Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-19 04:36:44 UTC
Update Date2024-04-30 20:01:31 UTC
Metabolite IDMMDBc0033149
Metabolite Identification
Common Namealpha-D-mannose 1-phosphate
DescriptionD-Mannose 1-phosphate (CAS: 27251-84-9) is a normal metabolite intermediate in fructose and mannose metabolism. It is a substrate of phosphomannomutase 1 (PMM, EC 5.4.2.8), an enzyme necessary for the synthesis of GDP-mannose (a substrate for dolichol-linked oligosaccharide synthesis). PMM converts mannose 6-phosphate into mannose-1-phosphate. A deficiency of phosphomannomutase in carbohydrate-deficient glycoprotein syndrome (CDGS) type I is associated with a decreased synthesis of mannose 1-phosphate. CDGS is a group of autosomal recessively transmitted disorders in which abnormally glycosylated proteins are formed (PMID: 9451026 , 8549746 , 12729595 ).
Structure
Synonyms
ValueSource
1-O-Phosphono-alpha-D-mannopyranoseChEBI
alpha-D-Mannose 1-phosphateKegg
1-O-Phosphono-a-D-mannopyranoseGenerator
1-O-Phosphono-α-D-mannopyranoseGenerator
a-D-Mannose 1-phosphateGenerator
a-D-Mannose 1-phosphoric acidGenerator
alpha-D-Mannose 1-phosphoric acidGenerator
Α-D-mannose 1-phosphateGenerator
Α-D-mannose 1-phosphoric acidGenerator
D-Mannose 1-phosphoric acidGenerator
Mannose phosphateHMDB
Mannosyl phosphateHMDB
alpha-D-Mannopyranosyl phosphateHMDB
Α-D-mannopyranosyl phosphateHMDB
D-Mannose 1-phosphateHMDB
Molecular FormulaC6H13O9P
Average Mass260.1358
Monoisotopic Mass260.029718526
IUPAC Name{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid
Traditional Nameα-D-mannose 1-phosphate
CAS Registry Number27251-84-9
SMILES
OC[C@H]1O[C@H](OP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]1O
InChI Identifier
InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6-/m1/s1
InChI KeyHXXFSFRBOHSIMQ-RWOPYEJCSA-N