| MMDBr0012920 | Dihydroneopterin | 6-Hydroxymethyl dihydropterin | Folic acid synthesis protein fol1 | Aldol addition (or reverse) | RHEA | 34755880 |
| MMDBr0012927 | 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid | Hydrogen Ion | Pyrroloquinoline-quinone synthase | Synthesis | RHEA | 34755880 |
| MMDBr0013007 | 6-Hydroxymethyl dihydropterin | 6-Hydroxymethyl-dihydropterin pyrophosphate | Folic acid synthesis protein fol1 | Phosphorylation; Synthesis | RHEA | 34755880 |
| MMDBr0013111 | 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetic acid | 4-Oxohex-2-enedioate | Carboxymethylenebutenolidase | Carboxylic ester bond hydrolysis | RHEA | 34755880 |
| MMDBr0013120 | (S)-malate(2-) | fumarate | Fumarate hydratase class I, aerobic | Reversible hydration of fumarate to malate | RHEA | 34755880 |
| MMDBr0013251 | Water | Hydrogen Ion | Sulfite reductase [NADPH] hemoprotein beta-component | Reduction | RHEA | 34755880 |
| MMDBr0013451 | Carbamate | Carbon dioxide | Putative aminoacrylate hydrolase RutD | Hydrolysis of bond | RHEA | 34755880 |
| MMDBr0013694 | (3R)-3-hydroxybutanoyl-CoA | Crotonoyl-CoA | 3-hydroxybutyryl-CoA dehydratase | Hydration/dehydration of C-O bond | RHEA | 34755880 |
| MMDBr0013695 | (3R)-3-hydroxybutanoyl-CoA | Crotonoyl-CoA | 3-hydroxybutyryl-CoA dehydratase | Hydration/dehydration of C-O bond | RHEA | 34755880 |
| MMDBr0013699 | Glyceric acid | 3-hydroxypyruvic acid | Glycerate dehydrogenase | Dehydrogenation; Reduction | RHEA | 34755880 |
| MMDBr0013719 | 5,6,7,8-Tetrahydromethanopterin | Methanofuran | Formyltransferase/hydrolase complex subunit D | Transfer of a formyl group | RHEA | 34755880 |
| MMDBr0013732 | Adenosine triphosphate | ADP | Pyruvate kinase | Phosphorylation | RHEA | 34755880 |
| MMDBr0013833 | 5,10-Methenyl-5,6,7,8-tetrahydromethanopterin | Hydrogen Ion | Methenyltetrahydromethanopterin cyclohydrolase | Hydrolysis | RHEA | 34755880 |
| MMDBr0013966 | (6S)-5,6,7,8-tetrahydrofolic acid | (6S)-10-formyltetrahydrofolic acid | C-1-tetrahydrofolate synthase, cytoplasmic | Ligation; Synthesis | RHEA | 34755880 |
| MMDBr0014105 | (S)-malate(2-) | Hydrogen Ion | Malate dehydrogenase | Dehydrogenation | RHEA | 34755880 |
| MMDBr0014122 | FMNH2 | Flavin mononucleotide | NAD(P)H-dependent FMN reductase atnL | Reduction | RHEA | 34755880 |
| MMDBr0014251 | (6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid | 5,10-Methenyltetrahydrofolate | C-1-tetrahydrofolate synthase, cytoplasmic | Synthesis | RHEA | 34755880 |
| MMDBr0014369 | 5,10-Methenyltetrahydrofolate | (6S)-10-formyltetrahydrofolic acid | C-1-tetrahydrofolate synthase, cytoplasmic | Reversible cyclization | RHEA | 34755880 |
| MMDBr0014474 | 5,6,7,8-Tetrahydromethanopterin | 5,10-Methylenetetrahydromethanopterin | 5,6,7,8-tetrahydromethanopterin hydro-lyase | Non-hydrolytic bond cleavage (or its reversal) | RHEA | 34755880 |
| MMDBr0014475 | 5,10-Methylenetetrahydromethanopterin | 5,10-Methenyl-5,6,7,8-tetrahydromethanopterin | Bifunctional protein MdtA | Dehydrogenation | RHEA | 34755880 |
| MMDBr0014476 | Water | formate | Formyltransferase/hydrolase complex Fhc subunit A | Hydrolysis of bond | RHEA | 34755880 |
| MMDBr0014624 | (S)-malate(2-) | (S)-malyl-CoA | Malate--CoA ligase subunit beta | Ligation | RHEA | 34755880 |
| MMDBr0014821 | Oxalacetic acid | Hydrogen carbonate | Phosphoenolpyruvate carboxylase | Carboxylation | RHEA | 34755880 |
| MMDBr0014976 | Water | Formaldehyde | Methylamine dehydrogenase heavy chain | Dehydrogenation | RHEA | 34755880 |
| MMDBr0015055 | FMNH2 | (Z)-3-Ureidoacrylate | Pyrimidine monooxygenase RutA | Oxygenation | RHEA | 34755880 |
| MMDBr0015056 | FMNH2 | (Z)-2-methylureidoacrylic acid | Pyrimidine monooxygenase RutA | Oxygenation | RHEA | 34755880 |
| MMDBr0015057 | (Z)-3-Ureidoacrylate | 3-Aminoacrylate | Ureidoacrylate amidohydrolase RutB | Hydrolysis of bond | RHEA | 34755880 |
| MMDBr0015136 | 3-Isopropylmalate | 2-Isopropylmalic acid | 3-isopropylmalate dehydratase large subunit gloJ | Isomerization | RHEA | 34755880 |
| MMDBr0015384 | 3-Aminoacrylate | Malonic semialdehyde | Putative aminoacrylate peracid reductase RutC | Reduction | RHEA | 34755880 |
| MMDBr0015452 | 5,6,7,8-Tetrahydromethanopterin | 7,8-dihydromethanopterin | Dihydromethanopterin reductase | Reduction | RHEA | 34755880 |
| MMDBr0015453 | 5,6,7,8-Tetrahydromethanopterin | 7,8-dihydromethanopterin | Dihydromethanopterin reductase | Reduction | RHEA | 34755880 |
| MMDBr0015860 | (Z)-2-methylureidoacrylic acid | (Z)-2-methylaminoacrylic acid | Ureidoacrylate amidohydrolase RutB | Hydrolysis of bond | RHEA | 34755880 |
| MMDBr0015861 | (Z)-3-Ureidoacrylate | 3-Aminoacrylate | Ureidoacrylate amidohydrolase RutB | Hydrolysis of bond | RHEA | 34755880 |
| MMDBr0016137 | (2R)-ethylmalonyl-CoA | Methyl-Succinyl Coenzyme A | Ethylmalonyl-CoA mutase | Intramolecular transfer of functional group | RHEA | 34755880 |
| MMDBr0016138 | (2R)-ethylmalonyl-CoA | Methyl-Succinyl Coenzyme A | Ethylmalonyl-CoA mutase | Intramolecular transfer of functional group | RHEA | 34755880 |
| MMDBr0016653 | 5,10-Methylenetetrahydromethanopterin | 5,10-Methenyl-5,6,7,8-tetrahydromethanopterin | NAD(P)-dependent methylenetetrahydromethanopterin dehydrogenase | Dehydrogenation | RHEA | 34755880 |
| MMDBr0017871 | (6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid | (6S)-5,6,7,8-tetrahydrofolic acid | Serine hydroxymethyltransferase | Methylation | RHEA | 34755880 |
| MMDBr0017883 | glyoxylate | 3-hydroxypyruvic acid | Serine--glyoxylate aminotransferase | Amine group addition | RHEA | 34755880 |
| MMDBr0025105 | S-Adenosylmethionine | Hydrogen Ion | Ribosomal RNA small subunit methyltransferase H | Methylation | RHEA | 34755880 |
| MMDBr0025372 | Iron(3+) | Hydrogen Ion | Methanol dehydrogenase [cytochrome c] subunit 1 | Dehydrogenation | RHEA | 34755880 |
| MMDBr0025514 | Acetyl-CoA | Malonyl-CoA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha | Carboxylation | RHEA | 34755880 |
| MMDBr0025630 | S-Adenosylmethionine | Hydrogen Ion | PqqA peptide cyclase | Cycle formation | RHEA | 34755880 |
