Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-23 23:16:33 UTC
Update Date2024-10-11 03:35:39 UTC
Metabolite IDMMDBc0047933
Metabolite Identification
Common NameFolinic acid
DescriptionFolinic acid (CAS: 58-05-9), also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate (a chemotherapy agent and immune system suppressant) and pyrimethamine (Wikipedia ). Folinic acid is the active metabolite of folic acid. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid.
Structure
Synonyms
ValueSource
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acidChEBI
(6S)-Folinic acidChEBI
(6S)-LeucovorinChEBI
(S)-LeucovorinChEBI
Citrovorum factorChEBI
L-Folinic acidChEBI
LevofoleneChEBI
Levofolinic acidChEBI
LevoleucovorinChEBI
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acidChEBI
(6S)-5-Formyl-5,6,7,8-tetrahydrofolateGenerator
(6S)-FolinateGenerator
L-FolinateGenerator
LevofolinateGenerator
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamateGenerator
FolinateGenerator
5-FormyltetrahydrofolateHMDB
Pteroyl-D-glutamateHMDB
5 FormyltetrahydropteroylglutamateHMDB
5-FormyltetrahydropteroylglutamateHMDB
Calcium folinateHMDB
Folinic acid-SFHMDB
LeucovorinHMDB
Leucovorin, (S)-isomerHMDB
Leucovorin, monosodium saltHMDB
Leucovorin, (R)-isomerHMDB
Leucovorin, calciumHMDB
Leucovorin, calcium (1:1) salt, (DL)-isomerHMDB
Leucovorin, calcium (1:1) salt, (S)-isomerHMDB
LeukovorinHMDB
LeukovorumHMDB
Monosodium salt leucovorinHMDB
WellcovorinHMDB
Levo leucovorinHMDB
6 S LeucovorinHMDB
Acid, folinicHMDB
Factor, citrovorumHMDB
Folinic acid SFHMDB
FusilevHMDB
Leucovorin, calcium (1:1) salt, pentahydrateHMDB
Leucovorin, monopotassium salt, (S)-isomerHMDB
N(5)-FormyltetrahydrofolateHMDB
S-LeucovorinHMDB
5 FormyltetrahydrofolateHMDB
6-S-LeucovorinHMDB
6S LeucovorinHMDB
6S-LeucovorinHMDB
Calcium leucovorinHMDB
Folinate, calciumHMDB
Leucovorin, (D)-isomerHMDB
Leucovorin, (DL)-isomerHMDB
Leucovorin, calcium (1:1) saltHMDB
Leucovorin, monosodium salt, (S)-isomerHMDB
S LeucovorinHMDB
Levo-leucovorinHMDB
5-Formyl-(6S)-tetrahydrofolic acidHMDB
5-Formyl-5,6,7,8-tetrahydrofolic acidHMDB
5-Formyltetrahydrofolic acidHMDB
5-Formyltetrahydropteroylglutamic acidHMDB
CFHMDB
KunyrinHMDB
LeucoverinHMDB
N5-Formyl-5,6,7,8-tetrahydrofolic acidHMDB
N5-Formyl-THFHMDB
N5-Formyltetrahydrofolic acidHMDB
WelcovorinHMDB
(6S)-5-FormyltetrahydrofolateHMDB
(6S)-5-Formyltetrahydrofolic acidHMDB
Folinic acidMeSH
Molecular FormulaC20H23N7O7
Average Mass473.4393
Monoisotopic Mass473.165896125
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number68538-85-2
SMILESNot Available
InChI Identifier
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1
InChI KeyVVIAGPKUTFNRDU-STQMWFEESA-N