is produced as a result of amino acid starvation within a bacterial cell.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Guanosine 3'-diphosphate 5'-diphosphate	ChEBI
Guanosine 5'-diphosphate,3'-diphosphate	ChEBI
GUANOSINE-5',3'-tetraphosphATE	ChEBI
Guanosine 3'-diphosphoric acid 5'-diphosphoric acid	Generator
Guanosine 5'-diphosphoric acid,3'-diphosphoric acid	Generator
GUANOSINE-5',3'-tetraphosphoric acid	Generator
Guanosine 3',5'-bis(diphosphoric acid)	Generator
3'-Diphosphate 5'-diphosphate, guanosine	HMDB
5'-Diphosphate 3'-diphosphate, guanosine	HMDB
Guanosine tetraphosphate	HMDB
Guanosine 5'-diphosphate 3'-diphosphate	HMDB
Tetraphosphate, guanosine	HMDB
3'-Diphosphate, guanosine 5'-diphosphate	HMDB
5'-Diphosphate, guanosine 3'-diphosphate	HMDB
Guanosine 3' diphosphate 5' diphosphate	HMDB
Guanosine 5' diphosphate 3' diphosphate	HMDB

Molecular Formula

C₁₀H₁₇N₅O₁₇P₄

Average Mass

603.1603

Monoisotopic Mass

602.956990191

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

33503-72-9

SMILES

Not Available

InChI Identifier

InChI=1S/C10H17N5O17P4/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6(30-36(26,27)32-34(21,22)23)3(29-9)1-28-35(24,25)31-33(18,19)20/h2-3,5-6,9,16H,1H2,(H,24,25)(H,26,27)(H2,18,19,20)(H2,21,22,23)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1

InChI Key

BUFLLCUFNHESEH-UUOKFMHZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside diphosphates

Alternative Parents

Substituents

Purine ribonucleoside 3',5'-bisphosphate
Purine ribonucleoside bisphosphate
Purine ribonucleoside diphosphate
Ribonucleoside 3'-phosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-oxopurine
Hypoxanthine
Monosaccharide phosphate
Organic pyrophosphate
Imidazopyrimidine
Purine
Aminopyrimidine
Monoalkyl phosphate
Pyrimidone
Alkyl phosphate
Pyrimidine
Phosphoric acid ester
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Tetrahydrofuran
Vinylogous amide
Azole
Imidazole
Heteroaromatic compound
Secondary alcohol
Organoheterocyclic compound
Azacycle
Oxacycle
Hydrocarbon derivative
Amine
Organic oxide
Organopnictogen compound
Organic oxygen compound
Alcohol
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Primary amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

guanosine bisphosphate (CHEBI:17633 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0194931	Protein prune homolog	Unknown	Q86TP1	Homo sapiens
MMDBp0196880	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1	Unknown	Q8N4P3

Human Pathways

Pathways

Name	SMPDB/PathBank
EGF Signalling Pathway

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	78	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool; River trout	Unknown
Bacteria	Actinobacteria	2	Human
Bacteria	Firmicutes	2	Human feces
Bacteria	Aquificae	1
Bacteria	Spirochaetes	1	Human
Bacteria	Tenericutes	3	Human
Bacteria	nah	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

HMDB0059638

DrugBank ID

DB04022

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

388557

KEGG Compound ID

C01228

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

439450

PDB ID

G4P

ChEBI ID

17633

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for Guanosine 3',5'-bis(diphosphate) (MMDBc0030068)

MOL for #<Metabolite:0x00007fab51d145d0>

3D MOL for #<Metabolite:0x00007fab51d145d0>

3D SDF for #<Metabolite:0x00007fab51d145d0>

3D-SDF for #<Metabolite:0x00007fab51d145d0>

PDB for #<Metabolite:0x00007fab51d145d0>

3D PDB for #<Metabolite:0x00007fab51d145d0>

SMILES for #<Metabolite:0x00007fab51d145d0>

INCHI for #<Metabolite:0x00007fab51d145d0>

Structure for #<Metabolite:0x00007fab51d145d0>

3D Structure for #<Metabolite:0x00007fab51d145d0>