Showing metabocard for 3,4-Dihydroxymandelaldehyde (MMDBc0047947)
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| Version | 1.0 | ||||||||||||||||||||||||||||
| Status | Detected and Quantified | ||||||||||||||||||||||||||||
| Creation Date | 2021-11-23 23:18:06 UTC | ||||||||||||||||||||||||||||
| Update Date | 2024-10-09 19:46:54 UTC | ||||||||||||||||||||||||||||
| Metabolite ID | MMDBc0047947 | ||||||||||||||||||||||||||||
| Metabolite Identification | |||||||||||||||||||||||||||||
| Common Name | 3,4-Dihydroxymandelaldehyde | ||||||||||||||||||||||||||||
| Description | 3,4-Dihydroxymandelaldehyde is the monoamine oxidase (MAO) aldehyde metabolite of both norepinephrine and epinephrine. 3,4- dihydroxymandelaldehyde generates a free radical and activates mitochondrial permeability transition, a mechanism implicated in neuron death. There is an increasing body of evidence suggesting that these compounds are neurotoxic, and it has been recently hypothesized that neurodegenerative disorders may be associated with increased levels of this biogenic aldehyde. It is possible to speculate that reduced detoxification of 3,4- dihydroxymandelaldehyde from impaired or deficient aldehyde dehydrogenase function may be a contributing factor in the suggested neurotoxicity of these compounds. Aldehyde dehydrogenases are a group of NAD(P)+ -dependent enzymes that catalyze the oxidation of aldehydes, such as those derived from catecholamines, to their corresponding carboxylic acids. To date, 19 aldehyde dehydrogenase genes have been identified in the human genome. Mutations in these genes and subsequent inborn errors in aldehyde metabolism are the molecular basis of several diseases. Several pharmaceutical agents and environmental toxins are also known to disrupt or inhibit aldehyde dehydrogenase function. (PMID: 17379813 , 14697885 , 11164826 ). | ||||||||||||||||||||||||||||
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| Molecular Formula | C8H8O4 | ||||||||||||||||||||||||||||
| Average Mass | 168.1467 | ||||||||||||||||||||||||||||
| Monoisotopic Mass | 168.042258744 | ||||||||||||||||||||||||||||
| IUPAC Name | Not Available | ||||||||||||||||||||||||||||
| Traditional Name | Not Available | ||||||||||||||||||||||||||||
| CAS Registry Number | 13023-73-9 | ||||||||||||||||||||||||||||
| SMILES | Not Available | ||||||||||||||||||||||||||||
| InChI Identifier | InChI=1S/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H | ||||||||||||||||||||||||||||
| InChI Key | YUGMCLJIWGEKCK-UHFFFAOYSA-N | ||||||||||||||||||||||||||||
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