MiMeDB: Showing metabocard for L-Tyrosine (MMDBc0000047)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:28:27 UTC

Update Date

2022-08-30 23:23:09 UTC

Metabolite ID

MMDBc0000047

Metabolite Identification

Common Name

L-Tyrosine

Description

Tyrosine is an essential amino acid that readily passes the blood-brain barrier. Once in the brain, it is a precursor for the neurotransmitters dopamine, norepinephrine and epinephrine, better known as adrenalin. These neurotransmitters are an important part of the body's sympathetic nervous system, and their concentrations in the body and brain are directly dependent upon dietary tyrosine. Tyrosine is not found in large concentrations throughout the body, probably because it is rapidly metabolized. Folic acid, copper and vitamin C are cofactor nutrients of these reactions. Tyrosine is also the precursor for hormones, thyroid, catecholestrogens and the major human pigment, melanin. Tyrosine is an important amino acid in many proteins, peptides and even enkephalins, the body's natural pain reliever. Valine and other branched amino acids, and possibly tryptophan and phenylalanine may reduce tyrosine absorption. A number of genetic errors of tyrosine metabolism occur, such as hawkinsinuria and tyrosinemia I. Most common is the increased amount of tyrosine in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Infection and intellectual deficits may occur. Vitamin C supplements reverse the disease. Some adults also develop elevated tyrosine in their blood. This indicates a need for more vitamin C. More tyrosine is needed under stress, and tyrosine supplements prevent the stress-induced depletion of norepinephrine and can cure biochemical depression. However, tyrosine may not be good for psychosis. Many antipsychotic medications apparently function by inhibiting tyrosine metabolism. L-dopa, which is directly used in Parkinson's, is made from tyrosine. Tyrosine, the nutrient, can be used as an adjunct in the treatment of Parkinson's. Peripheral metabolism of tyrosine necessitates large doses of tyrosine, however, compared to L-dopa (http://www.dcnutrition.com).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  C   UNK     0    8667.2958667.436   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    8668.6298666.666   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    8669.9608667.436   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0    8671.2908666.666   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0    8669.9608668.974   0.000  0.00  0.00           O+0
HETATM    6  N   UNK     0    8668.6298665.130   0.000  0.00  0.00           N+0
HETATM    7  O   UNK     0    8661.9688664.359   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0    8665.9668666.668   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8664.6328667.438   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8663.2988666.668   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0    8663.2988665.128   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    8664.6328664.358   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0    8665.9668665.128   0.000  0.00  0.00           C+0
CONECT    1    2    8                                                       
CONECT    2    1    3    6                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    2                                                            
CONECT    7   11                                                            
CONECT    8    9   13    1                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12    7                                                  
CONECT   12   11   13                                                       
CONECT   13   12    8                                                       
MASTER        0    0    0    0    0    0    0    0   13    0   26    0
END

Synonyms

Value	Source
(-)-alpha-Amino-p-hydroxyhydrocinnamic acid	ChEBI
(2S)-2-Amino-3-(4-hydroxyphenyl)propanoic acid	ChEBI
(S)-(-)-Tyrosine	ChEBI
(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid	ChEBI
(S)-3-(p-Hydroxyphenyl)alanine	ChEBI
(S)-alpha-Amino-4-hydroxybenzenepropanoic acid	ChEBI
(S)-Tyrosine	ChEBI
4-Hydroxy-L-phenylalanine	ChEBI
L-Tyrosin	ChEBI
Tyr	ChEBI
TYROSINE	ChEBI
Y	ChEBI
(-)-a-Amino-p-hydroxyhydrocinnamate	Generator
(-)-a-Amino-p-hydroxyhydrocinnamic acid	Generator
(-)-alpha-Amino-p-hydroxyhydrocinnamate	Generator
(-)-Α-amino-p-hydroxyhydrocinnamate	Generator
(-)-Α-amino-p-hydroxyhydrocinnamic acid	Generator
(2S)-2-Amino-3-(4-hydroxyphenyl)propanoate	Generator
(S)-2-Amino-3-(p-hydroxyphenyl)propionate	Generator
(S)-a-Amino-4-hydroxybenzenepropanoate	Generator
(S)-a-Amino-4-hydroxybenzenepropanoic acid	Generator
(S)-alpha-Amino-4-hydroxybenzenepropanoate	Generator
(S)-Α-amino-4-hydroxybenzenepropanoate	Generator
(S)-Α-amino-4-hydroxybenzenepropanoic acid	Generator
(S)-a-Amino-4-hydroxy-benzenepropanoate	HMDB
(S)-a-Amino-4-hydroxy-benzenepropanoic acid	HMDB
(S)-alpha-Amino-4-hydroxy-benzenepropanoate	HMDB
(S)-alpha-Amino-4-hydroxy-benzenepropanoic acid	HMDB
2-Amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoate	HMDB
2-Amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoic acid	HMDB
3-(4-Hydroxyphenyl)-L-alanine	HMDB
Benzenepropanoate	HMDB
Benzenepropanoic acid	HMDB
L-p-Tyrosine	HMDB
p-Tyrosine	HMDB
L Tyrosine	HMDB
Tyrosine, L-isomer	HMDB
Tyrosine, L isomer	HMDB
Para tyrosine	HMDB
Para-tyrosine	HMDB

Molecular Formula

C₉H₁₁NO₃

Average Mass

181.1885

Monoisotopic Mass

181.073893223

IUPAC Name

(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid

Traditional Name

L-tyrosine

CAS Registry Number

60-18-4

SMILES

N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

InChI Identifier

InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

InChI Key

OUYCCCASQSFEME-QMMMGPOBSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tyrosine and derivatives. Tyrosine and derivatives are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Tyrosine and derivatives

Alternative Parents

Substituents

Tyrosine or derivatives
Phenylalanine or derivatives
3-phenylpropanoic-acid
Alpha-amino acid
Amphetamine or derivatives
L-alpha-amino acid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Aralkylamine
Monocyclic benzene moiety
Benzenoid
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Organic oxide
Organooxygen compound
Organonitrogen compound
Amine
Primary aliphatic amine
Organic nitrogen compound
Carbonyl group
Organopnictogen compound
Organic oxygen compound
Hydrocarbon derivative
Primary amine
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:17895 )
L-alpha-amino acid (CHEBI:17895 )
tyrosine (CHEBI:17895 )
erythrose 4-phosphate/phosphoenolpyruvate family amino acid (CHEBI:17895 )
Common amino acids (C00082 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	7.67 g/L	ALOGPS
logP	-2.4	ALOGPS
logP	-1.5	ChemAxon
logS	-1.4	ALOGPS
pKa (Strongest Acidic)	2	ChemAxon
pKa (Strongest Basic)	9.19	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	83.55 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	47.1 m³·mol⁻¹	ChemAxon
Polarizability	18.01 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-014i-0690000000-cbbf40bb26fc84f2aead	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-014i-0890000000-ca45f993f95c8b0cee44	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-014i-0890000000-5749069211ba15d713ef	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-00xr-9240000000-2c87373c0d964e0edef5	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-014i-0890000000-848b2a4f247a0b3f14e8	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)	splash10-00xr-9450000000-6d4550940f4dde6f18ff	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (2 TMS)	splash10-004i-1910000000-5cc19cad5dc24b3b9b11	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-014i-1790000000-de22041357aadf60a06b	2014-06-16	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-014i-0690000000-cbbf40bb26fc84f2aead	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-014i-0890000000-ca45f993f95c8b0cee44	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-014i-0890000000-5749069211ba15d713ef	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00xr-9240000000-2c87373c0d964e0edef5	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-014i-0890000000-848b2a4f247a0b3f14e8	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-QQ (Non-derivatized)	splash10-0udi-3319000000-1d3d28a67f82366fff22	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00xr-9450000000-6d4550940f4dde6f18ff	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-004i-1910000000-5cc19cad5dc24b3b9b11	2017-09-12	View Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-014i-1790000000-de22041357aadf60a06b	2017-09-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-052r-4900000000-9be1412408207db5df4e	2016-09-22	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive	splash10-05fr-9750000000-937b6ee7a745865ee7ee	2017-10-06	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_2) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_3) - 70eV, Positive	Not Available	2021-11-05	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-01p9-0900000000-580de2c16cd24559cd5c	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0006-9400000000-f233fbc6c58236ee4aeb	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-002f-9100000000-8b5e12eba034bcfdf8a1	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0920000000-b43356ad3da227b488cb	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-c04f0be6515621dda5ac	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-3ed8b68bfade9194763b	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0900000000-fe6a1ce69851a8c5db00	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-aafdcea07be221817fd4	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0900000000-66a5b9a0a48bdc0a2b47	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-13eb4252ca23455a58da	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-fb85798746829bac3f3d	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03e9-0839226000-5504e667281c746669ec	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-f65cb3ad2fa730c922f7	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-a9276fe43ef61b4693e6	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a59-0039210000-21b4bd9870bf4965a6d1	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0848491200-aae99eb0b66dd1c7036d	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-4104a2ca5d5ef5f22f6d	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-f309996d57a95c719deb	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0013090000-112cd9c2eea42dbc079b	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-001i-0900000000-c7f95918d936586f633d	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-03yi-1900000000-d1682546c1e0893c71e4	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-014i-2900000000-a0cc78ed35e56dd812a5	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-00kf-9500000000-d3f399f5dd10e338e25a	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9200000000-8acd8d370f194bfe28ed	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-001i-0900000000-6b26ce2f5b326ace12a4	2012-08-31	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-0a4i-3900000000-7a26097fda66f2f445b5	2018-05-25	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)		2012-12-04	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)		2012-12-04	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)		2016-10-22	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)		2021-09-16	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)		2021-09-16	View Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)		2012-12-04	View Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 400 MHz, H₂O, experimental)		2012-12-04	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Mitochondria

Biospecimen Locations

All Tissues
Blood
Breast Milk
Cerebrospinal Fluid (CSF)
Feces
Placenta
Prostate
Saliva
Sweat
Urine

Tissue Locations

All Tissues
Placenta
Prostate

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191760	Tyrosinase	Unknown	P14679	Homo sapiens
MMDBp0191943	Tyrosine 3-monooxygenase	Enzyme	P07101	Homo sapiens
MMDBp0191946	Thyroid peroxidase	Unknown	P07202	Homo sapiens
MMDBp0191947	Tyrosine aminotransferase	Enzyme	P17735	Homo sapiens
MMDBp0191948	Aromatic-L-amino-acid decarboxylase	Enzyme	P20711	Homo sapiens
MMDBp0191950	Phenylalanine-4-hydroxylase	Enzyme	P00439	Homo sapiens
MMDBp0191953	Aspartate aminotransferase, cytoplasmic	Enzyme	P17174	Homo sapiens
MMDBp0191954	Aspartate aminotransferase, mitochondrial	Enzyme	P00505	Homo sapiens
MMDBp0192248	Tyrosine--tRNA ligase, cytoplasmic	Enzyme	P54577	Homo sapiens
MMDBp0192261	Tyrosine--tRNA ligase, mitochondrial	Enzyme	Q9Y2Z4	Homo sapiens
MMDBp0192717	Monocarboxylate transporter 8	Transporter	P36021	Homo sapiens
MMDBp0193013	Basic fibroblast growth factor receptor 1	Enzyme	P11362	Homo sapiens
MMDBp0193019	Epidermal growth factor receptor	Enzyme	P00533	Homo sapiens
MMDBp0194001	Monocarboxylate transporter 10	Transporter	Q8TF71	Homo sapiens
MMDBp0195052	L-amino-acid oxidase	Unknown	Q96RQ9	Homo sapiens
MMDBp0195066	Iodotyrosine dehalogenase 1	Unknown	Q6PHW0	Homo sapiens
MMDBp0195597	Tubulin--tyrosine ligase	Unknown	Q8NG68	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank
Protein Synthesis: Tyrosine

Metabolic Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0012731	L-Tyrosine	Tyramine	Not Available		RHEA	12089039
MMDBr0012736	L-Tyrosine	Phenol	Not Available		Manually annotated by MiMeDB team	Manually annotated by MiMeDB team
MMDBr0012738	L-Tyrosine	4-Hydroxyphenylpyruvic acid	Not Available		Manually annotated by MiMeDB team	Manually annotated by MiMeDB team
MMDBr0001499	Iodine	Iodotyrosine	Thyroid peroxidase	Iodide:Hydrogen-Peroxide Oxidoreductase	VMH	2997169 3153466 3475693
MMDBr0001935	Oxygen	4a-Hydroxytetrahydrobiopterin	Not Available	L-Phenylalanine, Tetrahydrobiopterin:Oxygen Oxidoreductase (4-Hydroxylating)	VMH	30371894
MMDBr0002295	Oxygen	L-Dopa	Tyrosine hydroxylase	Tyrosine 3-Monooxygenase	VMH	10727395 9920892
MMDBr0002297	Hydrogen Ion	Carbon dioxide	Not Available	L-Tyrosine Carboxy-Lyase	VMH	30371894
MMDBr0002298	Oxygen	L-Dopa	Tyrosinase	Tyrosine:Dopa Oxidase	VMH	5294951
MMDBr0002301	L-Tyrosine	L-Tyrosine	Not Available	L-Tyrosine Transport	VMH	11827462
MMDBr0002302	Sodium	Sodium	Not Available	L-Tyrosine Transport in via Sodium Symport	VMH	11133652 12719981
MMDBr0002303	Oxoglutaric acid	4-Hydroxyphenylpyruvic acid	Glutamic-oxaloacetic transaminase 2, mitochondrial	Tyrosine Transaminase, Mitochondrial	VMH	1973834
MMDBr0002538	Oxygen	4a-Carbinolamine tetrahydrobiopterin	Phenylalanine hydroxylase	L-Phenylalanine, Tetrahydrobiopterin:Oxygen Oxidoreductase (4-Hydroxylating) Phenylalanine, Tyrosine And Tryptophan Biosynthesis	VMH	3298976 4074362
MMDBr0002848	L-Tyrosine	L-Tyrosine	Not Available	Vesicular Transport	VMH	10049700 10574970 11389679 11557028 11564694 12824232 12930836 14574404 16288981 911815
MMDBr0002849	L-Tyrosine	L-Tyrosine	Not Available	Vesicular Transport	VMH	10049700 10574970 11389679 11557028 11564694 12824232 12930836 14574404 16288981 911815
MMDBr0002943	L-Alanine	ADP	Glycogenin 1	Glycogenin Protein Assembly	VMH	10395894 10721716 15489334 8602861 8661012
MMDBr0002944	Adenosine triphosphate	ADP	Not Available	Protein Degradation	VMH	10395894 10721716 15489334 8602861 8661012
MMDBr0003014	Glycine	Glycine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003025	L-Alanine	L-Alanine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003037	L-Glutamine	L-Glutamine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003047	L-Serine	L-Serine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003058	L-Methionine	L-Methionine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003067	L-Tryptophan	L-Tryptophan	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003076	L-Phenylalanine	L-Phenylalanine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003085	L-Cysteine	L-Cysteine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003086	L-Leucine	L-Leucine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003087	L-Proline	L-Proline	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003088	L-Asparagine	L-Asparagine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003089	L-Tyrosine	L-Tyrosine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003090	L-Threonine	L-Threonine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003091	L-Homoserine	L-Homoserine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003092	L-Isoleucine	L-Isoleucine	Solute carrier family 7 (amino acid transporter light chain, l system), member 5	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.1	VMH	14770309 14770310
MMDBr0003134	Glycine	Glycine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003147	L-Alanine	L-Alanine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003157	L-Glutamine	L-Glutamine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003167	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003179	L-Methionine	L-Methionine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003194	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003209	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003218	Glycine	Glycine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003219	L-Alanine	L-Alanine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003220	L-Glutamine	L-Glutamine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003221	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003222	L-Methionine	L-Methionine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003223	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003224	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003225	L-Cysteine	L-Cysteine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003226	L-Leucine	L-Leucine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003227	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003228	L-Asparagine	L-Asparagine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003229	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003230	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003231	L-Homoserine	L-Homoserine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003232	L-Isoleucine	L-Isoleucine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003237	L-Cysteine	L-Cysteine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003250	L-Leucine	L-Leucine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003265	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003277	L-Asparagine	L-Asparagine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003290	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003302	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003315	L-Homoserine	L-Homoserine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003330	L-Isoleucine	L-Isoleucine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003372	L-Lysine	L-Lysine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003373	L-Arginine	L-Arginine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003374	Sodium	Sodium	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003375	L-Histidine	L-Histidine	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003376	Citrulline	Citrulline	Solute carrier family 7 (amino acid transporter light chain, y+l system), member 6	Y+Lat2 Utilized Transport	VMH	14770309 14770310
MMDBr0003424	L-Lysine	L-Lysine	Solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15	VMH	14770309 14770310
MMDBr0003440	L-Arginine	L-Arginine	Solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15	VMH	14770309 14770310
MMDBr0003455	Ornithine	Ornithine	Solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15	VMH	14770309 14770310
MMDBr0003470	L-Histidine	L-Histidine	Solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15	VMH	14770309 14770310
MMDBr0003486	Citrulline	Citrulline	Solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15	VMH	14770309 14770310
MMDBr0005407	Chloride ion	Chloride ion	Solute carrier family 6 (amino acid transporter), member 14	Transport of L-Tyrosine by Atb0 Transporter	VMH	30371894
MMDBr0005408	L-Phenylalanine	L-Phenylalanine	Solute carrier family 3 (amino acid transporter heavy chain), member 2	Transport of L-Tyrosine and L-Phenylalanine l by Lat2	VMH	30371894
MMDBr0005674	Chloride ion	Chloride ion	Solute carrier family 6 (neutral amino acid transporter), member 18	Tyrosine Transport by B0At3	VMH	30371894
MMDBr0006445	Argtyrval	L-Arginine	Not Available	Metabolism (Formation/Degradation) of ArgtyrVal	VMH	30371894
MMDBr0006453	Asparaginyl-Tyrosyl-Glycine	L-Asparagine	Not Available	Metabolism (Formation/Degradation) of AsntyrGly	VMH	30371894
MMDBr0006454	Asparaginyl-Tyrosyl-Phenylalanine	L-Asparagine	Not Available	Metabolism (Formation/Degradation) of AsntyrPhe	VMH	30371894
MMDBr0006455	Asparaginyl-Tyrosyl-Threonine	L-Asparagine	Not Available	Metabolism (Formation/Degradation) of AsntyrThr	VMH	30371894
MMDBr0006476	Cystyl-Tyrosyl-Asparagine	L-Asparagine	Not Available	Metabolism (Formation/Degradation) of CystyrAsn	VMH	30371894
MMDBr0006484	Glutaminyl-Tyrosyl-Leucine	L-Glutamine	Not Available	Metabolism (Formation/Degradation) of GlntyrLeu	VMH	30371894
MMDBr0006499	Glycyl-Tyrosyl-Lysine	Glycine	Not Available	Metabolism (Formation/Degradation) of GlytyrLys	VMH	30371894
MMDBr0006527	Water	L-Isoleucine	Not Available	Metabolism (Formation/Degradation) of IleTrptyr	VMH	30371894
MMDBr0006537	Water	L-Leucine	Not Available	Metabolism (Formation/Degradation) of Leutyrtyr	VMH	30371894
MMDBr0006546	Water	L-Isoleucine	Not Available	Metabolism (Formation/Degradation) of LystyrIle	VMH	30371894
MMDBr0006550	Water	L-Asparagine	Not Available	Metabolism (Formation/Degradation) of MetAsntyr	VMH	30371894
MMDBr0006551	Water	L-Glutamine	Not Available	Metabolism (Formation/Degradation) of MetGlntyr	VMH	30371894
MMDBr0006572	Water	L-Phenylalanine	Not Available	Metabolism (Formation/Degradation) of Phetyr	VMH	30371894
MMDBr0006573	Water	L-Glutamine	Not Available	Metabolism (Formation/Degradation) of PhetyrGln	VMH	30371894
MMDBr0006574	Water	L-Lysine	Not Available	Metabolism (Formation/Degradation) of PhetyrLys	VMH	30371894
MMDBr0006582	Water	Hydrogen Ion	Not Available	Metabolism (Formation/Degradation) of ProHistyr	VMH	30371894
MMDBr0006598	Water	L-Arginine	Not Available	Metabolism (Formation/Degradation) of ThrArgtyr	VMH	30371894
MMDBr0006599	Water	L-Asparagine	Not Available	Metabolism (Formation/Degradation) of ThrAsntyr	VMH	30371894
MMDBr0006601	Water	L-Glutamine	Not Available	Metabolism (Formation/Degradation) of ThrGlntyr	VMH	30371894
MMDBr0006608	Water	L-Methionine	Not Available	Metabolism (Formation/Degradation) of ThrtyrMet	VMH	30371894
MMDBr0006616	Water	L-Glutamic acid	Not Available	Metabolism (Formation/Degradation) of TrpGlutyr	VMH	30371894
MMDBr0006631	Water	L-Serine	Not Available	Metabolism (Formation/Degradation) of TrpSertyr	VMH	30371894
MMDBr0006634	Water	L-Threonine	Not Available	Metabolism (Formation/Degradation) of TrpThrtyr	VMH	30371894
MMDBr0006635	Water	L-Glutamine	Not Available	Metabolism (Formation/Degradation) of TrptyrGln	VMH	30371894
MMDBr0006636	Water	L-Tryptophan	Not Available	Metabolism (Formation/Degradation) of Trptyrtyr	VMH	30371894
MMDBr0006638	Water	L-Alanine	Not Available	Metabolism (Formation/Degradation) of TyrAla	VMH	30371894
MMDBr0006639	Water	L-Alanine	Not Available	Metabolism (Formation/Degradation) of TyrAlaPhe	VMH	30371894
MMDBr0006640	Water	L-Arginine	Not Available	Metabolism (Formation/Degradation) of TyrArgGlu	VMH	30371894
MMDBr0006641	Water	L-Arginine	Not Available	Metabolism (Formation/Degradation) of TyrArgSer	VMH	30371894
MMDBr0006642	Water	L-Arginine	Not Available	Metabolism (Formation/Degradation) of TyrAspArg	VMH	30371894
MMDBr0006643	Water	L-Cysteine	Not Available	Metabolism (Formation/Degradation) of TyrCysGly	VMH	30371894
MMDBr0006644	Water	L-Cysteine	Not Available	Metabolism (Formation/Degradation) of TyrCysThr	VMH	30371894
MMDBr0006645	Water	L-Glutamic acid	Not Available	Metabolism (Formation/Degradation) of TyrGlu	VMH	30371894
MMDBr0006646	Water	L-Arginine	Not Available	Metabolism (Formation/Degradation) of TyrLeuArg	VMH	30371894
MMDBr0006647	Water	L-Phenylalanine	Not Available	Metabolism (Formation/Degradation) of TyrPhetyr	VMH	30371894
MMDBr0006648	Water	L-Threonine	Not Available	Metabolism (Formation/Degradation) of TyrThr	VMH	30371894
MMDBr0006649	Water	L-Phenylalanine	Not Available	Metabolism (Formation/Degradation) of TyrTrpPhe	VMH	30371894
MMDBr0006650	Water	L-Tyrosine	Not Available	Metabolism (Formation/Degradation) of Tyrtyr	VMH	30371894
MMDBr0006651	Water	L-Methionine	Not Available	Metabolism (Formation/Degradation) of TyrValMet	VMH	30371894
MMDBr0006655	Water	L-Lysine	Not Available	Metabolism (Formation/Degradation) of ValLystyr	VMH	30371894
MMDBr0007119	L-Arogenate	Carbon dioxide	Not Available	Arogenate dehydrogenase (NAD+)	VMH	30371894
MMDBr0007120	L-Arogenate	Carbon dioxide	Not Available	Arogenate dehydrogenase (NADP+)	VMH	30371894
MMDBr0007450	Glycyl-L-tyrosine	Glycine	Not Available	Hydrolysis of Glycyl-L-tyrosine	VMH	30371894
MMDBr0007636	Hydrogen Ion	Hydrogen Ion	Not Available	L-tyrosine reversible transport via proton symport	VMH	30371894
MMDBr0007987	Oxoglutaric acid	4-Hydroxyphenylpyruvic acid	Not Available	Tyrosine Transaminase	VMH	30371894
MMDBr0008334	Oxygen	4a-Carbinolamine tetrahydrobiopterin	Not Available	L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase	VMH	30371894
MMDBr0008475	Hydrogen Ion	NAD	Not Available	Tyrosine deamination, forming p-hydroxyphenylpropionic acid (hypothetical reaction)	VMH	30371894
MMDBr0008555	Acetyl-CoA	N-Acetyl-L-tyrosine	Not Available	Acetylation of Tyrosine	VMH	30371894
MMDBr0010407	Oxygen	L-Dopa	Tyrosine hydroxylase	L-Tyrosine, Tetrahydrobiopterin:Oxygen Oxidoreductase (3-Hydroxylating)	VMH	30371894
MMDBr0010408	Hydrogen Ion	L-Dopa	Tyrosinase	L-Tyrosine:Oxygen Oxidoreductase	VMH	30371894
MMDBr0010411	Water	4-Hydroxyphenylpyruvic acid	Interleukin 4 induced 1	L-Tyrosine:Oxygen Oxidoreductase (Deaminating)	VMH	30371894
MMDBr0010419	Iodine	Iodotyrosine	Thyroid peroxidase	HMR_6793	VMH	30371894
MMDBr0010438	Oxygen	Dopaquinone	Tyrosinase	L-Tyrosine, L-Dopa:Oxygen Oxidoreductase	VMH	30371894
MMDBr0010842	Hydrogen Ion	Hydrogen Ion	Not Available	HMR_5099	VMH	30371894
MMDBr0010954	Water	Ammonia	Not Available	L tyrosine phenol lyase deaminating pyruvate forming	VMH	30371894
MMDBr0017847	L-Arogenate	Carbon dioxide	Cyclohexadienyl dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0017863	Hydrogen Ion	Carbon dioxide	Probable L-tyrosine/L-aspartate decarboxylase	Carboxylation	RHEA	34755880
MMDBr0017864	Hydrogen Ion	Carbon dioxide	L-tyrosine decarboxylase	Carboxylation	RHEA	34755880
MMDBr0017868	alpha-Ketoglutarate	3-(4-hydroxyphenyl)pyruvic acid	L-tyrosine:2-oxoglutarate aminotransferase amt1	Amine group addition	RHEA	34755880
MMDBr0017873	L-Tyrosine	3-amino-3-(4-hydroxyphenyl)propanoic acid	Tyrosine 2,3-aminomutase	Non-hydrolytic bond cleavage (or its reversal)	RHEA	34755880
MMDBr0017881	L-Tyrosine	Water	Polyphenol oxidase 1	Oxidation	RHEA	34755880
MMDBr0017889	L-erythro-tetrahydrobiopterin	(6R)-6-(l-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin	Phenylalanine-4-hydroxylase	Hydroxylation	RHEA	34755880
MMDBr0017904	Water	Ammonium	Tyrosine phenol-lyase	Non-hydrolytic bond cleavage (or its reversal)	RHEA	34755880
MMDBr0017918	L-Tyrosine	(E)-4-coumarate	Phenylalanine/tyrosine ammonia-lyase	Non-hydrolytic bond cleavage (or its reversal)	RHEA	34755880
MMDBr0017925	L-Tyrosine	2-iminoacetate	2-iminoacetate synthase	Synthesis	RHEA	34755880
MMDBr0017932	Hydrogen Ion	Hydrogen Ion	Aromatic amino acid transport protein AroP	Transport	RHEA	34755880
MMDBr0017933	Hydrogen Ion	Hydrogen Ion	Aromatic amino acid transport protein AroP	Transport	RHEA	34755880
MMDBr0017968	L-Tyrosine	3-methyl-L-tyrosine	L-tyrosine C(3)-methyltransferase	Methylation	RHEA	34755880
MMDBr0017969	Dimethylallylpyrophosphate	4-O-dimethylallyl-L-tyrosine	4-O-dimethylallyl-L-tyrosine synthase	Synthesis	RHEA	34755880
MMDBr0017974	D-Ribulose 5-phosphate	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoic acid	L-tyrosine isonitrile synthase	Synthesis	RHEA	34755880
MMDBr0017975	D-Ribulose 5-phosphate	(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoic acid	L-tyrosine isonitrile synthase	Synthesis	RHEA	34755880
MMDBr0017976	4-methylsulfanyl-2-oxobutanoic acid	3-(4-hydroxyphenyl)pyruvic acid	Tyrosine aminotransferase	Amine group addition	RHEA	34755880
MMDBr0017987	5-amino-6-(D-ribitylamino)uracil	2-iminoacetate	5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase	Synthesis	RHEA	34755880
MMDBr0017996	Adenosine monophosphate	Adenosine triphosphate	Aldehyde reductase lnaA	Reduction	RHEA	34755880
MMDBr0017997	Adenosine triphosphate	Adenosine monophosphate	Aldehyde reductase lnaA	Reduction	RHEA	34755880
MMDBr0018009	L-Tyrosine	D-Tyrosine	Broad substrate specificity amino-acid racemase	Racemization	RHEA	34755880
MMDBr0018015	Water	3-(4-hydroxyphenyl)pyruvic acid	L-amino acid oxidase	Oxidation	RHEA	34755880
MMDBr0018229	L-Tyrosine	Adenosine monophosphate	Tyrosine--tRNA ligase	Ligation	PathBank	31602464
MMDBr0018247	L-Glutamic acid	L-Tyrosine	Aromatic-amino-acid aminotransferase	Amine group addition	PathBank	31602464
MMDBr0018858	L-Tyrosine	L-Methionine	2-iminoacetate synthase	Synthesis	PathBank	31602464
MMDBr0019145	Water	L-Tyrosine	Phytase AppA	Hydrolysis	PathBank	31602464
MMDBr0019228	L-Tyrosine	L-Methionine	2-iminoacetate synthase	Synthesis	PathBank	31602464
MMDBr0019628	L-Alanine	L-Tyrosine	Aromatic amino acid aminotransferase 2	Amine group addition	PathBank	31602464
MMDBr0019629	L-Glutamic acid	L-Tyrosine	Aromatic/aminoadipate aminotransferase 1	Amine group addition	PathBank	31602464
MMDBr0024345	Adenosine triphosphate	Hydrogen Ion	Tyrosine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024355	Adenosine triphosphate	Hydrogen Ion	Tyrosine-protein kinase ptk	Phosphorylation	RHEA	34755880
MMDBr0024356	Adenosine triphosphate	Hydrogen Ion	Tyrosine-protein kinase PtkA	Phosphorylation	RHEA	34755880
MMDBr0024459	Uridine triphosphate	diphosphate	Bifunctional uridylyltransferase/uridylyl-removing enzyme	Transfer of an uridylyl group	RHEA	34755880
MMDBr0024571	Adenosine triphosphate	Hydrogen Ion	Probable tubulin--tyrosine ligase PBY1	Ligation	RHEA	34755880
MMDBr0024602	Adenosine triphosphate	diphosphate	Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme	Synthesis	RHEA	34755880
MMDBr0024738	L-Tyrosine	Hydrogen Ion	Glycogenin-2	Glycogen synthesis	RHEA	34755880
MMDBr0025165	Phosphate	L-Tyrosine	Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme	Synthesis	RHEA	34755880
MMDBr0025396	L-Tyrosine	Hydrogen Ion	Toxin Afp18		RHEA	34755880
MMDBr0025493	Adenosine triphosphate	diphosphate	Protein adenylyltransferase MntA	Reversible transfer of an adenylyl group	RHEA	34755880
MMDBr0025494	Adenosine triphosphate	diphosphate	Protein adenylyltransferase SelO	Reversible transfer of an adenylyl group	RHEA	34755880
MMDBr0025497	Guanosine triphosphate	diphosphate	Multifunctional virulence effector protein DrrA		RHEA	34755880
MMDBr0025868	Hydrogen Ion	Water	Hybrid PKS-NRPS synthetase iccA	Synthesis	RHEA	34755880
MMDBr0025869	Hydrogen Ion	Water	Hybrid PKS-NRPS synthetase iccA	Synthesis	RHEA	34755880
MMDBr0026138	L-Tyrosine	D-Tyrosine	Broad substrate specificity amino-acid racemase	Racemization	RHEA	34755880
MMDBr0026154	4-Hydroxyphenylpyruvic acid	L-Tyrosine	Ornithine aminotransferase	Amine group addition	RHEA	34755880
MMDBr0036103	N-Acetyl-L-tyrosine	Acetic acid	Acylamidase	Hydrolysis	RHEA	34755880
MMDBr0036147	L-Tyrosine	3-(4-hydroxyphenyl)pyruvic acid	L-amino acid dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0039022	L-Tyrosine	D-Tyrosine	Broad specificity amino-acid racemase	Racemization	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Alzheimer's disease		Association	Human Urine	HMDB	17031479
Alzheimer's disease		Association	Human Blood	HMDB	17031479
Alzheimer's disease	Slight Increase	Association	Human Saliva	HMDB	23857558
Alzheimer's disease	Increased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	17031479
Cachexia	Slight Increase	Association	Human Urine	HMDB	18953024
Epilepsy	Slight Decrease	Association	Human Cerebrospinal Fluid (CSF)	HMDB	1705463
Epilepsy	Decreased	Association	Human Blood	HMDB	14992292
Frontotemporal dementia	Increased	Association	Human Saliva	HMDB	23857558
Fumarase deficiency		Association	Human Blood	HMDB	20549362
Fumarase deficiency	Slight Increase	Association	Human Urine	HMDB	20549362
Hawkinsinuria	Increased	Association	Human Blood	HMDB	26226126
Hypermethioninemia		Association	Human Blood	HMDB	2380820
Hypothyroidism	Increased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	9849813
Leukemia		Association	Human Cerebrospinal Fluid (CSF)	HMDB	15911239
Myocardial infarction		Association	Human Blood	HMDB	822705
Schizophrenia	Decreased	Association	Human Blood	HMDB	25004141
Schizophrenia	Slight Increase	Association	Human Cerebrospinal Fluid (CSF)	HMDB	7595563
Schizophrenia	Slight Increase	Association	Human Blood	HMDB	2480613
Sepsis	Increased	Association	Human Blood	HMDB	26847922
Tyrosinemia		Association	Human Blood	HMDB	15168722
Tyrosinemia i	Increased	Association	Human Blood	HMDB	25443793
Tyrosinemia i		Association	Human Blood	HMDB	12872835
Viral infection		Association	Human Blood	HMDB	822705
Eosinophilic esophagitis		Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Eosinophilic esophagitis		Association	Human Urine	HMDB	Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Obesity		Association	Human Blood	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Obesity		Association	Human Blood	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Schizophrenia	increased	Association	Human urine	PubMed	30295550

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Firmicutes	789	Human feces; Goat feces; Sheep feces; Human ; Human vaginal secretion; Human stool; Human urine; Human sputum; Human pleural fluid plaque; Pig ; Human subgingival plaque; Human saliva; Human mucosa; Human supragingival plaque; Cattle	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Bacteroidetes	166	Human feces; Human stool; Human saliva; Human appendix biopsy; Human ; Human gastric fluid; Human urine; Human supragingival plaque; Human subgingival plaque	Microbial culture; Metabolic reconstruction
Bacteria	Proteobacteria	391	Human ; Human feces; Human sputum; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal; Human subgingival plaque; Chicken ; Human urine; Human supragingival plaque	Microbial culture; Metabolic reconstruction
Bacteria	Actinobacteria	265	Human ; Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human supragingival plaque; Human mucosa; Human subgingival plaque; Human saliva; Cattle	Microbial culture; Metabolic reconstruction
Bacteria	Verrucomicrobia	3	Human feces; Human stool; Human ; Human urine	Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Synergistetes	7	Human feces	Metabolic reconstruction
Bacteria	Spirochaetes	2	Human feces	Metabolic reconstruction
Archaea	Thaumarchaeota	2		Metabolic reconstruction
Bacteria	Fusobacteria	39	Human feces; Human	Metabolic reconstruction
Archaea	Euryarchaeota	10		Metabolic reconstruction
Bacteria	Candidatus melainabacteria	2	Human feces	Metabolic reconstruction
Bacteria	Tenericutes	8	Human feces	Metabolic reconstruction
Bacteria	Planctomycetes	2	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	2		Metabolic reconstruction
Archaea/Archaea	Euryarchaeota	24		Metabolic reconstruction
Eukaryota/Fungi	Basidiomycota	5	Human feces
Eukaryota/Fungi	Ascomycota	12	Human feces; Human saliva	Unknown
Bacteria/NULL	Actinobacteria	3	Human ; Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human supragingival plaque; Human mucosa; Human subgingival plaque; Human saliva; Cattle	Microbial culture; Metabolic reconstruction
Bacteria	Cyanobacteria	10	Human
Bacteria	nah	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference
Animal	Fish	Smelt	FooDB	31437929
Animal	Egg	Chicken	FooDB	31437929
Animal		Chicken	FooDB	31437929
Animal		Pig	FooDB	31437929
Animal		Deer	FooDB	31437929
Animal	Cheese	Cow	FooDB	31437929
Animal	Milk	Cow	FooDB	31437929
Animal		Cow	FooDB	31437929
Animal		Rabbit	FooDB	31437929
Animal	Crustaceans	Snow crab	FooDB	31437929
Animal	Fish	Salmon	FooDB	31437929
Food	Cocoa products	Cocoa	FooDB	31437929
Food	Tofu	Soy	FooDB	31437929
Food	Cheese	Cow	FooDB	31437929
Food	Coffee	Coffea arabica	FooDB	31437929
Plant		White mustard	FooDB	31437929
Plant		Horseradish tree	FooDB	31437929
Plant		Peanut	FooDB	31437929
Plant		Soy	FooDB	31437929
Plant		White lupine	FooDB	31437929
Plant		Winged bean	FooDB	31437929
Plant		Carob	FooDB	31437929
Plant		Red bell pepper	FooDB	31437929

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB
Human Urine	Detected and Quantified	10.5	1.5			umol/mmol creatinine	Adult (>18 years old)	Both	Alzheimer's disease	HMDB	17031479
Human Blood	Detected and Quantified	143.77	15.49			uM	Elderly (>65 years old)	Both	Alzheimer's disease	HMDB	17031479
Human Saliva	Detected and Quantified	21.64	9.24			uM	Adult (>18 years old)	Male	Alzheimer's disease	HMDB	23857558
Human Cerebrospinal fluid (csf)	Detected and Quantified	27.18	4.8			uM	Adult (>18 years old)	Both	Alzheimer's disease	HMDB	17031479
Human Urine	Detected and Quantified	10.72	4.63			umol/mmol creatinine	Adult (>18 years old)	Not Specified	Cachexia	HMDB	18953024
Human Blood	Detected and Quantified			143	246	uM	Newborn (0-30 days old)	Both	Citrullinemia type II, neonatal-onset	HMDB	11281457
Human Blood	Detected and Quantified	54.1	15.3			uM	Adult (>18 years old)	Female	Early preeclampsia	HMDB	22494326
Human Cerebrospinal fluid (csf)	Detected and Quantified	12.3	9.3			uM	Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human Cerebrospinal fluid (csf)	Detected and Quantified	13.0	10.6			uM	Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human Cerebrospinal fluid (csf)	Detected and Quantified	14.2	12.5			uM	Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human Blood	Detected and Quantified	50.7		46.8	54.6	uM	Adult (>18 years old)	Both	Epilepsy	HMDB	14992292
Human Cerebrospinal fluid (csf)	Detected and Quantified	8.05	3.03			uM	Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human Blood	Detected and Quantified	81.0		75.9	86.1	uM	Adult (>18 years old)	Both	Epilepsy	HMDB	14992292
Human Cerebrospinal fluid (csf)	Detected and Quantified	9.4	4.9			uM	Adult (>18 years old)	Not Specified	Epilepsy	HMDB	1705463
Human Saliva	Detected and Quantified	25.82	9.25			uM	Adult (>18 years old)	Male	Frontotemporal lobe dementia	HMDB	23857558
Human Blood	Detected and Quantified	257				uM	Infant (0-1 year old)	Male	Fumaric aciduria	HMDB	20549362
Human Urine	Detected and Quantified			35.150	369	umol/mmol creatinine	Infant (0-1 year old)	Not Specified	Fumaric aciduria	HMDB	20549362
Human Blood	Detected and Quantified			395.1	586.7	uM	Newborn (0-30 days old)		Hawkinsinuria	HMDB	26226126
Human Blood	Detected and Quantified			108	146	uM	Children (1-13 years old)	Female	S-Adenosylhomocysteine hydrolase deficiency	HMDB	2380820
Human Blood	Detected and Quantified			48	95	uM	Children (1-13 years old)	Female	S-Adenosylhomocysteine hydrolase deficiency	HMDB	2380820
Human Cerebrospinal fluid (csf)	Detected and Quantified	15.3		10.4	20.2	uM	Adult (>18 years old)	Both	Hypothyroidism	HMDB	9849813
Human Cerebrospinal fluid (csf)	Detected and Quantified	15.3	4.9			uM	Adult (>18 years old)	Not Specified	hypothyroidism	HMDB	9849813
Human Cerebrospinal fluid (csf)	Detected and Quantified	15.3	4.9			uM	Adult (>18 years old)	Both	Hypothyroidism	HMDB	9849813
Human Blood	Detected and Quantified	65.1	23.7			uM	Adult (>18 years old)	Female	Late-onset preeclampsia	HMDB	23159745
Human Cerebrospinal fluid (csf)	Detected and Quantified	12.6	3.3			uM	Children (1-13 years old)	Both	Leukemia	HMDB	15911239
Human Cerebrospinal fluid (csf)	Detected and Quantified	13.0	4.1			uM	Children (1-13 years old)	Both	Leukemia	HMDB	15911239
Human Saliva	Detected and Quantified	25.05	8.02			uM	Adult (>18 years old)	Both	Lewy body disease	HMDB	23857558
Human Blood	Detected and Quantified	74.0		71.0	77.0	uM	Adult (>18 years old)	Both	Myocardial infarction	HMDB	822705
Human Blood	Detected and Quantified	45.63	19.15			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	24704061
Human Blood	Detected and Quantified	54.1	20.7			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23313728
Human Blood	Detected and Quantified	55.82	19.6			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23535240
Human Blood	Detected and Quantified	58.0	22.3			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	22494326
Human Blood	Detected and Quantified	62.3	21.7			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23159745
Human Blood	Detected and Quantified	57.2	3.33			uM	Adult (>18 years old)	Both	Schizophrenia	HMDB	25004141
Human Cerebrospinal fluid (csf)	Detected and Quantified	7.8	1.38			uM	Adult (>18 years old)	Both	Schizophrenia	HMDB	7595563
Human Blood	Detected and Quantified	73.0	20.0			uM	Adult (>18 years old)	Female	Schizophrenia	HMDB	2480613
Human Blood	Detected and Quantified	91.2	30.0			uM	Adult (>18 years old)	Male	Schizophrenia	HMDB	2480613
Human Blood	Detected and Quantified	108		80	350	uM	Adult (>18 years old)	Both	Sepsis	HMDB	26847922
Human Blood	Detected and Quantified	1471.948				uM	Children (1 - 13 years old)	Male	Hereditary tyrosinemia	HMDB	15168722
Human Blood	Detected and Quantified	>220				uM	Newborn (0-30 days old)	Both	Tyrosinemia I	HMDB	25443793
Human Blood	Detected and Quantified			310	1410	uM	Children (1-13 years old)	Both	Tyrosinemia I	HMDB	12872835
Human Blood	Detected and Quantified	90.0		81.0	99.0	uM	Adult (>18 years old)	Both	Viral Infection	HMDB	822705
Human Urine	Detected and Quantified	7.5				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	21388201
Human Urine	Detected and Quantified	21				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	19309105
Human Sweat	Detected and Quantified	40				uM	Adult (40 years old)	Male	Normal	HMDB	22194922
Human Saliva	Detected and Quantified	>10				uM	Adult (>18 years old)	Both	Normal	HMDB	12097436
Human Saliva	Detected and Quantified			1	127	uM	Adult (>18 years old)	Male	normal	HMDB	19259987
Human Saliva	Detected and Quantified			1	68	uM	Adult (>18 years old)	Male	normal	HMDB	19259987
Human Saliva	Detected and Quantified			1	77	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Urine	Detected and Quantified	1.0	0.5			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	3168222
Human Urine	Detected and Quantified	1.9	0.7			umol/mmol creatinine	Infant (1 - 6 months old)	Both	Normal	HMDB	3168222
Human Cerebrospinal fluid (csf)	Detected and Quantified	10.1		6.37	13.8	uM	Adult (>18 years old)	Both	Normal	HMDB	12834252
Human Feces	Detected and Quantified	1048.632		588.706	1508.558	nmol/g wet feces	Infant (0-1 year old)	Not Specified	Normal	HMDB	22435727
Human Saliva	Detected and Quantified	11.8	6.2			uM	Adult (>18 years old)	Male	Normal	HMDB	21164041
Human Feces	Detected and Quantified	110	100			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	27624970
Human Feces	Detected and Quantified	114.246	94.322			nmol/g wet feces	Not Specified	Not Specified	Normal	HMDB	19573517
Human Saliva	Detected and Quantified	12		<1	49	uM	Adult (>18 years old)	Female	Normal	HMDB	19259987
Human Saliva	Detected and Quantified	12.0	5.8			uM	Adult (>18 years old)	Male	Normal	HMDB	21164041
Human Cerebrospinal fluid (csf)	Detected and Quantified	12.0	9.0			uM	Adult (>18 years old)	Both	Normal	HMDB	18502700
Human Cerebrospinal fluid (csf)	Detected and Quantified	12.2	3.8			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	22546835
Human Saliva	Detected and Quantified	12.2	3.8			uM	Adult (>18 years old)	Male	Normal	HMDB	21164041
Human Saliva	Detected and Quantified	13.7	3.6			uM	Adult (>18 years old)	Male	Normal	HMDB	21164041
Human Blood	Detected and Quantified	142.0	4.0			uM	Adult (>18 years old)	Both	Normal	HMDB	16789974
Human Blood	Detected and Quantified	143	35.3			uM	Adult (>18 years old)	Both	Normal	HMDB	21359215
Human Feces	Detected and Quantified	1453.367		607.103	2299.631	nmol/g wet feces	Infant (0-1 year old)	Not Specified	Normal	HMDB	22435727
Human Breast milk	Detected and Quantified	15.0	6.6			uM	Adult (>18 years old)	Female	Normal	HMDB	24027187
Human Urine	Detected and Quantified			15.0370	168.459	umol/mmol creatinine	Infant (0-1 year old)	Not Specified	Normal	HMDB	20549362
Human Urine	Detected and Quantified	15.1		6.1	23.2	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected and Quantified			2.1	14.81	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	32340350
Human Urine	Detected and Quantified	2.7	0.8			umol/mmol creatinine	Infant (6 months - <1 year old)	Both	Normal	HMDB	3168222
Human Cerebrospinal fluid (csf)	Detected and Quantified	24.5	8.9			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	15911239
Human Urine	Detected and Quantified	27.35	13.98			umol/mmol creatinine	Infant (0-1 year old)	Both	Normal	HMDB	2026685
Human Saliva	Detected and Quantified	30		<1	91	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Blood	Detected and Quantified			34	94	uM	Newborn (0-30 days old)	Not Specified	Normal	HMDB	11281457
Human Saliva	Detected and Quantified	36.17	15.02			uM	Adult (>18 years old)	Female	Normal	HMDB	23857558
Human Urine	Detected and Quantified			4.3	9.2	umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	27012787
Human Urine	Detected and Quantified	42.96	27.13			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human Feces	Detected and Quantified	478.323		294.353	662.294	nmol/g wet feces	Infant (0-1 year old)	Not Specified	Normal	HMDB	22435727
Human Saliva	Detected and Quantified	5		<1	78	uM	Adult (>18 years old)	Male	Normal	HMDB	19259987
Human Urine	Detected and Quantified	5.82	3.26			umol/mmol creatinine	Newborn (0-30 days old)	Female	Normal	HMDB	32340350
Human Urine	Detected and Quantified	5.96	2.98			umol/mmol creatinine	Newborn (0-30 days old)	Male	Normal	HMDB	32340350
Human Blood	Detected and Quantified	54.5	9.7			uM	Adult (>18 years old)	Both	Normal	HMDB	21359215
Human Blood	Detected and Quantified			55	147	uM	Newborn (0-30 days old)	Both	Normal	HMDB	26226126
Human Blood	Detected and Quantified			55	147	uM	Infant (0-1 year old)	Not Specified	Normal	HMDB	20549362
Human Blood	Detected and Quantified	59.0		47.0	71.0	uM	Adult (>18 years old)	Both	Normal	HMDB	12297216
Human Urine	Detected and Quantified			6	57	umol/mmol creatinine	Infant (0-1 year old)	Both	Normal	HMDB	30830347
Human Urine	Detected and Quantified			6.1	11.1	umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	27012787
Human Blood	Detected and Quantified	60.8		48.3	71.9	uM	Children (1-13 uears old)	Both	Normal	HMDB	27294788
Human Blood	Detected and Quantified	62.9	12.2			uM	Adult (>18 years old)	Both	Normal	HMDB	28278231
Human Blood	Detected and Quantified	65.1	2.55			uM	Adult (>18 years old)	Both	Normal	HMDB	25004141
Human Urine	Detected and Quantified	66.71	47.49			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human Urine	Detected and Quantified	7.41	2.30			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	15992788
Human Cerebrospinal fluid (csf)	Detected and Quantified	7.9	3.0			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	6198473
Human Sweat	Detected and Quantified			70	270	uM	Adult (60 years old)	Male	Normal	HMDB	22194922
Human Urine	Detected and Quantified	70.10	45.22			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human Feces	Detected and Quantified	700	420			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	27624970
Human Cerebrospinal fluid (csf)	Detected and Quantified	8.0	1.0			uM	Adult (>18 years old)	Both	Normal	HMDB	7595563
Human Urine	Detected and Quantified	8.7		3.0	20.1	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Blood	Detected and Quantified	81.9		69.8	94	uM	Newborn (0-30 days old)		Normal	HMDB	25754623
Human Blood	Detected and Quantified	84.2		67.5	109	uM	Infant (0-1 year old)		Normal	HMDB	25754623
Human Cerebrospinal fluid (csf)	Detected and Quantified	9.3	2.0			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	6198473
Human Urine	Detected and Quantified	9.5		4.1	23.5	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected and Quantified	16.005	10.562			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	20.2606	11.9167			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Blood	Detected and Quantified	82.5	21.1			uM	Children (1-13 years old)	Both	Obesity	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Human Blood	Detected and Quantified	91.7	19.9			uM	Children (1-13 years old)	Both	Obesity	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Human Urine	Detected and Quantified	14.588	10.744			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	24.3893	10.0806			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified			1.36	27.70	umol/mmol creatinine	Adolescent (13 - 21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			1.36	27.70	umol/mmol creatinine	Adult (>21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			12.55	66.48	umol/mmol creatinine	Infant (6 months - <1 year old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			13.79	63.88	umol/mmol creatinine	Infant (1 - 6 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			15.04	59.02	umol/mmol creatinine	Children (1 - 2 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			24	105	uM	Children (3 months - 6 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			29	135	uM	Infant (1 - 3 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Cerebrospinal fluid (csf)	Detected and Quantified			3.9	17	uM	Adolescent (>11 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Cerebrospinal fluid (csf)	Detected and Quantified			3.9	18.5	uM	Children (0 - 10 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			32	124	uM	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			43	88	uM	Children (6 - 18 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			6.22	42.62	umol/mmol creatinine	Children (4 - 13 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			6.22	67.72	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			9.95	29.96	umol/mmol creatinine	Children (2 - 4 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			5.52	38.66	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	David F. Putnam Composition and Concentrative Properties of Human Urine. NASA Contractor Report. July 1971
Human Urine	Detected and Quantified	0.72		0.18	1.38	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	120.0	100.0			uM	Newborn (0-30 days old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	4.2	1.85			umol/mmol creatinine	Children (1-13 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	46	8			uM	Children (1 - 13 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cerebrospinal fluid (csf)	Detected and Quantified	6.4	1.5			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	61	13			uM	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	61.0	13.0			uM	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	68.0	10.0			uM	Children (1-13 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	7.0	3.0			umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	72	15			uM	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	72.0	15.0			uM	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	8.8	4.5			umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	6.72				umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	Shaykhutdinov RA, MacInnis GD, Dowlatabadi R, Weljie AM, Vogel HJ. Quantitative analysis of metabolite concentrations in human urine samples using 13C{1H} NMR spectroscopy. Metabolomics. 2009
Human Saliva	Detected and Quantified	11.1	7.65			uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	15.1	10.3			uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	39.85	24.71			uM	Adult (>18 years old)	Both	Normal	HMDB	Zerihun T. Dame, Farid Aziat, Rupasri Mandal, Ram Krishnamurthy, Souhaila Bouatra, Shima Borzouie, An Chi Guo, Tanvir Sajed, Lu Deng, Hong Lin, Philip Liu, Edison Dong, David S. Wishart "The human saliva metabolome" Metabolomics (2015) DOI 10.1007/s11306-015-0840-5
Human Blood	Detected and Quantified			35.0	80.0	uM	Adult (>18 years old)	Both	Normal	HMDB	Molecular You (https://molecularyou.com)
Human Urine	Detected and Quantified			1.36	23.53	umol/mmol creatinine	Adolescent (13-18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified			1.70	13.0086	umol/mmol creatinine	Adult (>18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified			2.49	27.71	umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified			2.60	28.73	umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified			4.30	54.18	umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified			4.42	77.47	umol/mmol creatinine	Infant (0-1 year old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human All tissues	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Placenta	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Prostate	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	20300169
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	22727327
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Saliva	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	22308371
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	18052033
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	18085514
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	19573517
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	20669995
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21761941
Human Feces	Detected but not Quantified						Infant (0-1 year old)	Both	Normal	HMDB	22411374
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	24029555
Human Feces	Detected but not Quantified						Infant (0-1 year old)	Both	Normal	HMDB	24375085
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	19678709
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25670064
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	19636438
Human Feces	Detected but not Quantified						Children (1-13 years old)	Both	Normal	HMDB	19636438
Human Feces	Detected but not Quantified						Adult (>18 years old)	Female	Normal	HMDB	26709303
Human Feces	Detected but not Quantified						Not Specified	Both	Normal	HMDB	25486321
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	17269711
Human Feces	Detected but not Quantified						Children (1-13 years old)	Both	Normal	HMDB	24130822
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25598765
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27065191
Human Feces	Detected but not Quantified						Children (6 - 18 years old)	Not Specified	Normal	HMDB	27609529
Human Sweat	Detected but not Quantified						Adult	Both	Normal	HMDB	26755145
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	19754154
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	25985090
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	28157703
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

HMDB ID

HMDB0000158

DrugBank ID

DB00135

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

6057

PDB ID

Not Available

ChEBI ID

17895

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

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Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50. doi: 10.1023/a:1024255208563. [PubMed:12834252 ]
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Showing metabocard for L-Tyrosine (MMDBc0000047)

MOL for #<Metabolite:0x00007f5abc4d94f0>

3D MOL for #<Metabolite:0x00007f5abc4d94f0>

3D SDF for #<Metabolite:0x00007f5abc4d94f0>

3D-SDF for #<Metabolite:0x00007f5abc4d94f0>

PDB for #<Metabolite:0x00007f5abc4d94f0>

3D PDB for #<Metabolite:0x00007f5abc4d94f0>

SMILES for #<Metabolite:0x00007f5abc4d94f0>

INCHI for #<Metabolite:0x00007f5abc4d94f0>

Structure for #<Metabolite:0x00007f5abc4d94f0>

3D Structure for #<Metabolite:0x00007f5abc4d94f0>