MiMeDB: Streptococcus pyogenes MGAS10270 (MMDBm0002599)

Microbe Identification

Microbe name

Streptococcus pyogenes MGAS10270

NCBI Taxonomy ID

370552

Microbe Taxonomy

Superkingdom

Bacteria

Kingdom

Eubacteria

Phylum

Firmicutes

Class

Bacilli

Order

Lactobacillales

Family

Streptococcaceae

Genus

Streptococcus

Species

pyogenes

Strain

Microbe Properties

Gram staining properties

Positive

Shape

Cocci

Mobility

Flagellar presence

Number of membranes

Oxygen preference

Facultative anaerobe

Optimal temperature

Temperature range

Mesophilic

Habitat

HostAssociated

Biotic relationship

Free living

Cell arrangement

Chains - Pairs

Sporulation

Chains - Pairs

Metabolism

Not Available

Energy source

Not Available

Host and Biospecimens

Host	Body site	Biospecimen	Details	Data Source	Reference
Human			Unknown

Health Effects

Host	Related Health Condition	Biospecimen	Microbal response/effect	Data Source	Reference

Related Metabolites

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0012860	(2R)-2-phosphoglyceric acid	Phosphoenolpyruvic acid	Enolase	Enolization	RHEA	34755880
MMDBr0012895	Orotidylic acid	Phosphoribosyl pyrophosphate	Orotate phosphoribosyltransferase	Transfer of a ribosyl group	RHEA	34755880
MMDBr0012943	Xanthylic acid	Phosphoribosyl pyrophosphate	Xanthine-guanine phosphoribosyltransferase	Transfer of a ribosyl group	RHEA	34755880
MMDBr0012975	Glycerol 3-phosphate	Dihydroxyacetone phosphate	Glycerol-3-phosphate dehydrogenase [NAD(+)]	Dehydrogenation	RHEA	34755880
MMDBr0012976	Glycerol 3-phosphate	Dihydroxyacetone phosphate	Glycerol-3-phosphate dehydrogenase [NAD(P)+]	Dehydrogenation	RHEA	34755880
MMDBr0012989	D-Alanine	D-Alanyl-D-alanine	D-alanine--D-alanine ligase	Ligation	RHEA	34755880
MMDBr0013001	Acetic acid	Acetyl phosphate	Acetate kinase	Transfer of a formyl group	RHEA	34755880
MMDBr0013026	Orotidylic acid	Uridine 5'-monophosphate	Orotidine 5'-phosphate decarboxylase	Decarboxylation	RHEA	34755880
MMDBr0013027	CMP	CDP	Cytidylate kinase	Phosphorylation	RHEA	34755880
MMDBr0013045	Alpha-D-glucose 6-phosphate	beta-D-Fructose 6-phosphate	Glucose-6-phosphate isomerase	Isomerization	RHEA	34755880
MMDBr0013081	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	7,8-dihydrofolate monoglutamate	Bifunctional dihydrofolate reductase-thymidylate synthase	Reduction; Synthesis	RHEA	34755880
MMDBr0013098	UDP-N-acetyl-alpha-D-muramate	UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine	UDP-N-acetylenolpyruvoylglucosamine reductase	Reduction	RHEA	34755880
MMDBr0013115	D-tagatofuranose 6-phosphate	D-Tagatose 1,6-bisphosphate	Tagatose-6-phosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0013152	L-Glutamic acid	D-Glutamate	L-alanine/L-glutamate racemase	Racemization; Synthesis	RHEA	34755880
MMDBr0013173	Uridine 5'-monophosphate	Phosphoribosyl pyrophosphate	Bifunctional protein PyrR	Transfer of phosphoribosyl group	RHEA	34755880
MMDBr0013187	Shikimate	Shikimate 3-phosphate	Pentafunctional AROM polypeptide	Phosphorylation	RHEA	34755880
MMDBr0013339	aldehydo-D-ribose 5-phosphate	D-Ribulose 5-phosphate	Bifunctional ribokinase/ribose-5-phosphate isomerase A	Isomerization	RHEA	34755880
MMDBr0013370	L-Glutamic acid	gamma-L-Glutamyl 5-phosphate	Glutamate 5-kinase	Phosphorylation	RHEA	34755880
MMDBr0013390	3'-dephospho-CoA	2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA	Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase	Synthesis	RHEA	34755880
MMDBr0013458	Guanosine triphosphate	Guanosine diphosphate	Adenylosuccinate synthetase	Synthesis	RHEA	34755880
MMDBr0013470	(2R)-2-phosphoglyceric acid	(2R)-3-phosphoglyceric acid	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	Intramolecular transfer of functional group	RHEA	34755880
MMDBr0013495	beta-D-Fructose 6-phosphate	beta-D-Fructose 1,6-bisphosphate	ATP-dependent 6-phosphofructokinase	Phosphorylation	RHEA	34755880
MMDBr0013526	Pantothenic acid	(R)-4'-phosphopantothenic acid	Bifunctional enzyme BirA/CoaX	Phosphorylation	RHEA	34755880
MMDBr0013529	D-Glutamate	UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamic acid	UDP-N-acetylmuramoylalanine--D-glutamate ligase	Ligation	RHEA	34755880
MMDBr0013547	Uridine triphosphate	Cytidine triphosphate	CTP synthase	Synthesis	RHEA	34755880
MMDBr0013611	D-Glyceraldehyde 3-phosphate	beta-D-Fructose 6-phosphate	Transaldolase	Transfer of aldol group	RHEA	34755880
MMDBr0013627	Inosinic acid	GMP	GMP reductase	Reduction	RHEA	34755880
MMDBr0013681	Shikimate	3-Dehydroshikimic acid	Pentafunctional AROM polypeptide	Dehydrogenation	RHEA	34755880
MMDBr0013683	S-Ribosyl-L-homocysteine	(4S)-4,5-Dihydroxypentan-2,3-dione	S-ribosylhomocysteine lyase	Non-hydrolytic bond cleavage (or its reversal)	RHEA	34755880
MMDBr0013707	L-Lysine	UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase	Ligation	RHEA	34755880
MMDBr0013770	Inosinic acid	Phosphoribosyl formamidocarboxamide	Bifunctional purine biosynthesis protein PurH	Hydrolysis; Synthesis	RHEA	34755880
MMDBr0013784	D-Glyceraldehyde 3-phosphate	Dihydroxyacetone phosphate	Bifunctional PGK/TIM	Isomerization	RHEA	34755880
MMDBr0013809	Ribose-1-phosphate	D-Ribose-5-phosphate	Phosphopentomutase	Transfers of a phosphate group; Isomerization; Intramolecular transfer of functional group	RHEA	34755880
MMDBr0013886	Carbamoylphosphate	Citrulline	Ornithine carbamoyltransferase	Transfer of a carbamoyl group	RHEA	34755880
MMDBr0013901	L-Arginine	Citrulline	Arginine deiminase	Hydrolysis of l-arginine to citrulline and ammonium ion	RHEA	34755880
MMDBr0013908	Guanosine triphosphate	Guanosine diphosphate	GTPase ArgK	Dephosphorylation; Hydrolysis; Nucleic acid synthesis and/or repair	RHEA	34755880
MMDBr0013921	(R)-4'-phosphopantetheine	3'-dephospho-CoA	Phosphopantetheine adenylyltransferase	Dephosphorylation	RHEA	34755880
MMDBr0013946	Carbamoylphosphate	N-carbamoyl-L-aspartate	Protein pyrABCN	Transfer of a carbamoyl group	RHEA	34755880
MMDBr0013966	(6S)-5,6,7,8-tetrahydrofolic acid	(6S)-10-formyltetrahydrofolic acid	C-1-tetrahydrofolate synthase, cytoplasmic	Ligation; Synthesis	RHEA	34755880
MMDBr0013970	L-Alanine	D-Alanine	L-alanine/L-glutamate racemase	Racemization	RHEA	34755880
MMDBr0014035	GMP	Guanosine diphosphate	Guanylate kinase	Phosphorylation	RHEA	34755880
MMDBr0014061	5-O-(1-Carboxyvinyl)-3-phosphoshikimate	Chorismate	Chorismate synthase	Synthesis	RHEA	34755880
MMDBr0014068	3-Dehydroquinate	3-Dehydroshikimic acid	Catabolic 3-dehydroquinase	Hydration/dehydration of C-O bond; Synthesis	RHEA	34755880
MMDBr0014083	Shikimate 3-phosphate	5-O-(1-Carboxyvinyl)-3-phosphoshikimate	Pentafunctional AROM polypeptide	Synthesis; Dehydration and isomerisation; Oxidation; Phosphorylation; Transfer of a carboxyvinyl group	RHEA	34755880
MMDBr0014126	Glycerol	Glycerol 3-phosphate	Glycerol kinase	Phosphorylation	RHEA	34755880
MMDBr0014153	di-trans,octa-cis-undecaprenyl phosphate	Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate	Phospho-N-acetylmuramoyl-pentapeptide-transferase	Transfer of phospho-N-acetylmuramoyl-pentapeptide	RHEA	34755880
MMDBr0014180	(6S)-10-formyltetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	Bifunctional purine biosynthesis protein PurH	Synthesis	RHEA	34755880
MMDBr0014217	Formiminoglutamic acid	Formamide	Formimidoylglutamase	Hydrolysis of carbon-nitrogen bond	RHEA	34755880
MMDBr0014251	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	5,10-Methenyltetrahydrofolate	C-1-tetrahydrofolate synthase, cytoplasmic	Synthesis	RHEA	34755880
MMDBr0014282	2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine	5-Aminoimidazole ribonucleotide	Bifunctional purine biosynthetic protein ADE5,7	Ligation	RHEA	34755880
MMDBr0014303	Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate	lipid II(3−)	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	Transfer of UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine	RHEA	34755880
MMDBr0014323	L-Alanine	UDP-N-acetyl-alpha-D-muramoyl-L-alanine	Bifunctional enzyme MurC/Ddl	Ligation	RHEA	34755880
MMDBr0014333	alpha-D-Glucosamine 1-phosphate	D-glucosamine 6-phosphate	Phosphoglucosamine mutase	Intramolecular transfer of functional group	RHEA	34755880
MMDBr0014365	4-Imidazolone-5-propionic acid	Formiminoglutamic acid	Imidazolonepropionase	Non-hydrolytic bond cleavage (or its reversal)	RHEA	34755880
MMDBr0014369	5,10-Methenyltetrahydrofolate	(6S)-10-formyltetrahydrofolic acid	C-1-tetrahydrofolate synthase, cytoplasmic	Reversible cyclization	RHEA	34755880
MMDBr0014447	Uridine 5'-monophosphate	Uridine 5'-diphosphate	UMP-CMP kinase	Phosphorylation	RHEA	34755880
MMDBr0014514	dCMP	dCDP	Cytidylate kinase	Phosphorylation	RHEA	34755880
MMDBr0017926	L-Glutamine	Cytidine triphosphate	CTP synthase	Synthesis	RHEA	34755880
MMDBr0014783	di-trans,octa-cis-undecaprenyl diphosphate	di-trans,octa-cis-undecaprenyl phosphate	Undecaprenyl-diphosphatase BcrC	Dephosphorylation	RHEA	34755880
MMDBr0017941	L-Serine	L-Serine	Serine/threonine transporter SstT	Transport	RHEA	34755880
MMDBr0017942	L-Serine	L-Serine	Serine/threonine transporter SstT	Transport	RHEA	34755880
MMDBr0014935	D-methionine	D-methionine	Methionine import ATP-binding protein MetN	Transport	RHEA	34755880
MMDBr0017943	L-Methionine	L-Methionine	Methionine import ATP-binding protein MetN	Transport	RHEA	34755880
MMDBr0017839	L-Aspartic acid	L-Asparagine	Aspartate--ammonia ligase	Ligation	RHEA	34755880
MMDBr0017843	L-Glutamine	GMP	GMP synthase [glutamine-hydrolyzing]	Synthesis	RHEA	34755880
MMDBr0017871	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	Serine hydroxymethyltransferase	Methylation	RHEA	34755880
MMDBr0017874	L-Glutamine	L-Glutamic acid	Thermolabile glutaminase	Synthesis	RHEA	34755880
MMDBr0017897	L-Methionine	S-Adenosylmethionine	S-adenosylmethionine synthase	Synthesis	RHEA	34755880
MMDBr0024345	L-Tyrosine	Hydrogen Ion	Tyrosine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024371	L-Asparagine	Hydrogen Ion	Asparagine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024389	L-Leucine	diphosphate	Leucine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024401	L-Serine	Adenosine 3',5'-diphosphate	Holo-[acyl-carrier-protein] synthase	Dehydrogenation; Synthesis	RHEA	34755880
MMDBr0024403	Hydrogen Ion	Carbon dioxide	3-oxoacyl-[acyl-carrier-protein] synthase 3	Synthesis	RHEA	34755880
MMDBr0024411	L-Serine	Hydrogen Ion	Type-2 serine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024418	L-Alanine	diphosphate	Alanine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024435	Deoxyribose 5-phosphate	Acetaldehyde	Deoxyribose-phosphate aldolase	Aldol addition (or reverse)	RHEA	34755880
MMDBr0024471	L-Methionine	L-Cysteine	Peptide methionine sulfoxide reductase MsrA	Reduction	RHEA	34755880
MMDBr0024474	L-Proline	diphosphate	Proline--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024477	Cytidine triphosphate	diphosphate	CCA-adding enzyme	Synthesis and repair of 3'-terminal CCA sequence of tRNA	RHEA	34755880
MMDBr0024483	L-Glutamine	L-Glutamic acid	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	Amide group addition	RHEA	34755880
MMDBr0024522	Glycine	diphosphate	Glycine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024546	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO	Methylation	RHEA	34755880
MMDBr0024568	L-Glutamine	L-Glutamic acid	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	Amide group addition	RHEA	34755880
MMDBr0024630	S-Adenosylmethionine	S-Adenosylhomocysteine	Ribosomal RNA small subunit methyltransferase A	Methylation	RHEA	34755880
MMDBr0024644	L-Cystine	L-Cysteine	Peptide methionine sulfoxide reductase MsrA	Reduction	RHEA	34755880
MMDBr0024650	di-mu-Sulfido-diiron(1+)	di-mu-Sulfido-diiron(2+)	Ferredoxin--NADP reductase	Dehydrogenation; Reduction	RHEA	34755880
MMDBr0024656	L-Arginine	diphosphate	Arginine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024745	L-Glutamic acid	diphosphate	Glutamate--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024765	7-Aminomethyl-7-carbaguanine	Guanine	Putative queuine tRNA-ribosyltransferase	Transfer of a ribosyl group	RHEA	34755880
MMDBr0024770	di-mu-Sulfido-diiron(1+)	L-Cysteine	Probable tRNA sulfurtransferase	Sulfuration	RHEA	34755880
MMDBr0024778	(6S)-10-formyltetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	Methionyl-tRNA formyltransferase	Transfer of a formyl group	RHEA	34755880
MMDBr0024779	N-Formyl-L-methionine	formate	Peptide deformylase 1	Removal of the N-terminal formyl group	RHEA	34755880
MMDBr0024787	L-Threonine	Hydrogen Ion	Threonine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024813	Dimethylallylpyrophosphate	diphosphate	tRNA dimethylallyltransferase	Transfer of a dimethylallyl group	RHEA	34755880
MMDBr0024826	2-deoxy-alpha-D-ribose 1-phosphate	Deoxyribose 5-phosphate	Phosphopentomutase	Transfers of a phosphate group; Isomerization; Intramolecular transfer of functional group	RHEA	34755880
MMDBr0024883	S-Adenosylmethionine	Adenine	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	Isomerization	RHEA	34755880
MMDBr0024925	Glycerol 3-phosphate	Phosphate	Glycerol-3-phosphate acyltransferase	Acylation	RHEA	34755880
MMDBr0024967	S-Adenosylmethionine	S-Adenosylhomocysteine	tRNA (guanine(37)-N1)-methyltransferase Trm5b	Methylation	RHEA	34755880
MMDBr0024971	L-Threonylcarbamoyladenylate	Hydrogen Ion	tRNA N6-adenosine threonylcarbamoyltransferase	Synthesis	RHEA	34755880
MMDBr0025060	L-Serine	Hydrogen Ion	Type-2 serine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0025071	S-Adenosylmethionine	S-Adenosylhomocysteine	tRNA (guanine-N(7)-)-methyltransferase	Methylation	RHEA	34755880
MMDBr0025102	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Ribosomal RNA large subunit methyltransferase N	Methylation	RHEA	34755880
MMDBr0025105	S-Adenosylmethionine	S-Adenosylhomocysteine	Ribosomal RNA small subunit methyltransferase H	Methylation	RHEA	34755880
MMDBr0025145	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Probable dual-specificity RNA methyltransferase RlmN	Methylation	RHEA	34755880
MMDBr0025258	Uridine 5'-monophosphate	L-Cysteine	tRNA-specific 2-thiouridylase MnmA	2-Thiolation of uridine	RHEA	34755880
MMDBr0025490	S-Adenosylmethionine	S-Adenosylhomocysteine	Ribosomal protein L11 methyltransferase	Methylation	RHEA	34755880
MMDBr0025514	Acetyl-CoA	Malonyl-CoA	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha	Carboxylation	RHEA	34755880
MMDBr0025556	D-Alanine	diphosphate	D-alanine--D-alanyl carrier protein ligase	Ligation	RHEA	34755880
MMDBr0025620	L-Cysteine	Sn-Glycerol-1-phosphate	Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase	Transfer of the diacylglyceryl group	RHEA	34755880
MMDBr0025656	Acetic acid	diphosphate	tRNA(Met) cytidine acetate ligase	Ligation	RHEA	34755880
MMDBr0025777	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO	Methylation	RHEA	34755880

Genome Data

Genome Link

MMDBm0002599

Genome Length

1955799 bp

# Predicted Proteins

1930

GenBank Sequence Modification Date

17-FEB-2022

MiMeDB Deposition Date

2022-08-25 01:34:10 UTC

Reference

PMID: 17704766

Source Links

GenBank

NC_008022