MiMeDB: Staphylococcus aureus (MMDBm0000423)

Microbe Identification

Microbe name

Staphylococcus aureus

NCBI Taxonomy ID

1280

Microbe Taxonomy

Superkingdom

Bacteria

Kingdom

Eubacteria

Phylum

Firmicutes

Class

Bacilli

Order

Bacillales

Family

Staphylococcaceae

Genus

Staphylococcus

Species

aureus

Strain

Not Available

Microbe Properties

Gram staining properties

Positive

Shape

Cocci

Mobility

Flagellar presence

Number of membranes

Oxygen preference

Facultative

Optimal temperature

Temperature range

Mesophilic

Habitat

HostAssociated

Biotic relationship

Free living

Cell arrangement

Clusters - Singles

Sporulation

Clusters - Singles

Metabolism

Not Available

Energy source

Not Available

Host and Biospecimens

Host	Body site	Biospecimen	Data Source	Reference
Human			Human Oral Microbiome Database (HOMD)	20624719
Human			Human Microbiome Project	28953883
Human	Fornix		BacDive	34718743
Human	Skin		BacDive	34718743
Human	Nasal cavity		BacDive	34718743
Human	Large intestine		BacDive	34718743
Human	Nasal cavity		BacDive	34718743
Human	Nasal cavity		BacDive	34718743
Human	Skin		BacDive	34718743
Human	Large intestine		BacDive	34718743
Human	Lung		BacDive	34718743
Human	Oral cavity		BacDive	34718743
Human	Gastrointestinal tract		BacDive	34718743
Human	Trachea		BacDive	34718743
Human	Nasopharynx		BacDive	34718743
Human	Pharynx		BacDive	34718743
Human	Vagina		BacDive	34718743
Human	Lower respiratory tract		BacDive	34718743
Human	Fornix		BacDive	34718743
Human	Lung		Disbiome	27388563
Human	Oral cavity	Subgingival plaque	Disbiome	23060013
Human	Gingiva	Subgingival plaque	Disbiome	23060013
Human	Oral cavity	Saliva	Disbiome	29576948
Human	Skin		Disbiome	31883828
Human	Nasopharynx		Disbiome	26492486
Human	Large intestine	Feces	Disbiome	18326589
Human	Nasal cavity		Disbiome	30420263
Human	Gingiva	Subgingival plaque	Disbiome	23060013

Health Effects

Host	Related Health Condition	Microbal response/effect	Data Source	Reference
Human	Chronic sinusitis		BacDive
Human	Diarrhea		BacDive
Human	Chronic lung disease	Elevated	Disbiome	27388563
Human	Crohn's disease	Elevated	Disbiome	23060013
Human	Crohn's disease	Elevated	Disbiome	23060013
Human	Obesity	Reduced	Disbiome	29576948
Human	Systemic Lupus Erythematosus	Elevated	Disbiome	31883828
Human	Cystic fibrosis	Elevated	Disbiome	26492486
Human	Obesity	Elevated	Disbiome	18326589
Human	Rheumatoid arthritis	Elevated	Disbiome	30420263
Human	Ulcerative colitis	Elevated	Disbiome	23060013

Related Metabolites

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0012860	(2R)-2-phosphoglyceric acid	Phosphoenolpyruvic acid	Enolase	Enolization	RHEA	34755880
MMDBr0012884	D-Glyceraldehyde 3-phosphate	(2R)-3-phospho-glyceroyl phosphate	Glyceraldehyde-3-phosphate dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0012920	Dihydroneopterin	6-Hydroxymethyl dihydropterin	Folic acid synthesis protein fol1	Aldol addition (or reverse)	RHEA	34755880
MMDBr0013053	5'-Methylthioadenosine	Adenine	S-methyl-5'-thioadenosine phosphorylase	Deamination; Phosphorylation	RHEA	34755880
MMDBr0013054	5'-Methylthioadenosine	Adenine	S-methyl-5'-thioadenosine phosphorylase	Deamination; Phosphorylation	RHEA	34755880
MMDBr0013081	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	7,8-dihydrofolate monoglutamate	Bifunctional dihydrofolate reductase-thymidylate synthase	Reduction; Synthesis	RHEA	34755880
MMDBr0013084	Cd(2+)	Cd(2+)	P-type cation-transporting ATPase	ATP hydrolysis	RHEA	34755880
MMDBr0013098	UDP-N-acetyl-alpha-D-muramate	UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine	UDP-N-acetylenolpyruvoylglucosamine reductase	Reduction	RHEA	34755880
MMDBr0013177	aldehydo-D-galactose 6-phosphate	keto-D-tagatose 6-phosphate	Galactose-6-phosphate isomerase subunit LacA	Isomerization	RHEA	34755880
MMDBr0013184	(S)-2,3,4,5-tetrahydrodipicolinate	N_Acetyl_L_2_amino_6_oxopimelate	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase	Acetylation	RHEA	34755880
MMDBr0013295	(S)-4-Amino-5-oxopentanoate	5-Aminolevulinic acid	Glutamate-1-semialdehyde 2,1-aminomutase	Non-hydrolytic bond cleavage (or its reversal)	RHEA	34755880
MMDBr0013357	(2R)-3-phosphoglyceric acid	(2R)-3-phospho-glyceroyl phosphate	Phosphoglycerate kinase	Phosphorylation	RHEA	34755880
MMDBr0013382	(6S)-5,6,7,8-tetrahydrofolic acid	7,8-dihydrofolate monoglutamate	Bifunctional dihydrofolate reductase-thymidylate synthase	Reduction	RHEA	34755880
MMDBr0013490	N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate	N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase	Conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol	RHEA	34755880
MMDBr0013529	D-Glutamate	UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamic acid	UDP-N-acetylmuramoylalanine--D-glutamate ligase	Ligation	RHEA	34755880
MMDBr0013602	2-Succinylbenzoate	2-Succinylbenzoyl-CoA	2-succinylbenzoate--CoA ligase	Ligation	RHEA	34755880
MMDBr0013766	Chloramphenicol	chloramphenicol 3-acetic acid	Chloramphenicol acetyltransferase	N-Acetylation	RHEA	34755880
MMDBr0013784	D-Glyceraldehyde 3-phosphate	Dihydroxyacetone phosphate	Bifunctional PGK/TIM	Isomerization	RHEA	34755880
MMDBr0013790	Oxalacetic acid	Phosphoenolpyruvic acid	Phosphoenolpyruvate carboxykinase (ATP)	Phosphorylation	RHEA	34755880
MMDBr0013886	Carbamoylphosphate	Citrulline	Ornithine carbamoyltransferase	Transfer of a carbamoyl group	RHEA	34755880
MMDBr0013936	6-Hydroxymethyl-dihydropterin pyrophosphate	7,8-Dihydropteroic acid	Dihydropteroate synthase type-1	Reduction; Synthesis	RHEA	34755880
MMDBr0014061	5-O-(1-Carboxyvinyl)-3-phosphoshikimate	Chorismate	Chorismate synthase	Synthesis	RHEA	34755880
MMDBr0014153	di-trans,octa-cis-undecaprenyl phosphate	Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate	Phospho-N-acetylmuramoyl-pentapeptide-transferase	Transfer of phospho-N-acetylmuramoyl-pentapeptide	RHEA	34755880
MMDBr0014171	Guanosine triphosphate	Guanosine 3'-diphosphate 5'-triphosphate	GTP pyrophosphokinase	Hydrolysis of bond; Phosphorylation	RHEA	34755880
MMDBr0014311	Isopentenyl pyrophosphate	Dimethylallylpyrophosphate	Isopentenyl-diphosphate Delta-isomerase	Isomerization	RHEA	34755880
MMDBr0014323	L-Alanine	UDP-N-acetyl-alpha-D-muramoyl-L-alanine	Bifunctional enzyme MurC/Ddl	Ligation	RHEA	34755880
MMDBr0014390	Hg	Hg(2+)	Mercuric reductase	Reduction	RHEA	34755880
MMDBr0014413	5-Aminolevulinic acid	Porphobilinogen	Delta-aminolevulinic acid dehydratase	Hydration/dehydration of C-O bond	RHEA	34755880
MMDBr0014432	Kanamycin A	kanamycin 3'-phosphate	Aminoglycoside 3'-phosphotransferase	Transfer of phosphate group	RHEA	34755880
MMDBr0014449	Deoxyadenosine	Inosine	Adenosine deaminase	Deamination; Phosphorylation	RHEA	34755880
MMDBr0014450	Deoxyadenosine	Inosine	Adenosine deaminase	Deamination; Phosphorylation	RHEA	34755880
MMDBr0014581	Cu(+)	Cu(+)	Probable copper-transporting ATPase PacS	ATP hydrolysis	RHEA	34755880
MMDBr0014619	L-3,4-Dihydroxybutan-2-one 4-phosphate	6,7-Dimethyl-8-(1-D-ribityl)lumazine	6,7-dimethyl-8-ribityllumazine synthase	Synthesis	RHEA	34755880
MMDBr0014708	Deoxyadenosine	Adenine	Purine nucleoside phosphorylase DeoD-type	Deamination; Phosphorylation	RHEA	34755880
MMDBr0014709	Deoxyadenosine	Adenine	Purine nucleoside phosphorylase aq_167	Deamination; Phosphorylation	RHEA	34755880
MMDBr0014710	Inosine	Ribose-1-phosphate	Purine nucleoside phosphorylase DeoD-type	Deamination; Phosphorylation	RHEA	34755880
MMDBr0014711	Inosine	Ribose-1-phosphate	Purine nucleoside phosphorylase DeoD-type	Deamination; Phosphorylation	RHEA	34755880
MMDBr0014783	di-trans,octa-cis-undecaprenyl diphosphate	di-trans,octa-cis-undecaprenyl phosphate	Undecaprenyl-diphosphatase BcrC	Dephosphorylation	RHEA	34755880
MMDBr0017938	L-Proline	L-Proline	Osmoregulated proline transporter OpuE	Transport	RHEA	34755880
MMDBr0015050	Farnesyl pyrophosphate	15-cis-4,4'-diapophytoene	4,4'-diapophytoene synthase	Synthesis	RHEA	34755880
MMDBr0016128	Dihydroneopterin	7,8-dihydromonapterin	Dihydroneopterin aldolase	Aldol addition (or reverse)	RHEA	34755880
MMDBr0016586	L-Arginine	Citrulline	Nitric oxide synthase oxygenase	Oxygenation	RHEA	34755880
MMDBr0016813	2-Aminobenzoic acid	2-(4-dimethylaminophenyl)diazenylbenzoic acid	FMN-dependent NADPH-azoreductase	Reduction	RHEA	34755880
MMDBr0017348	spectinomycin	9-O-adenylylspectinomycin	Aminoglycoside (3'') (9) adenylyltransferase	Reversible transfer of an adenylyl group	RHEA	34755880
MMDBr0017351	Streptomycin	6-O-adenylylstreptomycin	Aminoglycoside 6-adenylyltransferase	Reversible transfer of an adenylyl group	RHEA	34755880
MMDBr0017876	L-Glutamic acid	L-Glutamine	Glutamine synthetase	Synthesis	RHEA	34755880
MMDBr0017897	L-Methionine	S-Adenosylmethionine	S-adenosylmethionine synthase	Synthesis	RHEA	34755880
MMDBr0024355	L-Tyrosine	Hydrogen Ion	Tyrosine-protein kinase ptk	Phosphorylation	RHEA	34755880
MMDBr0024368	L-Isoleucine	diphosphate	Isoleucine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024408	alpha-Ketoglutarate	Carbon dioxide	Multifunctional 2-oxoglutarate metabolism enzyme	Dehydrogenation	RHEA	34755880
MMDBr0024460	S-Adenosylmethionine	S-Adenosylhomocysteine	Type II methyltransferase M.MthTI	Methylation	RHEA	34755880
MMDBr0024483	L-Glutamine	L-Glutamic acid	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	Amide group addition	RHEA	34755880
MMDBr0024493	NAD	Hydrogen Ion	Dihydrolipoyl dehydrogenase	Dehydrogenation	RHEA	34755880
MMDBr0024550	Acetyl-CoA	CoA	Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system	Dehydrogenation	RHEA	34755880
MMDBr0024559	Adenosine triphosphate	Hydrogen Ion	Histidine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024568	L-Glutamine	L-Glutamic acid	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	Amide group addition	RHEA	34755880
MMDBr0024586	L-Serine	Hydrogen Ion	Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein	Phosphorylation; Synthesis	RHEA	34755880
MMDBr0024590	Adenosine triphosphate	ADP	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0024619	Pyruvic acid	Carbon dioxide	Pyruvate dehydrogenase E1 component	Dehydrogenation	RHEA	34755880
MMDBr0024628	L-Phenylalanine	Hydrogen Ion	Phenylalanine--tRNA ligase beta subunit	Ligation	RHEA	34755880
MMDBr0024666	L-Lysine	diphosphate	Lysine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024757	L-Histidine	Pyruvic acid	Phosphoenolpyruvate-protein phosphotransferase	Transfer of phosphate group	RHEA	34755880
MMDBr0024779	N-Formyl-L-methionine	formate	Peptide deformylase 1	Removal of the N-terminal formyl group	RHEA	34755880
MMDBr0024859	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate	Lipid II:glycine glycyltransferase	Incorporation of amino acid(s)	RHEA	34755880
MMDBr0024860	beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate	MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc	Aminoacyltransferase FemA	Acylation	RHEA	34755880
MMDBr0024861	MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc	MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc	Aminoacyltransferase FemB	Acylation	RHEA	34755880
MMDBr0025016	Malonyl-CoA	CoA	Malonyl CoA-acyl carrier protein transacylase	Synthesis	RHEA	34755880
MMDBr0025057	Alpha-Lactose	L-Histidine	PTS system lactose-specific EIICB component	Phosphorylation	RHEA	34755880
MMDBr0025064	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Ribosomal RNA large subunit methyltransferase Cfr	Methylation	RHEA	34755880
MMDBr0025085	S-Adenosylmethionine	S-Adenosylhomocysteine	Putative ribosomal RNA large subunit methyltransferase H	Methylation	RHEA	34755880
MMDBr0025091	S-Adenosylmethionine	S-Adenosylhomocysteine	rRNA adenine N-6-methyltransferase	Methylation	RHEA	34755880
MMDBr0025163	ADP	Hydrogen Ion	Putative pyruvate, phosphate dikinase regulatory protein 1	Phosphorylation	RHEA	34755880
MMDBr0025164	Hydrogen Ion	diphosphate	Putative pyruvate, phosphate dikinase regulatory protein 1	Phosphorylation	RHEA	34755880
MMDBr0025177	L-Cysteine	Arsenite	Arsenate reductase	Reduction	RHEA	34755880
MMDBr0025193	Adenosine triphosphate	ADP	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0025237	L-Threonine	Hydrogen Ion	Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein	Phosphorylation; Synthesis	RHEA	34755880
MMDBr0025307	Guanosine triphosphate	Guanosine diphosphate	Bifunctional AAC/APH	Not Available	RHEA	34755880
MMDBr0025490	S-Adenosylmethionine	S-Adenosylhomocysteine	Ribosomal protein L11 methyltransferase	Methylation	RHEA	34755880
MMDBr0025556	D-Alanine	diphosphate	D-alanine--D-alanyl carrier protein ligase	Ligation	RHEA	34755880
MMDBr0025620	L-Cysteine	Sn-Glycerol-1-phosphate	Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase	Transfer of the diacylglyceryl group	RHEA	34755880
MMDBr0026046	Uridine 5'-diphosphate	Uridine triphosphate	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0026047	Uridine 5'-diphosphate	Cytidine triphosphate	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0026048	Guanosine 3',5'-bis(diphosphate)	Guanosine triphosphate	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0026085	Deoxyuridine-5'-diphosphate	Deoxyuridine triphosphate	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0026086	2'-Deoxycytidine 5'-diphosphate	Deoxycytidine 5'-triphosphate	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0026087	2'-Deoxyadenosine 5'-diphosphate	Deoxyadenosine triphosphate	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880
MMDBr0026088	2'-Deoxyguanosine 5'-diphosphate	2'-Deoxyguanosine 5'-triphosphate	Nucleoside diphosphate kinase	Phosphorylation	RHEA	34755880

Genome Data

Genome Link

MMDBm0000423

Genome Length

2861667 bp

# Predicted Proteins

3010

GenBank Sequence Modification Date

17-FEB-2022

MiMeDB Deposition Date

2022-08-28 03:47:42 UTC

Reference

PMID: 17704766

Source Links

GenBank

CP000253