Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-19 04:26:59 UTC
Update Date2022-12-15 22:51:51 UTC
Metabolite IDMMDBc0032910
Metabolite Identification
Common Name5-Methylthioribose 1-phosphate
Description5-Methylthioribose 1-phosphate, also known as 1-phospho-5-S-methylthioribose or D-ribofuranoside, belongs to the class of organic compounds known as pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms. 5-Methylthioribose 1-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). 5-methylthioribose 1-phosphate and L-methionine can be biosynthesized from 5'-methylthioadenosine; which is mediated by the enzyme S-methyl-5'-thioadenosine phosphorylase. In humans, 5-methylthioribose 1-phosphate is involved in the metabolic disorder called hypermethioninemia. In the methionine salvage pathway 5-methylthioribose 1-phosphate isomerase (M1Pi) catalyzes the conversion of 5-methylthioribose 1-phosphate (MTR-1-P) to 5-methylthioribulose 1-phosphate (MTRu-1-P).
Structure
Synonyms
ValueSource
5-Methylthioribose 1-phosphoric acidGenerator
1-Phospho-5-S-methylthioriboseHMDB
1-PhosphomethylthioriboseHMDB
5-Methylthio-5-deoxy-D-ribose 1-phosphateHMDB
5-Methylthio-5-deoxy-D-ribose-1-phosphateHMDB
5-Methylthio-D-ribose-1-phosphateHMDB
5-Methylthioribose-1-phosphateHMDB
D-RibofuranosideHMDB
S-Methyl-5-thio-alpha-D-ribose 1-phosphateHMDB
S5-Methyl-5-thio-D-ribose-1-phosphateHMDB
Molecular FormulaC6H13O7PS
Average Mass260.202
Monoisotopic Mass260.011959972
IUPAC Name{[(3R,4S)-3,4-dihydroxy-5-[(methylsulfanyl)methyl]oxolan-2-yl]oxy}phosphonic acid
Traditional Name[(3R,4S)-3,4-dihydroxy-5-[(methylsulfanyl)methyl]oxolan-2-yl]oxyphosphonic acid
CAS Registry Number72843-83-5
SMILES
CSCC1OC(OP(O)(O)=O)[C@H](O)[C@@H]1O
InChI Identifier
InChI=1S/C6H13O7PS/c1-15-2-3-4(7)5(8)6(12-3)13-14(9,10)11/h3-8H,2H2,1H3,(H2,9,10,11)/t3?,4-,5-,6?/m1/s1
InChI KeyJTFITTQBRJDSTL-WATOWXBHSA-N