MiMeDB: Showing metabocard for L-Methionine (MMDBc0000140)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:37:20 UTC

Update Date

2024-09-28 01:06:13 UTC

Metabolite ID

MMDBc0000140

Metabolite Identification

Common Name

L-Methionine

Description

Methionine is an essential amino acid (there are 9 essential amino acids) required for normal growth and development of humans, other mammals, and avian species. In addition to being a substrate for protein synthesis, it is an intermediate in transmethylation reactions, serving as the major methyl group donor in vivo, including the methyl groups for DNA and RNA intermediates. Methionine is a methyl acceptor for 5-methyltetrahydrofolate-homocysteine methyltransferase (methionine synthase), the only reaction that allows for the recycling of this form of folate, and is also a methyl acceptor for the catabolism of betaine. Methionine is the metabolic precursor for cysteine. Only the sulfur atom from methionine is transferred to cysteine; the carbon skeleton of cysteine is donated by serine (PMID: 16702340 ). There is a general consensus concerning normal sulfur amino acid (SAA) requirements. WHO recommendations amount to 13 mg/kg per 24 h in healthy adults. This amount is roughly doubled in artificial nutrition regimens. In disease or after trauma, requirements may be altered for methionine, cysteine, and taurine. Although in specific cases of congenital enzyme deficiency, prematurity, or diminished liver function, hypermethioninemia or hyperhomocysteinemia may occur, SAA supplementation can be considered safe in amounts exceeding 2-3 times the minimum recommended daily intake. Apart from some very specific indications (e.g. acetaminophen poisoning) the usefulness of SAA supplementation is not yet established (PMID: 16702341 ). Methionine is known to exacerbate psychopathological symptoms in schizophrenic patients, but there is no evidence of similar effects in healthy subjects. The role of methionine as a precursor of homocysteine is the most notable cause for concern. Acute doses of methionine can lead to acute increases in plasma homocysteine, which can be used as an index of the susceptibility to cardiovascular disease. Sufficiently high doses of methionine can actually result in death. Longer-term studies in adults have indicated no adverse consequences of moderate fluctuations in dietary methionine intake, but intakes higher than 5 times the normal amount resulted in elevated homocysteine levels. These effects of methionine on homocysteine and vascular function are moderated by supplements of vitamins B-6, B-12, C, and folic acid (PMID: 16702346 ). When present in sufficiently high levels, methionine can act as an atherogen and a metabotoxin. An atherogen is a compound that when present at chronically high levels causes atherosclerosis and cardiovascular disease. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of methionine are associated with at least ten inborn errors of metabolism, including cystathionine beta-synthase deficiency, glycine N-methyltransferase deficiency, homocystinuria, tyrosinemia, galactosemia, homocystinuria-megaloblastic anemia due to defects in cobalamin metabolism, methionine adenosyltransferase deficiency, methylenetetrahydrofolate reductase deficiency, and S-adenosylhomocysteine (SAH) hydrolase deficiency. Chronically elevated levels of methionine in infants can lead to intellectual disability and other neurological problems, delays in motor skills, sluggishness, muscle weakness, and liver problems. Many individuals with these metabolic disorders tend to develop cardiovascular disease later in life. Studies on feeding rodents high levels of methionine have shown that methionine promotes atherosclerotic plaques independently of homocysteine levels (PMID: 26647293 ). A similar study in Finnish men showed the same effect (PMID: 16487911 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₅H₁₁NO₂S

Average Mass

149.211

Monoisotopic Mass

149.051049291

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

63-68-3

SMILES

Not Available

InChI Identifier

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI Key

FFEARJCKVFRZRR-BYPYZUCNSA-N

Chemical Taxonomy

Functional Ontology

Physical Properties

Spectra

Biological Properties

Human Proteins and Enzymes

Human Pathways

Metabolic Reactions

Health Effects and Bioactivity

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Bacteroidetes	238	Human feces; Human stool; Human ; Human urine; Human saliva; Human subgingival plaque; Human appendix biopsy; Human gastric fluid; Human supragingival plaque	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Firmicutes	892	Human feces; Goat feces; Sheep feces; Human ; Human vaginal secretion; Human stool; Human urine; Human sputum; Human pleural fluid plaque; Pig ; Human subgingival plaque; Human saliva; Human mucosa; Human supragingival plaque; Cattle ; Catfish	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Eukaryota	Parabasalia	1		Microbial culture
Bacteria	Proteobacteria	727	Human saliva; Human feces; Human urine; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal; Cattle ; Lion ; Chicken ; River trout ; Turkey ; Rat ; Dog ; Human subgingival plaque	Microbial culture; Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Deinococcus-thermus	6		Microbial culture
Bacteria	Tenericutes	17	Human feces; Goat ; Human	Microbial culture; Metabolic reconstruction
Bacteria	Synergistetes	8	Human feces	Microbial culture; Metabolic reconstruction
Bacteria	Fusobacteria	42	Human mucosa; Human supragingival plaque; Human ; Human urine; Human feces; Human saliva; Human subgingival plaque	Microbial culture; Metabolic reconstruction
Bacteria	Verrucomicrobia	3	Human feces; Human stool; Human ; Human urine	Indirect association between microbiota composition and metabolites measured in host biospecimen; Metabolic reconstruction
Bacteria	Actinobacteria	294	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human supragingival plaque; Human mucosa; Human subgingival plaque; Human saliva; Cattle	Metabolic reconstruction
Bacteria	Spirochaetes	14	Human feces; Human ; Pig	Metabolic reconstruction
Archaea	Thaumarchaeota	2		Metabolic reconstruction
Archaea	Euryarchaeota	11		Metabolic reconstruction
Bacteria	Candidatus melainabacteria	2	Human feces	Metabolic reconstruction
Bacteria	Planctomycetes	3	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	2		Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	8	Human feces; Human saliva	Unknown
Bacteria	nah	2
Archaea/Archaea	Euryarchaeota	36		Metabolic reconstruction
Bacteria	Aquificae	1
Bacteria	Cyanobacteria	35	Human
Archaea/Archaea	Crenarchaeota	16		Metabolic reconstruction
Bacteria	Chloroflexi	8
Bacteria	Chlorobi	10
Bacteria	Thermotogae	10
Bacteria	Nitrospirae	1
Bacteria	Acidobacteria	1
Bacteria	Chlamydiae	5	Human ; Sheep ; Cat

Exposure Sources

Source Type	Source Sub-type	Source Name	Data Source	Reference
Animal	Not Available	African ostrich	FooDB	34893796
Animal	Not Available	Agar	FooDB	DTU
Animal	Not Available	American butterfish	FooDB	34893796
Animal	Not Available	American lobster	FooDB	34893796
Animal	Not Available	American shad	FooDB	34893796
Animal	Not Available	Anchovy	FooDB	34893796
Animal	Not Available	Anguilliformes	FooDB	DTU
Animal	Not Available	Atlantic cod	FooDB	34893796
Animal	Not Available	Atlantic croaker	FooDB	34893796
Animal	Not Available	Atlantic halibut	FooDB	DTU
Animal	Not Available	Atlantic herring	FooDB	34893796
Animal	Not Available	Atlantic pollock	FooDB	34893796
Animal	Not Available	Atlantic salmon	FooDB	34893796
Animal	Not Available	Atlantic wolffish	FooDB	DTU
Animal	Not Available	Blue crab	FooDB	34893796
Animal	Not Available	Blue mussel	FooDB	34893796
Animal	Not Available	Bluefish	FooDB	34893796
Animal	Not Available	Burbot	FooDB	DTU
Animal	Not Available	Carp bream	FooDB	DTU
Animal	Not Available	Catfish	FooDB	34893796
Animal	Not Available	Channel catfish	FooDB	34893796
Animal	Not Available	Charr	FooDB	DTU
Animal	Not Available	Chicken	FooDB	DTU
Animal	Not Available	Chinook salmon	FooDB	34893796
Animal	Not Available	Chum salmon	FooDB	34893796
Animal	Not Available	Cichlidae (tilapia)	FooDB	34893796
Animal	Not Available	Cisco	FooDB	34893796
Animal	Not Available	Clawed lobster	FooDB	DTU
Animal	Not Available	Clupeinae (herring, sardine, sprat)	FooDB	DTU
Animal	Not Available	Coho salmon	FooDB	34893796
Animal	Not Available	Common carp	FooDB	34893796
Animal	Not Available	Common dab	FooDB	DTU
Animal	Not Available	Common ling	FooDB	34893796
Animal	Not Available	Common octopus	FooDB	DTU
Animal	Not Available	Cow	FooDB	34893796
Animal	Not Available	Crab	FooDB	DTU
Animal	Not Available	Crayfish	FooDB	DTU
Animal	Not Available	Cusk	FooDB	34893796
Animal	Not Available	Cuttlefish	FooDB	34893796
Animal	Not Available	Domestic goat	FooDB	34893796
Animal	Not Available	Dungeness crab	FooDB	34893796
Animal	Not Available	Eastern oyster	FooDB	34893796
Animal	Not Available	European anchovy	FooDB	34893796
Animal	Not Available	Flatfish	FooDB	DTU
Animal	Not Available	Florida pompano	FooDB	34893796
Animal	Not Available	Freshwater drum	FooDB	34893796
Animal	Not Available	Freshwater eel	FooDB	34893796
Animal	Not Available	Gadiformes	FooDB	DTU
Animal	Not Available	Gadus (common cod)	FooDB	DTU
Animal	Not Available	Garfish	FooDB	DTU
Animal	Not Available	Greater sturgeon	FooDB	34893796
Animal	Not Available	Greenland halibut/turbot	FooDB	DTU
Animal	Not Available	Grouper	FooDB	34893796
Animal	Not Available	Haddock	FooDB	DTU
Animal	Not Available	Hippoglossus (common halibut)	FooDB	34893796
Animal	Not Available	Japanese sea bass	FooDB	34893796
Animal	Not Available	Kelp	FooDB	34893796
Animal	Not Available	King mackerel	FooDB	34893796
Animal	Not Available	Kombu	FooDB	DTU
Animal	Not Available	Lake trout	FooDB	DTU
Animal	Not Available	Laver	FooDB	34893796
Animal	Not Available	Lemon sole	FooDB	DTU
Animal	Not Available	Lingcod	FooDB	34893796
Animal	Not Available	Lumpsucker	FooDB	DTU
Animal	Not Available	Marine mussel	FooDB	DTU
Animal	Not Available	Milkfish	FooDB	34893796
Animal	Not Available	Mollusks	FooDB	34893796
Animal	Not Available	Monkfish	FooDB	34893796
Animal	Not Available	Mountain hare	FooDB	DTU
Animal	Not Available	Northern bluefin tuna	FooDB	34893796
Animal	Not Available	Northern pike	FooDB	DTU
Animal	Not Available	Norway lobster	FooDB	DTU
Animal	Not Available	Norway pout	FooDB	DTU
Animal	Not Available	Ocean pout	FooDB	34893796
Animal	Not Available	Orange roughy	FooDB	34893796
Animal	Not Available	Pacific cod	FooDB	34893796
Animal	Not Available	Pacific halibut	FooDB	34893796
Animal	Not Available	Pacific herring	FooDB	34893796
Animal	Not Available	Pacific jack mackerel	FooDB	34893796
Animal	Not Available	Pacific ocean perch	FooDB	DTU
Animal	Not Available	Pacific oyster	FooDB	34893796
Animal	Not Available	Pacific rockfish	FooDB	34893796
Animal	Not Available	Perciformes	FooDB	DTU
Animal	Not Available	Percoidei (bass and others)	FooDB	34893796
Animal	Not Available	Pig	FooDB	34893796
Animal	Not Available	Pikeperch	FooDB	DTU
Animal	Not Available	Pink salmon	FooDB	34893796
Animal	Not Available	Pleuronectidae (dab, halibut, plaice)	FooDB	DTU
Animal	Not Available	Pollock	FooDB	DTU
Animal	Not Available	Rainbow smelt	FooDB	34893796
Animal	Not Available	Rainbow trout	FooDB	DTU
Animal	Not Available	Red king crab	FooDB	34893796
Animal	Not Available	Sablefish	FooDB	34893796
Animal	Not Available	Salmonidae (salmon, trout)	FooDB	DTU
Animal	Not Available	Scallop	FooDB	34893796
Animal	Not Available	Scombridae (bonito, mackerel, tuna)	FooDB	DTU
Animal	Not Available	Scup	FooDB	34893796
Animal	Not Available	Sea trout	FooDB	34893796
Animal	Not Available	Shark	FooDB	34893796
Animal	Not Available	Sheefish	FooDB	34893796
Animal	Not Available	Sheepshead	FooDB	34893796
Animal	Not Available	Shrimp	FooDB	DTU
Animal	Not Available	Skipjack tuna	FooDB	34893796
Animal	Not Available	Smelt	FooDB	34893796
Animal	Not Available	Snail	FooDB	DTU
Animal	Not Available	Snapper	FooDB	34893796
Animal	Not Available	Snow crab	FooDB	34893796
Animal	Not Available	Sockeye salmon	FooDB	34893796
Animal	Not Available	Spanish mackerel	FooDB	34893796
Animal	Not Available	Spiny dogfish	FooDB	DTU
Animal	Not Available	Spiny lobster	FooDB	34893796
Animal	Not Available	Spirulina	FooDB	34893796
Animal	Not Available	Spot croaker	FooDB	34893796
Animal	Not Available	Squid	FooDB	34893796
Animal	Not Available	Striped bass	FooDB	34893796
Animal	Not Available	Striped mullet	FooDB	34893796
Animal	Not Available	Sturgeon	FooDB	DTU
Animal	Not Available	Swordfish	FooDB	34893796
Animal	Not Available	Thunnus	FooDB	DTU
Animal	Not Available	Tilefish	FooDB	34893796
Animal	Not Available	True sole	FooDB	34893796
Animal	Not Available	Turbot	FooDB	DTU
Animal	Not Available	Wakame	FooDB	34893796
Animal	Not Available	Whelk	FooDB	34893796
Animal	Not Available	White sucker	FooDB	34893796
Animal	Not Available	Whitefish	FooDB	DTU
Animal	Not Available	Whiting	FooDB	DTU
Animal	Not Available	Yellowfin tuna	FooDB	34893796
Animal	Not Available	Yellowtail amberjack	FooDB	34893796
Animal	Brain	Cow	FooDB	34893796
Animal	Egg	Anser	FooDB	DTU
Animal	Egg	Chicken	FooDB	DTU
Animal	Egg	Mallard duck	FooDB	DTU
Animal	Egg	Whitefish	FooDB	34893796
Animal	Fat	Anser	FooDB	DTU
Animal	Fat	Cow	FooDB	DTU
Animal	Fat	Domestic pig	FooDB	DTU
Animal	Fat	Wild boar	FooDB	DTU
Animal	Fillet	Blue whiting	FooDB	DTU
Animal	Fillet	Catfish	FooDB	DTU
Animal	Fillet	Common ling	FooDB	DTU
Animal	Fillet	Gadus (common cod)	FooDB	DTU
Animal	Fillet	Norway haddock	FooDB	DTU
Animal	Fillet	Pollock	FooDB	DTU
Animal	Fllet	Gadus (common cod)	FooDB	DTU
Animal	Hand	Pig	FooDB	DTU
Animal	Hand with rind	Pig	FooDB	DTU
Animal	Heart	Chicken	FooDB	DTU
Animal	Heart	Cow	FooDB	DTU
Animal	Heart	Pig	FooDB	DTU
Animal	Hind leg without rind	Pig	FooDB	DTU
Animal	Kidney	Cow	FooDB	DTU
Animal	Kidney	Pig	FooDB	DTU
Animal	Leg	Cow	FooDB	34893796
Animal	Leg	True frog	FooDB	DTU
Animal	Leg meat	Pig	FooDB	DTU
Animal	Leg with knuckle	Pig	FooDB	DTU
Animal	Liver	Chicken	FooDB	DTU
Animal	Liver	Cow	FooDB	DTU
Animal	Liver	Duck	FooDB	DTU
Animal	Liver	Gadus (common cod)	FooDB	DTU
Animal	Liver	Goose	FooDB	DTU
Animal	Liver	Pig	FooDB	DTU
Animal	Lung	Cow	FooDB	34893796
Animal	Meat	African ostrich	FooDB	34893796
Animal	Meat	Bison	FooDB	34893796
Animal	Meat	Buffalo	FooDB	34893796
Animal	Meat	Chicken	FooDB	DTU
Animal	Meat	Cow	FooDB	DTU
Animal	Meat	Crab	FooDB	DTU
Animal	Meat	Deer	FooDB	34893796
Animal	Meat	Domestic goat	FooDB	34893796
Animal	Meat	Domestic pigeon	FooDB	34893796
Animal	Meat	Duck	FooDB	DTU
Animal	Meat	Elk	FooDB	34893796
Animal	Meat	Emu	FooDB	34893796
Animal	Meat	Goose	FooDB	DTU
Animal	Meat	Helmeted guineafowl	FooDB	34893796
Animal	Meat	Horse	FooDB	34893796
Animal	Meat	Pheasant	FooDB	34893796
Animal	Meat	Pig	FooDB	DTU
Animal	Meat	Quail	FooDB	34893796
Animal	Meat	Rabbit	FooDB	DTU
Animal	Meat	Rock ptarmigan	FooDB	DTU
Animal	Meat	Sheep (mutton, lamb)	FooDB	DTU
Animal	Meat	Squab	FooDB	DTU
Animal	Meat	Turkey	FooDB	DTU
Animal	Meat	Wild boar	FooDB	34893796
Animal	Meat and skin	Chicken	FooDB	DTU
Animal	Meat and skin	Duck	FooDB	DTU
Animal	Meat and skin	Goose	FooDB	DTU
Animal	Meat and skin	Pig	FooDB	DTU
Animal	Meat and skin	Squab	FooDB	34893796
Animal	Meat and skin	Turkey	FooDB	DTU
Animal	Milk	Cow	FooDB	30994344
Animal	Milk	Domestic goat	FooDB	DTU
Animal	Milk	Human	FooDB	DTU
Animal	Neck	Pig	FooDB	DTU
Animal	Oil	Gadus (common cod)	FooDB	DTU
Animal	Oil	Haddock	FooDB	DTU
Animal	Pancreas	Cow	FooDB	34893796
Animal	Rib	Cow	FooDB	34893796
Animal	Rib	Pig	FooDB	DTU
Animal	Roe	Fish	FooDB	34893796
Animal	Roe	Gadus (common cod)	FooDB	DTU
Animal	Shoulder	Cow	FooDB	34893796
Animal	Shoulder	Pig	FooDB	DTU
Animal	Skin	Pig	FooDB	34893796
Animal	Spleen	Cow	FooDB	34893796
Animal	Suet	Cow	FooDB	34893796
Animal	Thymus	Cow	FooDB	DTU
Animal	Thymus	Sheep (mutton, lamb)	FooDB	DTU
Animal	Tongue	Cow	FooDB	DTU
Animal	Tongue	Pig	FooDB	DTU
Food	Not Available	Alcoholic beverage	FooDB	Manually Annotated
Food	Not Available	Arabica coffee	FooDB	DTU
Food	Not Available	Beer	FooDB	DTU
Food	Not Available	Brandy	FooDB	DTU
Food	Not Available	Red wine	FooDB	DTU
Food	Not Available	Robusta coffee	FooDB	DTU
Food	Not Available	Rose wine	FooDB	DTU
Food	Not Available	Spanish lager	FooDB	27664616
Food	Not Available	Whisky	FooDB	DTU
Food	Not Available	White wine	FooDB	DTU
Food	Not Available	White wine derived from fermenting yeast ec1118.	FooDB	21371950
Food	Not Available	White wine derived from fermenting yeast fermicru 4f9.	FooDB	21371950
Food	Not Available	White wine derived from fermenting yeast oenoferm veltliner.	FooDB	21371950
Food	Not Available	White wine derived from fermenting yeast weiss&komplex.	FooDB	21371950
Food	Cocoa products	Cocoa bean	FooDB	DTU
Food	Coffee	Arabica coffee	FooDB	DTU
Food	Coffee	Robusta coffee	FooDB	DTU
Plant	Not Available	Agave	FooDB	34893796
Plant	Not Available	Allium	FooDB	DTU
Plant	Not Available	Almond	FooDB	DTU
Plant	Not Available	Amaranth	FooDB	34893796
Plant	Not Available	Banana	FooDB	34893796
Plant	Not Available	Black salsify	FooDB	DTU
Plant	Not Available	Black walnut	FooDB	DTU
Plant	Not Available	Broccoli	FooDB	DTU
Plant	Not Available	Brussel sprouts	FooDB	DTU
Plant	Not Available	Cabbage	FooDB	34893796
Plant	Not Available	Carrot	FooDB	Manually Annotated
Plant	Not Available	Cassava	FooDB	DTU
Plant	Not Available	Cauliflower	FooDB	DTU
Plant	Not Available	Celery stalks	FooDB	34893796
Plant	Not Available	Chanterelle	FooDB	DTU
Plant	Not Available	Cherimoya	FooDB	DTU
Plant	Not Available	Chervil	FooDB	DTU
Plant	Not Available	Chicory	FooDB	DTU
Plant	Not Available	Chinese cabbage	FooDB	DTU
Plant	Not Available	Chinese chives	FooDB	34893796
Plant	Not Available	Chives	FooDB	DTU
Plant	Not Available	Cinnamon	FooDB	DTU
Plant	Not Available	Common bean	FooDB	Manually Annotated
Plant	Not Available	Common cabbage	FooDB	DTU
Plant	Not Available	Common mushroom	FooDB	DTU
Plant	Not Available	Common oregano	FooDB	34893796
Plant	Not Available	Common pea	FooDB	DTU
Plant	Not Available	Cucumber	FooDB	Manually Annotated
Plant	Not Available	Dill	FooDB	DTU
Plant	Not Available	Dock	FooDB	34893796
Plant	Not Available	Eggplant	FooDB	Manually Annotated
Plant	Not Available	Endive	FooDB	DTU
Plant	Not Available	Feijoa	FooDB	34893796
Plant	Not Available	French plantain	FooDB	DTU
Plant	Not Available	Garden cress	FooDB	DTU
Plant	Not Available	Garden onion	FooDB	Manually Annotated
Plant	Not Available	Garden rhubarb	FooDB	DTU
Plant	Not Available	Garlic	FooDB	DTU
Plant	Not Available	Globe artichoke	FooDB	DTU
Plant	Not Available	Green zucchini	FooDB	Manually Annotated
Plant	Not Available	Horseradish	FooDB	DTU
Plant	Not Available	Ice queen lettuce	FooDB	34893796
Plant	Not Available	Italian oregano	FooDB	34893796
Plant	Not Available	Jackfruit	FooDB	34893796
Plant	Not Available	Jerusalem artichoke	FooDB	DTU
Plant	Not Available	Jicama	FooDB	34893796
Plant	Not Available	Jute	FooDB	34893796
Plant	Not Available	Kale	FooDB	DTU
Plant	Not Available	Kohlrabi	FooDB	DTU
Plant	Not Available	Lambsquarters	FooDB	34893796
Plant	Not Available	Lentils	FooDB	DTU
Plant	Not Available	Lettuce	FooDB	DTU
Plant	Not Available	Longan	FooDB	34893796
Plant	Not Available	Loquat	FooDB	DTU
Plant	Not Available	Maitake	FooDB	34893796
Plant	Not Available	Mamey sapote	FooDB	34893796
Plant	Not Available	Mexican oregano	FooDB	34893796
Plant	Not Available	Mountain yam	FooDB	34893796
Plant	Not Available	Nopal	FooDB	34893796
Plant	Not Available	Nutmeg	FooDB	DTU
Plant	Not Available	Okra	FooDB	DTU
Plant	Not Available	Oyster mushroom	FooDB	DTU
Plant	Not Available	Pak choy	FooDB	DTU
Plant	Not Available	Papaya	FooDB	DTU
Plant	Not Available	Parsley	FooDB	DTU
Plant	Not Available	Parsnip	FooDB	DTU
Plant	Not Available	Peanut	FooDB	34893796
Plant	Not Available	Pepper	FooDB	Manually Annotated
Plant	Not Available	Pepper (spice)	FooDB	DTU
Plant	Not Available	Peppermint	FooDB	34893796
Plant	Not Available	Potato	FooDB	DTU
Plant	Not Available	Quinoa	FooDB	34893796
Plant	Not Available	Romaine lettuce	FooDB	DTU
Plant	Not Available	Rosemary	FooDB	34893796
Plant	Not Available	Round kumquat	FooDB	DTU
Plant	Not Available	Sapodilla	FooDB	34893796
Plant	Not Available	Saskatoon berry	FooDB	Manually Annotated
Plant	Not Available	Savoy cabbage	FooDB	DTU
Plant	Not Available	Shallot	FooDB	34893796
Plant	Not Available	Shiitake	FooDB	34893796
Plant	Not Available	Sorrel	FooDB	DTU
Plant	Not Available	Soy bean	FooDB	DTU
Plant	Not Available	Spearmint	FooDB	34893796
Plant	Not Available	Spinach	FooDB	DTU
Plant	Not Available	Sunburst squash (pattypan squash)	FooDB	Manually Annotated
Plant	Not Available	Swamp cabbage	FooDB	34893796
Plant	Not Available	Swede	FooDB	DTU
Plant	Not Available	Sweet basil	FooDB	34893796
Plant	Not Available	Sweet potato	FooDB	DTU
Plant	Not Available	Swiss chard	FooDB	DTU
Plant	Not Available	Tamarind	FooDB	34893796
Plant	Not Available	Taro	FooDB	34893796
Plant	Not Available	Teff	FooDB	34893796
Plant	Not Available	Turnip	FooDB	DTU
Plant	Not Available	Watercress	FooDB	DTU
Plant	Not Available	Welsh onion	FooDB	34893796
Plant	Not Available	White cabbage	FooDB	DTU
Plant	Not Available	Wild celery	FooDB	DTU
Plant	Not Available	Wild leek	FooDB	DTU
Plant	Not Available	Winter squash	FooDB	Manually Annotated
Plant	Not Available	Yardlong bean	FooDB	34893796
Plant	Bean	Common bean	FooDB	DTU
Plant	Bean sprout	Common bean	FooDB	DTU
Plant	Bean sprout	Mung bean	FooDB	DTU
Plant	Bulb	Garden onion	FooDB	DUKE
Plant	Bulb	Soft-necked garlic	FooDB	DUKE
Plant	Bulb and lower leaf-portion	Wild leek	FooDB	34893796
Plant	Flour	Arrowroot	FooDB	34893796
Plant	Flour	Carob	FooDB	34893796
Plant	Flour	Peanut	FooDB	34893796
Plant	Flour	Potato	FooDB	DTU
Plant	Flour	Soy bean	FooDB	DTU
Plant	Flower	Sesbania flower	FooDB	34893796
Plant	Fruit	Acorn squash	FooDB	34893796
Plant	Fruit	Apple	FooDB	DTU
Plant	Fruit	Apricot	FooDB	DTU
Plant	Fruit	Asian pear	FooDB	34893796
Plant	Fruit	Avocado	FooDB	DTU
Plant	Fruit	Bilberry	FooDB	DTU
Plant	Fruit	Blackcurrant	FooDB	DTU
Plant	Fruit	Breadfruit	FooDB	DUKE
Plant	Fruit	Butternut squash	FooDB	34893796
Plant	Fruit	Calabash	FooDB	DUKE
Plant	Fruit	Cantaloupe melon	FooDB	34893796
Plant	Fruit	Chayote	FooDB	DTU
Plant	Fruit	Coconut	FooDB	DTU
Plant	Fruit	Common bean	FooDB	DUKE
Plant	Fruit	Common grape	FooDB	DUKE
Plant	Fruit	Common pea	FooDB	DUKE
Plant	Fruit	Common persimmon	FooDB	34893796
Plant	Fruit	Cucumber	FooDB	DTU
Plant	Fruit	Cucurbita	FooDB	DTU
Plant	Fruit	Custard apple	FooDB	DUKE
Plant	Fruit	Date	FooDB	DTU
Plant	Fruit	Eggplant	FooDB	DTU
Plant	Fruit	Elderberry	FooDB	DTU
Plant	Fruit	European plum	FooDB	DTU
Plant	Fruit	Fig	FooDB	DTU
Plant	Fruit	Garden tomato	FooDB	DTU
Plant	Fruit	Garden tomato (var.)	FooDB	DUKE
Plant	Fruit	Gooseberry	FooDB	DTU
Plant	Fruit	Grape	FooDB	DTU
Plant	Fruit	Grapefruit	FooDB	DTU
Plant	Fruit	Grapefruit/pummelo hybrid	FooDB	34893796
Plant	Fruit	Green zucchini	FooDB	DTU
Plant	Fruit	Groundcherry	FooDB	DTU
Plant	Fruit	Guava	FooDB	DTU
Plant	Fruit	Highbush blueberry	FooDB	DUKE
Plant	Fruit	Japanese persimmon	FooDB	34893796
Plant	Fruit	Kiwi	FooDB	DTU
Plant	Fruit	Lemon	FooDB	DTU
Plant	Fruit	Lichee	FooDB	DTU
Plant	Fruit	Lime	FooDB	DTU
Plant	Fruit	Lingonberry	FooDB	DTU
Plant	Fruit	Loganberry	FooDB	DTU
Plant	Fruit	Malus (crab apple)	FooDB	DTU
Plant	Fruit	Mandarin orange (clementine, tangerine)	FooDB	DTU
Plant	Fruit	Mango	FooDB	DTU
Plant	Fruit	Matrimony vine	FooDB	34893796
Plant	Fruit	Monk fruit	FooDB	34893796
Plant	Fruit	Muskmelon	FooDB	DTU
Plant	Fruit	Nectarine	FooDB	DTU
Plant	Fruit	Papaya	FooDB	DUKE
Plant	Fruit	Passion fruit	FooDB	DTU
Plant	Fruit	Peach	FooDB	DTU
Plant	Fruit	Peach (var.)	FooDB	34893796
Plant	Fruit	Pear	FooDB	DTU
Plant	Fruit	Pepper	FooDB	All-Creatures
Plant	Fruit	Pepper (c. frutescens)	FooDB	DUKE
Plant	Fruit	Persian lime	FooDB	34893796
Plant	Fruit	Persimmon	FooDB	DTU
Plant	Fruit	Pineapple	FooDB	DTU
Plant	Fruit	Plums	FooDB	34893796
Plant	Fruit	Pomegranate	FooDB	DTU
Plant	Fruit	Prickly pear	FooDB	DTU
Plant	Fruit	Prunus (cherry, plum)	FooDB	DTU
Plant	Fruit	Quince	FooDB	DTU
Plant	Fruit	Redcurrant	FooDB	DTU
Plant	Fruit	Rose hip	FooDB	DTU
Plant	Fruit	Soursop	FooDB	DUKE
Plant	Fruit	Star fruit	FooDB	DTU
Plant	Fruit	Strawberry	FooDB	DTU
Plant	Fruit	Strawberry guava	FooDB	DUKE
Plant	Fruit	Sugar apple	FooDB	DUKE
Plant	Fruit	Sunburst squash (pattypan squash)	FooDB	DTU
Plant	Fruit	Sweet orange	FooDB	DTU
Plant	Fruit	Tamarind	FooDB	DTU
Plant	Fruit	Vaccinium (blueberry, cranberry, huckleberry)	FooDB	DTU
Plant	Fruit	Watermelon	FooDB	DTU
Plant	Fruit	Wax gourd	FooDB	DUKE
Plant	Fruit	Winter squash	FooDB	DTU
Plant	Fruit	Yardlong bean	FooDB	DUKE
Plant	Ground	Cinnamon	FooDB	34893796
Plant	Ground	Cloves	FooDB	34893796
Plant	Ground	Turmeric	FooDB	34893796
Plant	Herb	Purslane	FooDB	DUKE
Plant	Herb	Watercress	FooDB	DUKE
Plant	Juice	Blackcurrant	FooDB	DTU
Plant	Juice	Elderberry	FooDB	DTU
Plant	Juice	Grape	FooDB	DTU
Plant	Juice	Lemon	FooDB	DTU
Plant	Juice	Prunus (cherry, plum)	FooDB	DTU
Plant	Juice	Strawberry	FooDB	DTU
Plant	Leaves	Amaranth	FooDB	DUKE
Plant	Leaves	Brussel sprouts	FooDB	DUKE
Plant	Leaves	Cabbage	FooDB	DUKE
Plant	Leaves	Celery leaves	FooDB	DTU
Plant	Leaves	Chicory	FooDB	DUKE
Plant	Leaves	Chives	FooDB	DUKE
Plant	Leaves	Coriander	FooDB	DTU
Plant	Leaves	Dandelion	FooDB	DTU
Plant	Leaves	Endive	FooDB	DUKE
Plant	Leaves	Fenugreek	FooDB	DUKE
Plant	Leaves	Jute	FooDB	DUKE
Plant	Leaves	Lambsquarters	FooDB	DUKE
Plant	Leaves	Lettuce	FooDB	DUKE
Plant	Leaves	Malabar spinach	FooDB	DUKE
Plant	Leaves	Swamp cabbage	FooDB	DUKE
Plant	Leaves	Sweet basil	FooDB	DUKE
Plant	Leaves	Taro	FooDB	DUKE
Plant	Leaves	Tea	FooDB	DTU
Plant	Leaves	White cabbage	FooDB	DUKE
Plant	Leaves	Winged bean	FooDB	DUKE
Plant	Nut	Acorn	FooDB	34893796
Plant	Nut	Almond	FooDB	34893796
Plant	Nut	Beech nut	FooDB	34893796
Plant	Nut	Black walnut	FooDB	34893796
Plant	Nut	Brazil nut	FooDB	DTU
Plant	Nut	Butternut	FooDB	34893796
Plant	Nut	Chestnut	FooDB	DTU
Plant	Nut	Chinese chestnut	FooDB	34893796
Plant	Nut	Coconut	FooDB	34893796
Plant	Nut	Colorado pinyon	FooDB	34893796
Plant	Nut	Common hazelnut	FooDB	34893796
Plant	Nut	Common walnut	FooDB	34893796
Plant	Nut	European chestnut	FooDB	34893796
Plant	Nut	Ginkgo nuts	FooDB	34893796
Plant	Nut	Hazelnut	FooDB	DTU
Plant	Nut	Hickory nut	FooDB	34893796
Plant	Nut	Japanese chestnut	FooDB	34893796
Plant	Nut	Macadamia nut	FooDB	34893796
Plant	Nut	Macadamia nut (m. tetraphylla)	FooDB	34893796
Plant	Nut	Peanut	FooDB	DTU
Plant	Nut	Pecan nut	FooDB	DTU
Plant	Nut	Pili nut	FooDB	34893796
Plant	Nut	Pine nut	FooDB	DTU
Plant	Nut	Pistachio	FooDB	DTU
Plant	Nut	Walnut	FooDB	34893796
Plant	Oil	Canola oil	FooDB	34893796
Plant	Oil	Coconut	FooDB	DTU
Plant	Oil	Cottonseed	FooDB	DTU
Plant	Oil	Cottonseed oil	FooDB	34893796
Plant	Oil	Flaxseed	FooDB	DTU
Plant	Oil	Grapeseed oil	FooDB	34893796
Plant	Oil	Oil palm	FooDB	DTU
Plant	Oil	Olive	FooDB	DTU
Plant	Oil	Peanut	FooDB	DTU
Plant	Oil	Rape	FooDB	DTU
Plant	Oil	Safflower	FooDB	DTU
Plant	Oil	Sesame	FooDB	DTU
Plant	Oil	Soy bean	FooDB	DTU
Plant	Oil	Sunflower	FooDB	DTU
Plant	Oil	Thistle	FooDB	DTU
Plant	Oil	Ucuhuba	FooDB	34893796
Plant	Oil	Walnut	FooDB	DTU
Plant	Peel	Lemon	FooDB	DTU
Plant	Plant	Apple	FooDB	DUKE
Plant	Plant	Common thyme	FooDB	DUKE
Plant	Plant	Corn salad	FooDB	DUKE
Plant	Plant	Guava	FooDB	DUKE
Plant	Plant	Parsley	FooDB	DUKE
Plant	Plant	Spinach	FooDB	DUKE
Plant	Powder	Garlic	FooDB	DTU
Plant	Powder	Rose hip	FooDB	DTU
Plant	Rhizome	Sacred lotus	FooDB	DUKE
Plant	Root	Burdock	FooDB	DUKE
Plant	Root	Carrot	FooDB	DTU
Plant	Root	Cassava	FooDB	DUKE
Plant	Root	Common beet	FooDB	34893796
Plant	Root	Daikon radish	FooDB	DTU
Plant	Root	Fennel	FooDB	DTU
Plant	Root	Ginger	FooDB	DTU
Plant	Root	Horseradish	FooDB	DTU
Plant	Root	Lotus	FooDB	34893796
Plant	Root	Mountain yam	FooDB	DUKE
Plant	Root	Parsley	FooDB	DTU
Plant	Root	Prairie turnip	FooDB	DUKE
Plant	Root	Radish	FooDB	DUKE
Plant	Root	Red beetroot	FooDB	DTU
Plant	Root	Sweet potato	FooDB	DUKE
Plant	Root	Taro	FooDB	DUKE
Plant	Root	Wild carrot	FooDB	DUKE
Plant	Seed	Adzuki bean	FooDB	DTU
Plant	Seed	Alfalfa	FooDB	DTU
Plant	Seed	Amaranth	FooDB	34893796
Plant	Seed	Black-eyed pea	FooDB	34893796
Plant	Seed	Brazil nut	FooDB	DUKE
Plant	Seed	Breadfruit	FooDB	DUKE
Plant	Seed	Breadnut tree seed	FooDB	34893796
Plant	Seed	Broad bean	FooDB	DUKE
Plant	Seed	Butternut	FooDB	DUKE
Plant	Seed	Carob	FooDB	DUKE
Plant	Seed	Cashew nut	FooDB	DUKE
Plant	Seed	Catjang pea	FooDB	34893796
Plant	Seed	Chia	FooDB	34893796
Plant	Seed	Chickpea	FooDB	DTU
Plant	Seed	Colorado pinyon	FooDB	DUKE
Plant	Seed	Common bean	FooDB	DTU
Plant	Seed	Common pea	FooDB	DTU
Plant	Seed	Common walnut	FooDB	DUKE
Plant	Seed	Coriander	FooDB	DTU
Plant	Seed	Cottonseed	FooDB	34893796
Plant	Seed	Cowpea	FooDB	34893796
Plant	Seed	Dill	FooDB	DUKE
Plant	Seed	European chestnut	FooDB	DUKE
Plant	Seed	Evening primrose	FooDB	DUKE
Plant	Seed	Fennel	FooDB	DTU
Plant	Seed	Fenugreek	FooDB	DUKE
Plant	Seed	Flaxseed	FooDB	DTU
Plant	Seed	Ginkgo nuts	FooDB	DUKE
Plant	Seed	Gram bean	FooDB	34893796
Plant	Seed	Hyacinth bean	FooDB	DUKE
Plant	Seed	Lima bean	FooDB	DUKE
Plant	Seed	Lupine	FooDB	34893796
Plant	Seed	Macadamia nut	FooDB	DUKE
Plant	Seed	Moth bean	FooDB	DUKE
Plant	Seed	Mung bean	FooDB	DTU
Plant	Seed	Peanut	FooDB	DUKE
Plant	Seed	Peas	FooDB	34893796
Plant	Seed	Pigeon pea	FooDB	DUKE
Plant	Seed	Pistachio	FooDB	DUKE
Plant	Seed	Poppy	FooDB	DTU
Plant	Seed	Sacred lotus	FooDB	DUKE
Plant	Seed	Sesame	FooDB	DTU
Plant	Seed	Soy bean	FooDB	DTU
Plant	Seed	Sunburst squash (pattypan squash)	FooDB	34893796
Plant	Seed	Sunflower	FooDB	DTU
Plant	Seed	Watermelon	FooDB	DUKE
Plant	Seed	White lupine	FooDB	DUKE
Plant	Seed	White mustard	FooDB	DUKE
Plant	Seed	Winged bean	FooDB	DUKE
Plant	Seed	Winter squash	FooDB	34893796
Plant	Seed	Yardlong bean	FooDB	DUKE
Plant	Seed oil	Grape	FooDB	DTU
Plant	Shoot	Asparagus	FooDB	DTU
Plant	Shoot	Bamboo shoots	FooDB	DTU
Plant	Shoot	Celeriac	FooDB	DTU
Plant	Shoot	Horseradish tree	FooDB	DUKE
Plant	Sprout	Soy bean	FooDB	DTU
Plant	Sprout seedling	Common bean	FooDB	DUKE
Plant	Sprout seedling	Lentils	FooDB	DUKE
Plant	Sprout seedling	Mung bean	FooDB	DUKE
Plant	Stem	Kohlrabi	FooDB	DUKE
Plant	Tuber	Jerusalem artichoke	FooDB	DUKE
Plant	Tuber	Jicama	FooDB	DUKE
Plant	Tuber	Potato	FooDB	DUKE
Plant	Tuber	Winged bean	FooDB	DUKE
Plant	Tuber	Yam	FooDB	DTU

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB
Human Cerebrospinal fluid (csf)	Detected and Quantified	41				uM	Adolescent (13-18 years old)	Female	Adenosine kinase deficiency	HMDB	21963049
Human Cerebrospinal fluid (csf)	Detected and Quantified	44				uM	Adult (>18 years old)	Male	Adenosine kinase deficiency	HMDB	21963049
Human Blood	Detected and Quantified	455				uM	Adult (>18 years old)	Male	Adenosine kinase deficiency	HMDB	21963049
Human Blood	Detected and Quantified	550				uM	Children (1-13 years old)	Male	Adenosine kinase deficiency	HMDB	21963049
Human Blood	Detected and Quantified	800				uM	Adult (>18 years old)	Male	Adenosine kinase deficiency	HMDB	21963049
Human Blood	Detected and Quantified	886				uM	Adolescent (13-18 years old)	Female	Adenosine kinase deficiency	HMDB	21963049
Human Blood	Detected and Quantified			229	465	uM	Newborn (0-30 days old)	Both	Citrullinemia type II, neonatal-onset	HMDB	11281457
Human Blood	Detected and Quantified	10				uM	Infant (0-1 year old)	Female	Cobalamin F disease (cblF)	HMDB	21910240
Human Blood	Detected and Quantified	20.6	4.2			uM	Adult (>18 years old)	Female	Early preeclampsia	HMDB	22494326
Human Blood	Detected and Quantified	17.8		17.0	18.6	uM	Adult (>18 years old)	Both	Epilepsy	HMDB	14992292
Human Blood	Detected and Quantified	70				uM	Infant (0-1 year old)	Male	Fumaric aciduria	HMDB	20549362
Human Blood	Detected and Quantified			815	1247	uM	Children (1 - 13 years old)	Male	Glycine N-Methyltransferase deficiency	HMDB	27207470
Human Blood	Detected and Quantified	415.0	7.0			uM	Adult (>18 years old)	Both	Heart failure	HMDB	16789974
Human Blood	Detected and Quantified	503				uM	Children (1 - 13 years old)	Male	Homocystinuria	HMDB	8745393
Human Blood	Detected and Quantified	134.34				uM	Children (1-13 years old)	Female	Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type	HMDB	21559159
Human Blood	Detected and Quantified			20	273	uM	Newborn (0-30 days old)	Both	S-Adenosylhomocysteine hydrolase deficiency	HMDB	27671891
Human Blood	Detected and Quantified			230	1000	uM	Children (1-13 years old)	Female	S-Adenosylhomocysteine hydrolase deficiency	HMDB	2380820
Human Blood	Detected and Quantified			37	400	uM	Children (1-13 years old)	Female	S-Adenosylhomocysteine hydrolase deficiency	HMDB	2380820
Human Blood	Detected and Quantified			477	784	uM	Children (1-13 years old)	Male	Hypermethioninemia	HMDB	15024124
Human Blood	Detected and Quantified	24.7	7.4			uM	Adult (>18 years old)	Female	Late-onset preeclampsia	HMDB	23159745
Human Cerebrospinal fluid (csf)	Detected and Quantified	3.5	0.4			uM	Children (1-13 years old)	Not Specified	Leukemia	HMDB	15911239
Human Cerebrospinal fluid (csf)	Detected and Quantified	6.0	5.3			uM	Children (1-13 years old)	Not Specified	Leukemia	HMDB	15911239
Human Blood	Detected and Quantified			100	800	uM	Children (1-13 years old)	Female	Methionine adenosyltransferase deficiency	HMDB	7229751
Human Blood	Detected and Quantified			244	1270	uM	Infant (0-1 year old)	Both	Methionine adenosyltransferase deficiency	HMDB	7229751
Human Blood	Detected and Quantified	<6				uM	Adult (>18 years old)	Male	Methylenetetrahydrofolate reductase deficiency	HMDB	8456826
Human Blood	Detected and Quantified	27	6			uM	Children (1-13 years old)	Both	Obese	HMDB	24740590
Human Blood	Detected and Quantified	27.55	6.81			uM	Children (1-13 years old)	Both	Obese	HMDB	23108202
Human Blood	Detected and Quantified	29	6			uM	Children (1-13 years old)	Both	Obese	HMDB	24740590
Human Blood	Detected and Quantified	30	7			uM	Children (1-13 years old)	Both	Obese	HMDB	24740590
Human Blood	Detected and Quantified	30	9			uM	Children (1-13 years old)	Both	Obese	HMDB	24740590
Human Blood	Detected and Quantified	15.3	4.66			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	24704061
Human Blood	Detected and Quantified	23.5	7.1			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	22494326
Human Blood	Detected and Quantified	23.6	6.5			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23159745
Human Blood	Detected and Quantified	26.09	11.26			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23535240
Human Blood	Detected and Quantified	32.6	11.5			uM	Adult (>18 years old)	Female	Pregnancy	HMDB	23313728
Human Cerebrospinal fluid (csf)	Detected and Quantified	2.7	0.67			uM	Adult (>18 years old)	Both	Schizophrenia	HMDB	7595563
Human Blood	Detected and Quantified	26	7			uM	Adult (>18 years old)	Female	Schizophrenia	HMDB	2415198
Human Blood	Detected and Quantified	27	7			uM	Adult (>18 years old)	Male	Schizophrenia	HMDB	2415198
Human Blood	Detected and Quantified	1965.673				uM	Children (1 - 13 years old)	Male	Hereditary tyrosinemia	HMDB	15168722
Human Urine	Detected and Quantified	0.4				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	21388201
Human Urine	Detected and Quantified	1				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	19309105
Human Feces	Detected and Quantified	1834				nmol/g wet feces	Adult (>18 years old)	Not Specified	Normal	HMDB	26416813
Human Feces	Detected and Quantified	1953				nmol/g wet feces	Adult (>18 years old)	Not Specified	Normal	HMDB	26416813
Human Feces	Detected and Quantified	1957				nmol/g wet feces	Adult (>18 years old)	Not Specified	Normal	HMDB	26416813
Human Blood	Detected and Quantified			6	27	uM	Adult (>18 years old)	Both	Normal	HMDB	8456826
Human Sweat	Detected and Quantified	< 10				uM	Adult (60 years old)	Male	Normal	HMDB	22194922
Human Sweat	Detected and Quantified	< 10				uM	Adult (40 years old)	Male	Normal	HMDB	22194922
Human Cerebrospinal fluid (csf)	Detected and Quantified	<5				uM	Not Specified	Not Specified	Normal	HMDB	21963049
Human Blood	Detected and Quantified	<77				uM	Children (1 - 13 years old)	Male	Normal	HMDB	8745393
Human Blood	Detected and Quantified			0	90	uM	Children (1-13 years old)	Not Specified	Normal	HMDB	21559159
Human Urine	Detected and Quantified			0.32	21.05	umol/mmol creatinine	Newborn (0-30 days old)	Female	Normal	HMDB	25536744
Human Urine	Detected and Quantified			0.52	13.67	umol/mmol creatinine	Newborn (0-30 days old)	Male	Normal	HMDB	25536744
Human Urine	Detected and Quantified			0.54	4.81	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	32340350
Human Urine	Detected and Quantified	0.7	0.3			umol/mmol creatinine	Infant (1 - 6 months old)	Both	Normal	HMDB	3168222
Human Urine	Detected and Quantified	0.7	0.3			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	3168222
Human Urine	Detected and Quantified			0.75	1.1	umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	27012787
Human Urine	Detected and Quantified			0.75	1.4	umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	27012787
Human Urine	Detected and Quantified	0.8		0.4	1.6	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected and Quantified	1.21	1.20			umol/mmol creatinine	Infant (0-1 year old)	Both	Normal	HMDB	2026685
Human Urine	Detected and Quantified	1.4		0.5	2.5	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	24023812
Human Urine	Detected and Quantified	1.4	0.5			umol/mmol creatinine	Infant (6 months - <1 year old)	Both	Normal	HMDB	3168222
Human Urine	Detected and Quantified	1.70	1.01			umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	15992788
Human Blood	Detected and Quantified			10	60	uM	Infant (0-1 year old)	Not Specified	Normal	HMDB	20549362
Human Urine	Detected and Quantified			11.758	98.927	umol/mmol creatinine	Infant (0-1 year old)	Not Specified	Normal	HMDB	20549362
Human Blood	Detected and Quantified			13	32	uM	Newborn (0-30 days old)	Not Specified	Normal	HMDB	11281457
Human Blood	Detected and Quantified			13	45	uM	Adult (>18 years old)	Not Specified	Normal	HMDB	15024124
Human Blood	Detected and Quantified			13	45	uM	Not Specified	Not Specified	Normal	HMDB	21963049
Human Urine	Detected and Quantified	14.59	20.35			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human Blood	Detected and Quantified			15	35	uM	Not Specified	Not Specified	Normal	HMDB	21963049
Human Blood	Detected and Quantified			16	37	uM	Children (1-13 years old)	Both	Normal	HMDB	21910240
Human Feces	Detected and Quantified	17246.271		0	35118.0543	nmol/g wet feces	Infant (0-1 year old)	Not Specified	Normal	HMDB	22435727
Human Urine	Detected and Quantified	2.17	0.77			umol/mmol creatinine	Newborn (0-30 days old)	Female	Normal	HMDB	32340350
Human Urine	Detected and Quantified	2.29	0.94			umol/mmol creatinine	Newborn (0-30 days old)	Male	Normal	HMDB	32340350
Human Cerebrospinal fluid (csf)	Detected and Quantified	2.9	0.69			uM	Adult (>18 years old)	Both	Normal	HMDB	7595563
Human Blood	Detected and Quantified	20.6		17.9	24.8	uM	Children (1-13 uears old)	Both	Normal	HMDB	27294788
Human Blood	Detected and Quantified	22	4			uM	Adult (>18 years old)	Female	Normal	HMDB	2415198
Human Blood	Detected and Quantified	25	6			uM	Adult (>18 years old)	Male	Normal	HMDB	2415198
Human Blood	Detected and Quantified	25.0		21.0	29.0	uM	Adult (>18 years old)	Both	Normal	HMDB	12297216
Human Blood	Detected and Quantified	25.4	5.05			uM	Adult (>18 years old)	Both	Normal	HMDB	28278231
Human Blood	Detected and Quantified	28.90		21.60	37.6	uM	Infant (0-1 year old)		Normal	HMDB	25754623
Human Blood	Detected and Quantified	29.8	6.3			uM	Adult (>18 years old)	Both	Normal	HMDB	21359215
Human Cerebrospinal fluid (csf)	Detected and Quantified	3.6	0.98			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	22546835
Human Blood	Detected and Quantified	33.4	9			uM	Adult (>18 years old)	Both	Normal	HMDB	21359215
Human Blood	Detected and Quantified	35.09	8.76			uM	Children (1-13 years old)	Both	Normal	HMDB	23108202
Human Blood	Detected and Quantified	35.8		28.90	44.2	uM	Newborn (0-30 days old)		Normal	HMDB	25754623
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.07		3.00	5.14	uM	Adult (>18 years old)	Both	Normal	HMDB	12834252
Human Cerebrospinal fluid (csf)	Detected and Quantified	4.3	2.5			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	6198473
Human Feces	Detected and Quantified	450	290			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	27624970
Human Cerebrospinal fluid (csf)	Detected and Quantified	5	4			uM	Adult (>18 years old)	Both	Normal	HMDB	18502700
Human Blood	Detected and Quantified			5	34	uM	Infant (0-1 year old)	Both	Normal	HMDB	21910240
Human Urine	Detected and Quantified	5.31	18.09			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human Urine	Detected and Quantified	5.59	3.92			umol/mmol creatinine	Children (0-2 years old)	Male	Normal	HMDB	25536744
Human Urine	Detected and Quantified	5.73	3.64			umol/mmol creatinine	Newborn (0-30 days old)	Male	Normal	HMDB	25536744
Human Cerebrospinal fluid (csf)	Detected and Quantified	6.1	3.1			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	15911239
Human Urine	Detected and Quantified	6.66	4.88			umol/mmol creatinine	Children (0-2 years old)	Female	Normal	HMDB	25536744
Human Urine	Detected and Quantified	6.96	5.20			umol/mmol creatinine	Newborn (0-30 days old)	Female	Normal	HMDB	25536744
Human Feces	Detected and Quantified	60	50			nmol/g wet feces	Adult (>18 years old)	Both	Normal	HMDB	27624970
Human Feces	Detected and Quantified	6724.258		0	16397.361	nmol/g wet feces	Infant (0-1 year old)	Not Specified	Normal	HMDB	22435727
Human Blood	Detected and Quantified			7	47	uM	Children (1 - 13 years old)	Male	Normal	HMDB	27207470
Human Feces	Detected and Quantified	7863.585		0	16352.682	nmol/g wet feces	Infant (0-1 year old)	Not Specified	Normal	HMDB	22435727
Human Urine	Detected and Quantified	9.38	16.96			umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	19468821
Human Urine	Detected and Quantified	2.1201	1.2082			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	6.941	6.54			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Eosinophilic esophagitis	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Blood	Detected and Quantified	25.6	5.4			uM	Children (1-13 years old)	Both	Obesity	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Human Blood	Detected and Quantified	29.5	7.5			uM	Children (1-13 years old)	Both	Obesity	HMDB	Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
Human Blood	Detected and Quantified	9.00		0.00	18.00	uM	Children (1-13 years old)	Both	Homocystinuria	HMDB	MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
Human Urine	Detected and Quantified	3.1668	1.2788			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified	7.134	5.264			umol/mmol creatinine	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work)
Human Urine	Detected and Quantified			0	4.97	umol/mmol creatinine	Children (2 - 4 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	4.97	umol/mmol creatinine	Children (4 - 13 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	4.97	umol/mmol creatinine	Adolescent (13 - 21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	4.97	umol/mmol creatinine	Adult (>21 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	7.01	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	7.01	umol/mmol creatinine	Infant (1 - 6 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	7.01	umol/mmol creatinine	Infant (6 months - <1 year old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified			0	7.01	umol/mmol creatinine	Children (1 - 2 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Cerebrospinal fluid (csf)	Detected and Quantified			0	5	uM	Children (0 - 10 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Cerebrospinal fluid (csf)	Detected and Quantified			0	6.5	uM	Adolescent (>11 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			16	37	uM	Children (6 - 18 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			4	39	uM	Infant (1 - 3 months old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			5	40	uM	Children (3 months - 6 years old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Blood	Detected and Quantified			6	36	uM	Newborn (0-30 days old)	Both	Normal	HMDB	BC Children's Hospital Biochemical Genetics Lab
Human Urine	Detected and Quantified	0.611	0.45			umol/mmol creatinine	Children (1-13 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	1.12	0.97			umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	1.3	0.97			umol/mmol creatinine	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cerebrospinal fluid (csf)	Detected and Quantified	1.9	0.7			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	16	3			uM	Children (1 - 13 years old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	27	5			uM	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	27.0	5.0			uM	Children (1-13 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	27.0	5.0			uM	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	32	6			uM	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	32.0	6.0			uM	Adult (>18 years old)	Male	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	35.0	5.0			uM	Newborn (0-30 days old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	4.45		0	8.89	umol/mmol creatinine	Newborn (0-30 days old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Saliva	Detected and Quantified	0.0354	0.0873			uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.176	0.152			uM	Adult (>18 years old)	Female	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.418	0.420			uM	Adult (>18 years old)	Both	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	2.88	5.55			uM	Adult (>18 years old)	Male	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	8.81	5.94			uM	Adult (>18 years old)	Both	Normal	HMDB	https://doi.org/10.1007/s11306-015-0840-5
Human Blood	Detected and Quantified			10.0	45.0	uM	Adult (>18 years old)	Both	Normal	HMDB	Molecular You (https://molecularyou.com)
Human Urine	Detected and Quantified	<1.81				umol/mmol creatinine	Adult (>18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<2.26				umol/mmol creatinine	Adolescent (13-18 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<2.60				umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<2.83				umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<4.64				umol/mmol creatinine	Infant (0-1 year old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Urine	Detected and Quantified	<4.64				umol/mmol creatinine	Children (1-13 years old)	Not Specified	Normal	HMDB	Mayo Clinic (https://neurology.testcatalog.org/show/AAPD)
Human Fibroblasts	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Kidney	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Liver	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Pancreas	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Placenta	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Prostate	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Skeletal muscle	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Spleen	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Urine	Detected but not Quantified						Adult (>18 years old)	Male	Normal	HMDB	16939360
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	18052033
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	19573517
Human Feces	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	20669995
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	21761941
Human Feces	Detected but not Quantified						Children (1-13 years old)	Not Specified	Normal	HMDB	21970810
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	24029555
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25670064
Human Feces	Detected but not Quantified						Adult (>18 years old)	Female	Normal	HMDB	26709303
Human Feces	Detected but not Quantified						Not Specified	Both	Normal	HMDB	25486321
Human Feces	Detected but not Quantified						Children (1-13 years old)	Both	Normal	HMDB	21970810
Human Feces	Detected but not Quantified						Children (1-13 years old)	Both	Normal	HMDB	24130822
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27065191
Human Feces	Detected but not Quantified						Children (1-13 years old)	Not Specified	Normal	HMDB	27452636
Human Feces	Detected but not Quantified						Children (6 - 18 years old)	Not Specified	Normal	HMDB	27609529
Human Feces	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	27622378
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified						Adult (>18 years old)	Not Specified	Normal	HMDB	25985090
Human Feces	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

References

General References

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Showing metabocard for L-Methionine (MMDBc0000140)

MOL for #<Metabolite:0x000055b2ed9ca9a0>

3D MOL for #<Metabolite:0x000055b2ed9ca9a0>

3D SDF for #<Metabolite:0x000055b2ed9ca9a0>

3D-SDF for #<Metabolite:0x000055b2ed9ca9a0>

PDB for #<Metabolite:0x000055b2ed9ca9a0>

3D PDB for #<Metabolite:0x000055b2ed9ca9a0>

SMILES for #<Metabolite:0x000055b2ed9ca9a0>

INCHI for #<Metabolite:0x000055b2ed9ca9a0>

Structure for #<Metabolite:0x000055b2ed9ca9a0>

3D Structure for #<Metabolite:0x000055b2ed9ca9a0>