Showing metabocard for p-Cresol (MMDBc0000003)

Record Information
Version1.0
StatusDetected and Quantified
Creation Date2020-10-27 23:39:38 UTC
Update Date2022-12-15 22:51:38 UTC
Metabolite IDMMDBc0000003
Metabolite Identification
Common Namep-Cresol
Descriptionp-Cresol (4-methylphenol), a 108.1 Da volatile low-molecular-weight compound, is a phenol. It is a partially lipophilic moiety which strongly binds to plasma protein (close to 100%) under normal conditions. p-Cresol is metabolized through conjugation, mainly sulphation and glucuronization, but removal of the unconjugated p-cresol is, at least in part, via the urine. Therefore it is not surprising that this compound, together with several other phenoles, is retained when the kidneys fail. P-Cresol is an end-product of protein breakdown, and an increase of the nutritional protein load in healthy individuals results in enhanced generation and urinary excretion. The serum p-cresol concentration in uremic patients can be decreased by changing to a low-protein diet. p-Cresol is one of the metabolites of the amino acid tyrosine, and to a certain extent also of phenylalanine, which are converted to 4-hydroxyphenylacetic acid by intestinal bacteria, before being decarboxylated to p-cresol (putrefaction). The main contributing bacteria are aerobes (mainly enterobacteria), but to a certain extent also anaerobes play a role (mainly Clostridium perfringens). In uremia, modifications in the intestinal flora result in the specific overgrowth of bacteria that are specific p-cresol producers. The administration of antibiotics reduces urinary excretion of p-cresol, as a result of the liquidation of the producing bacteria. Environmental factors might also contribute. The liver cytochrome P450 metabolizes toluene to benzyl alcohol, but also to o-cresol and p-cresol. Toluene is not only used industrially, but it is also the most widely abusively inhaled solvent. Furthermore, p-cresol is a metabolite of menthofuran, one of the metabolites of R-(+)-pulegone, which is found in extracts from the plants Mentha pulegium and Hedeoma pulegioides, commonly known as pennyroyal oil and pennyroyal tea. These extracts are popular as unconventional herbal therapeutic agents and are applied as abortiva, diaphoretics, emmenagogues, and psychedelic drugs. Pennyroyal oil is extensively used for its pleasant mint-like smell in the flavoring industry. The toxicity of pennyroyal oil and menthofuran is well known. Another compound used in traditional medicine, especially in Japan, which is a precursor of p-cresol is wood tar creosote. p-Cresol has been reported to affect several biochemical, biological and physiological functions: (i) it diminishes the oxygen uptake of rat cerebral cortex slices; (ii) it increases the free active drug concentration of warfarin and diazepam; (iii) it has been related to growth retardation in the weanling pig; (iv) it alters cell membrane permeability, at least in bacteria; (v) it induces LDH leakage from rat liver slices; (vi) it induces susceptibility to auditive epileptic crises; and (vii) it blocks cell K+ channels. (PMID: 10570076 ). p-Cresol is a uremic toxin that is at least partially removed by peritoneal dialysis in haemodialysis patients, and has been involved in the progression of renal failure. (PMID: 11169029 ). At concentrations encountered during uremia, p-cresol inhibits phagocyte function and decreases leukocyte adhesion to cytokine-stimulated endothelial cells. (PMID: 14681860 ). p-Cresol can be found in Bacteroides, Bifidobacterium, Clostridium, Enterobacter and Lactobacillus (PMID: 2394806 ; PMID: 30208103 ). As a volatile organic compound, it has been identified as a fecal biomarker of Clostridium difficile infection (PMID: 30986230 ). 
Structure
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for #<Metabolite:0x00005619a6ee49e8>


  Mrv1652309272007362D          

  8  8  0  0  0  0            999 V2000
    0.5801    1.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    1.5169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    0.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5801    0.2793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2946    0.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2946    1.5169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0092    1.9294    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8482    0.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  6  7  1  0  0  0  0
  3  8  1  0  0  0  0
M  END
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3D MOL for #<Metabolite:0x00005619a6ee49e8>

HMDB0001858
     RDKit          3D
p-Cresol
 16 16  0  0  0  0  0  0  0  0999 V2000
    2.4917    0.0122   -0.1070 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9960   -0.0026   -0.0795 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -1.1791   -0.1632 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1004   -1.1644   -0.1355 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8225    0.0083   -0.0245 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2196    0.0251    0.0037 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0871    1.1759    0.0581 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2912    1.1789    0.0319 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8257   -0.8254   -0.7535 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7842    1.0063   -0.4837 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8746   -0.1906    0.9267 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8275   -2.1089   -0.2507 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6608   -2.0960   -0.2019 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6584   -0.0457    0.9352 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6601    2.0913    0.1449 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8383    2.1146    0.0989 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  1  9  1  0
  1 10  1  0
  1 11  1  0
  3 12  1  0
  4 13  1  0
  6 14  1  0
  7 15  1  0
  8 16  1  0
M  END
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3D SDF for #<Metabolite:0x00005619a6ee49e8>


  Mrv1652309272007362D          

  8  8  0  0  0  0            999 V2000
    0.5801    1.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    1.5169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    0.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5801    0.2793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2946    0.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2946    1.5169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0092    1.9294    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8482    0.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  6  7  1  0  0  0  0
  3  8  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0000003

> <DATABASE_NAME>
MIME

> <SMILES>
CC1=CC=C(O)C=C1

> <INCHI_IDENTIFIER>
InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3

> <INCHI_KEY>
IWDCLRJOBJJRNH-UHFFFAOYSA-N

> <FORMULA>
C7H8O

> <MOLECULAR_WEIGHT>
108.1378

> <EXACT_MASS>
108.057514878

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
16

> <JCHEM_AVERAGE_POLARIZABILITY>
11.926991180769898

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
4-methylphenol

> <ALOGPS_LOGP>
1.95

> <JCHEM_LOGP>
2.1831018836666667

> <ALOGPS_LOGS>
-0.67

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.357335371423924

> <JCHEM_PKA_STRONGEST_BASIC>
-5.436049745016864

> <JCHEM_POLAR_SURFACE_AREA>
20.23

> <JCHEM_REFRACTIVITY>
33.0801

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.31e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
P-cresol

> <JCHEM_VEBER_RULE>
1

$$$$
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3D-SDF for #<Metabolite:0x00005619a6ee49e8>

HMDB0001858
     RDKit          3D
p-Cresol
 16 16  0  0  0  0  0  0  0  0999 V2000
    2.4917    0.0122   -0.1070 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9960   -0.0026   -0.0795 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -1.1791   -0.1632 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1004   -1.1644   -0.1355 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8225    0.0083   -0.0245 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2196    0.0251    0.0037 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0871    1.1759    0.0581 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2912    1.1789    0.0319 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8257   -0.8254   -0.7535 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7842    1.0063   -0.4837 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8746   -0.1906    0.9267 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8275   -2.1089   -0.2507 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6608   -2.0960   -0.2019 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6584   -0.0457    0.9352 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6601    2.0913    0.1449 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8383    2.1146    0.0989 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  2  1  0
  1  9  1  0
  1 10  1  0
  1 11  1  0
  3 12  1  0
  4 13  1  0
  6 14  1  0
  7 15  1  0
  8 16  1  0
M  END
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PDB for #<Metabolite:0x00005619a6ee49e8>

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  C   UNK     0       1.083   3.602   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.250   2.832   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.250   1.291   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.083   0.521   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.417   1.291   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.417   2.832   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       3.750   3.602   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -1.583   0.522   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4    8                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    1    7                                                  
CONECT    7    6                                                            
CONECT    8    3                                                            
MASTER        0    0    0    0    0    0    0    0    8    0   16    0
END
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3D PDB for #<Metabolite:0x00005619a6ee49e8>

COMPND    HMDB0001858
HETATM    1  C1  UNL     1       2.492   0.012  -0.107  1.00  0.00           C  
HETATM    2  C2  UNL     1       0.996  -0.003  -0.080  1.00  0.00           C  
HETATM    3  C3  UNL     1       0.280  -1.179  -0.163  1.00  0.00           C  
HETATM    4  C4  UNL     1      -1.100  -1.164  -0.135  1.00  0.00           C  
HETATM    5  C5  UNL     1      -1.823   0.008  -0.024  1.00  0.00           C  
HETATM    6  O1  UNL     1      -3.220   0.025   0.004  1.00  0.00           O  
HETATM    7  C6  UNL     1      -1.087   1.176   0.058  1.00  0.00           C  
HETATM    8  C7  UNL     1       0.291   1.179   0.032  1.00  0.00           C  
HETATM    9  H1  UNL     1       2.826  -0.825  -0.754  1.00  0.00           H  
HETATM   10  H2  UNL     1       2.784   1.006  -0.484  1.00  0.00           H  
HETATM   11  H3  UNL     1       2.875  -0.191   0.927  1.00  0.00           H  
HETATM   12  H4  UNL     1       0.828  -2.109  -0.251  1.00  0.00           H  
HETATM   13  H5  UNL     1      -1.661  -2.096  -0.202  1.00  0.00           H  
HETATM   14  H6  UNL     1      -3.658  -0.046   0.935  1.00  0.00           H  
HETATM   15  H7  UNL     1      -1.660   2.091   0.145  1.00  0.00           H  
HETATM   16  H8  UNL     1       0.838   2.115   0.099  1.00  0.00           H  
CONECT    1    2    9   10   11
CONECT    2    3    3    8
CONECT    3    4   12
CONECT    4    5    5   13
CONECT    5    6    7
CONECT    6   14
CONECT    7    8    8   15
CONECT    8   16
END
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SMILES for #<Metabolite:0x00005619a6ee49e8>

CC1=CC=C(O)C=C1
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INCHI for #<Metabolite:0x00005619a6ee49e8>

InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3
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Synonyms
ValueSource
1-Hydroxy-4-methylbenzeneChEBI
4-CresolChEBI
4-HydroxytolueneChEBI
4-MethylphenolChEBI
p-KresolChEBI
p-MethylphenolChEBI
p-Tolyl alcoholChEBI
ParacresolChEBI
1-Methyl-4-hydroxybenzeneHMDB
4-(Pentafluorosulfanyl)phenolHMDB
4-Methyl phenolHMDB
4-Methyl-phenolHMDB
P-CresylateHMDB
P-Cresylic acidHMDB
P-HydroxytolueneHMDB
P-Methyl phenolHMDB
P-MethylhydroxybenzeneHMDB
P-OxytolueneHMDB
P-ToluolHMDB
Paramethyl phenolHMDB
4-Cresol, potassium saltMeSH, HMDB
m-CresolMeSH, HMDB
4-Cresol, aluminum saltMeSH, HMDB
4-Cresol, sodium saltMeSH, HMDB
Para-cresolMeSH, HMDB
Molecular FormulaC7H8O
Average Mass108.1378
Monoisotopic Mass108.057514878
IUPAC Name4-methylphenol
Traditional NameP-cresol
CAS Registry Number106-44-5
SMILES
CC1=CC=C(O)C=C1
InChI Identifier
InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3
InChI KeyIWDCLRJOBJJRNH-UHFFFAOYSA-N