MiMeDB: Showing metabocard for N-Acetyl-D-Glucosamine 6-Phosphate (MMDBc0029541)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:31:36 UTC

Update Date

2024-10-13 07:32:22 UTC

Metabolite ID

MMDBc0029541

Metabolite Identification

Common Name

N-Acetyl-D-Glucosamine 6-Phosphate

Description

N-Acetyl-D-Glucosamine 6-Phosphate is an intermediate in the metabolism of Aminosugars. It is a substrate for Glucosamine 6-phosphate N-acetyltransferase.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Acetamido-2-deoxy-6-O-phosphono-D-glucopyranose	ChEBI
N-Acetyl-D-glucosamine 6-phosphoric acid	Generator
N-Acetyl-D-glucosamine-6-p	HMDB
N-Acetyl-D-glucosamine-6-phosphate	HMDB
N-Acetyl-glucosamine-6-p	HMDB
N-Acetyl-glucosamine-6-phosphate	HMDB
N-Acetylglucosamine-6-p	HMDB
N-Acetylglucosamine 6-phosphate	HMDB
GlcNAc6p	HMDB

Molecular Formula

C₈H₁₆NO₉P

Average Mass

301.1877

Monoisotopic Mass

301.056267627

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

102029-88-9

SMILES

Not Available

InChI Identifier

InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1

InChI Key

BRGMHAYQAZFZDJ-RTRLPJTCSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Acylaminosugars

Alternative Parents

Substituents

Acylaminosugar
Hexose phosphate
N-acyl-alpha-hexosamine
Monosaccharide phosphate
Monoalkyl phosphate
Monosaccharide
Organic phosphoric acid derivative
Alkyl phosphate
Oxane
Phosphoric acid ester
Acetamide
1,2-diol
Carboxamide group
Hemiacetal
Secondary carboxylic acid amide
Secondary alcohol
Oxacycle
Carboxylic acid derivative
Organoheterocyclic compound
Polyol
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Alcohol
Organic nitrogen compound
Organonitrogen compound
Carbonyl group
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

N-acyl-D-glucosamine 6-phosphate (CHEBI:15784 )

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Feces
Saliva

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191726	Glucosamine 6-phosphate N-acetyltransferase	Enzyme	Q96EK6	Homo sapiens
MMDBp0191881	Glucosamine-6-phosphate isomerase 1	Unknown	P46926	Homo sapiens
MMDBp0192639	N-acetyl-D-glucosamine kinase	Enzyme	Q9UJ70	Homo sapiens
MMDBp0193141	Phosphoacetylglucosamine mutase	Unknown	O95394	Homo sapiens
MMDBp0193927	Putative N-acetylglucosamine-6-phosphate deacetylase	Enzyme	Q9Y303	Homo sapiens
MMDBp0196018	Glucosamine-6-phosphate isomerase 2	Enzyme	Q8TDQ7	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Data Source	Reference
MMDBr0000174	Glucosamine 6-phosphate	N-Acetyl-D-Glucosamine 6-Phosphate	Not Available	VMH	30371894
MMDBr0000175	N-Acetyl-D-glucosamine	N-Acetyl-D-Glucosamine 6-Phosphate	Not Available	VMH; KEGG	10824116
MMDBr0000176	N-Acetyl-D-Glucosamine 6-Phosphate	N-Acetyl-glucosamine 1-phosphate	Not Available	VMH	11004509
MMDBr0006904	N-Acetyl-D-mannosamine 6-phosphate	N-Acetyl-D-Glucosamine 6-Phosphate	Not Available	VMH	30371894
MMDBr0007703	N-Acetyl-D-Glucosamine 6-Phosphate	Acetic acid	Not Available	VMH; KEGG	30371894

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria	Proteobacteria	232	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal; Chicken ; Cattle	Unknown; Metabolic reconstruction
Bacteria	Firmicutes	408	Human feces; Human pleural fluid plaque; Pig ; Human sputum; Human ; Human subgingival plaque; Human saliva; Human urine; Human mucosa; Human supragingival plaque; Cattle ; Human stool	Metabolic reconstruction
Bacteria	Actinobacteria	118	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human mucosa; Human saliva; Human supragingival plaque; Human subgingival plaque	Metabolic reconstruction
Bacteria	Verrucomicrobia	1	Human ; Human feces	Metabolic reconstruction
Bacteria	Bacteroidetes	72	Human feces; Human appendix biopsy; Human ; Human stool; Human saliva	Metabolic reconstruction
Bacteria	Spirochaetes	1	Human feces	Metabolic reconstruction
Bacteria	Fusobacteria	20	Human feces; Human	Metabolic reconstruction
Archaea	Euryarchaeota	1		Metabolic reconstruction
Bacteria	Candidatus melainabacteria	1	Human feces	Metabolic reconstruction
Bacteria	Tenericutes	4	Human feces	Metabolic reconstruction
Bacteria	Synergistetes	1	Human feces	Metabolic reconstruction
Bacteria	Planctomycetes	2	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	1		Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	5	Human feces; Human saliva; Human supragingival plaque	Unknown
Viruses/Bamfordvirae	Nucleocytoviricota	1
Eukaryota/Fungi	Microsporidia	1
Bacteria	Cyanobacteria	22	Human
Bacteria	Deinococcus-thermus	2
Bacteria	Thermotogae	2
Bacteria	nah	1

Exposure Sources

Source Type	Source Sub-type	Species	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified							HMDB
Human Saliva	Detected and Quantified	0.173	0.163	uM	Adult (>18 years old)	Not Specified	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.
Human Saliva	Detected and Quantified	0.192	0.574	uM	Adult (>18 years old)	Not Specified	Normal	HMDB	Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.

External Links

HMDB ID

HMDB0001062

DrugBank ID

DB03951

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

Not Available

BiGG ID

34733

Wikipedia Link

Not Available

METLIN ID

5975

PubChem Compound

440996

PDB ID

Not Available

ChEBI ID

15784

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Komatsuzawa H, Fujiwara T, Nishi H, Yamada S, Ohara M, McCallum N, Berger-Bachi B, Sugai M: The gate controlling cell wall synthesis in Staphylococcus aureus. Mol Microbiol. 2004 Aug;53(4):1221-31. doi: 10.1111/j.1365-2958.2004.04200.x. [PubMed:15306023 ]

Showing metabocard for N-Acetyl-D-Glucosamine 6-Phosphate (MMDBc0029541)

MOL for #<Metabolite:0x00007f46ed22f340>

3D MOL for #<Metabolite:0x00007f46ed22f340>

3D SDF for #<Metabolite:0x00007f46ed22f340>

3D-SDF for #<Metabolite:0x00007f46ed22f340>

PDB for #<Metabolite:0x00007f46ed22f340>

3D PDB for #<Metabolite:0x00007f46ed22f340>

SMILES for #<Metabolite:0x00007f46ed22f340>

INCHI for #<Metabolite:0x00007f46ed22f340>

Structure for #<Metabolite:0x00007f46ed22f340>

3D Structure for #<Metabolite:0x00007f46ed22f340>