Showing metabocard for 3,4-Dihydroxymandelaldehyde (MMDBc0047947)

Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-23 23:18:06 UTC
Update Date2024-10-09 19:46:54 UTC
Metabolite IDMMDBc0047947
Metabolite Identification
Common Name3,4-Dihydroxymandelaldehyde
Description3,4-Dihydroxymandelaldehyde is the monoamine oxidase (MAO) aldehyde metabolite of both norepinephrine and epinephrine. 3,4- dihydroxymandelaldehyde generates a free radical and activates mitochondrial permeability transition, a mechanism implicated in neuron death. There is an increasing body of evidence suggesting that these compounds are neurotoxic, and it has been recently hypothesized that neurodegenerative disorders may be associated with increased levels of this biogenic aldehyde. It is possible to speculate that reduced detoxification of 3,4- dihydroxymandelaldehyde from impaired or deficient aldehyde dehydrogenase function may be a contributing factor in the suggested neurotoxicity of these compounds. Aldehyde dehydrogenases are a group of NAD(P)+ -dependent enzymes that catalyze the oxidation of aldehydes, such as those derived from catecholamines, to their corresponding carboxylic acids. To date, 19 aldehyde dehydrogenase genes have been identified in the human genome. Mutations in these genes and subsequent inborn errors in aldehyde metabolism are the molecular basis of several diseases. Several pharmaceutical agents and environmental toxins are also known to disrupt or inhibit aldehyde dehydrogenase function. (PMID: 17379813 , 14697885 , 11164826 ).
Structure
MOLSDFPDBSMILESInChI

MOL for #<Metabolite:0x00007f46c8914a68>

Download
3D MOL for #<Metabolite:0x00007f46c8914a68>
Download
3D SDF for #<Metabolite:0x00007f46c8914a68>
Download
3D-SDF for #<Metabolite:0x00007f46c8914a68>
Download
PDB for #<Metabolite:0x00007f46c8914a68>
Download
3D PDB for #<Metabolite:0x00007f46c8914a68>
Download
SMILES for #<Metabolite:0x00007f46c8914a68>
Download
INCHI for #<Metabolite:0x00007f46c8914a68>
Download
Synonyms
ValueSource
3,4-Dihydroxymandelic aldehydeChEBI
3,4-DihydroxyphenylglycolaldehydeChEBI
3,4-Dihydroxyphenylglycolic aldehydeChEBI
alpha,3,4-TrihydroxybenzeneacetaldehydeChEBI
alpha,3,4-TrihydroxyphenylacetaldehydeChEBI
DHMALChEBI
DHPGALDChEBI
DOPEGALChEBI
a,3,4-TrihydroxybenzeneacetaldehydeGenerator
Α,3,4-trihydroxybenzeneacetaldehydeGenerator
a,3,4-TrihydroxyphenylacetaldehydeGenerator
Α,3,4-trihydroxyphenylacetaldehydeGenerator
a,3,4-Trihydroxy-benzeneacetaldehydeHMDB
alpha,3,4-Trihydroxy-benzeneacetaldehydeHMDB
Molecular FormulaC8H8O4
Average Mass168.1467
Monoisotopic Mass168.042258744
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number13023-73-9
SMILESNot Available
InChI Identifier
InChI=1S/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H
InChI KeyYUGMCLJIWGEKCK-UHFFFAOYSA-N