Record Information
Version1.0
StatusDetected and Quantified
Creation Date2021-11-17 23:35:49 UTC
Update Date2024-04-30 19:39:58 UTC
Metabolite IDMMDBc0029643
Metabolite Identification
Common NameGlucose 6-phosphate
DescriptionGlucose 6 phosphate (alpha-D-glucose 6 phosphate or G6P) is the alpha-anomer of glucose-6-phosphate. There are two anomers of glucose 6 phosphate, the alpha anomer and the beta anomer Glucose-6-phosphate is a phosphorylated glucose molecule on carbon 6. When glucose enters a cell, it is immediately phosphorylated to G6P. This is catalyzed with hexokinase enzymes, thus consuming one ATP. A major reason for immediate phosphorylation of the glucose is so that it cannot diffuse out of the cell. The phosphorylation adds a charged group so the G6P cannot easily cross cell membranes. G6P can travel down two metabolic pathways, glycolysis and the pentose phosphate pathway. Note, the molecule now has 2 phosphoryl groups attached. The addition of the 2nd phosphoryl group is an irreversible step, so once this happens G6P will enter glycolysis and be turned into pyruvate (ATP production occurs). After being converted to G6P, phosphoglucose mutase (isomerase) can turn the molecule into glucose-1-phosphate. Glucose-1-phosphate can then be combined with uridine triphosphate (UTP) to form UDP-glucose. This reaction is driven by the hydrolysis of pyrophosphate that is released in the reaction. (Wikipedia )
Structure
Synonyms
ValueSource
6-O-Phosphono-D-glucopyranoseChEBI
D-Glucose 6-phosphateChEBI
GLC6pChEBI
Robison esterChEBI
D-Glucose 6-phosphoric acidGenerator
Glucose 6-phosphoric acidGenerator
a-D-Glucose 6- phosphateHMDB
alpha-D-Glucose 6- phosphateHMDB
alpha-D-Glucose 6-phosphateHMDB
alpha-D-Hexose 6-phosphateHMDB
D(+)-Glucopyranose 6-phosphateHMDB
D-Glucose-6-dihydrogen phosphateHMDB
D-Hexose 6-phosphateHMDB
Glucose-6-phosphateHMDB
Glucose 6-phosphateKEGG
D-Glucopyranose 6-phosphoric acidGenerator
Molecular FormulaC6H13O9P
Average Mass260.1358
Monoisotopic Mass260.029718526
IUPAC Name{[(2R,3S,4S,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid
Traditional Nameglucose 6-phosphate
CAS Registry Number56-73-5
SMILES
OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O
InChI Identifier
InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6?/m1/s1
InChI KeyNBSCHQHZLSJFNQ-GASJEMHNSA-N