MiMeDB: Thermotoga neapolitana DSM 4359 (MMDBm0002713)

Microbe Identification

Microbe name

Thermotoga neapolitana DSM 4359

NCBI Taxonomy ID

309803

Microbe Taxonomy

Superkingdom

Bacteria

Kingdom

Eubacteria

Phylum

Thermotogae

Class

Thermotogae

Order

Thermotogales

Family

Thermotogaceae

Genus

Thermotoga

Species

neapolitana

Strain

Microbe Properties

Gram staining properties

Positive

Shape

Bacilli

Mobility

Flagellar presence

Number of membranes

Oxygen preference

Microaerophilic

Optimal temperature

Temperature range

Hyperthermophilic

Habitat

Specialized

Biotic relationship

Free living

Cell arrangement

Not Available

Sporulation

Nonsporulating

Metabolism

Sulfur reducer

Energy source

Heterotroph

Host and Biospecimens

Host	Body site	Biospecimen	Details	Data Source	Reference
Human	Gut	Feces	Expected but not quantified

Health Effects

Host	Related Health Condition	Biospecimen	Microbal response/effect	Data Source	Reference

Related Metabolites

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0012860	(2R)-2-phosphoglyceric acid	Water	Enolase	Enolization	RHEA	34755880
MMDBr0012895	diphosphate	Phosphoribosyl pyrophosphate	Orotate phosphoribosyltransferase	Transfer of a ribosyl group	RHEA	34755880
MMDBr0012954	Adenosine triphosphate	Argininosuccinic acid	Argininosuccinate synthase	Synthesis	RHEA	34755880
MMDBr0012970	D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate	3-(Imidazol-4-yl)-2-oxopropyl phosphate	Imidazoleglycerol-phosphate dehydratase	Hydration/dehydration of C-O bond; Synthesis	RHEA	34755880
MMDBr0013027	Adenosine triphosphate	ADP	Cytidylate kinase	Phosphorylation	RHEA	34755880
MMDBr0013046	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	3-methyl-2-oxobutanoate hydroxymethyltransferase	Methylation	RHEA	34755880
MMDBr0013083	Glucose 1-phosphate	ADP-alpha-D-glucose	Glucose-1-phosphate adenylyltransferase	Reversible transfer of an adenylyl group	RHEA	34755880
MMDBr0013143	Putrescine	Hydrogen Ion	Polyamine aminopropyltransferase	Synthesis	RHEA	34755880
MMDBr0013170	Adenosine monophosphate	ADP	Adenylate kinase	Phosphorylation	RHEA	34755880
MMDBr0013173	diphosphate	Phosphoribosyl pyrophosphate	Bifunctional protein PyrR	Transfer of phosphoribosyl group	RHEA	34755880
MMDBr0013178	D-Glucuronic acid	D-Fructofuranuronic acid	Uronate isomerase	Isomerization	RHEA	34755880
MMDBr0013184	(S)-2,3,4,5-tetrahydrodipicolinate	CoA	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase	Acetylation	RHEA	34755880
MMDBr0013213	2-C-methyl-D-erythritol 4-phosphate	4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	Transfer of a cytidylyl group	RHEA	34755880
MMDBr0013221	(R)-2,3-Dihydroxy-3-methylpentanoate	(S)-2-ethyl-2-hydroxy-3-oxobutanoic acid	Ketol-acid reductoisomerase, mitochondrial	Isomerization	RHEA	34755880
MMDBr0013245	Acetyl-CoA	CoA	L-serine/homoserine O-acetyltransferase	N-Acetylation; Synthesis	RHEA	34755880
MMDBr0013246	2-C-methyl-D-erythritol 4-phosphate	1-Deoxy-D-xylulose 5-phosphate	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Isomerization	RHEA	34755880
MMDBr0013333	Adenosine triphosphate	ADP	Protein ARG5,6, mitochondrial	Phosphorylation	RHEA	34755880
MMDBr0013362	L-Arabinose	L-Ribulose	L-arabinose isomerase	Isomerization	RHEA	34755880
MMDBr0013416	L-Glutamic acid	Ornithine	Arginine biosynthesis bifunctional protein ArgJ	Acetylation; Synthesis	RHEA	34755880
MMDBr0013431	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	Isomerization	RHEA	34755880
MMDBr0013470	(2R)-2-phosphoglyceric acid	(2R)-3-phosphoglyceric acid	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	Intramolecular transfer of functional group	RHEA	34755880
MMDBr0013495	Adenosine triphosphate	ADP	ATP-dependent 6-phosphofructokinase	Phosphorylation	RHEA	34755880
MMDBr0013529	Adenosine triphosphate	ADP	UDP-N-acetylmuramoylalanine--D-glutamate ligase	Ligation	RHEA	34755880
MMDBr0013549	Adenosine monophosphate	Phosphoribosyl pyrophosphate	Adenine phosphoribosyltransferase	Transfer of a ribosyl group	RHEA	34755880
MMDBr0013659	Guanosine triphosphate	7,8-dihydroneopterin 3'-triphosphate	Bifunctional protein FolKE	Hydrolysis	RHEA	34755880
MMDBr0013681	NADP(+)	3-Dehydroshikimic acid	Pentafunctional AROM polypeptide	Dehydrogenation	RHEA	34755880
MMDBr0013755	D-Ribose-5-phosphate	Water	Pseudouridine-5'-phosphate glycosidase	Transfer of a glycosyl group	RHEA	34755880
MMDBr0013773	1-(5-phosphoribosyl)-ATP	Phosphoribosyl pyrophosphate	ATP phosphoribosyltransferase	Transfer of a ribosyl group	RHEA	34755880
MMDBr0013792	Adenosine triphosphate	ADP	NAD kinase	Phosphorylation	RHEA	34755880
MMDBr0013883	Cellobiose	Glucose 1-phosphate	Cellobiose phosphorylase	Phosphorylation	RHEA	34755880
MMDBr0013921	(R)-4'-phosphopantetheine	3'-dephospho-CoA	Phosphopantetheine adenylyltransferase	Dephosphorylation	RHEA	34755880
MMDBr0013941	S-Methyl-5-thio-alpha-D-ribose 1-phosphate	5-Methylthioribulose 1-phosphate	5-deoxyribose 1-phosphate isomerase	Isomerization	RHEA	34755880
MMDBr0013956	D-Mannonate	2-Dehydro-3-deoxy-D-gluconate	D-galactonate dehydratase family member ManD	Hydration/dehydration of C-O bond	RHEA	34755880
MMDBr0014068	3-Dehydroquinate	3-Dehydroshikimic acid	Catabolic 3-dehydroquinase	Hydration/dehydration of C-O bond; Synthesis	RHEA	34755880
MMDBr0014080	Adenosine triphosphate	Adenosine monophosphate	NH(3)-dependent NAD(+) synthetase	Synthesis	RHEA	34755880
MMDBr0014083	Shikimate 3-phosphate	5-O-(1-Carboxyvinyl)-3-phosphoshikimate	Pentafunctional AROM polypeptide	Synthesis; Dehydration and isomerisation; Oxidation; Phosphorylation; Transfer of a carboxyvinyl group	RHEA	34755880
MMDBr0014111	alpha-Ketoisovaleric acid	2-Isopropylmalic acid	Isopropyl malate synthase AMT7	Synthesis	RHEA	34755880
MMDBr0014114	N-(5-Phospho-D-ribosyl)anthranilate	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	Phosphoribosyl isomerase A	Isomerization	RHEA	34755880
MMDBr0014117	N-Acetyl-L-glutamate 5-semialdehyde	Hydrogen Ion	Protein ARG5,6, mitochondrial	Reduction	RHEA	34755880
MMDBr0014167	(R)-2,3-Dihydroxy-isovalerate	(2S)-2-acetolactic acid	Ketol-acid reductoisomerase, mitochondrial	Isomerization	RHEA	34755880
MMDBr0014254	D-Xylose	D-Xylulose	Xylose isomerase	Isomerization	RHEA	34755880
MMDBr0014323	Adenosine triphosphate	ADP	Bifunctional enzyme MurC/Ddl	Ligation	RHEA	34755880
MMDBr0014333	alpha-D-Glucosamine 1-phosphate	D-glucosamine 6-phosphate	Phosphoglucosamine mutase	Intramolecular transfer of functional group	RHEA	34755880
MMDBr0014377	alpha-Ketoglutarate	3-(Imidazol-4-yl)-2-oxopropyl phosphate	Histidinol-phosphate aminotransferase	Amine group addition	RHEA	34755880
MMDBr0014392	2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	2-C-Methyl-D-erythritol-2,4-cyclodiphosphate	Bifunctional enzyme IspD/IspF	Synthesis	RHEA	34755880
MMDBr0014407	Argininosuccinic acid	fumarate	Bifunctional protein ArgHA	Non-hydrolytic bond cleavage (or its reversal)	RHEA	34755880
MMDBr0014436	Acetyl-CoA	CoA	Amino-acid acetyltransferase	Acetylation; Synthesis	RHEA	34755880
MMDBr0017917	5-Aminoimidazole ribonucleotide	4-Amino-2-methyl-5-phosphomethylpyrimidine	Phosphomethylpyrimidine synthase	Synthesis	RHEA	34755880
MMDBr0014514	Adenosine triphosphate	ADP	Cytidylate kinase	Phosphorylation	RHEA	34755880
MMDBr0014559	beta-D-Ribopyranose	beta-D-ribofuranose	L-fucose mutarotase	Mutarotation	RHEA	34755880
MMDBr0014596	Dihydroxyacetone phosphate	Hydrogen Ion	Quinolinate synthase	Synthesis	RHEA	34755880
MMDBr0014597	Dihydroxyacetone phosphate	Hydrogen Ion	Quinolinate synthase	Synthesis	RHEA	34755880
MMDBr0014619	L-3,4-Dihydroxybutan-2-one 4-phosphate	6,7-Dimethyl-8-(1-D-ribityl)lumazine	6,7-dimethyl-8-ribityllumazine synthase	Synthesis	RHEA	34755880
MMDBr0014720	D-Galacturonate	D-Tagaturonate	Uronate isomerase	Isomerization	RHEA	34755880
MMDBr0014825	di-trans,octa-cis-undecaprenyl phosphate	di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine	Phospho-N-acetylmuramoyl-pentapeptide-transferase	Transfer of phospho-N-acetylmuramoyl-pentapeptide	RHEA	34755880
MMDBr0014891	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	Flavin-dependent thymidylate synthase	Synthesis	RHEA	34755880
MMDBr0015026	di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine	di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 3	RHEA	34755880
MMDBr0017950	aldehydo-D-ribose 5-phosphate	Hydrogen Ion	Pyridoxal 5'-phosphate synthase subunit PDX1	Synthesis	RHEA	34755880
MMDBr0015316	L-Aspartate-semialdehyde	(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate	4-hydroxy-tetrahydrodipicolinate synthase	Synthesis	RHEA	34755880
MMDBr0015402	(S)-2,3,4,5-tetrahydrodipicolinate	(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate	4-hydroxy-tetrahydrodipicolinate reductase	Reduction	RHEA	34755880
MMDBr0015405	(S)-2,3,4,5-tetrahydrodipicolinate	(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate	4-hydroxy-tetrahydrodipicolinate reductase	Reduction	RHEA	34755880
MMDBr0015425	Adenosine triphosphate	3',3'-c-di-AMP	Cyclic di-AMP synthase CdaA	Cycle formation; Synthesis	RHEA	34755880
MMDBr0016907	Adenosine triphosphate	ADP	ATP synthase subunit alpha	ATP hydrolysis; Synthesis	RHEA	34755880
MMDBr0017834	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate	D-Glyceraldehyde 3-phosphate	Tryptophan synthase	Synthesis	RHEA	34755880
MMDBr0017871	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	(6S)-5,6,7,8-tetrahydrofolic acid	Serine hydroxymethyltransferase	Methylation	RHEA	34755880
MMDBr0017872	L-Glutamic acid	alpha-Ketoglutarate	Archaeal glutamate synthase [NADPH]	Synthesis	RHEA	34755880
MMDBr0017874	Water	L-Glutamic acid	Thermolabile glutaminase	Synthesis	RHEA	34755880
MMDBr0017882	Adenosine triphosphate	ADP	Carbamoyl-phosphate synthase small chain	Synthesis	RHEA	34755880
MMDBr0017897	Adenosine triphosphate	diphosphate	S-adenosylmethionine synthase	Synthesis	RHEA	34755880
MMDBr0024368	Adenosine triphosphate	diphosphate	Isoleucine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024411	Adenosine triphosphate	Hydrogen Ion	Type-2 serine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024454	D-Galactose	Hydrogen Ion	Galactokinase	Phosphorylation	RHEA	34755880
MMDBr0024474	Adenosine triphosphate	diphosphate	Proline--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024483	Water	Hydrogen Ion	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	Amide group addition	RHEA	34755880
MMDBr0024522	Adenosine triphosphate	diphosphate	Glycine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024546	Hydrogen Ion	(6S)-5,6,7,8-tetrahydrofolic acid	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO	Methylation	RHEA	34755880
MMDBr0024548	(6S)-5,6,7,8-tetrahydrofolic acid	(6R)-5,10-methylene-5,6,7,8-tetrahydrofolic acid	Probable aminomethyltransferase	Methylation	RHEA	34755880
MMDBr0024568	Water	Hydrogen Ion	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	Amide group addition	RHEA	34755880
MMDBr0024578	Adenosine triphosphate	diphosphate	Cysteine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024597	L-Aspartic acid	diphosphate	Aspartate--tRNA(Asp/Asn) ligase	Ligation	RHEA	34755880
MMDBr0024628	Adenosine triphosphate	Hydrogen Ion	Phenylalanine--tRNA ligase beta subunit	Ligation	RHEA	34755880
MMDBr0024630	S-Adenosylmethionine	Hydrogen Ion	Ribosomal RNA small subunit methyltransferase A	Methylation	RHEA	34755880
MMDBr0024707	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Biotin synthase	Synthesis	RHEA	34755880
MMDBr0024765	7-Aminomethyl-7-carbaguanine	Guanine	Putative queuine tRNA-ribosyltransferase	Transfer of a ribosyl group	RHEA	34755880
MMDBr0024774	Hydrogen Ion	Carbon dioxide	Probable glycine dehydrogenase (decarboxylating) subunit 1	Dehydrogenation	RHEA	34755880
MMDBr0024778	(6S)-10-formyltetrahydrofolic acid	Hydrogen Ion	Methionyl-tRNA formyltransferase	Transfer of a formyl group	RHEA	34755880
MMDBr0024779	Water	formate	Peptide deformylase 1	Removal of the N-terminal formyl group	RHEA	34755880
MMDBr0024782	Water	Hydrogen Ion	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	Reduction	RHEA	34755880
MMDBr0024787	Adenosine triphosphate	Hydrogen Ion	Threonine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0024789	Water	Hydrogen Ion	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	Reduction	RHEA	34755880
MMDBr0024813	Dimethylallylpyrophosphate	diphosphate	tRNA dimethylallyltransferase	Transfer of a dimethylallyl group	RHEA	34755880
MMDBr0024971	L-Threonylcarbamoyladenylate	Hydrogen Ion	tRNA N6-adenosine threonylcarbamoyltransferase	Synthesis	RHEA	34755880
MMDBr0025060	Adenosine triphosphate	Hydrogen Ion	Type-2 serine--tRNA ligase	Ligation	RHEA	34755880
MMDBr0025085	S-Adenosylmethionine	Hydrogen Ion	Putative ribosomal RNA large subunit methyltransferase H	Methylation	RHEA	34755880
MMDBr0025102	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Ribosomal RNA large subunit methyltransferase N	Methylation	RHEA	34755880
MMDBr0025105	S-Adenosylmethionine	Hydrogen Ion	Ribosomal RNA small subunit methyltransferase H	Methylation	RHEA	34755880
MMDBr0025145	di-mu-Sulfido-diiron(1+)	5'-Deoxyadenosine	Probable dual-specificity RNA methyltransferase RlmN	Methylation	RHEA	34755880
MMDBr0025258	Adenosine triphosphate	Hydrogen Ion	tRNA-specific 2-thiouridylase MnmA	2-Thiolation of uridine	RHEA	34755880
MMDBr0025490	S-Adenosylmethionine	Hydrogen Ion	Ribosomal protein L11 methyltransferase	Methylation	RHEA	34755880
MMDBr0025777	Hydrogen Ion	(6S)-5,6,7,8-tetrahydrofolic acid	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO	Methylation	RHEA	34755880
MMDBr0026022	Adenosine monophosphate	Adenosine	5'-nucleotidase SurE	Hydrolysis of nucleotide; Dephosphorylation	RHEA	34755880
MMDBr0026023	Cytidine monophosphate	Adenosine	5'-nucleotidase SurE	Hydrolysis of nucleotide; Dephosphorylation	RHEA	34755880
MMDBr0026024	Uridine 5'-monophosphate	Uridine	5'-nucleotidase SurE	Hydrolysis of nucleotide; Dephosphorylation	RHEA	34755880
MMDBr0026025	Guanosine monophosphate	Guanosine	5'-nucleotidase SurE	Hydrolysis of nucleotide; Dephosphorylation	RHEA	34755880

Genome Data

Genome Link

Not Available

Genome Length

Not Available

# Predicted Proteins

GenBank Sequence Modification Date

17-FEB-2022

MiMeDB Deposition Date

Reference

PMID: 17704766

Source Links

GenBank