Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-18 02:02:39 UTC
Update Date2022-08-31 18:30:36 UTC
Metabolite IDMMDBc0032107
Metabolite Identification
Common Name3-deoxy-D-arabino-heptulosonate-7-phosphate
Description3-Deoxy-D-arabino-heptulosonate-7-phosphate is a member of the chemical class known as Medium-chain Keto Acids and Derivatives. These are keto acids with a 6 to 12 carbon atoms long side chain. DAHPS is involved in the biosynthesis of aromatic amino acids. Maritima DAHP synthase is a metalloenzyme. This report is the first description of a thermophilic eubacterial DAHP synthase. (PMID 12743122 ) DAHPS(Phe) is a metal-catalyzed oxidation system wherein bound substrate protects active-site residues from oxidative attack catalyzed by bound redox metal cofactor. (PMID 10049398 ) The first regulatory step in the synthesis of aromatic amino acids is catalyzed by 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS). (PMID 15378531 ) While several similarities exist between the two enzymatic reactions, classic studies on the Escherichia coli enzymes have established that DAHPS is a metalloenzyme, whereas KDO8PS has no metal requirement. aeolicus KDO8PS is a metalloenzyme in vivo and point to a previously unrecognized relationship between the KDO8PS and DAHPS families. (PMID 10811802 )
Structure
Synonyms
ValueSource
3-Deoxy-D-arabino-2-heptulosonate 7-phosphateChEBI
3-Deoxy-D-erythro-hept-2-ulosonate 7-phosphateChEBI
7-Phospho-2-dehydro-3-deoxy-D-arabino-heptonate anionChEBI
7-Phospho-2-dehydro-3-deoxy-D-arabino-heptonate(1-)ChEBI
3-Deoxy-D-arabino-2-heptulosonic acid 7-phosphoric acidGenerator
3-Deoxy-D-erythro-hept-2-ulosonic acid 7-phosphoric acidGenerator
7-Phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid anionGenerator
7-Phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid(1-)Generator
3-Deoxy-D-arabino-heptulosonic acid-7-phosphoric acidGenerator
7-phospho-2-dehydro-3-Deoxy-D-arabino-heptonic acidGenerator
DAHPMeSH
2-dehydro-3-Deoxy-D-arabino-heptulosonic acid-7-phosphateMeSH
2-DAHPMeSH
3-Deoxyarabinoheptulosonate-7-phosphateMeSH
5-DAHPMeSH
3-Deoxy-D-arabino-2-heptulosonic acidMeSH
7-phospho-2-keto-3-Deoxy-D-arabinoheptonateMeSH
3-Deoxy-D-arabino-heptulosonate-7-phosphateMeSH
5-dehydro-3-Deoxy-D-arabino-heptulosonic acid-7-phosphateMeSH
Molecular FormulaC7H10O10P
Average Mass285.122
Monoisotopic Mass285.00280426
IUPAC Name(4R,5S,6R)-4,5,6-trihydroxy-2-oxo-7-(phosphonatooxy)heptanoate
Traditional Name(4R,5S,6R)-4,5,6-trihydroxy-2-oxo-7-(phosphonatooxy)heptanoate
CAS Registry NumberNot Available
SMILES
[H][C@@](O)(COP([O-])([O-])=O)[C@@]([H])(O)[C@]([H])(O)CC(=O)C([O-])=O
InChI Identifier
InChI=1S/C7H13O10P/c8-3(1-4(9)7(12)13)6(11)5(10)2-17-18(14,15)16/h3,5-6,8,10-11H,1-2H2,(H,12,13)(H2,14,15,16)/p-3/t3-,5-,6+/m1/s1
InChI KeyPJWIPEXIFFQAQZ-PUFIMZNGSA-K